Morphofunctional patterns in Neotropical felids: Species co-existence and historical assembly
Morales, Miriam Mariana; Giannini, Norberto Pedro
Extant felids are morphologically homogeneous, probably as a result of recent radiation and constraints from their predatory specializations. The Neotropical assemblage comprises 12 of the 41 extant felid species, which occupy all habitats available, with many species coexisting locally. We studied this assemblage on the basis of 31 craniodental variables reflecting morphofunctional variation, measured from 229 specimens representing all 12 species. Multivariate patterns were summarized allowing for phylogenetic covariation. Additional factors (geographical distribution, use of habitat and stratum, and activity pattern) were coded for each species. As expected, body size accounted for most variation, covarying with membership to three deep clades and, to a lesser extent, with large-scale geographic variation. The species tend to segregate in morphospace plus one or more factors (e.g. habits) that make interspecific overlap in niche space minimal. Using dated phylogenies, biogeographic history, and the fossil record, we reconstructed the historical assembly of the Neotropical felid guild. We found a pattern of successive invasions and speciation in which new lineages occupied previously vacant areas of morphospace, or new species occupied overlapping areas but with contrasting habits. This may be general among antagonistic species of historically structured guilds, and we predict similar patterns in other continents.
Effects of the inclusion of bending-to-stretching transitions in the non-LTE modeling of ozone vibrational temperatures
Fernandez, Rafael Pedro; Kaufmann, Martín; Toselli, Beatriz Margarita
A description of the non-LTE intramolecular ozone relaxation cascade considering the relative importance of different transitions on the O3(v1v2v3) vibrational levels has been studied by quantifying the kinetic law of every process and transition that affect each level population. The analysis considers the inclusion for the first-time of bending-to-stretching (k2D) transitions in the energy relaxation cascade of ozone after it is formed by three-body recombination. In this way, the vibrational temperatures and the relative contribution of every transition are presented as a function of altitude. The results show that the inclusion of the bending-to-stretching transitions in the O3 non-LTE relaxation scheme decreases the ν2-mode overpopulation and therefore the stretching levels' population increases, as required for a correct radiance simulation of the 4.8γm ozone emission in the upper atmosphere.
Design and synthesis of active vitamin D analogs
Eduardo, Silvina Laura; Fraga, Ramón; Sigüeiro, Rita; Marco, Maria; Rochel, Natacha; Moras, Dino; Mouriño, Antonio
A review of the design and synthesis of structural analogs of the vitamin D hormone recently investigated in our laboratories, and the first report on a new class of vitamin D analogs characterized by an aromatic D-ring, is described.
Direct and correlated responses to artificial selection for high and low knockdown resistance to high temperature in Drosophila buzzatii
Sambucetti, Pablo Daniel; Scannapieco, Alejandra Carla; Norry, Fabian Marcelo
Knockdown resistance to high temperature (KRHT) is a genetically variable trait for thermal adaptation in insects. Selection for KRHT may affect a number of fitness components as well as resistance to several forms of environmental stress. To test for heritable (co)-variation in KRHT, we examined direct and correlated responses to bi-directional selection on this trait in Drosophila buzzatii. Replicated lines were artificially selected for decreased and increased KRHT. After 12 generations of artificial selection, lines diverged significantly for high KRHT only. Starvation resistance increased in two lines that strongly responded to selection for high KRHT, and these two lines also showed relatively longer chill-coma recovery time. Developmental time and body size showed no correlated responses to KRHT-selection. These results suggest that KRHT is a heritable trait that can evolve towards increased thermotolerance with no genetic trade-offs associated to starvation resistance, developmental time and body size.
Eficiencia agronómica del azufre elemental relativa a una fuente azufrada soluble en trigo en la región pampeana; Agronomic efficiency of elemental sulphur in wheat relative to a soluble sulphur source in the Pampas Region
Torres Duggan, Martin; Rodríguez, Monica B.; Lavado, Raul Silvio; Melgar, Ricardo
La eficiencia agronómica del azufre elemental (AE) en relación a fuentes azufradas solubles y sulfatadas, depende de su reactividad (e.g. tamaño de partícula) y de las condiciones edafo-climáticas. Para las condiciones de la Región Pampeana algunas publicaciones sugieren que el AE puede ser una fuente de S tan efectiva como las fuentes solubles, aunque la información no concluyente. Se hipotetiza que en las condiciones de la Región Pampeana, ambas fuentes poseen similar eficiencia agronómica en la mayoría de los años. Los objetivos del trabajo fueron: i. Evaluar la respuesta al agregado de S con una fuente reactiva de AE en relación a un fertilizante azufrado sulfatado, aplicado en trigo en diferentes dosis y en distintas condiciones edafo-climáticas; ii. Comparar, para el conjunto de experimentos, la eficiencia agronómica del S aplicado con las distintas fuentes. iii. Relacionar las respuestas a la fertilización azufrada con variables de suelo y clima. Se realizaron ocho ensayos de campo durante dos años consecutivos en lotes de producción ubicados en la Región Pampeana. Se aplicó un diseño en bloques completos aleatorizados con cuatro o seis repeticiones en un arreglo factorial de tratamientos (factor 1: fuente azufrada, factor 2: dosis de S). Los tratamientos fueron: un testigo absoluto; fertilización con AE micronizado (95% de S) en dos niveles de dosis y fertilización con sulfato de amonio granulado (SA, 24% S), también en dos niveles de dosis. Las dosis evaluadas fueron 10 y 30 kg ha-1 de S (año 1) y 15 y 30 kg ha1 (año 2). La fertilización azufrada afectó significativamente (p<0,05) los rendimientos del trigo en cuatro de cinco sitios en el primer año y en todos los sitios durante el segundo año de experimentos. Las respuestas del trigo al S se ubicaron en el rango de 231 a 857 kg ha-1 en el primer año y entre 702 y 2.119 kg ha-1 en el segundo año. No se observaron efectos significativos de fuente (efectividad) en las respuestas observadas o en la eficiencia agronómica del S aplicado (kg de grano kg de S aplicado en la mayoría de los sitios), confirmándose que, para el conjunto de experimentos, ambos fertilizantes fueron igualmente efectivos para proveer SO 2-al cultivo. Tampoco se detectó efecto significativo de dosis o interacción fuente x dosis (p>0,05) en la mayoría de los sitios. La dosis más baja (10 o 15 kg ha-1) fue suficiente para cubrir el requerimiento de S del cultivo. Se observó una asociación positiva entre las respuestas y el contenido de MO del suelo y las precipitaciones (macollaje y total del ciclo) y una relación inversa con el contenido de S-SO42- disponibles a la siembra, ésta última con bajo ajuste (r2 medio=0,18). No se observó asociación entre las respuestas y la temperatura en macollaje o en el ciclo. Se concluye que el AE resultó una fuente azufrada con similar eficiencia que el SA para aportar S al trigo en la Región Pampeana.; Agronomic efficiency of elemental sulphur (AE) compared with soluble and S-sulphate sulphur sources depends on reactivity of AE (e.g. particle size) and environmental conditions (soil and climate). Although there is published information suggesting that elemental sulphur has similar effectiveness than soluble sulphur sources, the information is not conclusive. We hypothesized that agronomic efficiency of AE and soluble S sources are similar under the Pampas Region conditions. The objectives of the study were to: i. Evaluate S grain response to a reactive source of AE compared to a soluble S source under different S rates and soil and climate conditions. ii. Compare, for the group of experiments, agronomic S efficiency between S sources. iii: Relate S responses with soil and climatic variables. Eight field experiments were conducted during two successive years on cropping systems in the Pampas Region. The experimental design was a randomized complete block with four or six replicates and a factorial treatment arrangement (factor 1: S source, factor 2: S rate). The treatments were: check (without S application), fertilization with a micronized source of AE (95% of S) and a fertilization treatment with ammonium sulphate (SA, 24%). Both sulphur sources were applied at two S rates. Sulphur rates were 10 and 30 kg ha1 (year 1) and 15 and 30 kg ha-1 (year 2). In the first year, wheat responded significantly to S in four of five sites (p<0.05) with yield increases of 231 to 857 kg ha-1. Significant yield increases were observed in all sites in the second year, ranging from 702 to 2,119 kg ha-1. There were no significant differences in grain yield among S sources, rates or interaction source x S rates (p>0.05) in most sites. When all sites were combined, sulphur sources presented similar agronomic S efficiencies (p>0.05). The lower S rate (10 or 15 kg ha1) was enough to provide S to the crop under the Pampas Region conditions. Grain yield responses to S were positively correlated with organic matter content and rainfall (during tillering or the whole crop cycle) and inversely associated with SO42- at planting, although with a poor adjustment. No correlation was detected between S response and temperatures during tillering or the whole crop cycle.
Garlic powder and wheat bran as fillers: Their effect on the physicochemical properties of edible biocomposites
Fama, Lucia Mercedes; Bittante, Ana Mônica B. Q.; Sobral, Paulo J. A.; Goyanes, Silvia Nair; Gerschenson, Lia Noemi
Biocomposites with two different fillers, garlic and wheat bran, were studied. They were based on cassava starch and contained glycerol as a plasticizer and potassium sorbate as an antimicrobial agent and were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and infrared spectroscopy (IR). The mechanical performance at room and lower temperatures was also studied. SEM micrographies of fractured surfaces of the wheat bran composite films showed some ruptured particles of fiber while fibrils of garlic on the order of nanometers were observed when garlic composite films were studied. Mechanical tests, at room temperature, showed that the addition of wheat bran led to an increment in the storage modulus (E′) and hardening and a decrease in Tan δ, while the garlic composite showed a diminishing in the E′ and hardening and did not produce significant changes in Tan δ values when compared with systems without fillers (matrix). In the range between -90 °C and 20 °C, all the materials studied presented two peaks in the Tan δ curve. In the case of the wheat bran composite, both relaxation peaks shifted slightly to higher temperatures, broadened and diminished their intensity when compared with those of the matrix; however garlic composite showed a similar behavior to the matrix. DSC thermograms of aqueous systems showed a slight shift of gelatinization temperature (Tgelatinization) to higher values when the fillers were present. Thermograms of films showed that both, garlic and wheat bran composites, had a lower melting point than the matrix. IR data indicated that interaction between starch and fillers determined an increase in the availability of hydroxyl groups to be involved in a dynamic exchange with water.
The INGV–CMCC Seasonal Prediction System: Improved Ocean Initial Conditions
Alessandri, Andrea; Borrelli, Andrea; Masina, Simona; Cherchi, Annalisa; Gualdi, Silvio; Navarra, Antonio; Di Pietro, Pierluigi; Carril, Andrea Fabiana
The development of the Istituto Nazionale di Geofisica e Vulcanologia (INGV)–Centro Euro-Mediterraneo per i Cambiamenti Climatici (CMCC) Seasonal Prediction System (SPS) is documented. In this SPS the ocean initial-conditions estimation includes a reduced-order optimal interpolation procedure for the assimilation of temperature and salinity profiles at the global scale. Nine-member ensemble forecasts have been produced for the period 1991–2003 for two starting dates per year in order to assess the impact of the subsurface assimilation in the ocean for initialization. Comparing the results with control simulations (i.e., without assimilation of subsurface profiles during ocean initialization), it is shown that the improved ocean initialization increases the skill in the prediction of tropical Pacific sea surface temperatures of the system for boreal winter forecasts. Considering the forecast of the 1997/98 El Nin˜o, the data assimilation in the ocean initial conditions leads to a considerable improvement in the representation of its onset and development. The results presented in this paper indicate a better prediction of global-scale surface climate anomalies for the forecasts started in November, probably because of the improvement in the tropical Pacific. For boreal winter, significant increases in the capability of the system to discriminate above-normal and below-normal temperature anomalies are shown in both the tropics and extratropics.
On sign conditions over real multivariate polynomials
Jeronimo, Gabriela Tali; Perrucci, Daniel Roberto; Sabia, Juan Vicente Rafael
We present a new probabilistic algorithm to find a finite set of points intersecting the closure of each connected component of the realization of every sign condition over a family of real polynomials defining regular hypersurfaces that intersect transversally. This enables us to show a probabilistic procedure to list all feasible sign conditions over the polynomials. In addition, we extend these results to the case of closed sign conditions over an arbitrary family of real multivariate polynomials. The complexity bounds for these procedures improve the known ones.
Las principales reformas de la relación salarial operadas durante el período 2002-2009
Berasueta, Ana Cecilia; Biafore, Eugenio; Neffa, Julio Cesar; Wahlerb, Verónica Laura
El tema de los cambios en las instituciones y en las normas de derecho del trabajo y de la seguridad social a lo largo del tiempo da lugar a muchos estudios y controversias, dada la tendencia a evolucionar en diversos sentidos. En un primer documento (Neffa, Biafore, Cardelli y Gioia, 2005) la atención del equipo de investigación se centró en el relevamiento de las reformas laborales que se introdujeron durante el régimen de la convertibilidad (periodo 1989-2001) confrontándolo con la situación precedente. De allí surgió la evidencia de que a pesar de que se considera que en ese periodo la política económica tuvo como objetivo la desregulación, sucedió lo contrario en materia laboral: fue uno de los periodos en que más se sancionaron leyes, decretos y normas ministeriales. Pero tuvieron otra dirección: fue para re-regular el funcionamiento del mercado de trabajo y hacerlo coherente con el modo de desarrollo. El resultado de ese proceso contradijo los postulados de la teoría neoclásica del mercado de trabajo: estos cambios para desregular, re-regular y flexibilizar no dieron como resultado el pleno empleo, sino por el contrario las tasas más elevadas de desempleo, de subempleo, de trabajo no registrado, de pobreza e indigencia a lo largo de la historia económica y social argentina. En el presente documento, se realiza el mismo ejercicio, pero en el periodo de la post-convertibilidad (2002-2009). Nuevamente se pudo verificar la hipótesis de que el mundo del trabajo argentino es plenamente dinámico y en transformación y que las normas se modificaron en varias direcciones, al impulso de los cambios estructurales del sistema productivo, que a su vez los condicionan. No hay determinismos, la relación es dialéctica y refleja la correlación de las fuerzas sociales en pugna. El contenido central del documento sigue una estructura similar al anterior. La introducción se propone caracterizar y sistematizar los cambios ocurridos durante la vigencia del régimen de convertibilidad en las instituciones y normas laborales, procurando encontrar la lógica subyacente. Es una visión sintética y de conjunto inspirada en el primer documento. Lo denominaremos "La herencia recibida. El punto de partida"
Effects of reproductive stage and temperature on rates of oxygen consumption in Paralithodes platypus (Decapoda: Anomura)
Romero, Maria Carolina; Tapella, Federico; Stevens, Bradley; Loren Buck, C.
Paralithodes platypus is a large decapod that inhabits Alaskan and North Pacific waters. Females exhibit a biennial spawning cycle, requiring two years for production of fully mature oöcytes. We used respirometry and video recording to determine: 1) metabolic rates of brooding and post-brooding females, embryos, and larvae at different temperatures, 2) if females exhibit active brood care, 3) oxygen availability within the clutch, and 4) the timing of larval hatching. The rates of oxygen consumption (MO2) of brooding females was significantly higher than that of post-brooding females at night, but was similar during the day and increased significantly with temperature. MO2 of crab embryos did not differ with position in the clutch, whereas MO2 of zoeae averaged 4-fold higher than that of embryos. Larvae from the periphery of the embryo mass, either top or bottom, hatched prior to larvae from the middle of the clutch. Oxygen availability in the embryo mass varied significantly with position in the clutch; saturation was highest at the top (~ 91%), and lowest at the middle (~ 66%). Flapping of the pleon in brooding females was coincident with sudden increases in oxygen availability at the bottom of the embryo mass. The percentage of time that brooding females were engaged in flapping of the pleon was 30% higher at night than during the day. Our results address the cost of brooding in a lithodid crab and the effects of temperature on this behavior. The importance of pleonal flapping to ventilation of the embryo mass and alternative hatching mechanisms is discussed.
Weighted Best Local ||.|| - Approximation in Orlicz Spaces
Cuenya, Hector Hugo; Favier, Sergio José; Levis, Fabián Eduardo; Ridolfi, Claudia Vanina
In this paper we prove the existence of best multipoint local ||·||−approximation to a function f from an N−dimensional space SN for a suitable integer N. This problem is considered in an arbitrary Orlicz space for both the Luxemburg and the Orlicz norms when some bits of data are more important than others. For this purpose, we introduce the concept of || · ||−balanced integer.
Molecular diversity of peanut-nodulating rhizobia in soils of Argentina
Bogino, Pablo Cesar; Banchio, Erika; Giordano, Walter Fabian
RSα sequencing is a valuable tool for identification of bacterial strains, and for evaluating the genetic structure of indigenous rhizobial populations. The purpose of this study was to evaluate, qualitatively, the presence or absence of RSα fragment in peanut‐nodulating strains isolated from plants grown at four sites in central Argentina. RSα fragment was found in only three of 26 indigenous strains, and in one of three inoculant strains analyzed. In contrast to results from studies of other symbiotic nitrogen‐fixing bacteria, such as soybean‐nodulating strains, no correlation was found between generation time and presence of RSα sequence. Phylogenetic analysis of the 16S rRNA gene sequence grouped peanut‐nodulating strains into two clusters, Bradyrhizobium japonicum vs. B. elkanii, and showed divergence among strains positive for RSα sequence. Our results confirm the genetic diversity previously reported for various peanut‐nodulating rhizobial strains, and indicate that the RSα fragment is not applicable as a marker or tool for competition assays at the field or ecological level.
Investigation of UPQC for Sag Compensation in Wind Farms to Weak Grid Connections
Farias, M. F.; Battaiotto, Pedro Eduardo; Cendoya, Marcelo Gustavo
In the last years, the wind power generation incorporated into standard grids has been increased significantly. This situation forced the revision of grid connection code requirements, to guarantee the reliability in systems with high wind power penetration. In case of events like voltage sags, wind farms must keep connected to power system avoiding power imbalance and even system collapse. For induction generator based wind farms connected to weak grids, such sag may lead to wind farm outage. Several strategies have been proposed in the literature, but often for full or partial amplitude voltage restoration, without caring phase jump associated to voltage sags. In this work a voltage sag compensation strategy is proposed for voltage magnitude restoration with phase jump compensation, and compared with a magnitude only restoration strategy. These strategies were implemented using a Unified Power Quality Compensator UPQC. A model of wind farm with induction generators connected to a weak grid system, including a detailed UPQC compensator was developed on simulation software. Then simulations were conducted in order to compare the proposed compensation strategy with previous methods. Results show a better wind farm performance in proposed strategy than that found in magnitude only compensation schemes. Also, the power rating of the compensators used in the proposed strategy is similar than the one that would be required in classical strategies. Thus, considering the improvement in performance, the proposed strategy is recommended in retrofitting the existing installed fixed speed induction generators based wind farms.
El Marx de Dussel: Notas acerca de la recepción dusseliana de la obra teórica de Karl Marx; The Marx of Dussel: Notes on dusselian receipt of the theoretical work of Karl Marx
Teruel, Flavio Hernán
A partir de su exilio en México, a mediados de la década del setenta del siglo pasado, Enrique Dussel se entrega a la tarea de "leer seria y directamente" la obra teórica de Karl Marx producida entre los años 1857 y 1882. Al cabo de diez semestres de arduo trabajo, el resultado es una interpretación novedosa de las cuatro redacciones de El Capital. En efecto, ante los ojos de Dussel la obra maestra de Karl Marx se revela no solo como un tratado de economía sino antes bien como uno de antropología y ética. Marx, afirma Dussel, "deconstruye la economía capitalista críticamente y la reconstruye antropológica y éticamente". Asimismo, Dussel descubre que la producción teórica de Marx quedó inconclusa y, sobre todo, abierta a futuros desarrollos. Para el filósofo mendocino es necesario, en nuestro tiempo, no solo reinterpretar la totalidad de la obra de Marx sino también continuar su labor teórica, en especial desde América Latina, para el estudio del capitalismo periférico latinoamericano. Nuestro interés es indicar aquellos elementos que constituyen lo novedoso en la interpretación dusseliana de la obra teórica de Marx.; From his exile in Mexico in the mid seventies of last century, Enrique Dussel is given the task of "reading seriously and directly" the theoretical work of Karl Marx produced between 1857 and 1882. After ten semesters of hard work, the result is a novel interpretation of the four drafts of The Capital. Indeed, in the eyes of Dussel, the masterpiece of Karl Marx is revealed not only as an economic treatise but rather as an anthropology and ethics. Marx "capitalist economy critically deconstructs and reconstructs anthropological and ethically". Moreover, Dussel finds that the theoretical yield of Marx was inconclusive and, above all, open to future developments. For the philosopher is needed in our time, not only reinterpret the whole work of Marx but also to continue his theoretical work, especially from Latin America, for the study of Latin American peripheral capitalism. Our interest is to indicate those elements which constitute the novelty in dusseliana interpretation of Marx's theoretical work.
Additional morphometrical data on some Heligmonellidae (Nematoda: Trichostrongylina) parasitic in Neotropical rodents (Cricetidae); Nouvelles données métriques et morphologiques sur_ quelques Heligmonellidae (Nematoda : Trichostrongylina) parasites de Rongeurs néotropicaux (Cricetidae)
Durette Desset, M. C.; Digiani, Maria Celina
Some additional morphological and metrical data are provided, particularly on the synlophe of the following species: Hassalstrongylus dessetae Pinto, 1978, Stilestrongylus eta (Travassos, 1937), Stilestrongylus manni Denké & Murúa, 1977 and Stilestrongylus valdivianus Durette-Desset & Murúa, 1979, based on type and voucher material deposited in Brazilian and French collections. Heligmonoides crassidorsualis Franco, 1967 is considered as a Nippostrongylinae incertae sedis: its synlophe not being known it is impossible to report the species to a given genus. However, it is unlikely that the species belong to the genus Heligmonoides Baylis, 1928, present only in commensal Murinae from the Old World. Heligmonoides mirzai Smales, 2009, is also regarded, temporarily, as a Nippostrongylinae incertae sedis.; Nous apportons quelques nouvelles données métriques et morphologiques, en particulier sur le synlophe des espèces suivantes: Hassalstrongylus dessetae Pinto, 1978, Stilestrongylus eta (Travassos, 1937), Stilestrongylus manni Denké & Murúa, 1977 et Stilestrongylus valdivianus Durette-Desset & Murúa, 1979, sur la base de matériel type et de matériel complémentaire déposés dans des collections brésiliennes et françaises. Heligmonoides crassidorsualis Franco, 1967 est considéré comme un Nippostrongylinae incertae sedis: son synlophe étant inconnu, il est impossible d’attribuer l’espèce à un genre donné. Il est pourtant improbable que l’espèce concerne le genre Heligmonoides Baylis, 1928, présent seulement chez des Murinae commensaux de l’Ancien Monde. Heligmonoides mirzai Smales, 2009, est aussi considérée, temporairement, comme un Nippostrongylinae incertae sedis.
La técnica y la política en la configuración de la segunda línea del peronismo
Biernat, Carolina; Ramacciotti, Karina
Este artículo rastrea las redes de relaciones que permitieron a dos de los funcionarios accedan y permanezcan en la administración pública durante los años del primer peronismo. Se centra en los recorridos académicos y políticos de Santiago Peralta, Director de Inmigración, y Ramón Carrillo, Secretario de Salud y luego el primer Ministro de Salud de la Argentina. Además, se propone indagar sobre nuevos cortes temporales en el alejamiento de estas figuras de la función pública, como 1947 y 1954, relacionándolos con razones de orden político, administrativo y con los vínculos establecidos con Juan Domingo Perón. La propuesta permite avanzar en el estudio de las formas de reclutamiento en la administración pública y en las capacidades reales o potenciales con que cuenta el Estado a la hora de diseñar e implementar una política pública.
Tumores del sistema nervioso central de localización selar y supraselar. Alteraciones neuro-oftalmológicas y de la función endócrina al diagnóstico
Warman, M.; Guercio, G.; Ciaccio, M.; Costanzo, M.; Di Palma, M. I.; Vaiani, E.; Maceiras, M.; Chaler, E.; Mendilaharzu, H.; Belgorosky, Alicia; Rivarola, Marco Aurelio
Los tumores del SNC constituyen la segunda enfermedad oncológica en edad pediátrica, con una incidencia referida aproximada que oscila entre el 10 y 15 %. La ubicación es selar-supraselar. En 309 pacientes con tumores selares y supraselares, seguidos durante 15 años, se evaluó en función de los distintos oncotipos tumorales, síntomas iniciales y alteraciones endocrinológicas previas al inicio del tratamiento. De ellos, 227 pacientes presentaron el tumor a edad prepuberal. Los oncotipos tumorales más frecuentes fueron craneofaringioma (CRA), glioma (GLIA) y tumor de células germinales (GERM). También, se encontró una mayor incidencia de presentación en varones. En edad puberal (n:92), el oncotipo tumoral más frecuente fue adenoma (ADENO), seguido de GLIA y CRA. En este ultimo oncotipo tumoral, y, a diferencia del grupo prepuberal, su incidencia fue significativamente mayor en niñas. Aproximadamente 90% de los pacientes tuvieron anormalidades neuro-oftalmológicas (hipertensión craneal, dolores de cabeza, vómitos y pérdida progresiva de la visión) como uno de los signos iniciales y/o síntomas. Alteraciones clínicas endocrinológicas como baja talla, velocidad de crecimiento anormal, diabetes insípida y alteraciones del tempo puberal son frecuentes en estos pacientes y están frecuentemente asociados con las alteraciones clínico-neuro-oftalmológicas como los ya mencionadas. No obstante, la mayoría de los tumores del SNC localizados en la línea media suelen ser diagnosticados por manifestaciones neuro-oftalmológicas. Los resultados del estudio muestran alteración de la función endócrina al diagnostico del Tu. Se concluye que en todo paciente con crecimiento lento o baja talla, así como también signos clínicos que orienten a un diagnóstico de pubertad precoz y/o retardada debe alertar al pediatra de incluir dentro de los diagnósticos diferenciales, el diagnóstico del tumor selar o supraselar. La morbilidad aumenta frecuentemente luego de la cirugía.; During the last 15 years, 309 patients with tumors of the sellar and suprasellar areas of CNS were followed in our Hospital (Endocrine Service). Tumor oncotype, initial symptoms and endocrine disturbances before any treatment was started are presented. In 227 patients, the tumor was diagnosed at prepubertal age. In this group, the most frequent tumoral oncotypes were craniopharyngioma (CRA), glial tumors (GLIA) and germ cells tumors (GERM). The incidence was higher in boys. At pubertal age (n:92), the most frequent tumoral oncotype was pituitary adenoma (ADENO), followed by GLIA and CRA. In the latter, and different from the prepubertal group, the incidence was significantly higher in girls. Approximately 90% of patients had neuro-ophtalmological abnormalities (cranial hypertension, headaches, vomits, and progressive loss of vision) as one of the initial signs and/or symptoms. Clinical endocrine disorders, such as short stature, low growth velocity, diabetes insipidus, and alterations in pubertal “tempo” are frequent in these patients and are often associated with the neuro-ophtalmological abnormalities mentioned above. This clinical symptomatology has to alert the medical team to discard the presence of a CNS tumor at the sellar and/or suprasellar level. We conclude that tumors of the SNC localized in the midline, have potential capacity to provoke abnormalities in endocrine function. Morbidity is often increased after surgery.
