Segunda biblioteca de RADSeq de Pleoticus muelleri Biblioteca de secuencias de ADN asociado a sitios de restricción (RADSeq) de 96 individuos de Pleoticus muelleri.

Modeling and solving an integrated periodic vehicle routing and capacitated facility location problem in the context of solid waste collection González, Begoña; Rossit, Diego Gabriel; Frutos, Mariano; Méndez, Máximo Few activities are as crucial in urban environments as waste management. Mismanagement of waste can cause significant economic, social, and environmental damage. However, waste management is often a complex system to manage and therefore where computational decision-support tools can play a pivotal role in assisting managers to make faster and better decisions. In this sense, this article proposes, on the one hand, a unified optimization model to address two common waste management system optimization problem: the determination of the capacity of waste bins in the collection network and the design and scheduling of collection routes. The integration of these two problems is not usual in the literature since each of them separately is already a major computational challenge. Two improved exact formulations based on mathematical programming and two metaheuristic methods are provided to solve this proposed unified optimization model. It should be noted that the metaheuristics consider a mixed chromosome representation of the solutions combining binary and integer alleles, in order to solve realistic instances of this complex problem. Different parameters of the metaheuristics considered – a Genetic Algorithm and a Simulated Annealing algorithm – have been tested to study which combination of them obtained better results in execution times on the order of that of the exact solvers. The achieved results show that the proposed metaheuristic methods perform efficient on large instances, where exact formulations are not applicable, and offer feasible, high-quality solutions in reasonable calculation times.

Spectrally distinguishing symmetric spaces I Lauret, Emilio Agustin; Rodríguez, Juan Sebastián We prove that the irreducible symmetric space of complex structures on (resp. quaternionic structures on ) is spectrally unique within a 2-parameter (resp. 3-parameter) family of homogeneous metrics on the underlying differentiable manifold. Such families are strong candidates to contain all homogeneous metrics admitted on the corresponding manifolds. The main tool in the proof is an explicit expression for the smallest positive eigenvalue of the Laplace-Beltrami operator associated to each homogeneous metric involved. As a second consequence of this expression, we prove that any non-symmetric Einstein metric in the homogeneous families mentioned above is -unstable.

Fipronil tissue residues and withdrawal period feasibility in laying hens after extra‐label use Cantón, Lucila; Berkovic, Andrea Mariela; Ceballos, Laura; Cantón, Candela; Lanusse, Carlos Edmundo; Alvarez, Luis Ignacio; Moreno Torrejon, Laura Fipronil, a broad-spectrum insecticide, is often used off-label in laying hens to control red mites. This study investigatedfipronil residue levels in hen tissues after simulating common extra-label administrations: in-feed (1 mg kg−1 twice) and transdermal (1 mg kg−1 once). Fipronil residues were quantified by HPLC-MS/MS. Both administrations resulted in quantifiableresidues in edible tissues (muscle, liver, kidney, skin, fat) and feathers for up to 60 days. Fipronil-sulfone, the primary metabolite, was the dominant residue in tissues. Fat accumulated the highest concentrations. In-feed administration led to higheroverall residues in edible tissues, while transdermal application resulted in higher concentrations in feathers. Calculated withdrawal periods, based on established MRLs, ranged from 36 days (muscle, transdermal) to 131 days (fat, transdermal). Theselong withdrawal periods render both administration routes impractical for poultry production. The study highlights the riskof fipronil residues in poultry products and suggests feather/fecal sampling for monitoring illicit use.

Concentración de compuestos organobromados en Delphinus delphis y Lagenodelphis hosei Concentración de compuestos organobromados expresados en ng.g−1 de peso húmedo, determinados en tejido adiposo de Delphinus delphis y Lagenodelphis hosei

Isospectral CR Manifolds with Respect to the Kohn Laplacian Gutierrez, Gerson; Lauret, Emilio Agustin; Rossetti, Juan Pablo We prove that the spectrum of the Kohn Laplacian does not determine the equivalence classes of CR manifolds. We construct pairs of odd-dimensional elliptic manifolds that are not equivalent as CR manifolds but whose Kohn Laplacians have the same spectrum. These manifolds are endowed with the CR structures inherited from the canonical CR structure on the sphere of the same dimension.We provide three different constructions among lens spaces and an additional one among elliptic manifolds with non-cyclic fundamental groups.

Causality by Vote: Aggregating Evidence on Causal Relations in Economic Growth Processes de Mier, Manuel; Delbianco, Fernando Andrés; Tohmé, Fernando Abel In this paper, we investigate the performance of fivecausality-detection methods and the aggregation of their resultswhen considering multiple units in a panel data setting. We employvoting rules as an aggregation procedure to determine which causalpaths are identified for the sample population. Using both simu-lated and real-world panel data, we show the performance of thesemethods in detecting the correct causal paths by comparing themto a benchmark that represents a standard growth model as theground truth.

“Segundo Censo de la República Argentina” del año 1895" Terriotrios Naci Neuquen y Rio Negro - paginas 658 “Cuadro VII a.” - 659 “Cuadro VII a.”- 661 “Cuadro VII b.” “Segundo Censo de la República Argentina” del año 1895, Página 658 “Cuadro VII a.” “Población por nacionalidad y sexo” Población que corresponde a los países americanos que corresponde a los territorios Nacionales del Chaco, territorio nacional de La Pampa y territorio nacional de Neuquén, Página 659 “Cuadro VII a.” “Población por nacionalidad y sexo” Población que corresponde a los países americanos que corresponde a los territorios Nacionales de Río Negro, territorio nacional de Chubut, territorio nacional de Santa Cruz y territorio nacional de Tierra del Fuego. Página 661 “Cuadro VII b.” “Población por nacionalidad y sexo” Población que corresponde a los países europeos que corresponde a los territorios Nacionales de Neuquén, de Río Negro, de Chubut y de Tierra del Fuego. Los datos de estos cuadros resultan de gran relevancia para poder conocer, a partir de una fuente de información documental, la composición de la población de los territorios nacionales de Rio Negro y Neuquén (área de investigación en especial la zona cordillerana) por aquel entonces y el peso de la población argentina, chilena y europea. Adquiere doblemente importancia como fuente de información ya que existen muy pocas fuentes documentales de aquel entonces. Las cuadros se presentan en publicaciones a modo de soporte documental (y cuantitativo) de la información analizada cualitativamente.

Quercetin-loaded magnetic nanoparticles: a promising tool for antitumor treatment in human breast cancer cells Tiburzi, Silvina Mabel; Lezcano, Virginia Alicia; Principe, Gabriel; Montiel Schneider, María Gabriela; Miravalles, Alicia Beatriz; Lassalle, Verónica Leticia; Bruzzone, Ariana; González Pardo, María Verónica Quercetin (QUE) is a phytoestrogen with known antitumor properties; however, its hydrophobic nature and low bioavailability limit its efficacy as an anticancer drug. To address this, we explored loading QUE onto a non-toxic nanocarrier. This study focused on the biological activity of magnetic iron oxide nanoparticles coated with polyethylene glycol (MAG@PEG) loaded with QUE (MAG@PEG@QUE) in MCF-7 cells. The MAG@PEG nanosystem was synthesised using a hydrothermal method, and QUE was incorporated by adding an alcoholic solution of QUE to an aqueous dispersion of MAG@PEG. QUE incorporation was confirmed qualitatively by FTIR spectroscopy and quantitatively through UV–visible spectroscopy. Cytotoxicity studies showed that MAG@PEG@QUE, at a concentration equivalent to the half-maximal inhibitory concentration (IC50) of free QUE, significantly reduced cell proliferation and viability while increasing apoptosis. MCF-7 cells treated with MAG@PEG@QUE also displayed actin cytoskeleton alterations typical of apoptotic cells. Transmission electron microscopy revealed clusters of magnetic nanoparticles within cellular vesicles. Targeted delivery of these nanoparticles was achieved using a static magnetic field, leading to high intracellular accumulation and selective cell death in targeted areas, without affecting adjacent cells. In conclusion, MAG@PEG@QUE shows comparable antitumor effects to free QUE and has the potential to enhance QUE’s bioavailability and targeted delivery for breast cancer treatment

Tecnologías de modificación corporal y personas travestis y trans en Argentina: un estudio cuantitativo sobre desigualdades en el uso y acceso; Body modification technologies and transvestite and trans people in Argentina: A quantitative study on inequalities in use and access Farji Neer, Anahí; Dellacasa, María Alejandra; Sustas, Sebastián Ezequiel; Antoniucci, Melina Beatriz; Rustoyburu, Cecilia Alejandra; Noceti, Clara Inés; Mateo, Natacha; Roca, Alejandra Rosario La salud colectiva ha aportado perspectivas analíticas de gran riqueza para comprender la determinación social de la salud y cómo las dinámicas de desigualdad, inequidad e iniquidad son productoras de padecimientos, enfermedades, morbilidad y mortalidad. Desde esta mirada, en este trabajo se identifican y analizan modalidades de apropiación y uso de distintas hormonas e intervenciones de modificación corporal de la población travesti y trans en Argentina, con el propósito de visibilizar las situaciones de vulnerabilidad que puedan estar implicadas en estas prácticas, tanto aquellas realizadas fuera del sistema de salud como las que tuvieron acompañamiento profesional en una institución. Se adoptó una estrategia metodológica cuantitativa, con un diseño descriptivo, observacional y de corte transversal. En 2023, se realizó un relevamiento a través de un cuestionario a nivel federal a personas travestis y trans mayores de 16 años (n=1.196). Los datos analizados dan cuenta de procesos de vulnerabilidad que no se extienden de manera homogénea en toda la población y que responden a desigualdades en salud.; Collective health has provided valuable analytical perspectives for understanding the social determinants of health and how dynamics of inequality, inequity, and injustice contribute to suffering, disease, morbidity, and mortality. From this perspective, this study identifies and analyzes the ways in which transvestite and trans people in Argentina appropriate and use different hormones and body modification interventions, aiming to highlight the vulnerabilities associated with these practices, both those performed outside the healthcare system and those carried out with professional support in an institution. A quantitative methodological strategy was adopted, with a descriptive, observational, and cross-sectional design. In 2023, a nationwide survey was conducted using a questionnaire targeting transvestite and trans people aged 16 and older (n=1,196). The analyzed data reveal vulnerability processes that do not extend uniformly across the entire population and are linked to health inequalities.

Late Miocene expansion of grasslands in northwest Argentina linked to shifting hydroclimate: A complex interaction among tectonics, climate, and ecology Azmi, Iffat; Hyland, Ethan; Cotton, Jennifer; Ghosh, Adit; Raigemborn, María Sol; Tineo, David; Hauswirth, Scott; Insel, Nadja Factors driving the late Miocene expansion of C4 grasses remain widely debated. Here, we explored the role of climate and fire in controlling the abundance of C4 vegetation in the Angastaco Basin (Palo Pintado area) and La Viña Basin, NW Argentina, during the late Miocene (ca. 14−5.33 Ma). From paleosol horizons, we reconstructed paleoclimate and paleovegetation conditions using phytolith assemblages, geochemical and isotopic proxies, and polycyclic aromatic hydrocarbons (PAHs) to determine fire input. Our paleoclimate reconstructions suggest a stable mean annual temperature (MAT) of ∼10 °C and a gradual decline in mean annual precipitation (MAP) from 1100 mm yr−1 to 850 mm yr−1. Paleovegetation reconstructions from carbon isotopic composition and phytolith assemblages show a maximum of ∼15% C4 vegetation by 6 Ma. No significant increases in fire occurrence or establishment of fire feedbacks were identified from the PAH data. Though low in abundance (∼3% on average), our data identified the presence of C4 grass by the late Miocene. The lack of significant C4 expansion in this region was likely controlled by the changing hydroclimatic conditions associated with the Andes mountain range—increasing aridity and elevation constraints along with the lack of a fire feedback might have limited the distribution of C4 vegetation.

Datos crudos de secuenciación masiva del gen 16S-ARNr obtenidos a partir de muestras ambientales durante un proceso de oxidación-bioestímulo-fitorremediación aplicado a barros petroquímicos The generation of oily sludges with a high hydrocarbon content is an unavoidable problem for the petrochemical industry. The goal of this project is to study microbial community structure of oily sludges from petroleum refineries, treated with chemical (e.g. oxidation) and/or biological remediation strategies (e.g. composting, phytoremediation) throughout the full process. A deep understanding of microbial community dynamics during the remediation process provides the support for a better design of sustainable management strategies to treat oily sludges.

Censo de puestos por productos en la Manka Fiesta, en las ediciones de 2018 a 2024 Censo realizado en días domingos durante la Manka Fiesta, feria anual realizada en La Quiaca entre el 2do y el 3er domingo de cada octubre. Se censaron todos los puestos según su tipo de producto mayoritario. En cada columna (toma específica) se indica el día del relevamiento, desde 2018 a 2024, excepto 2020, y quién realizó el censo

Datos crudos de secuenciación masiva del gen 16S-ARNr obtenidos a partir de muestras de un suelo contaminado con PAH de manera aguda e inoculado con distintos consorcios bacterianos The goal of this project is to compare bioaugmentation with different inocula on an artificially hydrocarbon contaminated soil and understand how it impacts on contaminant degradation and bacterial community diversity.

Unraveling anthelmintic targets and mechanisms of action of trans-cinnamaldehyde from cinnamon essential oil Hernando, Guillermina Silvana; Turani, Ornella; Rodriguez Araujo, Noelia; Pulido Carrasquero, Alcibeth Yoselin; Bouzat, Cecilia Beatriz Parasitic nematodes pose a significant global socio-economic threat and contribute to neglected diseases. Current infection control relies on drug therapy, but increasing anthelmintic resistance highlights the urgent need for novel treatments. In this study, we investigate the molecular targets and mechanisms of action of trans-cinnamaldehyde (TCA), a principal component of Cinnamon Essential Oil (Cinnamomum verum EO), using Caenorhabditis elegans as a model organism. Our research offers new insights into the anthelmintic effects of TCA by identifying its specific interactions with key Cys-loop receptors and detailing its inhibitory mechanisms. The anthelmintic activity of C. verum EO and TCA manifests as rapid alterations in locomotor activity and inhibition of egg hatching. TCA screening of mutant worms lacking Cys-loop receptors reveal multiple receptor targets, including the levamisole-sensitive nicotinic ACh receptor (L-AChR), GABA-activated chloride channel (UNC-49) and glutamate-activated chloride channel. The mechanism behind the egg hatching inhibition by TCA remains unclear, as none of the mutants studied were found to be resistant to TCA. Furthermore, TCA increases the paralyzing effects of the anthelmintics levamisole and monepantel in a synergistic manner, offering a route for more effective polytherapy strategies. Electrophysiological studies on C. elegans Cys-loop receptors, in both native and heterologous systems, were used to elucidate the molecular mechanisms of TCA-induced paralysis. TCA reduces ACh- and GABA-elicited macroscopic currents and decreases single-channel activity and open durations of native muscle L-AChR channels, indicating an inhibitory action. Thus, by acting through a different mechanism to that of classical anthelmintics, TCA may be beneficial to counteract resistance in combined anthelmintic therapies. Our findings underscore the potential of the multitarget compound TCA as a valuable tool in integrated pharmacological strategies

Planted pioneer trees function as nurses after a decade in the mountains of Central Argentina Early enrichment of non-pioneer tree species in forest restoration sites is challenging, especially where nurse trees and soil nutrients have been lost promoting sapling dieback and death from sun, wind, and frost exposure. We hypothesized that pioneer tree stand age, microsite and fertilization would enhance performance of non-pioneer species by reducing dieback, with fertilization being most effective when planting at open microsites or with younger nurse trees. Our study was performed in the first montane forest restoration in Central Argentina, where pioneer trees were successfully planted but Maytenus boaria, a late-successional species, struggled with dieback during dry/cold seasons. We experimentally planted M. boaria saplings in a three factor design: Pioneer tree stand age (2, 6, and 11 years), microsite (closed and open), and NPK fertilization (with or without). We monitored M. boaria for 15 years. Survival was almost double at closed (69%) compared to open microsites (37%), and marginally higher at the 11-year-old stand. Final height was over double at the 11-year-old stand compared to the 2- and 6-year-old stand. Fertilization increased height only in the 11-year-old stand, both in closed and open microsites. Contrary to our expectations, fertilization and proximity to trees slightly increased dieback. We conclude pioneer trees act as nurses for M. boaria but not due to protection from dieback causing agents. When natural regeneration does not occur, a good practice would be to plant non-pioneers a decade after planting the pioneer trees, at closed microsites and applying fertilization.

Entrenamiento de la Inhibición Cognitiva en personas adultas mayores La base presenta datos del trabajo realizado con personas adultas mayores de entre 60 y 70 años de edad. Se han recolectado datos sociodemográficos y de desempeño en actividades cognitivas de evaluación y entrenamiento, con un grupo experimental y uno control. Los mismos fueron recabados desde finales del año 2023 hasta finales del año 2024, en el Partido de General Pueyrredón, Provincia de Buenos Aires.

Base de datos de especies de Calliphoridae recolectadas en el Departamento O'Higgins, Provincia del Chaco, Argentina Base de datos de especies de Calliphoridae recolectadas en diferentes hábitats del Departamento O'Higgins, Provincia del Chaco, Argentina, utilizando trampas cebadas con calamar en estado de descomposición.

Base de datos de especies de Sarcophagidae recolectadas en el Departamento O'Higgins, Provincia del Chaco, Argentina Base de datos de especies de Sarcophagidae recolectadas en diferentes hábitats del Departamento O'Higgins, Provincia del Chaco, Argentina, utilizando trampas cebadas con calamar en estado de descomposición.

Liquid-phase benzyl alcohol oxidation on gold-based catalysts: Effect of catalyst support and gold loading Se adjuntan datos en crudo de caracterización y aplicación de sólidos catalíticos basados Au sopportado sobre diferentes óxidos metálicos empleados en la oxidación de alcohol bencílico a benzaldehído. Estos resultados fueron empleados en la discusión, análisis y obtención de conclusiones presentados en el artículo publicado en Materials Science and Engineering B. Abstract del trabajo: Selective synthesis of benzaldehyde from benzyl alcohol was investigated using Au-based catalysts supported on -Al2O3, TiO2, and ZnO. Commercial -Al2O3 was modified with gold added by deposition-precipitation method producing xAu/Al2O3 solids (x = 0.2-0.9 wt.% Au). Catalysts were thoroughly characterized. In general, transition metal (Cu, Ag, Pd) catalysts favored alcohol oxidation reactions due to their ability to activate O2 and facilitate electron transfer. However, the higher catalytic activity of gold has emerged as a noteworthy area of exploration. The catalytic performance of Au-based solids supported on different oxides (with ≈1.0 wt. % Au) depended on its acid-base properties. Alumina was the support that allow to obtain the most effective catalysts for benzaldehyde synthesis probably due to the highest acid site density with weak and moderate strength. Initial reaction rate values increase with increasing x while the turnover frequency reaches a maximum for 0.4Au/Al2O3. The reuse of this catalyst was also studied.