An Ethnoarchaeological Study on Anthropic Markers from a Shell-midden in Tierra del Fuego (Southern Argentina): Lanashuaia II Zurro Hernández, Débora; Negre Pérez, Joan; Ruiz Pérez, Javier; Alvarez, Myrian Rosa; Briz Godino, Ivan; Caro, Jorge For many years the identification of activity areas has been carried out through the spatial distribution of lithics, zooarchaeological remains and specific features such as fireplaces. However, these data are rarely combined and integrated with results from specific analytical techniques such as phytoliths, organic matter, carbonates and multielemental analysis. This research presents the first results of an intrasite spatial analysis on a layer from the site Lanashuaia II, a shell-midden located on the Beagle Channel coast (Tierra del Fuego, Argentina). Ethnoarchaeology is used as a methodological tool to give content to the concept of anthropic markers by means of formulating archaeological hypothesis on the basis of ethnological information. This paper presents the application of specific anthropic markers, which have been designed and applied to identify ashy remains and waste areas through different combinations of proxies. The results show how an approach that integrates different techniques enhances data interpretation and allows to give visibility to activities that may not leave visible evidences.

A comparative study of Three–Phase Dual Active Bridge Converters for renewable energy applications Núñez, Rubén Orlando; Oggier, German Gustavo; Botterón, Fernando; Garcia, Guillermo The influence of different transformers in the operation of a three–phase dual active bridges DC–DC converter is analyzed. The transformers considered have their windings connected in star–star, delta–delta, star–delta and delta–star. The main objective of this paper is to obtain factors of merits to allow the selection of a transformer which will yield higher converter performance for a given application. These factors of merits allows estimate the losses in power semiconductors and high frequency transformers. Additionally, operation regions under soft switching are deduced for each transformer.

À la recherche d’importations européennes dans les peintures de paysage de la région de Córdoba (Argentine) au début du xx siècle; In search of European introductions in the landscapes near Córdoba (Argentina) at the beginning of the XXth century Metzger, Alexis; Tabeaud, Martine; Mafferra, Luis Eduardo; Marconetto, María Bernarda En la provincia de Córdoba (centro de la Argentina) durante la primer mitad del siglo XX, los pintores presentan especies vegetales europeas. Estos elementos del paisaje, muestran una mixtura entre lo local y lo venido de afuera. Los migrantes importaron sus imaginarios paisajísticos europeos que van a reproducir en su nuevo hogar. Los indicadores de estas transformaciones en el paisaje observadas en las pinturas fueron cruzadas con otros testimonios contemporáneos.; Dans la région de Córdoba (centre de l’Argentine) durant la première moitié du XXe siècle, les peintres montrent des espèces végétales venues d’Europe. Ces éléments du paysage participent d’un mixte entre ce qui est argentin et ce qui vient d’ailleurs. Car les migrants qui ont importé leurs imaginaires paysagers européens vont s’attacher à les reproduire dans leur nouvelle patrie. Les indices de ces transformations paysagères fournis par les peintures seront croisés avec des témoignages de contemporains.; In the Córdoba area in Central Argentina during the first half of the XXth century, painters show vegetal species coming from Europe. Those landscape elements are part of a mixt between what is argentine and what comes from elsewhere. The emigrants with their European mental pictures apply themselves to recreate them in their new world. The indication of landscape transformations in the works of art will be pointed out under the light of contemporary testimonies.

Las políticas científicas recientes en las universidades nacionales Unzué, Martín; Rovelli, Laura Ines El presente trabajo enseña un análisis panorámico de dos políticas científicas implementadas en Argentina durante el período 2004-2015 y propone indagar su incidencia en el plano de las universidades nacionales. En primer lugar, se estudiaron los alcances de la política de formación de doctores con su influencia en la configuración reciente del posgrado y de la carrera docente en la universidad pública. Luego se examinó el influjo de la política de priorización de la investigación científica en las estrategias y orientaciones de los dispositivos universitarios de promoción de la investigación...

Study of the effects of spray drying in whey-starch on the probiotic capacity of Lactobacillus rhamnosus 64 in the gut of mice Lavari, Luisina; Burns, Patricia Graciela; Páez, R.; Reinheimer, Jorge Alberto; Vinderola, Celso Gabriel Aims: To evaluate the effects of spray drying of Lactobacillus rhamnosus 64 on its capacity to modulate the gut immune response and on the attenuation of TNBS-induced colitis in mice. Methods and Results: Lactobacillus rhamnosus 64 was spray dried in cheese whey-starch solution and administered to mice for 3, 6 or 10 consecutive days. Peritoneal macrophage phagocytic activity, secretory IgA levels in the small intestinal fluid and TNFα, IFNγ, IL-10, IL-6 and IL-2 levels in homogenates of the small and large intestine were determined. The effects of spray drying were also evaluated in an acute model of Trinitrobenzenesulfonic acid (TNBS)-induced colitis. A shift in the regulation of immune parameters, particularly the cytokine profile, was observed for mice treated with the spray-dried culture, compared to the profile observed in animals that received the strain as fresh culture (FC). The spray-dried culture of L. rhamnosus 64 showed anti-inflammatory properties in murine model of TNBS-induced colitis. Conclusions: The spray-drying process of L. rhamnosus 64 in whey-starch modified its immunomodulating capacity in healthy animals and conferred enhanced protection in an in vivo model of inflammation. Significance and Impact of the Study: Probiotic capacity can be affected by spray drying in relation to the properties observed for the strain as an overnight FC. This fact should be taken into account when producing the culture for its application in the industry.

Correlation between in vitro and in vivo assays in selection of probiotics from traditional species of bacteria Vinderola, Celso Gabriel; Gueimonde, Miguel; Gomez-Gallego, Carlos; Delfederico, Lucrecia; Salminen, Seppo Background In vitro selection tests such as exposure to low pH and bile salts, competitive exclusion of pathogens, adherence to cell lines and prokaryotic-eukaryotic co-cultures have been commonly used to predict the functional properties of lactobacilli and bifidobacteria for their use as probiotics. However, the correlation of in vitro results with in vivo performance remains obscure. Scope and approach To review the current state of evidence linking in vitro predictions to in vivo outcomes in selecting probiotic candidates and to discuss the advantages and limitations of the various assays presently available. Key findings and conclusions The successful use of lactobacilli and bifidobacteria as traditional probiotics is based on their occurrence in human milk, naturally fermented foods, in the gastrointestinal tract and feces of infants and adults as well as on their culturability, technological robustness and long history of safe use. The lack of standardized protocols for in vitro and in vivo studies hampers comparison of the potential of new species and strains. There is thus a need to conduct selection of potential probiotics in a more robust manner and to focus well-defined in vitro and in vivo studies to document health benefits.

Interpretable interval type-2 fuzzy predicates for data clustering: A new automatic generation method based on self-organizing maps Comas, Diego Sebastián; Pastore, Juan Ignacio; Bouchet, Agustina; Ballarin, Virginia Laura; Meschino, Gustavo Javier In previous works, we proposed two methods for data clustering based on automatically discovered fuzzy predicates which were referred to as SOM-based Fuzzy Predicate Clustering (SFPC) [Meschino et al., Neurocomputing, 147, 47–59 (2015)] and Type-2 Data-based Fuzzy Predicate Clustering (T2-DFPC) [Comas et al., Expert Syst. Appl., 68, 136–150 (2017)]. In such methods, fuzzy predicates allow both data clustering and knowledge discovering about the obtained clusters. This last feature constitutes novelty comparing to other existing approaches and it is a major contribution in the data clustering field. Based on these previous methods, in the present paper a new automatic clustering method based on fuzzy predicates is proposed which uses Self-Organizing Maps (SOMs) and is called Type-2 SOM-based Fuzzy Predicate Clustering (T2-SFPC). The new method does not require any prior knowledge about the clustering addressed. First, a random partition is defined on the dataset to be clustered and SOMs are configured and trained using the resulting data subsets. Second, an automatic clustering approach is applied on the SOM codebooks, discovering representative data of the different clusters, which are called cluster prototypes. Third, interval type-2 membership function formed by Gaussian-shape sub-functions and fuzzy predicates are defined, allowing data clustering and its interpretation. The proposed method preserves all the advantages of the previous methods SFPC and T2-DFPC in relation to the knowledge extraction capabilities and their potential application on distributed clustering and parallel computing, but results obtained on several public datasets tested showed more compactness and separation of the clusters defined by the T2-SFPC, outperforming both the previous methods and the several classical clustering approaches tested, considering internal and external validation indices. Additionally, both clustering interpretation and optimization capabilities are improved by the proposed method when compared to the methods SFPC and T2-DFPC.

Los ambientes acuáticos en arqueología Prates, Luciano Raúl; Bonomo, Mariano En este trabajo se discute sobre la importancia de los ambientes acuáticos para el estudio del pasado en arqueología. Aunque el tema es abordado de modo global, el énfasis está puesto en sociedades con economías basadas en la caza, la recolección, la pesca y la horticultura a pequeña escala, y se ilustran con ejemplos arqueológicos mayoritariamente regionales de nuestro país y Sudamérica. El concepto de ambiente acuático es considerado en su sentido amplio, en el que se incluyen los ambientes marinos y del interior continental, de aguas quietas y de aguas corrientes, someras y profundas. Luego de una síntesis sobre el uso de los ambientes acuáticos a lo largo de la historia de la humanidad, el trabajo se enfoca en tres temas principales. Primero, en los modos y estrategias tecnológicas de explotación de los ambientes acuáticos (navegación, uso del agua, y explotación de minerales, plantas y animales). Luego, en los distintos grados de intensidad con que las sociedades humanas hicieron uso de estos entornos, para lo cual se definen y caracterizan cuatro modalidades principales (uso puntual, uso ocasional, uso sostenido y uso intensivo), se derivan algunas expectativas arqueológicas y se puntualizan algunos ejemplos. Por último, se resumen los aspectos principales de la relación entre los ambientes acuáticos y la comunicación y el simbolismo de las sociedades.; In this article we discuss the importance of aquatic environments for past societies, and the ways in which this topic has been approached in archaeological research. Although framed at a global scale, the focus is on hunter-gatherer, fisher, and/or smallscale horticulture societies, with special emphasis on Argentina and Southern South America. Aquatic environments are considered here in their broadest sense, including both marine and continental lands, and also still/moving, and shallow/deep bodies of water. After a general summary on the importance of aquatic environments throughout human history, this article focuses on three main topics. First, the different ways, and technological strategies in which humans exploit aquatic landscapes (navigation, use of water, and exploitation of mineral, animal and plant resources). Following, the differences in the use intensity of aquatic environments by humans; in order to categorize this diversity four different variants were defined (punctual use, occasional use, sustained use, and intensive use) for each of which archaeological expectations were defined. Finally, we also review certain relevant aspects connecting aquatic environments to social communication and symbolism.

Combinación de hongos movilizadores y solubilizadores de fósforo con rocas fosfóricas y materiales volcánicos para la promoción del crecimiento de plantas de lechuga (Lactuca sativa L.); Combination of phosphorus solubilizing and mobilizing fungi with phosphate rocks and volcanic materials to promote plant growth of lettuce (Lactuca sativa L.) Velázquez, María Silvana; Cabello, Marta Noemí; Eliades, Lorena Alejandra; Russo, Maria Leticia; Allegrucci, Natalia; Schalamuk, Santiago Los hongos formadores de micorrizas arbusculares (HFMA)incrementan la toma de fosfatos solubles, mientras que los hongossolubilizadores de P (HSP) promueven la solubilización de complejosinsolubles de fosfato, beneficiando la nutrición de las plantas. Otraalternativa para mantener la productividad de los cultivos es lacombinación de minerales o rocas que aporten nutrientes entre otraspropiedades deseables. El objetivo de este trabajo fue combinar HFMA yHSP con materiales piroclásticos (cenizas y pumicitas) del Volcán Puyehuey rocas fosfóricas (RP) del Grupo Río Chico (Chubut)- en la elaboraciónde un sustrato para la producción en maceta de Lactuca sativa. Paraformular los sustratos se utilizó una mezcla de Terrafertil® : ceniza.Penicillium thomii fue el HSP y esporas de Rhizophagus intraradices(HFMA) (AEGIS® Irriga). Los tratamientos fueron: 1) Sustrato 2) Sustrato+ HFMA 3) Sustrato + HSP 4) Sustrato + HFMA + HSP 5) Sustrato: RP 6)Sustrato: RP + HFMA 7) Sustrato: RP + HSP y 8) Sustrato: RP + HFMA + HSP.Se efectuaron 3 repeticiones por tratamiento. Todos los parámetrosevaluados: contenidos de P total y asimilable en sustrato, P en tejido ybiomasa seca vegetal fueron significativamente mayores en las plantas quecrecieron en el sustrato con RP, HPS y HFMA. Este trabajo confirma que lacombinación HSP/HFMA con cenizas volcánicas del Puyehue y las RP delGrupo Río Chico formuladas con un sustrato comercial promueven elcrecimiento de L. sativa, incrementando de este modo el valor agregado degeomateriales de origen nacional.; Arbuscular mycorrhizal fungi (AMF) increase the uptake of soluble phosphates, while phosphorus solubilizing fungi (S) promote solubilization of insoluble phosphates complexes, favoring plant nutrition. Another alternative to maintaining crop productivity is to combine minerals and rocks that provide nutrients and other desirable properties. The aim of this work was to combine AMF and S with pyroclastic materials (ashes and pumices) from Puyehue volcano and phosphate rocks (PR) from Rio Chico Group (Chubut) - to formulate a substrate for the production of potted Lactuca sativa. A mixture of Terrafertil®:ashes was used as substrate. Penicillium thomii was the solubilizing fungus and Rhizophagus intraradices spores (AMF) was the P mobilizer (AEGIS® Irriga). The treatments were: 1) Substrate; 2) Substrate + AMF; 3) Substrate + S; 4) Substrate + AMF + S; 5) Substrate: PR; 6) Substrate: PR + AMF; 7) Substrate: PR + S and 8) Substrate: PR + AMF + S. Three replicates were performed per treatment. All parameters evaluated (total and assimilable P content in substrate, P in plant tissue and plant dry biomass) were significantly higher in plants grown in substrate containing PR and inoculas with S and AMF. This work confirms that the combination of S/AMF with Puyehue volcanic ashes, PR from the Río Chico Group and a commercial substrate promote the growth of L. sativa, thus increasing the added value of national geomaterials.

Transport Properties of Co in Cu(100) from Density Functional Theory Calculations García Fernández, Carlos; Abufager, Paula Natalia; Lorente Palacios, Nicolas The electronic transport properties of a point-contact system formed by a single Co atom adsorbed on Cu (100) and contacted by a copper tip is evaluated in the presence of intra-atomic Coulomb interactions and spin-orbit coupling. The calculations are performed using equilibrium Green's functions evaluated within density functional theory completed with a Hubbard U term and spin-orbit interaction, as implemented in the Gollum package. We show that the contribution to the transmission between electrodes of spin-flip components is negative and scaling as λ2/Δ2 where λ is the SOC and Δ the Co atom-electrode coupling. Hence, due to this unfavorable ratio, SOC effects in transport in this system are small. However, we show that the spin-flip transmission component can increase by 2 orders of magnitude depending on the value of the Hubbard U term. These effects are particularly important in the contact regime because of the prevalence of d-electron transport, while in the tunneling regime, transport is controlled by the sp-electron transmission, and results are less dependent on the values of U and SOC. Using our electronic structure and the elastic transmission calculations, we discuss the effect of U and SOC on the well-known Kondo effect of this system.

l-Hemi-Implicative Semilattices Castiglioni, José Luis; San Martín, Hernán Javier An l-hemi-implicative semilattice is an algebra A=(A,∧,→,1) such that (A,∧,1) is a semilattice with a greatest element 1 and satisfies: (1) for every a,b,c∈A , a≤b→c implies a∧b≤c and (2) a→a=1 . An l-hemi-implicative semilattice is commutative if if it satisfies that a→b=b→a for every a,b∈A . It is shown that the class of l-hemi-implicative semilattices is a variety. These algebras provide a general framework for the study of different algebras of interest in algebraic logic. In any l-hemi-implicative semilattice it is possible to define an derived operation by a∼b:=(a→b)∧(b→a) . Endowing (A,∧,1) with the binary operation ∼ the algebra (A,∧,∼,1) results an l-hemi-implicative semilattice, which also satisfies the identity a∼b=b∼a . In this article, we characterize the (derived) commutative l-hemi-implicative semilattices. We also provide many new examples of l-hemi-implicative semilattice on any semillatice with greatest element (possibly with bottom). Finally, we characterize congruences on the classes of l-hemi-implicative semilattices introduced earlier and we characterize the principal congruences of l-hemi-implicative semilattices.

INGAP-PP effects on β-cell mass and function are related to its positive effect on islet angiogenesis and VEGFA production Román, Carolina Lisi; Maiztegui, Barbara; del Zotto, Hector Herminio; Gagliardino, Juan Jose; Flores, Luis Emilio Our aim was to determine whether islet angiogenesis and VEGFA production/release participate in the mechanism by which INGAP-PP enhances β-cell function and mass. We used two models: a) in vivo (normal rats injected with INGAP-PP for 10 days) and b) in vitro (normal islets cultured for 4 days with INGAP-PP, VEGFA, Rapamycin, and the specific VEGF-Receptor inhibitor, SU5416). INGAP-PP administration enhanced insulin secretion, β-cell mass, islet vascularization, and angiogenesis without affecting glucose homeostasis. Normal islets cultured with INGAP-PP and VEGFA increased insulin and VEGFA secretion while apoptosis decreased. INGAP-PP-induced effects were prevented by both Rapamycin and SU5416. INGAP-PP effects on β-cell mass and function were significantly associated with a positive effect on islet angiogenesis and VEGFA production/release. VEGF-A possibly potentiates INGAP-PP effect through mTORC pathway.

Depressive symptoms and the role of affective temperament in adults with attention-deficit/hyperactivity disorder (ADHD): A comparison with bipolar disorder Torrente, Fernando; López, Pablo; Lischinsky, Alicia; Cetkovich Bakmas, Marcelo; Manes, Facundo Francisco Objectives: To investigate the characteristics of depressive symptoms and the influence of affective temperament in adults with attention-deficit/hyperactivity disorder (ADHD), in comparison with bipolar disorder (BD) patients and healthy controls (HCs). Method: Sixty patients with ADHD, 50 patients with BD, and 30 HCs were assessed with instruments for measuring depressive symptoms (Beck Depression Inventory-II), and affective temperaments (Temperament Scale of Memphis, Pisa and San Diego, self-administered version; TEMPS-A). In addition, participants were evaluated with scales for measuring ADHD symptoms, impulsiveness, anxiety, executive dysfunction, and quality of life. Results: ADHD patients showed levels of depressive symptoms similar to BD patients and higher than HCs. Only neurovegetative symptoms of depression differentiated ADHD and BD groups (BD > ADHD). Depressive symptoms in ADHD patients correlated positively with core ADHD, impulsivity, anxiety, and dysexecutive symptoms and negatively with quality of life. Thirty-eight percent of patients with ADHD scored above the cutoff for at least one affective temperament. Cyclothymic was the more common affective temperament (25%). ADHD patients with affective temperamental traits were more depressed and impulsive than patients without those traits and showed a symptomatic profile analogous to BD patients. Limitations: The small size of resultant samples when ADHD group was stratified by the presence of affective temperament. In addition, results may not generalize to less severe ADHD patients from the community. Conclusions: Concomitant depressive symptoms constitute a common occurrence in adults with ADHD that carries significant psychopathological and functional consequences. The concept of affective temperaments may be an interesting link for explaining depressive symptomatology and emotional impulsivity in a subgroup of patients with ADHD, beyond the classic idea of comorbidity.

Studies on lignin extraction from rice husk by a soda-ethanol treatment: kinetics, separation, and characterization of products Dagnino, Eliana Paola; Felissia, Fernando Esteban; Chamorro, Ester Ramona; Area, Maria Cristina The delignification kinetics of lignocellulosic waste is an important tool for the study of the technical-economic viability of biorefinery processes. The aim of this work was to study the kinetic of lignin extraction by a soda-ethanol treatment of hemicelluloses-free rice husk, within the framework of a biorefinery. Additionally, the type of phenolic structures in the extracted lignin and the behavior of inorganics were evaluated. The kinetic study was carried out at 140, 150, and 160 °C, at different times between 3 and 100 min of reaction for each temperature. A first order kinetic model was adjusted to the experimental data of residual lignin in the treated solid in the fast and slow phase. The kinetic constant k0 varied from 0.021 to 0.035min-1 for 140 to 160 °C. The activation energies were 38.59 KJ/mol and 33.47KJ/mol for the fast and slow phase, respectively. The inorganics components remained in the solid and the proportion of silicon increased through all treatments. About 50% of the initial lignin with 1% of inorganics was recovered by precipitation. The percentage of total OH in lignin remained high, about 8.5%, and decreased with the temperature but not with the time of the reaction.

Comparison of different strategies for nitrogen removal by simultaneous nitrification and denitrification process in a batch rotating disk reactor Miranda Zoppas, Fernanda; Meneguzzi, Alvaro; Urrutia, Homero; Bernardes, Andrea Moura; Antileo, Cristian In this paper, different strategies of aeration and organics feed in the reactor were studied toevaluate the simultaneous nitrification and denitrification (SND) process efficiency for a sequencing batchrotating disk biofilm reactor (SBRDR). The effect of C/N ratio on biological nitrogen removal was also studied.Among the four strategies used, the ones with organic feeding showed the best results to promote SND. It wasalso observed a different behavior: the efficiency of SND as a function of the C/N ratio shows a tendency to ahave a lower value than values previously reported in the literature. A continuous or intermittent aeration in theprocess did not improved the nitrogen removal. These results provide sufficient knowledge of the parametersthat have the most influence on the efficient nitrogen removal via SND in batch rotating disk reactors.Keywords: batch reactor,denitrification, nitrification, nitrogen removal, rotating disk.

Optimization of reaction parameters in the conversion of PET to produce BHET Capeletti, Maria Rosa; Passamonti, Francisco Javier The conversion of poly(ethylene terephthalate) (PET) was analyzed in order to define the optimal conditions for the Bis(2-Hydroxyethyl) terephthalate (BHET) yield as regards catalyst use (zinc acetate), glycol (ethylene glycol), reaction time and temperature. These conditions were optimized so as to decrease the consumption of catalyst and glycolytic agents aiming to extend the analysis to achieve continuous recycling at a greater scale. At the same time, an analysis of the activity of different catalysts (zeolites, acid, and basic resins) was performed; no BHET yields of commercial interest were obtained. The results indicate that a very small catalyst/PET mass ratio and a low glycol/PET ratio are necessary. The reactions were carried out at a temperature of 1958C and a reaction time of 1 h: under these conditions, BHET yield is 30% (starting from pure PET) and up to 88.2% (recycling oligomers plus pure PET).

Anafilaxias y reacciones alérgicas durante cirugías y procedimientos médicos; Anaphylaxis and allergic reactions during surgery and medical procedures Larrauri, Blas J.; Torre, Gabriela; Malbran, Eloisa; Juri, María Cecilia; Fernández Romero, Diego S.; Malbrán, Alejandro Las reacciones anafilácticas intraoperatorias son impredecibles, infrecuentes y pueden poner en riesgo al paciente. Tienen una incidencia de 1/10 000 a 1/20 000 produciéndose en la mayoría de los casos por bloqueantes musculares, látex y antibióticos. No hay estadística de las reacciones alérgicas sistémicas durante otros procedimientos médicos. El estudio diagnóstico posterior a una reacción es complejo debiendo incluir toda la medicación utilizada en el procedimiento. En este estudio retrospectivo describimos 15 pacientes, de los cuales 10 tuvieron reacciones anafilácticas en un procedimiento quirúrgico, 2 en endoscopías y 1 en una ecografía transvaginal. Los dos pacientes restantes presentaron una reacción alérgica sistémica durante una ecografía transvaginal y un procedimiento odontológico. Estudiamos los pacientes con toda la medicación utilizada, incluimos látex y, eventualmente, los detergentes y desinfectantes, de haber sido empleados. Tres de las 10 cirugías no pudieron realizarse por desarrollarse la reacción durante la inducción anestésica, en cinco casos debieron interrumpirse y solo en dos se terminaron. Las reacciones posteriores a endoscopías fueron severas, requiriendo internación en terapia intensiva; las reacciones en ecografías transvaginales y procedimientos odontológicos fueron asistidas en emergencias. Los agentes causales en las cirugías incluyeron bloqueantes musculares, látex, cefalosporina, azul patente y ranitidina; en endoscopías el agente causal fue el orto-ftalaldehído (OPA), en las ecografías transvaginales el látex y en el procedimiento odontológico la amoxicilina. El objetivo de este artículo es describir la etiología de las reacciones alérgicas sistémicas y anafilácticas intraoperatorias y en procedimientos médicos, recalcando su gravedad y la necesidad de su identificación.; Anaphylaxis during anesthesia is an unpredictable, severe, and rare reaction. It has an incidence of 1/10 000 to 1/20 000 surgeries. In most series, the responsible drugs include neuromuscular blocking agents, latex, or antibiotics. The frequency and etiology of systemic allergic reactions in other medical procedures are largely unknown. The identification of responsible drugs of anaphylaxis is a complex task, requiring testing of all medications and substances used during surgery. We describe our experience in a retrospective study of 15 patients. Ten subjects developed anaphylaxis during surgery, two in endoscopic studies and one in a trans-vaginal ultrasound. The remaining two subjects, one in a trans-vaginal ultrasound and another during a dental procedure had a systemic allergic reaction. We studied all patients with all medications administered during the procedures, including latex and detergents and disinfectants. Three surgeries had to be suspended at induction of anesthesia, five were stopped incomplete and two were completed. Both patients that presented a reaction during endoscopy required intensive care unit admission and the rest were observed in a Hospital. The responsible drugs during surgery anaphylaxis were neuromuscular blocking agents, latex, patent blue, and ranitidine. Ortho-phthalaldehyde (OPA) was identified during endoscopic studies; latex was responsible in transvaginal ultrasounds; and amoxicillin in the dental procedure. The aim of the present article is to review our experience studying allergic systemic reactions and anaphylaxis during general anesthesia and medical procedures, emphasizing the severity of these reactions and the need for causative drug identification.

El proyecto formativo de Schiller en las Briefe über “Don Carlos”; Schiller’s Formative Project in the Briefe über “Don Carlos” Napoli, Santiago Juan El artículo intenta analizar un texto teórico de Friedrich Schiller, las Briefe über “Don Carlos” (Cartas sobre “Don Carlosˮ). El objetivo principal que se propone es dar cuenta de una de las problemáticas centrales que atraviesan la obra: la educación del estadista. Para ello ha sido necesario el abordaje de dicha fuente desde el punto de vista de su autonomía respecto de la pieza teatral a la que hace referencia, Don Carlos, Infant von Spanien, representada y publicada el año anterior. Las Briefe über “Don Carlos”, más que una defensa contra los críticos dramáticos, constituyen un ensayo de gran complejidad filosófica, marcado por la intención de mostrar la formación de un gobernante promisorio. Asimismo, la obra exhibe un proyecto de ciudadano delineado por Schiller para su propia época.; The article intends to examine Friedrich Schiller’s theoretical text, the Briefe über “Don Carlos” (Letters upon “Don Carlos”). The main objective it proposes is to show one of the main questions throughout the work: the education of a statesman. In order to accomplish that, it has been necessary to approach to the mentioned source from the point of view of its autonomy with regard to the play to which it refers, Don Carlos, Infant von Spanien, represented and published the previous year. The Briefe über “Don Carlos”, rather than a defense against drama critics, constitute an essay with a great philosophical complexity, characterized by the purpose of showing the formation of a future political leader. Likewise, the work exhibits an outline of a citizen created by Schiller for his own period.

Regulation of NADPH oxidase NOX4 by delta iodolactone (IL-δ) in thyroid cancer cells Thomasz, Lisa; Oglio, Andrea Romina; Salvarredi, Leonardo Andres; Perona, Marina; Rossich, Luciano Esteban; Copelli, Silvia Beatriz; Pisarev, Mario Alberto; Juvenal, Guillermo Juan Introduction: Iodine is not used only by the thyroid to synthesize thyroid hormones but also directly influences a number of thyroid parameters such as thyroid proliferation and function. Several iodinated lipids, biosynthesized by the thyroid, were postulated as intermediaries in the action of iodide. Among these, iodolactone (IL-δ) and 2-iodohexadecanal (2-IHDA) have shown to inhibit several thyroid parameters. The antiproliferative effect of IL-δ is not restricted to the thyroid gland. IL-δ exhibits anti-tumor properties in breast cancer, neuroblastoma, glioblastoma, melanoma and lung carcinoma cells suggesting that IL-δ could be used as a chemotherapeutic agent. Moreover in a colon cancer cell line (HT-29), IL-δ induced cell death, and this effect was mediated by reactive oxygen species (ROS) generation. The aim of the present study was to analyze the sources of reactive oxygen species induced by IL-δ and to explore the contribution of ROS induced by IL-δ on cell proliferation and apoptosis. Methodology and results: Cancer thyroid follicular (WRO) and papilar (TPC-1) cells lines were treated with IL-δ. Proliferation and apoptosis was analyzed. IL-δ caused a significant loss of cell viability on WRO and TPC-1 cells in a concentration dependent manner and induced apoptosis after 3 h of treatment. Furthermore, IL-δ (10 μM) increased ROS production (39% WRO and 20% TPC-1). The concomitant treatment of WRO and TPC-1 cells with Trolox or NAC plus IL-δ abrogated the augment of ROS induced by IL-δ exposure. Additionally Trolox and NAC reversed the effect of IL-δ on cell proliferation and apoptosis. Only in WRO cells IL-δ upregulates NADPH oxidase NOX4 expression, and siRNA targeted knock-down of NOX4 attenuates ROS production, apoptosis (p < 0.05) and the inhibitory effect of IL-δ on cell proliferation and PCNA expression (p < 0.05). Conclusions: The antiproliferative and pro-apoptotic effect of IL-δ is mediated by different mechanisms and pathway involving different sources of ROS generation depending on the cellular context.

Galactic perturbations on the population of wide binary stars with exoplanets Correa Otto, Jorge Alfredo; Gil Hutton, Ricardo Alfredo Aims. The aim of this work is to study the dynamical effects of the Galaxy on binary star systems with physical and orbital characteristics similar to those of the population of known wide binary stars with exoplanets. As secondary goal we analyse the possible consequences on the stability of a hypothetical planetary system orbiting one of the stellar components. Methods. We numerically reproduced the temporal evolution of a sample of 3 × 105 binary star systems disturbed by the Galactic potential and passing stars in an environment similar to the solar neighbourhood. Results. Our results show that the dynamical evolution of the population of wide binary stars with exoplanets in the solar neighbourhood is modelled by the process of disruption of binary star systems induced by the Galaxy. We found that this process depends mainly on the separation between both stars, whereas it is almost independent of the initial orbital configuration. Moreover, our calculations are in agreement with the results of previous works regarding the indirect influence of the Galaxy on the stability of planetary systems in wide binary stars. However, the effects on the planetary region show a dependence on the initial configuration of binary stars. Finally, we obtain an indirect test of the impulse approximation model for dynamical studies of binary star systems.