Crises e desigualdades em tempos de Pandemias no Brasil e na Argentina Diniz, Leticia; Darling, Victoria Inés O cenário de pandemia será de extrema importância para avaliar o estado da situação socioeconômica da nossa região nos próximos anos, mas também, para fazer uma reflexão profunda sobre as desigualdades ampliadas no início do século XXI. A pandemia do COVID-19 implicou o retorno dos nacionalismos, a ausência de alternativas regionais, a proibição de entrada á migrantes, trabalhadorxs fronteiriçxs e o concomitante processo de retorno das mulheres, em muitos casos, ao âmbito doméstico. Esses são apenas alguns elementos que se destacam e que alteraram a vida de nós, homens, mulheres e diversidades, que habitamos o Mercosul. As medidas para enfrentar tamanha situação crítica têm sido diversas, mas nulas podem ser consideradas propostas de transformação estrutural. Os níveis de desemprego, subemprego, desigualdade e pobreza aumentaram notavelmente e políticas como taxação de grandes fortunas ou renda cidadã são apenas consideradas exceção.

Hormonal endogenous changes in response to the exogenous 6-benzylaminopurine application in pre and post harvesting lilium flower stalks Mantilla Alarcon, Gunther Alfredo; Lorenzo, Gabriel Antonio; Mascarini, Libertad Phyto-hormones play a key role in regulating plant responses to stress. Cytokines are a type of phyto-hormones involved in the regulation of many important biological processes related to growth, development, and response to environmental variables. The exogenous application of cytokines increases the possibility of delaying senescence; however, this is a physiological process, and, under certain conditions, degradation processes may be triggered. The effect of 6-bencilaminopurine application and the endogenous hormonal changes involved in lilies floral stalks after their cutting were studied. In order to improve vase life and quality of Lilium longiflorum ‘Brindisi' flower stalks, they were sprayed with 6-BAP, at a concentration of 300 ppm at pre-harvest, post-harvest, and pre- and postharvest stages. After that, they were compared to non-sprayed control stalks. The application of 6-BAP caused endogenous hormonal changes in abscisic acid and cytokinin levels, and the most effective treatment was pre-harvest spraying. This treatment proved to be an appropriate method to improve the stalk tolerance to post-harvest stress as it delayed the appearance of senescence symptoms and reduced the speed of chlorophyll degradation with differences of up to 10% with respect to untreated stalks. In addition, the opening of flowers was delayed by up to 2 days, although there were no significant differences in total vase life.

Silver bionanoparticles toxicity in trophoblast is mediated by nitric oxide and glutathione pathways Bustos, Pamela Soledad; Quinteros, Melisa de Los Ángeles; Gomez, Diego Sebastian; Ortega, María Gabriela; Páez, Paulina Laura; Guiñazú, Natalia Lorena Silver bionanoparticles (AgNPs) biosynthesized by Pseudomonas aeruginosa culture supernatant have an important antibacterial activity mediated by ROS increase; however their toxicity in human cells is not known. Due to the high susceptibility of the developing tissues to xenobiotics, the aim of this study was to investigate the AgNPs effect on first trimester human trophoblasts. The HTR8/SVneo cell line was treated with AgNPs (0.3–1.5 pM), for 6 and 24 h. Cell viability, reactive nitrogen and oxygen species (RNS and ROS) production, nitric oxide synthase expression, antioxidant defenses and biomolecule damage were evaluated. The exposure to AgNPs produced changes in HTR8/SVneo cell morphology and decreased cell viability. Alterations in redox balance were observed, with an increase in ROS and RNS levels, and NOS2 protein expression. Superoxide dismutase and catalase augmented their activity accompanied with a decreased in glutathione content and glutathione S-transferase activity. Protein oxidation and genotoxic damage were observed at concentrations greater than 0.6 pM. The pre-incubation with L-NMMA, NAC, mannitol and peroxidase demonstrated that AgNPs-induced cytotoxicity was not mediated by HO[rad] and H2O2, but nitric oxide and glutathione pathways were implicated in cell death. Since reported AgNPs microbicidal mechanism is mediated by increasing ROS (mainly HO[rad] and H2O2) without an increase in RNS, this work indicates an interesting difference in the reactive species and oxidative pathways involved in AgNPs toxicity in eukaryotic and prokaryotic cells. Highlighting the importance of toxicity evaluation to determine the safety of AgNPs with pharmaceutical potential uses.

Masculinidad, intimidad y cuidados: ¿nuevas reconfiguraciones en la pandemia?; Masculinidade, intimidade e cuidado: novas reconfigurações na pandemia?; Masculinity, intimacy and care: new reconfigurations in the pandemic? Castilla, María Victoria; Canevaro, Santiago La pandemia del covid-19 modificó la cotidianeidad y reconfiguró los modos en que vivimos nuestras intimidades, el espacio público y el de nuestros hogares. El denominado Aislamiento Social Preventivo y Obligatorio decretado por el gobierno nacional argentino se acompañó con una crisis económica y sanitaria trastocando, a su vez, las actividades de “cuidado” y de “trabajo”. En este contexto, las distinciones taxativas e infranqueables entre lo público y privado quedaron en jaque junto con la vida íntima que comenzó a percibirse como amenazada ya que, su par antagónico -lo “público”- había perdido su tradicional espacio, esto es, todo aquello que estaba por fuera de los hogares. En el marco de las investigaciones y ejes de indagación que venimos realizando en el Núcleo de Estudios sobre Intimidades, Política y Sociedad de la Universidad Nacional de San Martín en este artículo analizamos las implicancias que la pandemia tuvo en la vida cotidiana y familiar de varones de sectores medios de Buenos Aires. Sostenemos que el confinamiento decretado a partir de la pandemia visibilizó la porosidad de las fronteras entre lo íntimo y lo público. La dificultad y los esfuerzos para hacer convivir estas dos esferas se expresaron en los modos como vivenciaron y gestionaron la espacialidad y practicaron los cuidados durante dicho aislamiento, así como también en la forma en que se representaron y significaron el espacio del hogar y a sus propias tareas como padres y trabajadores.; A pandemia de covid-19 mudou nossas vidas diárias e reconfigurou a forma como vivemos nossa privacidade, o espaço público e o de nossas casas. O denominado Isolamento Social Preventivo e Obrigatório decretado pelo governo nacional argentino foi acompanhado por uma crise econômica e sanitária, interrompendo, por sua vez, as atividades de “cuidado” e “trabalho”. Nesse contexto, as distinções específicas e intransponíveis entre o público e o privado estavam em xeque a vida íntima que passou a ser percebida como ameaçada desde que seu par antagônico - o "público" - havia perdido seu espaço tradicional, ou seja, tudo o que estava fora de casa. No quadro das investigações e eixos de investigação que temos vindo a desenvolver no Núcleo de Estudos sobre Intimidades, Política e Sociedade da Universidade Nacional de San Martín, neste artigo analisamos as implicações que a pandemia teve no quotidiano e vida familiar de homens de setores médios de Buenos Aires. Afirmamos que o confinamento decretado da pandemia tornou visível a porosidade das fronteiras entre o íntimo e o público. A dificuldade e o esforço para fazer coexistir essas duas esferas se expressaram nas formas como vivenciaram e administraram a espacialidade e exerceram o cuidado durante esse isolamento, bem como na forma como o espaço da casa e as próprias tarefas foram representados e significados como pais e trabalhadores.; The covid-19 pandemic changed everyday life and reconfigured the ways we live our intimacy, public space and our homes. The so-called Preventive and Compulsory Social Isolation decreed by the Argentine national government was accompanied by an economic and health crisis, disrupting the “care” and “work” activities. In this scenario, the specific and insurmountable distinctions between the public and the private spheres were affected and the intimate life began to be perceived as threatened since its antagonistic pair - the "public" - had lost its traditional space, that is, all outside the homes. According to investigations and axes of research that we have been carrying out in the Nucleus of Studies on Intimacies, Politics and Society of the National University of San Martín, in this article we analyze the implications that the pandemic had on the family and everyday life of men from middle class of Buenos Aires. We argue that the confinement made visible the porosity of the borders between the intimate and the public. The difficulty and efforts to make these two spheres coexist were expressed in the ways in which men experienced and managed spatiality and practiced care during the confinement, as well as in the way in which the space of the home and their own tasks were represented and signified as parents and workers.

Auxin-Environment Integration in Growth Responses to Forage for Resources Casal, Jorge José; Estevez, Jose Manuel Plant fitness depends on the adequate morphological adjustment to the prevailing conditions of the environment. Therefore, plants sense environmental cues through their life cycle, including the presence of full darkness, light, or shade, the range of ambient temperatures, the direction of light and gravity vectors, and the presence of water and mineral nutrients (such as nitrate and phosphate) in the soil. The environmental information impinges on different aspects of the auxin system such as auxin synthesis, degradation, transport, perception, and downstream transcriptional regulation to modulate organ growth. Although a single environmental cue can affect several of these points, the relative impacts differ significantly among the various growth processes and cues. While stability in the generation of precise auxin gradients serves to guide the basic developmental pattern, dynamic changes in the auxin system fine-tune body shape to optimize the capture of environmental resources.

Machine-learning algorithm incorporating capacitated sperm intracellular pH predicts conventional in vitro fertilization success in normospermic patients Gunderson, Stephanie Jean; Puga Molina, Lis del Carmen; Spies, Nicholas; Balestrini, Paula Ania; Buffone, Mariano Gabriel; Jungheim, Emily Susan; Riley, Joan; Santi, Celia Maria To measure human sperm intracellular pH (pHi) and develop a machine-learning algorithm to predict successful conventional in vitro fertilization (IVF) in normospermic patients.

Bioindicadores de calidad de nuestros ecosistemas acuáticos Tagliaferro, Marina Beatriz Los ecosistemas acuáticos experimentan variaciones naturales en el tiempo, en el espacio, así como por factores externos como las diferentes acciones humanas. Tradicionalmente la caldad de estos ambientes se evaluaba a través de sus características fisicoquímicas. Sin embargo, poco sabíamos si esas características afectaban a los organismos que allí vivían. Los indicadores biológicos son organismos que por su sola presencia o cambios en su abundancia indican la condición o integridad ecológica de un ambiente. A través de estos organismos podemos conocer si las características fisicoquímicas están alterando la vida en los ambientes acuáticos.

El Gran Carnicero y la pandemia; The Great Butcher and the Pandemic; Der Grosse Schlächter und die Pandemie Cragnolini, Monica Beatriz Se plantea en este artículo el vínculo entre pandemias zoonóticas de los últimos tiempos y tratamiento de los animales: ya sea de los animales de producción intensiva, que viven en condiciones de hacinamiento y stress, como de los animales salvajes, que son expulsados de sus hábitats para desmonte de bosques y uso de los suelos para monocultivos, que generalmente representan el alimento de los animales de producción. La figura del Gran Carnicero de la novela La jungla de Upton Sinclair permite pensar ese modelo capitalista de producción cárnica, que en la época actual se concentra en contadas compañías de agronegocios. Se plantea, al final, la necesidad de pensar en "otro modo de ser" diferente del sujeto que se cree dueño del mundo y de las vidas de los otros.; In this paper, the link between recent zoonotic pandemics and treatment of animals is discussed: whether intensively produced animals, living in conditions of overcrowding and stress, or wild animals, which are expelled from their habitats to clear forests and use the soil for monocultures, which are generally used as food for production animals. The figure of the Great Butcher in Upton Sinclair´s novel The jungle allows us to think about this capitalist model of meat production, which at the present time is concentrated in few agribusiness companies. In conclusion, is necessary to think in "another way of being" different from the subject who believes himself to be the owner of the world and of the lives of others.; Dieser Artikel untersucht den Zusammenhang zwischen zoonotischen Pandemien der letzten Zeit und der Behandlung von Tieren: seien es intensiv produzierte Nutztiere, die unter Bedingungen von Überbelegung und Stress leben, oder Wildtiere, die aus ihren Lebensräumen vertrieben werden, um Wälder zu roden, die in der Regel die Nahrung der Nutztiere darstellen, und das Land für Monokulturen zu nutzen. Die Figur des "Großen Schlächters" in Upton Sinclairs Roman Der Dschungel erlaubt es uns, über dieses kapitalistische Modell der Fleischproduktion nachzudenken, das in der heutigen Zeit in einigen wenigen Agrarkonzernen konzentriert ist. Am Ende wird das Bedürfnis geweckt, über eine "andere Art des Seins" nachzudenken, die sich von dem Subjekt unterscheidet, das denkt, dass ihm die Welt und das Leben der anderen gehört.

Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during early Drosophila development Espínola, Sergio Martín; Götz, Markus; Bellec, Maelle; Messina, Olivier; Fiche, Jean Bernard; Houbron, Christophe; Dejean, Matthieu; Reim, Ingolf; Cardozo Gizzi, Andres Mauricio; Lagha, Mounia; Nollmann, Marcelo Acquisition of cell fate is thought to rely on the specific interaction of remote cis-regulatory modules (CRMs), for example, enhancers and target promoters. However, the precise interplay between chromatin structure and gene expression is still unclear, particularly within multicellular developing organisms. In the present study, we employ Hi-M, a single-cell spatial genomics approach, to detect CRM–promoter looping interactions within topologically associating domains (TADs) during early Drosophila development. By comparing cis-regulatory loops in alternate cell types, we show that physical proximity does not necessarily instruct transcriptional states. Moreover, multi-way analyses reveal that multiple CRMs spatially coalesce to form hubs. Loops and CRM hubs are established early during development, before the emergence of TADs. Moreover, CRM hubs are formed, in part, via the action of the pioneer transcription factor Zelda and precede transcriptional activation. Our approach provides insight into the role of CRM–promoter interactions in defining transcriptional states, as well as distinct cell types.

Surface Laser Treatment on Ferritic Ductile Iron: Effect of Linear Energy on Microstructure, Chemical Composition, and Hardness Catalán, Néstor; Ramos Moore, Esteban; Boccardo, Adrian Dante; Celentano, Diego Javier; Alam, Nazmul; Walczak, Magdalena; Gunasegaram, Dayalan Surface transformation treatments like laser surface melting and laser surface hardening have been mostly developed in austempered ductile iron and gray cast iron. In this work, we explore the effects of the linear laser energy of the treatment on the microstructure, chemical composition, and hardness of ferritic nodular cast iron, using a fiber delivery diode laser. We found changes in the microstructure above 120 J/mm, characterized by the presence of graphite nodules surrounded by martensitic/dendritic shells. Above 316 J/mm, Fe3C and γ-Fe2O3 phases arise, together with a saturation of the microhardness around 1000 HV0.3 within the first 200 μm of depth, and of the surface hardness around 90 HR15N. Changes in microstructure and composition due to the laser treatment directly affect the thermal diffusion between the surface-modified zones and the nodular cast iron bulk. Our work highlights the importance of the linear energy in the design and planning of laser treatments.

Vulnerabilidad hídrica del gran Córdoba ante escenarios de sequías y análisis de alternativas para la provisión de agua Lopez, Erica Elizabeth; Pintos, Gabriela; Corral, Mariano Andres; Rodriguez, Andres En este trabajo se presenta un análisis preliminar de la situación actual del abastecimiento de agua al Gran Córdoba y los departamentos de la región central de la Provincia, en donde se han estudiado fuentes alternativas de provisión y las respectivas obras con el objetivo de asegurar el suministro de agua potable a la población actual y permitir el desarrollo de la región en un futuro a mediano y largo plazo. En este sentido, se actualizan estudios previos, y se analizan diferentes alternativas para garantizar la provisión de agua potable a mediano y corto plazo en condiciones de escasez hídrica.; This paper presents a preliminary analysis of the current situation of water supply to Gran Córdoba and the departments of the central region of the Province. Alternative sources of supply and the respective works have been studied with the aim of ensuring the supply of drinking water to the current population and allowing the development of the region in the medium and long term. In this sense, previous studies are updated, and different alternatives are analyzed to guarantee the provision of drinking water in the medium and short term under conditions of water scarcity.

Bosques maduros de talas y pájaros carpinteros Jauregui, Adrian; Rodríguez, Sabrina; Segura, Luciano Noel Los pájaros carpinteros de la bahía de Samborombón horadan troncos de talas maduros y nidifican en las cavidades que crean. De ahí la importancia de conservar esos árboles.

Dietas saludables y sustentables, ¿Son posibles en la Argentina? Arrieta, Ezequiel Martín; González, Alejandro D.; Fernández, Roberto J. Para afrontar el reto de alimentar a una población creciente que cambia su estilo de vida y su dieta y, al mismo tiempo, tratar de conservar los recursos naturales y proteger la biodiversidad, se proponen tres estrategias principales para lograr tales objetivos: 1) cambiar la forma de producir los alimentos en el campo (aumentando la eficiencia), 2) reducir las pérdidas y desperdicios a lo largo de la cadena agroalimentaria, y 3) promover la adopción de dietas saludables y sostenibles. Las dos primeras estrategias fueron contempladas en nuestro país y forman parte de la agenda académica, gubernamental y productiva, pero la tercera ha sido muy poco explorada. A través de un análisis de la bibliografía destacamos la importancia de incluir a las dietas saludables como herramienta para contribuir simultáneamente a la sustentabilidad del sistema agroalimentario y al mejoramiento de la salud pública, y resaltamos los desafíos que esto implicaría para el abastecimiento del mercado interno. Para ello, primero presentamos información de los impactos ambientales de los sistemas agroalimentarios y las dos primeras estrategias nombradas, utilizadas tradicionalmente para abordarlos. Segundo, exponemos los motivos por los cuales la búsqueda de la eficiencia no debería ser el único camino a seguir debido a las consecuencias esperadas del cada vez mejor conocido "Efecto Rebote" (o Paradoja de Jevons). Tercero, analizamos las evidencias a favor de una correlación positiva entre los beneficios para la salud de varios grupos de alimentos (en general, de origen vegetal) y el impacto relativamente bajo que tiene su producción sobre el ambiente. Finalmente, hacemos un breve análisis físico (no económico) sobre la capacidad que tendría el sistema agroalimentario nacional para proveer de alimentos saludables en cantidad suficiente y sus consecuencias para el ambiente y el sector productivo.

Conocimiento ecológico tradicional, técnicas de pesca y manejo de la ictiofauna en la población de San Javier (Santa Fe, Argentina). Martino, Juan Pablo; Arias Toledo, Barbara El sistema formado por el río Paraná, sus afluentes y la llanura aluvial asociada tiene aproximadamente 200 especies de peces pertenecientes a 11 órdenes. En el sentido ictiogeográfico, es una de las regiones con mayor abundancia y diversidad de especies de agua dulce en el mundo. Numerosas poblaciones a lo largo del río Paraná hacen de la ictiofauna su principal recurso de subsistencia.El conocimiento general de los hábitos de vida y alimentación de los peces es sin duda la herramienta más valiosa para la pesca a través de diversos artes de pesca heredados a lo largo de la historia. En la mayoría de los casos, el conocimiento popular coincide plenamente con la literatura científica, que a su vez refleja la efectividad y el manejo adecuado de la fauna íctica por parte de los pescadores.

Bio-paraffin from Soybean Oil as Eco-friendly Alternative to Mineral Waxes Romero, Sandra Zulema; Minari, Roque Javier; Collins, Sebastián Enrique Blends of fully and partial hydrogenated soybean oil, with 50/50 and 80/20 wt %, were chemically interesterified. The composition-texture relationships were investigated and established for the set of investigated materials. The raw materials, the original and interesterified blends, were analyzed in terms of their fatty acid and triacylglycerol compositions by gas chromatography. All materials were characterized by differential scanning calorimetry (DSC), polymorphic forms were characterized by X-ray diffraction (XRD), crystalline structures were characterized by polarized light microscopy (PLM), and textures were characterized by penetration testing. Interesterification caused a rearrangement of triacylglycerol species, reducing the concentration of trisaturated, triunsaturated, and diunsaturated triacylglycerols, increasing the amount of monounsaturated triacylglycerol, and resulting in a lowering of melting points as compared with the original blends. This modification in the chemical composition clearly changed the crystallization behavior, producing reductions in crystal size, alterations in crystalline polymorphism, and increases in plasticity in the blends. Interesterified materials displayed melting and textural characteristics suited for potential mineral wax substitutes.

Biased agonism at histamine H1 receptor: desensitization, internalization and MAPK activation triggered by antihistamines Burghi, Valeria; Echeverría, Emiliana Beatriz; Zappia, Carlos Daniel; Díaz, Antonela Susana; Ripoll, Sonia; Gómez, Natalia; Shayo, Carina Claudia; Davio, Carlos Alberto; Monczor, Federico; Fernández, Natalia C. Histamine H1 receptor ligands used clinically as antiallergics rank among the most widely prescribed and over-the-counter drugs in the world. They exert the therapeutic actions by blocking the effects of histamine, due to null or negative efficacy towards Gαq-phospholipase C (PLC)-inositol triphosphates (IP3)?Ca2+ and nuclear factor-kappa B cascades. However, there is no information regarding their ability to modulate other receptor responses. The aim of the present study was to investigate whether histamine H1 receptor ligands could display positive efficacy concerning receptor desensitization, internalization, signaling through Gαq independent pathways or even transcriptional regulation of proinflammatory genes. While diphenhydramine, triprolidine and chlorpheniramine activate ERK1/2 (extracellular signal-regulated kinase 1/2) pathway in A549 cells, pre-treatment with chlorpheniramine or triprolidine completely desensitize histamine H1 receptor mediated Ca2+ response, and both diphenhydramine and triprolidine lead to receptor internalization. Unlike histamine, histamine H1 receptor desensitization and internalization induced by antihistamines prove to be independent of G protein-coupled receptor kinase 2 (GRK2) phosphorylation. Also, unlike the reference agonist, the recovery of the number of cell-surface histamine H1 receptors is a consequence of de novo synthesis. On the other hand, all of the ligands lack efficacy regarding cyclooxygenase-2 (COX-2) and interleukin-8 (IL-8) mRNA regulation. However, a prolonged exposure with each of the antihistamines impaires the increase in COX-2 and IL-8 mRNA levels induced by histamine, even after ligand removal. Altogether, these findings demonstrate the biased nature of histamine H1 receptor ligands contributing to a more accurate classification, and providing evidence for a more rational and safe use of them.

Influence of steroids on hydrogen bonds in membranes assessed by near infrared spectroscopy Wenz, Jorge Javier The covalent O[sbnd]H bonds of water vibrate and absorb radiation in the near infrared (NIR) region at wavelengths that vary according to the strength of the bonds which, at the same time, are sensitive to the number and/or strength of hydrogen bonds. By means of multivariate analytical tools, such spectral shift was exploited to study the effect of temperature, 25-hydroxycholesterol and progesterone on the H-bonded network of water in DMPA membranes. Temperature was found as the dominating factor altering the NIR spectra of water and then the H-bonds. Increasing temperatures disrupt the H-bonds network, strengthening the O[sbnd]H covalent bonds. The disruption of the H-bonds along the 13–58 °C range was noticeably greater than that caused by lipids or steroids at 500 μM. The H-bonded network of the interfacial water in DMPA membranes was disrupted by the presence of 25-hydroxycholesterol, but no significant disruption was observed in the presence of progesterone. The reduction of the H-bonds entails a reduction in the aggregation of the interfacial water by a reduction in the number of H-bonded molecules. It is proposed that the number of water molecules bonded with two H-bonds diminishes and the number of molecules with no H-bond increases roughly at similar proportions, with a constant population of molecules with one H-bond. The opposed effects of steroids are discussed in the context of their opposed effects on the phase state of membranes, the membrane water content and the steroid molecular structure.

A new species of Cosmoclopius Stål, 1866 from Argentina (Hemiptera, Reduviidae) Varela, Pablo Sebastian; Melo, María Cecilia A new species of Cosmoclopius Stål, 1866, C. joceliae sp. nov. is described based on specimens collected in northern Argentina. This new species is recognized by the vertical and truncate median process of pygophore, and the shortrecurved spine on the apex of the dorsal phallothecal sclerite; and other features such as the dorsally black head, pronotum, and femora, and the thoracic sterna black with median pale markings; some females show lighter posterior pronotal lobe and femora with more conspicuous dark and pale bands. Digital images of the adult male and female and male genitalia are provided, as well as a comparison with the species of the genus are given.

Variaciones espacio-temporales de la mortalidad por COVID-19 en barrios de la Ciudad Autónoma de Buenos Aires; Spatiotemporal variations in mortality from COVID-19 in neighborhoods of the Autonomous City of Buenos Aires, Argentina Leveau, Carlos Marcelo INTRODUCCIÓN: Estudios recientes muestran un riesgo mayor de mortalidad por la enfermedad por el nuevo coronavirus (COVID-19) en áreas de nivel socioeconómico bajo. El objetivo del presente estudio es describir las variaciones espacio-temporales de la mortalidad por COVID-19 al interior de la Ciudad Autónoma de Buenos Aires (CABA). MÉTODOS: Se utilizaron datos notificados al día, mes y año, y el lugar de residencia de las personas fallecidas por COVID-19 en CABA desde el 3 de marzo hasta el 3 de octubre de 2020. Las unidades espaciales fueron los 48 barrios que componen CABA y se analizaron dos poblaciones (menores de 60 años y a partir de esta edad o mayores). Se utilizaron técnicas de escaneo espacio-temporal para detectar conglomerados de mortalidad alta y baja. Se comparó el porcentaje de hogares con necesidades básicas insatisfechas (NBI), como medida de pobreza estructural, de los barrios con conglomerados de mortalidad alta con el de los barrios con conglomerados de mortalidad baja. RESULTADOS: Los conglomerados de mortalidad alta se localizaron, en su mayoría, en el sur de la ciudad, mientras que los conglomerados de mortalidad baja lo hicieron en las zonas Oeste y Norte. Los barrios de conglomerados de mortalidad alta mostraron porcentajes de hogares con NBI más elevados en comparación con los barrios con conglomerados de mortalidad baja. DISCUSIÓN: Este estudio encontró desigualdades socio-espaciales de la mortalidad por COVID-19 entre barrios de CABA, lo que refleja una brecha socioeconómica con un eje Norte-Sur, persistente desde hace varias décadas.; INTRODUCTION: Recent studies show an increased risk of mortality from COVID-19 in areas of low socioeconomic status. The objective of this study is to describe the spatio-temporal variations in mortality from COVID-19 within the Ciudad Autónoma de Buenos Aires (CABA). METHODS: Data referring to the day, month and year, and the place of residence of the people who died from COVID-19 in CABA from March 3 to October 3, 2020 were used. The spatial units were the 48 neighborhoods that make up the CABA and two populations were analyzed (under 60 years and from this age or older). Spatio-temporal scan statistics were used to detect high and low mortality clusters. The percentage of households with Unsatisfied Basic Needs (UBN), as a measure of structural poverty, was compared between neighborhoods belonging to high mortality clusters and neighborhoods belonging to low mortality clusters. RESULTS: The high mortality clusters were located mainly in the southern half of CABA, while the low mortality clusters were located in the west and north of the city. The neighborhoods of high mortality clusters showed higher percentages of households with UBN compared to the neighborhoods belonging to low mortality clusters. DISCUSSION: This study found socio-spatial inequalities in mortality from COVID-19 between neighborhoods in CABA, reflecting a persistent north-south socioeconomic gap for several decades.

“Entonces, Victoria, plante su cruz ahora, la cruz de los suyos”: Los inicios de Ocampo como gestora artística y cultural en Argentina durante el gobierno de Marcelo T de Alvear; "Then, Victoria, plant your cross now, the cross of yours": Ocampo's beginnings as an artistic and cultural manager in Argentina during the government of Marcelo T de Alvear González, María Soledad El presente artículo se propone abordar a Victoria Ocampo como gestora artística y cultural antes de Sur. Para esto, recurriremos al abordaje de algunos pasajes de sus Testimonios y al cuarto volumen de su Autobiografía titulado “Viraje”, para comprender su labor antes de su consagración a partir de los treinta. Como hipótesis expresamos que Ocampo inicia su recorrido como gestora artística y cultural en los veinte en el marco del gobierno de Marcelo T. de Alvear y que dicho posicionamiento escasamente abordado por la crítica permite leerla en el trayecto inicial a partir de los nexos entre cultura, arte y política, y de la legitimación que buscaba lograr a partir de ese entrelazamiento. Buscaremos por medio del recurso de la comparación interpretarla en dos escenarios que permiten explicar su agencia: el de la hospitalidad y de lo institucional.; This article aims to address Victoria Ocampo as an artistic and cultural manager before Sur. For this, we will turn to the approach of some passages of her Testimonios and the fourth volume of his Autobiografía entitled "Viraje", to understand her work before her consecration from the thirties. As a hypothesis, we express that Ocampo began her journey as an artistic and cultural manager in the twenties within the framework of the government of Marcelo T. de Alvear and that position rarely addressed by critics allows reading it in the initial journey from the links between culture, art and politics, and from the legitimation that it sought to achieve from that intertwining. We will seek through the resource of comparison to interpret it in two scenarios that allow us to explain its agency:the hospitality and the institutional.