Ciencia y Tecnología
A tetrasporic Octospora (Pyronemataceae, Pezizales) in South America; Octospora tetrasporado (Pyronemataceae, Pezizales) en Sudamérica
Suarez, Guillermo Martin
Octospora gemmicola var. tetraspora (Pyronemataceae), a species of bryophilous ascomycete, is recorded for the first time in South America from Argentina. This taxon is characterized by its parasitism on the propaguliferous moss Bryum klinggraeffii and the presence of tetrasporic asci. Macroscopic and microscopic features and ecological aspects of Octospora gemmicola var. tetraspora are discussed. Furthermore, pictures regarding conditions of the Argentinian occurrences, microscopic characters including spores, and infection structure are provided. Other related Octospora species with four-spored asci are discussed with the Argentinian collection, including a comparative illustration.; Octospora gemmicola var. tetraspora (Pyronemataceae), un ascomiceto briófilo, se registra para Sudamérica, en Argentina. Este espécimen se caracteriza por su parasitismo sobre el musgo propagulífero Bryum klinggraeffii y por la presencia de ascas tetrasporadas. Se discuten las características macroscópicas, microscópicas y aspectos ecológicos de Octospora gemmicola var. tetraspora. Además, se proporcionan imágenes que documentan las condiciones de las ocurrencias argentinas, así como los caracteres microscópicos, incluidas las esporas y las estructuras de infección. Otras especies de Octospora de ascas con cuatro esporas se relacionan con la colección de Argentina, incluyendo una ilustración comparativa.
Novedades del género Sematophyllum (Sematophyllaceae, Bryophyta) en Uruguay
Novedades del género Sematophyllum (Sematophyllaceae, Bryophyta) en Uruguay; Novelties of the genus Sematophyllum (Sematophyllaceae, Bryophyta) in Uruguay
Colotti, María T.; Suarez, Guillermo Martin
El presente estudio documenta novedades del género Sematophyllum para la República Oriental del Uruguay. Cuatro especies: S. cuspidiferum, S. galipense, S. lithophilum y S. subsimplex, se citan como nuevos registros para la brioflora del país y se amplía el área de distribución de S. subpinnatum. Se incluye la descripción de los taxa, su ilustración, comentarios y observaciones taxonómicas de cada una de las especies aquí tratadas. Además, se presenta una clave de identificación.; This study documents new records of the genus Sematophyllum in Uruguay. Four species, S. cuspidiferum, S. galipense, S. lithophilum, and S. subsimplex, are newly reported for the bryophyte flora of Uruguay, while the known distribution of S. subpinnatum is expanded. The study includes descriptions, illustrations, taxonomic notes, and additional observations for each species. An identification key is also provided.
Segunda biblioteca de RADSeq de Pleoticus muelleri
Segunda biblioteca de RADSeq de Pleoticus muelleri
Biblioteca de secuencias de ADN asociado a sitios de restricción (RADSeq) de 96 individuos de Pleoticus muelleri.
Modified natural mineral with a biogenic compound to control microbial growth in waterborne paint
Modified natural mineral with a biogenic compound to control microbial growth in waterborne paint
Barberia Roque, Leyanet; Lopez, Guillermo Pablo; Gámez Espinosa, Erasmo Junior; Igal, Katerine; Fernandez, Mariela Alejandra; Deyá, Cecilia; Bellotti, Natalia
Hygienic paints are designed to control microbial growth by imparting antimicrobial activity both in-film and incan. Biogenic compounds like terpenes in essential oils (EOs) have potential antimicrobial properties. Additionally, modified montmorillonites (Mt) show promise as nanoscale carriers for these compounds. This research aimed to obtain a functionalized antimicrobial montmorillonite hybrid to be applied in the formulation of bioactive paints. The biogenic compounds evaluated were the essential oils of white thyme and mint, to be applied for the first time in hygienic coatings. A soybean derivative was used as an organic modifier of the clay mineral. The synthesized hybrids were characterized by Fourier-Transform Infrared (FTIR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and energy dispersive spectrometer (EDS). Bioassays were carried out against fungal strains including Cladosporium cladosporioides, Chaetomium globosum, and Aspergillus versicolor, as well as bacterial strains such as Staphylococcus aureus and Escherichia coli. White thyme was the EO with the higher antimicrobial activity. Added to this, white thyme oil managed to impart its antimicrobial activity to the synthesized hybrid. The formulated paints with 0.75 concentration of pigment per volume (PVC) efficiently prevented in-can pollution.
Low-cost algorithms for clinical notes phenotype classification to enhance epidemiological surveillance: A case study
Low-cost algorithms for clinical notes phenotype classification to enhance epidemiological surveillance: A case study
Petri, Javier; Barcena Barbeira, Pilar; Pesce, Martina; Xhardez, Verónica; Laje, Rodrigo; Cotik, Viviana Erica
Objective:Our study aims to enhance epidemic intelligence through event-based surveillance in an emerging pandemic context. We classified electronic health records (EHRs) from La Rioja, Argentina, focusing on predicting COVID-19-related categories in a scenario with limited disease knowledge, evolving symptoms, non-standardized coding practices, and restricted training data due to privacy issues.Methods:Using natural language processing techniques, we developed rapid, cost-effective methods suitable for implementation with limited resources. We annotated a corpus for training and testing classification models, ranging from simple logistic regression to more complex fine-tuned transformers.Results:The transformer-based, Spanish-adapted models BETO Clínico and RoBERTa Clínico, further pre-trained with an unannotated portion of our corpus, were the best-performing models (F1= 88.13% and 87.01%). A simple logistic regression (LR) model ranked third (F1=85.09%), outperforming more complex models like XGBoost and BiLSTM. Data classified as COVID-confirmed using LR and BETO Clínico exhibit stronger time-series Pearson correlation with official COVID-19 case counts from the National Health Surveillance System (SNVS 2.0) in La Rioja province compared to the correlations observed between the International Code of Diseases (ICD-10) codes and the SNVS 2.0 data (0.840, 0.873, and 0.663, p-values < 3x10^-7). Both models have a good Pearson correlation with ICD-10 codes assigned to the clinical notes for confirmed (0.940 and 0.902) and for suspected cases (0.960 and 0.954), p-values < 3x10^-18.Conclusion:This study shows that simple, resource-efficient methods can achieve results comparable to complex approaches. BETO Clínico and LR strongly correlate with official data, revealing uncoded confirmed cases at the pandemic’s onset. Our results suggest that annotating a smaller set of EHRs and training a simple model may be more cost-effective than manual coding. This points to potentially efficient strategies in public health emergencies, particularly in resource-limited settings, and provides valuable insights for future epidemic response efforts.
Psychometric properties analysis of the Motivational Self-Regulation Strategies Questionnaire
Psychometric properties analysis of the Motivational Self-Regulation Strategies Questionnaire; Análisis de las propiedades psicométricas del Cuestionario de Estrategias de Autorregulación Motivacional; Análise das propriedades psicométricas do Questionário de Estratégias de Autorregulação Motivacional
Freiberg Hoffmann, Agustín; Motta, Florencia Anabel; Tisocco, Franco; Sánchez Rosas, Javier
Motivational self-regulation allows students tosustain and/or improve their motivation to achieve their goals. Thisself-regulation variant is related to variables such as academic performance,classroom climate, and academic procrastination, among others. The MotivationalSelf-Regulation Strategies Questionnaire (MRSQ) operationalized the construct. Thequestionnaire was adapted in Córdoba (Argentina), dividing the dimensions ofgoal regulation according to the strategies employed — whether by approximationor avoidance. The present research proposes to analyze new evidence of thevalidity and reliability of the MRSQ. A total of 412 university students fromBuenos Aires (Argentina) participated in the study. The analysis of theinternal structure of the instrument using confirmatory factor analysis (CFA)and exploratory structural equation modeling (ESEM) verified a better fit forthe 8-factor model. Further, a measurement invariance analysis between samplesof students from Buenos Aires and Córdoba verified the metric equivalence ofthe MRSQ. The internal consistency of the dimensions was adequate (> .70).Next, the concurrent validity test yielded positive and significantcorrelations with learning approaches and negative correlations with academicprocrastination. Statistical norms were also computed. This work provides newevidence on the psychometric properties of the MRSQ and norms that enable itsuse and interpretation within applied settings.; La autorregulación motivacional permite a los estudiantes sostener o mejorar su motivación para alcanzar sus metas. Esta autorregulación se relaciona con variables relevantes como el rendimiento académico, el clima de clase y la procastinación académica, entre otras. El Cuestionario de Estrategias de Autorregulación Motivacional (CEAM) operacionaliza el constructo y fue adaptado en Córdoba (Argentina), dividiendo las dimensiones de regulación de metas según las estrategias empleadas sean por aproximación o evitación. Esta investigación propone analizar nuevas evidencias de validez y confiabilidad del CEAM. Participaron 412 estudiantes universitarios de Buenos Aires (Argentina). El análisis de la estructura interna del instrumento mediante análisis factorial confirmatorio (AFC) y el análisis de ecuaciones estructurales exploratorio (ESEM) verificaron el mejor ajuste para el modelo de ocho factores. Luego, un análisis de invarianza factorial entre muestras de estudiantes de Buenos Aires y Córdoba verificó la equivalencia métrica del CEAM. La consistencia interna de las dimensiones fue adecuada (> .70). Seguidamente, el examinen de validez concurrente arrojó correlaciones positivas y significativas con los enfoques de aprendizaje, y negativas con la procastinación académica. También se estimaron normas estadísticas. Este trabajo proporciona nuevas evidencias sobre las propiedades psicométricas del CEAM y baremos que posibilitan su uso e interpretación dentro del campo de aplicación.; A autorregulação motivacional permite aos estudantes manterem e/ou melhorarem sua motivação para alcançar suas metas. Essa autorregulação está relacionada com variáveis relevantes, como o desempenho acadêmico, o clima de sala de aula e a procrastinação acadêmica, entre outras. O Questionário de Estratégias de Autorregulação Motivacional (QEAM) operacionaliza o construto e foi adaptado em Córdoba (Argentina), dividindo as dimensões da regulação de metas de acordo com as estratégias empregadas, sejam elas por aproximação ou evitação. Esta pesquisa propõe analisar novas evidências de validade e confiabilidade do QEAM. Participaram 412 estudantes universitários de Buenos Aires (Argentina). A análise da estrutura interna do instrumento, por meio da análise fatorial confirmatória (AFC), e da análise exploratória de equações estruturais (ESEM) verificou o melhor ajuste para o modelo de oito fatores. Em seguida, uma análise de invariância fatorial entre amostras de estudantes de Buenos Aires e Córdoba verificou a equivalência métrica do QEAM. A consistência interna das dimensões foi adequada (> 0,70). Em seguida, o teste de validade concorrente revelou correlações positivas e significativas com as abordagens de aprendizagem e correlações negativas com a procrastinação acadêmica. As normas estatísticas também foram estimadas. Este trabalho fornece novas evidências sobre as propriedades psicométricas do QEAM e escalas que permitem seu uso e interpretação no campo de aplicação.
Tall salt marshes play a crucial role in the long-term geomorphic evolution of the Jiuduansha wetland, Yangtze estuary, China
Tall salt marshes play a crucial role in the long-term geomorphic evolution of the Jiuduansha wetland, Yangtze estuary, China
Ma, Hao; Wang, Lihua; Pratolongo, Paula Daniela; Wu, Guoxiang; Shi, Benwei
Salt marshes play a pivotal role in shaping coastal wetlands by influencing hydrodynamics and sediment transport, a topic that has garnered increasing attention in recent studies. However, the specific roles of different vegetation types in driving geomorphic evolution remain unclear. This study aims to assess the impact of varying salt marsh vegetation on the long-term geomorphic evolution of coastal wetlands. Using 1449 satellite images spanning 39 years (1984–2023) from the Google Earth Engine data archive, we investigated how different salt marsh types influences geomorphic changes on Jiuduansha Island, the largest uninhabited island in the Yangtze Estuary, China. Our analysis focused on the long-term salt marsh expansion and geomorphic evolution of Jiuduansha. The results revealed that the total area of Jiuduansha, as well as the extent of tall salt marshes, has increased significantly over the past decade. Notably, tall salt marshes exert a profound influence on geomorphic evolution. Specifically, in the accretionary sections of Jiuduansha Island, the natural expansion of tall salt marshes (Spartina alterniflora and Phragmites australis, with mean heights of 1.8 m and 2.5 m, respectively) drives seaward progradation. Conversely, in erosional sections, these tall salt marshes play a crucial role in mitigating further shoreline erosion. This study underscores the significant role of tall salt marshes in the long-term geomorphic evolution of coastal wetlands, offering valuable insights into the dynamics of wetland ecosystems and their resilience to environmental changes.
Modeling and solving an integrated periodic vehicle routing and capacitated facility location problem in the context of solid waste collection
Modeling and solving an integrated periodic vehicle routing and capacitated facility location problem in the context of solid waste collection
González, Begoña; Rossit, Diego Gabriel; Frutos, Mariano; Méndez, Máximo
Few activities are as crucial in urban environments as waste management. Mismanagement of waste can cause significant economic, social, and environmental damage. However, waste management is often a complex system to manage and therefore where computational decision-support tools can play a pivotal role in assisting managers to make faster and better decisions. In this sense, this article proposes, on the one hand, a unified optimization model to address two common waste management system optimization problem: the determination of the capacity of waste bins in the collection network and the design and scheduling of collection routes. The integration of these two problems is not usual in the literature since each of them separately is already a major computational challenge. Two improved exact formulations based on mathematical programming and two metaheuristic methods are provided to solve this proposed unified optimization model. It should be noted that the metaheuristics consider a mixed chromosome representation of the solutions combining binary and integer alleles, in order to solve realistic instances of this complex problem. Different parameters of the metaheuristics considered – a Genetic Algorithm and a Simulated Annealing algorithm – have been tested to study which combination of them obtained better results in execution times on the order of that of the exact solvers. The achieved results show that the proposed metaheuristic methods perform efficient on large instances, where exact formulations are not applicable, and offer feasible, high-quality solutions in reasonable calculation times.
Spectrally distinguishing symmetric spaces I
Spectrally distinguishing symmetric spaces I
Lauret, Emilio Agustin; Rodríguez, Juan Sebastián
We prove that the irreducible symmetric space of complex structures on (resp. quaternionic structures on ) is spectrally unique within a 2-parameter (resp. 3-parameter) family of homogeneous metrics on the underlying differentiable manifold. Such families are strong candidates to contain all homogeneous metrics admitted on the corresponding manifolds. The main tool in the proof is an explicit expression for the smallest positive eigenvalue of the Laplace-Beltrami operator associated to each homogeneous metric involved. As a second consequence of this expression, we prove that any non-symmetric Einstein metric in the homogeneous families mentioned above is -unstable.
Obvious manipulations in matching with and without contracts
Obvious manipulations in matching with and without contracts
Arribillaga, Roberto Pablo; Pepa Risma, Eliana Beatriz
This paper explores many-to-one matching models, both with and without contracts, where doctors’ preferences are private and hospitals’ preferences are public and substitutable. It is known that any stable-dominating mechanism --which is either stable or individually rational and Paretodominates (from the doctors’ perspective) a stable mechanism–, is susceptible to manipulation by doctors. Our study focuses on obvious manipulations and identifies stable-dominating mechanisms that prevent them. Without contracts, we show that any stable-dominating mechanism is not obviously manipulable. However, with contracts, none of these results hold. While we demonstrate that the Doctor-Proposing Deferred Acceptance (DA) Mechanism remains not obviously manipulable, we show that the Hospital-Proposing DA Mechanism and any efficient mechanism that Pareto-dominates the Doctor-Proposing DA Mechanism become (very) obviously manipulable, in the model with contracts.
Fipronil tissue residues and withdrawal period feasibility in laying hens after extra‐label use
Fipronil tissue residues and withdrawal period feasibility in laying hens after extra‐label use
Cantón, Lucila; Berkovic, Andrea Mariela; Ceballos, Laura; Cantón, Candela; Lanusse, Carlos Edmundo; Alvarez, Luis Ignacio; Moreno Torrejon, Laura
Fipronil, a broad-spectrum insecticide, is often used off-label in laying hens to control red mites. This study investigatedfipronil residue levels in hen tissues after simulating common extra-label administrations: in-feed (1 mg kg−1 twice) and transdermal (1 mg kg−1 once). Fipronil residues were quantified by HPLC-MS/MS. Both administrations resulted in quantifiableresidues in edible tissues (muscle, liver, kidney, skin, fat) and feathers for up to 60 days. Fipronil-sulfone, the primary metabolite, was the dominant residue in tissues. Fat accumulated the highest concentrations. In-feed administration led to higheroverall residues in edible tissues, while transdermal application resulted in higher concentrations in feathers. Calculated withdrawal periods, based on established MRLs, ranged from 36 days (muscle, transdermal) to 131 days (fat, transdermal). Theselong withdrawal periods render both administration routes impractical for poultry production. The study highlights the riskof fipronil residues in poultry products and suggests feather/fecal sampling for monitoring illicit use.
Concentración de compuestos organobromados en Delphinus delphis y Lagenodelphis hosei
Concentración de compuestos organobromados en Delphinus delphis y Lagenodelphis hosei
Concentración de compuestos organobromados expresados en ng.g−1 de peso húmedo, determinados en tejido adiposo de Delphinus delphis y Lagenodelphis hosei
Isospectral CR Manifolds with Respect to the Kohn Laplacian
Isospectral CR Manifolds with Respect to the Kohn Laplacian
Gutierrez, Gerson; Lauret, Emilio Agustin; Rossetti, Juan Pablo
We prove that the spectrum of the Kohn Laplacian does not determine the equivalence classes of CR manifolds. We construct pairs of odd-dimensional elliptic manifolds that are not equivalent as CR manifolds but whose Kohn Laplacians have the same spectrum. These manifolds are endowed with the CR structures inherited from the canonical CR structure on the sphere of the same dimension.We provide three different constructions among lens spaces and an additional one among elliptic manifolds with non-cyclic fundamental groups.
Prosodic Reading in Students with Specific Comprehension Difficulties
Prosodic Reading in Students with Specific Comprehension Difficulties
Roldán, Luis Ángel; Arnés, Victoria; Fernández, Valentina Nahir; Zabaleta, Verónica
This study explores the expressive reading skills of Spanish-speaking students experiencing challenges in reading comprehension during the first year of secondary school in Argentina (grade 7). Initially, a cohort of 187 students was examined, leading to the formation of two groups: 27 students with specific comprehension difficulties (SCD) and 27 with proficient comprehension. The groups were matched in terms of decoding skills. Students were tested with a task requiring the computation of punctuation marks and an analytical prosodic reading scale that assesses various parameters such as volume, intonation, pauses, phrasing, and quality. Notably, statistically significant differences emerged between the two groups across all measures. Moreover, robust correlations were identified between expressive reading measures and text comprehension in students with SCD. A logistic regression analysis pinpointed phrasing as the sole significant predictor of group classification. These results underscore the pivotal role of prosodic reading in text comprehension.
Considering land use complexity and overlap is critical for sustainability planning
Considering land use complexity and overlap is critical for sustainability planning
Pratzer, Marie; Maillard, Oswaldo; Baldi, Germán; Baumann, Matthias; Burton, Jamie; Fernandez, Pedro; Levers, Christian; Meyfroidt, Patrick; Tasquer, Macarena; Vallejos, María; Kuemmerle, Tobias
Land use is both a driver and a lever to address sustainability challenges like biodiversity loss, climatechange, and food security. Yet, it is often oversimplified in sustainability planning, ignoring the diversity ofactors or the multiple claims on land. We developed an approach to capture the complex and contested nature of land use by mapping it as social-ecological systems that can overlap in space. Demonstrating ourapproach for the Dry Chaco and Chiquitano forests in South America revealed three main insights. First,we mapped actors that are typically overlooked, such as forest-dwelling smallholders. Second, substantialland use overlap, particularly between smallholders and agribusinesses, signals land competition that risksmarginalizing smallholders. Third, our maps showed conservation areas overlapping with other land systems, highlighting opportunities for co-benefits but also competition. Overall, our transferable approach captures land use complexity and visualizes often overlooked actors, thereby potentially contributing to morejust and effective sustainability planning.
First repor t of the interac tion between the toad Melanophryniscus nigricans and the leech Helobdella cordobensis in the Tandilia Mountains
First repor t of the interac tion between the toad Melanophryniscus nigricans and the leech Helobdella cordobensis in the Tandilia Mountains
Tejedor, Facundo; Trofino Falasco, Clara; Cortelezzi, Agustina; Gullo, Bettina; Gárgano, Lucía; Santiago, Manuela; Berkunsky, Igor
Melanophryniscus nigricans is an endangered endemic anuran species restricted to the TandiliaMountains in Argentina. We report for the first time the interaction between this toad speciesand the leech Helobdella cordobensis. We observed the interaction in a temporary pond at the“Sierra del Tigre” Natural Reserve during a breeding event of M. nigricans on February 7th, 2024.A leech was found attached to the belly of a toad and removed manually with no evidence ofinjury in the amphibian, suggesting a case of phoresis instead of parasitism. This report is alsothe first documented phoretic interaction between H. cordobensis and anurans from Argentina.
Causality by Vote: Aggregating Evidence on Causal Relations in Economic Growth Processes
Causality by Vote: Aggregating Evidence on Causal Relations in Economic Growth Processes
de Mier, Manuel; Delbianco, Fernando Andrés; Tohmé, Fernando Abel
In this paper, we investigate the performance of fivecausality-detection methods and the aggregation of their resultswhen considering multiple units in a panel data setting. We employvoting rules as an aggregation procedure to determine which causalpaths are identified for the sample population. Using both simu-lated and real-world panel data, we show the performance of thesemethods in detecting the correct causal paths by comparing themto a benchmark that represents a standard growth model as theground truth.
“Segundo Censo de la República Argentina” del año 1895" Terriotrios Naci Neuquen y Rio Negro - paginas 658 “Cuadro VII a.” - 659 “Cuadro VII a.”- 661 “Cuadro VII b.”
“Segundo Censo de la República Argentina” del año 1895" Terriotrios Naci Neuquen y Rio Negro - paginas 658 “Cuadro VII a.” - 659 “Cuadro VII a.”- 661 “Cuadro VII b.”
“Segundo Censo de la República Argentina” del año 1895, Página 658 “Cuadro VII a.” “Población por nacionalidad y sexo” Población que corresponde a los países americanos que corresponde a los territorios Nacionales del Chaco, territorio nacional de La Pampa y territorio nacional de Neuquén, Página 659 “Cuadro VII a.” “Población por nacionalidad y sexo” Población que corresponde a los países americanos que corresponde a los territorios Nacionales de Río Negro, territorio nacional de Chubut, territorio nacional de Santa Cruz y territorio nacional de Tierra del Fuego. Página 661 “Cuadro VII b.” “Población por nacionalidad y sexo” Población que corresponde a los países europeos que corresponde a los territorios Nacionales de Neuquén, de Río Negro, de Chubut y de Tierra del Fuego. Los datos de estos cuadros resultan de gran relevancia para poder conocer, a partir de una fuente de información documental, la composición de la población de los territorios nacionales de Rio Negro y Neuquén (área de investigación en especial la zona cordillerana) por aquel entonces y el peso de la población argentina, chilena y europea. Adquiere doblemente importancia como fuente de información ya que existen muy pocas fuentes documentales de aquel entonces. Las cuadros se presentan en publicaciones a modo de soporte documental (y cuantitativo) de la información analizada cualitativamente.
Quercetin-loaded magnetic nanoparticles: a promising tool for antitumor treatment in human breast cancer cells
Quercetin-loaded magnetic nanoparticles: a promising tool for antitumor treatment in human breast cancer cells
Tiburzi, Silvina Mabel; Lezcano, Virginia Alicia; Principe, Gabriel; Montiel Schneider, María Gabriela; Miravalles, Alicia Beatriz; Lassalle, Verónica Leticia; Bruzzone, Ariana; González Pardo, María Verónica
Quercetin (QUE) is a phytoestrogen with known antitumor properties; however, its hydrophobic nature and low bioavailability limit its efficacy as an anticancer drug. To address this, we explored loading QUE onto a non-toxic nanocarrier. This study focused on the biological activity of magnetic iron oxide nanoparticles coated with polyethylene glycol (MAG@PEG) loaded with QUE (MAG@PEG@QUE) in MCF-7 cells. The MAG@PEG nanosystem was synthesised using a hydrothermal method, and QUE was incorporated by adding an alcoholic solution of QUE to an aqueous dispersion of MAG@PEG. QUE incorporation was confirmed qualitatively by FTIR spectroscopy and quantitatively through UV–visible spectroscopy. Cytotoxicity studies showed that MAG@PEG@QUE, at a concentration equivalent to the half-maximal inhibitory concentration (IC50) of free QUE, significantly reduced cell proliferation and viability while increasing apoptosis. MCF-7 cells treated with MAG@PEG@QUE also displayed actin cytoskeleton alterations typical of apoptotic cells. Transmission electron microscopy revealed clusters of magnetic nanoparticles within cellular vesicles. Targeted delivery of these nanoparticles was achieved using a static magnetic field, leading to high intracellular accumulation and selective cell death in targeted areas, without affecting adjacent cells. In conclusion, MAG@PEG@QUE shows comparable antitumor effects to free QUE and has the potential to enhance QUE’s bioavailability and targeted delivery for breast cancer treatment
Tecnologías de modificación corporal y personas travestis y trans en Argentina: un estudio cuantitativo sobre desigualdades en el uso y acceso
Tecnologías de modificación corporal y personas travestis y trans en Argentina: un estudio cuantitativo sobre desigualdades en el uso y acceso; Body modification technologies and transvestite and trans people in Argentina: A quantitative study on inequalities in use and access
Farji Neer, Anahí; Dellacasa, María Alejandra; Sustas, Sebastián Ezequiel; Antoniucci, Melina Beatriz; Rustoyburu, Cecilia Alejandra; Noceti, Clara Inés; Mateo, Natacha; Roca, Alejandra Rosario
La salud colectiva ha aportado perspectivas analíticas de gran riqueza para comprender la determinación social de la salud y cómo las dinámicas de desigualdad, inequidad e iniquidad son productoras de padecimientos, enfermedades, morbilidad y mortalidad. Desde esta mirada, en este trabajo se identifican y analizan modalidades de apropiación y uso de distintas hormonas e intervenciones de modificación corporal de la población travesti y trans en Argentina, con el propósito de visibilizar las situaciones de vulnerabilidad que puedan estar implicadas en estas prácticas, tanto aquellas realizadas fuera del sistema de salud como las que tuvieron acompañamiento profesional en una institución. Se adoptó una estrategia metodológica cuantitativa, con un diseño descriptivo, observacional y de corte transversal. En 2023, se realizó un relevamiento a través de un cuestionario a nivel federal a personas travestis y trans mayores de 16 años (n=1.196). Los datos analizados dan cuenta de procesos de vulnerabilidad que no se extienden de manera homogénea en toda la población y que responden a desigualdades en salud.; Collective health has provided valuable analytical perspectives for understanding the social determinants of health and how dynamics of inequality, inequity, and injustice contribute to suffering, disease, morbidity, and mortality. From this perspective, this study identifies and analyzes the ways in which transvestite and trans people in Argentina appropriate and use different hormones and body modification interventions, aiming to highlight the vulnerabilities associated with these practices, both those performed outside the healthcare system and those carried out with professional support in an institution. A quantitative methodological strategy was adopted, with a descriptive, observational, and cross-sectional design. In 2023, a nationwide survey was conducted using a questionnaire targeting transvestite and trans people aged 16 and older (n=1,196). The analyzed data reveal vulnerability processes that do not extend uniformly across the entire population and are linked to health inequalities.
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