El primer intento en defensa del patrimonio jesuítico o una excusa para extirpar su memoria. El expediente sobre la demolición de la iglesia jesuítica de Asunción.; An attempt to defend the Jesuit Heritage or an excuse to erase its memory. The case of the Jesuit Church in Asunción, Paraguay Page, Carlos Alberto En el Archivo General de la Nación Argentina se encuentra un voluminoso expediente que trata sobre el tema de la demolición de la iglesia jesuítica de Asunción y del que Furlong se ocupó al pasar, cuando trabajó el tema en su libro sobre los arquitectos del Río de la Plata. Se trata de un estupendo alegato confeccionado por el ingeniero español Julio Ramón de César, quien intenta conservar un edificio jesuítico. Pero además de ello, encierra un testimonio contemporáneo que vislumbra las intenciones de extirpar de la memoria el paso de los jesuitas. Una actitud muy usada cuando se pretende diezmar la identidad de los pueblos: borrar su memoria, tanto oral como escrita, y también su memoria construida. Este trabajo intenta rescatar esa memoria justamente para dar a conocer las intenciones de un grupo humano que actuó en un tiempo no favorable a los jesuitas.; In the General Archives of the Argentine Nation there is a large fi le that deals with the issue of the demolition of the Jesuit Church in Asunción, subject which Furlong dealt with somewhat superfi cially, when he worked on the theme of his book on the architects of the River Plate. It is about a great argument made by the Spanish engineer Julio Ramón de César, who tries to preserve a Jesuit building. Moreover, it contains a contemporary testimony that envisages the attempts to erase from the memory the presence of the Jesuits. A very frequently used approach when the purpose is to decimate the identity of the peoples: erase both the oral as well as the written memory, and also their architetural memory. Th is paper attempts to rescue that memory so as to reveal the intentions of a human group that acted in a time that was unfavorable to the Jesuits.

PPARalpha agonists regulate lipid metabolism and nitric oxide production and prevents placental overgrowth in tern in placentas from diabetic rats Martinez, Nora Alicia; Kurtz, Melisa Lidia Amelia; Capobianco, Evangelina Lorena; Higa, Romina Daniela; White, Verónica; Jawerbaum, Alicia Sandra Maternal diabetes impairs fetoplacental metabolism and growth. Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor capable of regulating lipid metabolism and inflammatory pathways. In this study, we analyzed whether placental and fetal PPARα activation regulates lipid metabolism and nitric oxide (NO) production in term placentas from diabetic rats. Diabetes was induced by neonatal streptozotocin administration. On day 21 of pregnancy, placentas from control and diabetic rats were cultured in the presence of PPARα agonists (clofibrate and leukotriene B4 (LTB4)) for further evaluation of levels, synthesis, and peroxidation of lipids as well as NO production. Besides, on days 19, 20, and 21 of gestation, fetuses were injected with LTB4, and the placentas were explanted on day 21 of gestation for evaluation of placental weight and concentrations of placental lipids, lipoperoxides, and NO metabolites. We found that placentas from diabetic rats showed reduced PPARα concentrations. They presented no lipid overaccumulation but reduced lipid synthesis, parameters negatively regulated by PPARα activators. Lipid peroxidation and NO production, increased in placentas from diabetic rats, were negatively regulated by PPARα activators. Fetal PPARα activation in diabetic rats does not change placental lipid concentrations but reduced placental weight and NO production. In conclusion, PPARα activators regulate lipid metabolism and NO production in term placentas from diabetic rats, an activation that regulates placental growth and can partly be exerted by the developing fetus.

Problemáticas socioambientales producidas por el avance de urbanizaciones sobre producciones intensivas del periurbano de Buenos Aires Feito, Maria Carolina Analizamos la dimensión socioambiental de ciertos conflictos desencadenados por la instalación de barrios residenciales en ámbitos tradicionalmente rurales del periurbano de la Ciudad de Buenos Aires. Tomamos el caso de la producción intensiva de aves, en la juridiscción de Exaltación de la Cruz, en la zona Norte del periurbano mencionado, en donde nuevas formas de uso del espacio rural basadas en aspectos residenciales, implican una mercantilización de lo rural, produciendo un aumento de heterogeneidad del espacio rural mediante instalación de countrys en una zona con fuerte revalorización inmobiliaria, que compite con la tradicional actividad avícola. Estos avicultores entran en conflicto por uso del espacio rural con los nuevos vecinos que los acusan de supuesta “contaminación ambiental”. Considerando que los problemas ambientales no son "naturales" sino que se originan en fenómenos de distintos tipos: naturales (medio físico); sociales (relaciones entre los hombres); antrópicos (actividad humana), mostramos que las distintas percepciones que las personas tienen sobre el medioambiente y los riesgos ambientales que corren, varían según los contextos culturales en donde los peligros percibidos tienen lugar. En este marco, el municipio de Exaltación intenta crear nuevas regulaciones e instancias de concertación para participación consensuada entre distintos actores, para promover la convivencia de distintas ruralidades en el partido. El desarrollo local puede articular la reconstrucción y compensación de los daños con el debate acerca de la gestión ambiental y la toma de decisiones participativas.

El valor económico de la información climática; The economic value of climate information Bert, Federico Esteban; Letson, David; Podesta, Guillermo

Effect of lithium on the electrical properties of polycystin-2 (TRPP2) Cantero, Maria del Rocio; Cantiello, Horacio Fabio Polycystin-2 (PC2, TRPP2) is a TRP-type, non-selective cation channel whose dysfunction is implicated in changes in primary cilium structure and genesis of autosomal dominant polycystic kidney disease (ADPKD). Lithium (Li+) is a potent pharmaceutical agent whose effect on cell function is largely unknown. In this work, we explored the effect of Li+ on PC2 channel function. In vitro translated PC2 was studied in a lipid bilayer reconstitution system exposed to different chemical conditions such as Li+ or K+ chemical gradients and different symmetrical concentrations of either cation. Li+ inhibited PC2 function only from the external side, by decreasing the single-channel conductance and modifying the reversal potential consistent with both permeability to and blockage of the channel. When a chemical gradient was imposed, the PC2 single-channel conductance was 144 pS and 107 pS for either K+ or Li+, respectively. Data were analysed in terms of the Goldman–Hodgkin–Katz approximation and energy models based on absolute rate theory to understand the mechanism(s) of Li+ transport and blockage of PC2. The 2S3B model better explained the findings, including saturation, anomalous mole fraction, non-linearity of the current–voltage curves under bi-ionic conditions and concentration dependence of permeability ratios. The data indicate that Li+ modifies PC2 channel function, whose effect unmasks a high-affinity binding site for this ion, and an intrinsic asymmetry in the pore structure of the channel. The findings provide insights into possible mechanism(s) of Li+ regulation of ciliary length and dysfunction mediated by this cation.

Identidad y colonialidad en los relatos de Alberto Alabí; Identity and Coloniality in Alberto Alabí’s Short Stories López, Irene Noemí En este artículo proponemos un análisis de algunos relatos del escritor argentino Alberto Alabí desde la noción de colonialidad en sus tres dimensiones —del poder, del saber y del ser— y sus implicaciones en las formaciones identitarias. Consideramos que los conflictos que estos relatos textualizan nos permiten comprender algunas de las problemáticas sociales candentes en el espacio norteño, como la racialización de la diferencia y, consecuentemente, el color de piel, tanto en la subalternización de sujetos y prácticas como en la construcción de representaciones identitarias.; In this paper we propose an analysis of short stories of an argentinean writter, Alberto Alabí, from the notion of coloniality of power, of knowledge and being and its implications for identity formations. We believe that the conflicts textualized in these short stories permit us to understand many of social problems in the north of Argentina, such as the role played by the racialization of difference and, consequently, the color of skin in the subalternization of subjects and practices as well as in construction of identity representations.

Determinación de residuos de deoxicolato de sodio en formulaciones vacunales por cromatografía electrocinética micelar; Determination of Sodium deoxycolate residues in vaccinal formulation by micellar electrokinetic chromatography Yaima, Merchan; Lucangioli, Silvia Edith; Carducci, Clyde; Fajardo, Esther María; Rico, Jeannete; Tamayo, Yolexis; Delgado, Ileana El deoxicolato de sodio (DCNa) es el surfactante por excelencia empleado en la industria biofarmacéutica para la solubilización de vesículas de membrana externa. Es bien conocida la importancia que reviste el control de este metabolito en materiales biológicos, debido a su alta toxicidad para el organismo humano. Para demostrar la presencia de bajas concentraciones de este metabolito en formulaciones vacunales es necesario el empleo de una metodología altamente selectiva, sensible, específica y reproducible. En el presente reporte se utilizó la cromatografía electrocinética micelar (MEKC) en un analizador capilar de iones (Water corp. Milford MA), con una detección a 185 nm, con lámpara de mercurio. Se empleó un capilar de sílica fundida (Waters Corp. Milford MA); se evaluó la pureza de dos lotes de deoxicolato de sodio y se analizaron 15 muestras de vesículas purificadas, ingrediente farmacéutico activo de formulaciones vacunales. Los datos fueron registrados y procesados con el software Millennium TM (Waters Corp. Milford MA). Se determinó que los lotes de deoxicolato de sodio contenían 1,19% y 0,44% de ácido cólico contaminante y que el 93% de las muestras de vesículas purificadas tenían de 0 a 2,44 µg DCNa/100 µg de proteína. Los resultados obtenidos por MEKC fueron comparados con una modificación de una prueba cinética empleada para determinar ácidos biliares en sangre (Merckotest). El sistema MEKC mostró mejores resultados con respecto al Merkotest.; The sodium deoxycholate (DCNa) source is the surfactant used in the biopharmaceutical industry for the solubilization of outer membrane vesicles. It is well known the importance of control of this metabolite in biological materials due to its high toxicity for humans. To demonstrate significant small variations of this metabolite in vaccine formulations it is necessary to use a methodology highly selective, sensitive, specific and reproducible. In this report we used the micellar electrokinetic chromatography (MEKC) in a Capillary Ion Analyzer (Water corp. Milford MA) detection at 185 nm mercury lamp. It employed a fused silica capillary uncoated (Waters Corp. Milford MA). We assessed the purity of 2 lots of sodium deoxycholate and analyzed 15 samples of purified vesicles active pharmaceutical ingredient vaccine formulations. Data were recorded and processed with software Millennium TM (Waters Corp. Milford MA). It was found that lots of sodium deoxycholate containing 1.19 and 0.44% cholic acid and contaminate that 93% of the purified vesicles samples were from 0 to 2.44 mg protein DCNa/100 µg. MECK's results were compared with a kinetic test used to determine bile acids in blood (Merckotest). MECK system showed better results regarding the Merkotest.

Supramolecular analytical chemistry: Spectrofluorimetric determination of 6-hydroxymelatonin with hydroxypropyl-β-cyclodextrin Bracamonte, Angel Guillermo; Miñambres, Guadalupe Gloria; Veglia, Alicia Viviana The effect of the addition of native (α, β and γ) and derivative (methyl-β and hydroxypropyl-β) cyclodextrins (CD) on the fluorescence of 6-hydroxymelatonin (6HM) in water solutions was studied. The fluorescence of the substrate in the presence of hydroxypropyl-β-CD (HPCD) showed the maximum enhancement and the association constant (KA, mol-1 L) was determined (60±2) and interpreted. The fluorescence quantum yield ratio between the complex and free substrate (φ6HMCD/φ6HM) = 6.0±0.2 provides analytical advantages. On the basis of this supramolecular interaction, an alternative and sensitive spectrofluorimetric method for the determination of 6HM was developed with a detection limit of 0.71 ng mL-1. The validation of the method was performed in urine samples with very good recoveries 95-109 %.

Highly Dispersed MoO3/Al2O3 Shell‐Core Composites Synthesized by CVD of Mo(CO)6 under Atmospheric Pressure Shi, Guojun; Franzke, Thomas; Xia, Wei; Sanchez, Miguel Dario; Muhler, Martin MoO3/γ‐Al2O3 composites are synthesized by CVD under atmospheric pressure using Mo(CO)6 as the precursor and porous γ‐Al2O3 particles in a horizontal, rotating, hot‐wall reactor, which is also used for calcination in air. The composites are characterized by N2 physisorption, atomic absorption spectroscopy, X‐ray photoelectron spectroscopy (XPS), X‐ray diffraction (XRD), transmission electron microscopy (TEM), and laser Raman spectroscopy (LRS). The synthesized samples exhibit excellent porosity, even at high Mo loadings. A much higher Mo yield is achieved when applying sublimation‐adsorption in static air instead of using flowing N2. A high degree of Mo dispersion on alumina is confirmed by XRD, LRS, and TEM; with a Mo surface density as high as 5.2 atoms nm−2, the sample is X‐ray amorphous, there are no polymeric molybdate species detectable by LRS, and the island size of the molybdate species is about 1 nm according to TEM. The XPS analysis shows that exclusively MoVI species are present on all synthesized samples. Thus, the applied rotating, hot‐wall reactor achieves efficient mixing and homogeneous deposition.

El porvenir de Jacques Derrida Chun, Sebastián El porvenir de Jacques Derrida se juega en su reflexión sobre lo político, la cual gira a su vez sobre este mismo concepto: porvenir. Por lo tanto, pensar en la deconstrucción de lo político llevada a cabo por Derrida necesariamente nos conducirá a analizar algunos ejes que atraviesan la cuestión del porvenir: herencia, aporía, mesianicidad sin mesianismo e invención. Nos proponemos en este recorrido destacar la importancia del pensamiento de Derrida dentro del debate político contemporáneo y la herencia que nos ha legado, la cual nos obliga a seguir pensando la deconstrucción y su vínculo con la democracia por venir.; If there´s a future (à-venir) for Derrida´s philosophy, it depends on his political analysis, where the concept of «à-venir» has a fundamental role. Then, Derrida´s deconstruction of the political issue will take us to analyze some issues related to the à-venir question: inheritance, aporia, messianicity without messianism and invention. In this article we will emphasize the importance of Derrida´s philosophy for the contemporary political debate. This inheritance makes us go on thinking about the deconstruction and its connection with the democracy to come.

"Natura multipliciter dicitur": Variantes en el uso del concepto de "natura" en la teoría política medieval a partir de la segunda mitad del siglo XIII Bertelloni, Carlos Francisco La circulación hacia mediados del siglo XIII de los libri morales de Aristóteles transformó ampliamente la ética y el pensamiento político de la edad media. El conocimiento medieval de la filosofía moral aristotélica produjo un cambio cualitativo en diferentes temas de la filosofía práctica; como consecuencia de ello, a partir del siglo XIII, una parte importante de la teoría política tomó de Aristóteles el concepto de natura y muchos tratados se apoyaron en él y lo utilizaron para fundamentar el nacimiento del orden político que Aristóteles llamó polis, Tomás de Aquino civitas vel provincia y Juan de París communitas civitatis vel regni. Con todo, aunque el concepto aristotélico de natura fue relevante y aunque el modelo aristotélico logró inspirar a los autores de textos políticos medievales, la natura aristotélica no fue la única natura a la que recurrieron los textos políticos al momento de fundamentar teóricamente el surgimiento del orden político. El artículo analiza los diferentes conceptos de natura y reconstruye su lugar dentro de las explicaciones del nacimiento y constitución de las distintas variantes del orden político en la filosofía política medieval.; The circulation at the end of the thirteenth century of the librimorales of Aristotle widely transformed medieval Ethics and medieval Political Theory producing a conceptual winding on chief topics. From thirteenth century onwards an important section of Political Theory was based on the aristotelian concept of natura, that some political treatises used in order to find a theoretical foundation of political order. It was called pólis by Aristotle, civitasvel provincia by Thomas Aquinas, com-munitas civitatis vel regni by Jean Quidort, and so on. But even though the influence of Aristotle ́s concept of natura was decidedly relevant and Aristotelian model markedly inspired medieval authors of political texts, it was not the unique. The paper researchs on the different meanings of natura, and shall reconstruct the place that this key concept takes in each treatise in the explanation of the raise and constitution of political order.

Acerca del carácter ontológico del esquematismo trascendental; On the ontological character of transcendental schematism Arias, Martin El objetivo de este artículo es demostrar que la doctrina kantiana del esquematismo trascendental trata una problemática ontológica. Con ese fin, en primer lugar, estudiamos las relaciones entre categorías, esquemas y principios del entendimiento. De esta manera señalamos la íntima relación entre los esquemas y los principios. En segundo lugar, mostramos que el sistema de los principios del entendimiento puede entenderse como un tratado de ontología. En tercer lugar, presentamos y criticamos un grupo de interpretaciones semánticas del esquematismo trascendental.; The aim of this paper is to demonstrate that the Kantian doctrine of transcendental schematism deals with an ontological problematic. With this purpose in mind, in the first place, I study the relationships between categories, schemata and principles of understanding. In this way I point out the close relationship between schemata and principles. In the second place, I demonstrate that the system of the principles of understanding can be conceived as an ontological treatise. In the third place, I present and review a group of semantic interpretations of transcendental schematism.

Using mLearning and MOOCs to understand chaos, emergence, and complexity in education deWaard, Inge; Abajian, Sean; Gallagher, Michael Sean; Hogue, Rebecca; Keskin, Nilgün; Koutropoulos, Apostolos; Rodriguez, Carlos Osvaldo In this paper, we look at how the massive open online course (MOOC) format developed by connectivist researchers and enthusiasts can help analyze the complexity, emergence, and chaos at work in the field of education today. We do this through the prism of a MobiMOOC, a six-week course focusing on mLearning that ran from April to May 2011. MobiMOOC embraced the core MOOC components of self-organization, connectedness, openness, complexity, and the resulting chaos, and, as such, serves as an interesting paradigm for new educational orders that are currently emerging in the field. We discuss the nature of participation in MobiMOOC, the use of mobile technology and social media, and how these factors contributed to a chaotic learning environment with emerging phenomena. These emerging phenomena resulted in a transformative educational paradigm.

Continental and oceanic crustal structure of the Pampean flat slab region, western Argentina, using receiver function analysis: New high-resolution results Gans, Christine R.; Beck, Susan L.; Zandt, George; Gilbert, Hersh; Alvarado, Patricia Monica; Anderson, Megan; Linkimer, Lepolt The Pampean flat slab of central Chile and Argentina (30°-32°S) has strongly influenced Cenozoic tectonics in western Argentina, which contains both the thick-skinned, basement-cored uplifts of the Sierras Pampeanas and the thin-skinned Andean Precordillera fold and thrust belt. In this region of South America, the Nazca Plate is subducting nearly horizontally beneath the South American Plate at ∼100km depth. To gain a better understanding of the deeper structure of this region, including the transition from flat to 'normal' subduction to the south, three IRIS-PASSCAL arrays of broad-band seismic stations have been deployed in central Argentina. Using the dense SIEMBRA array, combined with the broader CHARGE and ESP arrays, the flat slab is imaged for the first time in 3-D detail using receiver function (RF) analysis. A distinct pair of RF arrivals consisting of a negative pulse that marks the top of the oceanic crust, followed by a positive pulse, which indicates the base of the oceanic crust, can be used to map the slab's structure. Depths to Moho and oceanic crustal thicknesses estimated from RF results provide new, more detailed regional maps. An improved depth to continental Moho map shows depths of more than 70km in the main Cordillera and ∼50km in the western Sierras Pampeanas, that shallow to ∼35km in the eastern Sierras Pampeanas. Depth to Moho contours roughly follow terrane boundaries. Offshore, the hotspot seamount chain of the Juan Fernández Ridge (JFR) is thought to create overthickened oceanic crust, providing a mechanism for flat slab subduction. By comparing synthetic RFs, based on various structures, to the observed RF signal we determine that the thickness of the oceanic crust at the top of the slab averages at least ∼13-19km, supporting the idea of a moderately overthickened crust to provide the additional buoyancy for the slab to remain flat. The overthickened region is broader than the area directly aligned with the path of the JFR, however, and indicates, along with the slab earthquake locations, that the flat slab area is wider than the JFR volcanic chain observed in the offshore bathymetry. Further, RFs indicate that the subducted oceanic crust in the region directly along the path of the subducted ridge is broken by trench-parallel faults. One explanation for these faults is that they are older structures within the oceanic crust that were created when the slab subducted. Alternatively, it is possible that faults formed recently from tectonic underplating caused by increased interplate coupling in the flat slab region.

Cell Viability and Functionality of Probiotic Bacteria in Dairy Products Vinderola, Celso Gabriel; Binetti, Ana Griselda; Burns, Patricia Graciela; Reinheimer, Jorge Alberto Probiotic bacteria, according to the definition adopted by the World Health Organization in 2002, are live microorganisms, which when administered in adequate amounts confer a health benefit to the host. Recent studies show that the same probiotic strain produced and/or preserved under different storage conditions, may present different responses regarding their susceptibility to the adverse conditions of the gastrointestinal tract, its capacity to adhere to the intestinal epithelium, or its immunomodulating capacity, the functionality being affected without changes in cell viability. This could imply that the control of cell viability is not always enough to guarantee the functionality (probiotic capacity) of a strain. Therefore, a new challenge arises for food technologists and microbiologists when it comes to designing and monitoring probiotic food: to be able to monitor the functionality of a probiotic microorganism throughout all the stages the strain goes through from the moment it is produced and included in the food vehicle, until the moment of consumption. Conventional methodological tools or others still to be developed must be used. The application of cell membrane functionality markers, the use of tests of resistance to intestinal barriers, the study of surface properties and the application of in vivo models come together as complementary tools to assess the actual capacity of a probiotic organism in a specific food, to exert functional effects regardless of the number of viable cells present at the moment of consumption.

Biased Perceptions of Income Distribution and Preferences for Redistribution: Evidence from a Survey Experiment Cruces, Guillermo Antonio; Perez Truglia, Ricardo Nicolas; Tetaz, Martin Alberto Individual perceptions of income distribution play a vital role in political economy and public finance models, yet there is little evidence regarding their origins or accuracy. This study examines how individuals form these perceptions and posits that systematic biases arise from the extrapolation of information extracted from reference groups. A tailored household survey provides original evidence on the significant biases in individuals’ evaluations of their own relative position in the distribution. Furthermore, the data supports the hypothesis that the selection process into the reference groups is the source of those biases. Finally, this study also assesses the practical relevance of these biases by examining their impact on attitudes towards redistributive policies. An experimental design incorporated into the survey provides consistent information on the own ranking within the income distribution to a randomly selected group of respondents. Confronting agents’ biased perceptions with this information has a significant effect on their stated preferences for redistribution. Those who had overestimated their relative position and thought of themselves relatively richer than they were demand higher levels of redistribution when informed of their true ranking. This relationship between biased perceptions and political attitudes provides an alternative explanation for the relatively low degree of redistribution observed in modern democracies.

Optimal Contracts with Hidden Information: An Export Consortium Case Alderete, Maria Veronica This paper analyzes the creation of an export consortium among small and medium sized enterprises (SME) by the State. A hidden information principal agent model is introduced to explain the presence of SME export consortiums. The State (principal) can not observe the random realization of the firm’s (agent) disutility from effort. We introduce a setting where the informational asymmetry is post-contractual. The contract specifies the subsidy and effort levels that result from different announcements of the state by the firm. By means of the subsidy payments, the revelation of firms’ competitiveness can be achieved. The results obtained are that subsidies are ex post inefficient and they can constraint the participation of the less competitive firms to the export consortium.

Jasmonate-induced defenses: A tale of intelligence, collaborators and rascals Ballare, Carlos Luis Plants have sophisticated defense systems to protect their tissues against the attack of herbivorous organisms. Many of these defenses are orchestrated by the oxylipin jasmonate. A growing body of evidence indicates that the expression of jasmonate-induced responses is tightly regulated by the ecological context of the plant. Ecological information is provided by molecular signals that indicate the nature of the attacker, the value of the attacked organs, phytochrome status and thereby proximity of competing plants, association with beneficial organisms and history of plant interactions with pathogens and herbivores. This review discusses recent advances in this field and highlights the need to map the activities of informational modulators to specific control points within our emerging model of jasmonate signaling.

First record of Liolaemus lentus Gallardo, 1966 (Squamata, Iguania, Liolaemini) in Río Negro province, Argentina Perez, Cristian Hernan Fulvio; Avila, Luciano Javier Se da a conocer un nuevo registro de Liolaemus lentus. Además, se amplía el área de distribución de esta especie a la provincia de Río Negro, Patagonia Argentina.

The effect of TP53 codon 72 and RNASEL codon 462 polymorphisms on the development of cervical cancer in Argentine women Barbisan, Gisela; Contreras, Anahí; Perez, Luis Orlando; Difranza, Leonardo; Golijow, Carlos Daniel Epidemiological evidence suggests that genetic factors, such as variants in cancer suppressor genes, may play an important role in the etiology of cervical carcinoma. . TP53 is an outstanding cell cycle regulator, mutated in most human cancers, and . RNASEL is thought to be involved in antiviral and apoptotic responses. To determine whether . TP53 Arg72Pro and . RNASEL Arg462Gln polymorphisms are associated with susceptibility to cervical cancer, a case-control study of 98 cancer patients and 123 healthy controls was conducted. Cervical samples were genotyped for both polymorphisms by pyrosequencing technology. The association between cervical cancer risk and the studied SNPs was evaluated by logistic regression, and potential gene-gene interactions were studied by Multifactor Dimensionality Reduction analysis. In the single-locus analysis, only the heterozygous . TP53 Arg72Pro genotype was significantly associated with the risk of developing a cervical carcinoma, while the . RNASEL polymorphism showed no association after age adjustment. In addition, the combination of both polymorphisms gives near-null information gain. Consequently, the effect provided by each single nucleotide polymorphism individually is considered higher than the effect resulting from the interaction between these two genes in cervical cancer risk. These results suggest that a heterozygous . TP53 Arg72Pro genotype may contribute to cervical cancer susceptibility.