El Fondo para la Investigación Científica y Tecnológica (FONCyT) informa que se ha prorrogado la fecha límite para la presentación de propuestas de la convocatoria PICTO GRAN LOGIA según disposición administrativa N°009 del 20 de febrero de 2018.

Distribution of anisakid nematodes parasitizing rajiform skates under commercial exploitation in the Southwestern Atlantic Irigoitia, Manuel Marcial; Braicovich, Paola Elizabeth; Lanfranchi, Ana Laura; Farber, Marisa Diana; Timi, Juan Tomas In order to evaluate the infestation by anisakids present in elasmobranchs and their distribution in the Argentine Sea, this study was carried at a regional scale with the following aims: 1) to identify those anisakid species present in skates under exploitation; 2) to characterize quantitatively these infestations and 3) to determine those factors driving the variability in parasite burdens across skate species. A total of 351 skates, belonging to 3 species (218 Sympterygia bonapartii, 86 Zearaja chilensis and 47 Atlantoraja castelnaui) and from different localities of the Argentine Sea were examined for anisakids. Parasites were found in the stomach wall at high prevalence in some samples. Based on morphology and mtDNA cox2 sequences analyses (from 24 larval worms), specimens were identified as Anisakis berlandi, A. pegreffii and Pseudoterranova cattani; the last two known as potentially pathogenic for humans. Differential distribution patterns were observed across parasite and hosts species. In general, fish caught in southern and deeper waters exhibited higher loads of Anisakis spp., whereas infestation levels by P. cattani increase in larger skates. Taking into account that the mere presence of worms or their antigens in fish meat can provoke allergic responses, information on distribution of parasites and their variability is essential for the implementation of food safety practices.

El Fondo para la Investigación Científica y Tecnológica (FONCyT) informa que se ha prorrogado la fecha límite para la presentación de propuestas de la convocatoria PICTO COVIAR según disposición administrativa N°6 del 19 de febrero de 2018.

"Sweeter than a rose", at least to Triatoma phyllosoma complex males (Triatominae: Reduviidae) May Concha, Irving Jesus; Cruz López, Leopoldo C.; Rojas, Julio C.; Ramsey, Janine Background: The Triatoma phyllosoma complex of Trypanosoma cruzi vectors (Triatominae: Reduviidae) is distributed in both Neotropical and Nearctic bioregions of Mexico. Methods: Volatile organic compounds emitted by disturbed Triatoma longipennis, Triatoma pallidipennis and Triatoma phyllosoma, and from their Brindley's and metasternal glands, were identified using solid-phase microextraction coupled with gas chromatography-mass spectrometry. Results: Disturbed bugs and the metasternal glands from T. phyllosoma released or had significantly fewer compounds than T. longipennis and T. pallidipennis. Isobutyric acid was the most abundant compound secreted by disturbed bugs of the three species, while Brindley's glands of all species produced another four compounds: propanoic acid, isobutyric acid, pentyl butanoate, and 2-methyl hexanoic acid. Two novel compounds, both rose oxide isomers, were produced in MGs and released only by disturbed females of all three species, making this the first report in Triatominae of these monoterpenes. The principal compound in MGs of both sexes of T. longipennis and T. phyllosoma was 3-methyl-2-hexanone, while cis-rose oxide was the principal compound in T. pallidipennis females. The major components in male effluvia of T. pallidipennis were 2-decanol and 3-methyl-2-hexanone. Conclusion: Discriminant analysis of volatile organic compounds was significant, separating the three species and was consistent with morphological and genetic evidence for species distinctions within the complex.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia los resultados del proceso de reconsideración para la convocatoria ANR Empresa Jóven 2016 C2 mediante Resolución de Directorio N°049/18.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia los resultados del proceso de evaluación para la convocatoria ANR Fonsoft 2017 C1 mediante Resolución de Directorio N°046/18.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia los resultados del proceso de evaluación para la convocatoria Crédito Exporta 2014 mediante Resolución de Directorio N°050/18.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia los resultados del proceso de reconsideración para la convocatoria Emprendedores FONSOFT 2016 C2 mediante Resolución de Directorio N°041 y 047/18.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia los resultados del proceso de evaluación para la convocatoria Emprendedores FONSOFT 2017 C1 mediante Resolución de Directorio N°048/18.

La Agencia Nacional de Promoción Científica y Tecnológica (ANPCYT), a través del Fondo para la Investigación Científica y Tecnológica (FONCyT) llama, en forma conjunta con la Universidad Nacional de Lanús (UNLa), a la presentación de proyectos de Investigación Científica y Tecnológica para la adjudicación de subsidios a grupos de investigadores formados y activos de la UNLa orientados a áreas de interés común con el co-financiador.

Bone marrow mesenchymal stem cells as nuclear donors improve viability and health of cloned horses Olivera, R.; Moro, Lucía Natalia; Jordan, R.; Pallarols, N.; Guglielminetti, A.; Luzzani, Carlos Daniel; Miriuka, Santiago Gabriel; Vichera, Gabriel Damian Introduction: Cell plasticity is crucial in cloning to allow an efficient nuclear reprogramming and healthy offspring. Hence, cells with high plasticity, such as multipotent mesenchymal stem cells (MSCs), may be a promising alternative for horse cloning. In this study, we evaluated the use of bone marrow-MSCs (BM-MSCs) as nuclear donors in horse cloning, and we compared the in vitro and in vivo embryo development with respect to fibroblasts. Materials and methods: Zona-free nuclear transfer was performed using BM-MSCs (MSC group, n=3432) or adult fibroblasts (AF group, n=4527). Embryos produced by artificial insemination (AI) recovered by uterine flushing and transferred to recipient mares were used as controls (AI group). Results: Blastocyst development was higher in the MSC group than in the AF group (18.1% vs 10.9%, respectively; p<0.05). However, pregnancy rates and delivery rates were similar in both cloning groups, although they were lower than in the AI group (pregnancy rates: 17.7% [41/232] for MSC, 12.5% [37/297] for AF and 80.7% [71/88] for AI; delivery rates: 56.8% [21/37], 41.5% [17/41] and 90.1% [64/71], respectively). Remarkably, the gestation length of the AF group was significantly longer than the control (361.7}10.9 vs 333.9}8.7 days), in contrast to the MSC group (340.6}8.89 days). Of the total deliveries, 95.2% (20/21) of the MSC-foals were viable, compared to 52.9% (9/17) of the AF-foals (p<0.05). In addition, the AF-foals had more physiological abnormalities at birth than the MSC-foals; 90.5% (19/21) of the MSC-delivered foals were completely normal and healthy, compared to 35.3% (6/17) in the AF group. The abnormalities included flexural or angular limb deformities, umbilical cord enlargement, placental alterations and signs of syndrome of neonatal maladjustment, which were treated in most cases. Conclusion: In summary, we obtained 29 viable cloned foals and found that MSCs are suitable donor cells in horse cloning. Even more, these cells could be more efficiently reprogrammed compared to fibroblasts.

Perfil psicológico deportivo en una muestra de triatletas amateurs y diferencias con otros deportes; Sports psychological profile in a sample of amateur triathletes and differences with other sports; Perfil psicológico de esportes em uma amostra de triatletas amadores e diferenças com outros esportes Reigal, Rafael Enrique; Delgado Giralt, Joaquín Eleazar; Raimundi, María Julia; Hernández Mendo, Antonio El propósito de este trabajo fue evaluar el perfil psicológico de una muestra de triatletas amateurs y compararlo con deportistas de otras modalidades: atletismo, fútbol y golf. Participaron en el estudio 520 deportistas: 72 triatletas con edades entre los 19 y 45 años (M= 34.90; DT= 6.97), 109 atletas con edades entre los 18 y 41 años (M=27.71; DT= 6.25), 252 futbolistas con edades entre los 18 y 42 años (M=30.62; DT= 6.92) y 87 golfistas con edades entre los 18 y 44 años (M=27.21; DT= 7.55). Se utilizó el Inventario Psicológico de Ejecución Deportiva (IPED) para realizar el perfil psicológico de los participantes. Los análisis pusieron de manifiesto que el grupo de triatletas tuvo mayores puntuaciones que los atletas en control de afrontamiento negativo y positivo, control atencional, nivel motivacional y control actitudinal. También mostraron mayores puntuaciones que los futbolistas en control de afrontamiento negativo y positivo. Respecto a los golfistas, puntuaron más en todos los factores del IPED menos en nivel motivacional. En general, se aprecian puntuaciones más elevadas en triatletas que en el resto de deportes analizados.; The purpose of this work was to evaluate the psychological profile of a sample of amateur triathletes and compare it with athletes of other modalities: athletics, soccer and golf. 520 athletes participated in the study: 72 triathletes with ages between 19 and 45 years (M = 34.90, SD = 6.97), 109 athletes aged between 18 and 41 years (M = 27.71, DT = 6.25), 252 players with ages between 18 and 42 (M = 30.62; SD = 6.92) and 87 golfers with ages between 18 and 44 years (M = 27.21; SD = 7.55). The Psychological Inventory of Sports Performance (IPED) was used to perform the psychological profile of the participants. The analyzes showed that the group of triathletes had higher scores than the athletes in control of negative and positive coping, attentional control, motivational level and attitudinal control. They also showed higher scores than the players in control of negative and positive coping. Regarding the golfers, they scored more in all the factors of the IPED less in motivational level. In general, higher scores are seen in triathletes than in the other sports analyzed.; O objetivo deste trabalho foi avaliar o perfil psicológico de uma amostra de triatletas amador e compará-la com atletas de outras modalidades: atletismo, futebol e golfe. 520 atletas participaram do estudo: 72 triatletas com idade entre 19 e 45 anos (M = 34,90, DP = 6,97), 109 atletas com idade entre 18 e 41 anos (M = 27,71, DT = 6,25), 252 jogadores com idade entre 18 e 42 (M = 30,62; SD = 6,92) e 87 golfistas com idade entre 18 e 44 anos (M = 27,21; SD = 7,55). O Inventário Psicológico do Desempenho Desportivo (IPED) foi utilizado para realizar o perfil psicológico dos participantes. As análises mostraram que o grupo de triatletas teve pontuações mais altas do que os atletas no controle de enfrentamentos negativos e positivos, controle de atenção, nível motivacional e controle atitudinal. Eles também apresentaram pontuações mais altas do que os jogadores no controle de enfrentamentos negativos e positivos. Quanto aos golfistas, eles marcaram mais em todos os fatores do IPED menos em nível motivacional. Em geral, pontuações mais altas são observadas nos triatletas do que nos outros esportes analisados.

El Fondo Argentino Sectorial (FONARSEC) anuncia la lista con los evaluadores que integran la comisión EBT 2.0 mediante Resolución de Directorio N° 043/18 del día 01/02/2018

El Fondo Argentino Sectorial (FONARSEC) anuncia los resultados de proceso de adjudicación para enzimas, medicina de precisión y alimentos para adultos mayores mediante la resolución 609, 563 y 509/17.

El Fondo Argentino Sectorial (FONARSEC) anuncia los resultadoos de la convocatoria INNOVACUA 2016 mediante Resolución de Directorio N° 471/17.

El Fondo Argentino Sectorial (FONARSEC) anuncia el resultado del proceso de adjudicación para Desarrollos de partes nacionales para satélites mediante la resolución 479, 619/17.

La Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT), a través de su Fondo para la Investigación Científica y Tecnológica (FONCyT), llama a concurso de Proyectos de Investigación destinados a la compra de Equipamiento Científico – PICTE -, con el objeto de financiar la adquisición de equipamiento científico destinado a Unidades Ejecutoras de I+D pertenecientes a Instituciones Públicas dedicadas a la investigación científica o tecnológica.

Mutation of Agr Is Associated with the Adaptation of Staphylococcus aureus to the Host during Chronic Osteomyelitis Suligoy Lozano, Carlos Mauricio; Lattar, Santiago Martín; Noto Llana, Mariangeles; Gonzalez, Cintia Daniela; Alvarez, Lucía Paula; Robinson, D. Ashley; Gómez, Marisa Ileana; Buzzola, Fernanda Roxana; Sordelli, Daniel Oscar Selection pressures exerted on Staphylococcus aureus by host factors may lead to the emergence of mutants better adapted to theevolving conditions at the infection site. This study was aimed at identifying the changes that occur in S. aureus exposed to thehost defense mechanisms during chronic osteomyelitis and evaluating whether these changes affect the virulence of the organism.Genome assessment of two S. aureus isolates collected 13 months apart (HU-85a and HU-85c) from a host with chronicosteomyelitis was made by full genome sequencing. Agr functionality was assessed by qRT-PCR. Isolates were tested in a rat modelof osteomyelitis and the bacterial load (CFU/tibia) and the morphometric osteomyelitic index (OI) were determined. The ability ofthe isolates to trigger the release of proinflammatory cytokines was determined on macrophages in culture. Persistence of S.aureus within the host resulted in an agrC frameshift mutation that likely led to the observed phenotype. The capacity to causebone tissue damage and trigger proinflammatory cytokines by macrophages of the agr-deficient, unencapsulated derivative(HU-85c) was decreased when compared with those of the isogenic CP8-capsulated parental strain (HU-85a). By comparison, nosignificant differences were found in the bacterial load or the OI from rats challenged with isogenic Reynolds strains [CP5, CP8 andnon-typeable (NT)], indicating that lack of CP expression alone was not likely responsible for the reduced capacity to cause tissuedamage in HU-85c compared with HU-85a. The production of biofilm was significantly increased in the isogenic derivative HU-85c.Lack of agr-dependent factors makes S. aureus less virulent during chronic osteomyelitis and alteration of the agr functionalityseems to permit better adaptation of S. aureus to the chronically infected host.

Water Resource Distribution and Tectonics in the Tulum Valley, Western Central Argentina Rodríguez, Aixa Inés; Martínez, Myriam Patricia; Abarca, María Graciela A gravimetric analyse over the Tulum Valley was made. This data was used to reveal the tectonic structures in the Valley. Gravity data was processed using upward continuation and vertical derivative filters and all the results were compared with drainage systems and groundwater maps of the area. Both groundwater and surface-water are highly demanded resources due to theirscarcity. The drainage network and groundwater are influenced by tectonic structures in the Tulum valley. In the piedmont of the Sierra Chica de Zonda the broom-shaped river pattern correspond to Quaternary faults. While in the central Tulum Valley, the depocenter basin is a water recipient, the groundwater table permanently close to the surface and they are considered discharge. The depocenter is linked to paleo-swamps and wetlands in a pastwetter environment. In the Tulum fault systems area, streams adapt its drainagenetwork bordering basements blocks uplifts. In turn, the blocks uplift behavesas a hydrogeological barrier for the groundwater basin. Also, in the alluvial fan of San Juan River the free aquifer is affected by a Tertiary uplift block.From this study, it was concluded that tectonic structures control surface and groundwater resources in the Tulum Valley.

Vaccine potential of antigen cocktails composed of recombinant Toxoplasma gondii TgPI-1, ROP2 and GRA4 proteins against chronic toxoplasmosis in C3H mice Picchio, Mariano Sergio; Sánchez, Vanesa Roxana; Arcon, Nadia; Soto, Ariadna Soledad; Perrone Sibilia, Matias; Aldirico, María de Los Ángeles; Urrutia, Mariela; Moretta, Rosalia Ester; Fenoy, Ignacio Martín; Goldman, Alejandra; Martín, Valentina The development of an effective and safe vaccine to prevent Toxoplasma gondii infection is an important aim due to the great clinical and economic impact of this parasitosis. We have previously demonstrated that immunization with the serine protease inhibitor-1 (TgPI-1) confers partial protection to C3H/HeN and C57BL/6 mice. In order to improve the level of protection, in this work, we combined this novel antigen with ROP2 and/or GRA4 recombinant proteins (rTgPI-1+rROP2, rTgPI-1+rGRA4, rTgPI-1+rROP2+rGRA4) to explore the best combination against chronic toxoplasmosis in C3H/HeN mice. All tested vaccine formulations, administered following a homologous prime-boost protocol that combines intradermal and intranasal routes, conferred partial protection as measured by the reduction of brain cyst burden following oral challenge with tissue cysts of Me49 T. gondii strain. The highest level of protection was achieved by the mixture of rTgPI-1 and rROP2 proteins with an average parasite burden reduction of 50% compared to the unvaccinated control group. The vaccine-induced protective effect was related to the elicitation of systemic cellular and humoral immune responses that included antigen-specific spleen cell proliferation, the release of Th1/Th2 cytokines, and the generation of antigen-specific antibodies in serum. Additionally, mucosal immune responses were also induced, characterized by secretion of antigen-specific IgA antibodies in intestinal lavages and specific mesenteric lymph node cell proliferation. Our results demonstrate that rTgPI-1+rROP2 antigens seem a promising mixture to be combined with other immunogenic proteins in a multiantigenic vaccine formulation against toxoplasmosis.