Comparison of different strategies for nitrogen removal by simultaneous nitrification and denitrification process in a batch rotating disk reactor Miranda Zoppas, Fernanda; Meneguzzi, Alvaro; Urrutia, Homero; Bernardes, Andrea Moura; Antileo, Cristian In this paper, different strategies of aeration and organics feed in the reactor were studied toevaluate the simultaneous nitrification and denitrification (SND) process efficiency for a sequencing batchrotating disk biofilm reactor (SBRDR). The effect of C/N ratio on biological nitrogen removal was also studied.Among the four strategies used, the ones with organic feeding showed the best results to promote SND. It wasalso observed a different behavior: the efficiency of SND as a function of the C/N ratio shows a tendency to ahave a lower value than values previously reported in the literature. A continuous or intermittent aeration in theprocess did not improved the nitrogen removal. These results provide sufficient knowledge of the parametersthat have the most influence on the efficient nitrogen removal via SND in batch rotating disk reactors.Keywords: batch reactor,denitrification, nitrification, nitrogen removal, rotating disk.

Optimization of reaction parameters in the conversion of PET to produce BHET Capeletti, Maria Rosa; Passamonti, Francisco Javier The conversion of poly(ethylene terephthalate) (PET) was analyzed in order to define the optimal conditions for the Bis(2-Hydroxyethyl) terephthalate (BHET) yield as regards catalyst use (zinc acetate), glycol (ethylene glycol), reaction time and temperature. These conditions were optimized so as to decrease the consumption of catalyst and glycolytic agents aiming to extend the analysis to achieve continuous recycling at a greater scale. At the same time, an analysis of the activity of different catalysts (zeolites, acid, and basic resins) was performed; no BHET yields of commercial interest were obtained. The results indicate that a very small catalyst/PET mass ratio and a low glycol/PET ratio are necessary. The reactions were carried out at a temperature of 1958C and a reaction time of 1 h: under these conditions, BHET yield is 30% (starting from pure PET) and up to 88.2% (recycling oligomers plus pure PET).

Anafilaxias y reacciones alérgicas durante cirugías y procedimientos médicos; Anaphylaxis and allergic reactions during surgery and medical procedures Larrauri, Blas J.; Torre, Gabriela; Malbran, Eloisa; Juri, María Cecilia; Fernández Romero, Diego S.; Malbrán, Alejandro Las reacciones anafilácticas intraoperatorias son impredecibles, infrecuentes y pueden poner en riesgo al paciente. Tienen una incidencia de 1/10 000 a 1/20 000 produciéndose en la mayoría de los casos por bloqueantes musculares, látex y antibióticos. No hay estadística de las reacciones alérgicas sistémicas durante otros procedimientos médicos. El estudio diagnóstico posterior a una reacción es complejo debiendo incluir toda la medicación utilizada en el procedimiento. En este estudio retrospectivo describimos 15 pacientes, de los cuales 10 tuvieron reacciones anafilácticas en un procedimiento quirúrgico, 2 en endoscopías y 1 en una ecografía transvaginal. Los dos pacientes restantes presentaron una reacción alérgica sistémica durante una ecografía transvaginal y un procedimiento odontológico. Estudiamos los pacientes con toda la medicación utilizada, incluimos látex y, eventualmente, los detergentes y desinfectantes, de haber sido empleados. Tres de las 10 cirugías no pudieron realizarse por desarrollarse la reacción durante la inducción anestésica, en cinco casos debieron interrumpirse y solo en dos se terminaron. Las reacciones posteriores a endoscopías fueron severas, requiriendo internación en terapia intensiva; las reacciones en ecografías transvaginales y procedimientos odontológicos fueron asistidas en emergencias. Los agentes causales en las cirugías incluyeron bloqueantes musculares, látex, cefalosporina, azul patente y ranitidina; en endoscopías el agente causal fue el orto-ftalaldehído (OPA), en las ecografías transvaginales el látex y en el procedimiento odontológico la amoxicilina. El objetivo de este artículo es describir la etiología de las reacciones alérgicas sistémicas y anafilácticas intraoperatorias y en procedimientos médicos, recalcando su gravedad y la necesidad de su identificación.; Anaphylaxis during anesthesia is an unpredictable, severe, and rare reaction. It has an incidence of 1/10 000 to 1/20 000 surgeries. In most series, the responsible drugs include neuromuscular blocking agents, latex, or antibiotics. The frequency and etiology of systemic allergic reactions in other medical procedures are largely unknown. The identification of responsible drugs of anaphylaxis is a complex task, requiring testing of all medications and substances used during surgery. We describe our experience in a retrospective study of 15 patients. Ten subjects developed anaphylaxis during surgery, two in endoscopic studies and one in a trans-vaginal ultrasound. The remaining two subjects, one in a trans-vaginal ultrasound and another during a dental procedure had a systemic allergic reaction. We studied all patients with all medications administered during the procedures, including latex and detergents and disinfectants. Three surgeries had to be suspended at induction of anesthesia, five were stopped incomplete and two were completed. Both patients that presented a reaction during endoscopy required intensive care unit admission and the rest were observed in a Hospital. The responsible drugs during surgery anaphylaxis were neuromuscular blocking agents, latex, patent blue, and ranitidine. Ortho-phthalaldehyde (OPA) was identified during endoscopic studies; latex was responsible in transvaginal ultrasounds; and amoxicillin in the dental procedure. The aim of the present article is to review our experience studying allergic systemic reactions and anaphylaxis during general anesthesia and medical procedures, emphasizing the severity of these reactions and the need for causative drug identification.

El proyecto formativo de Schiller en las Briefe über “Don Carlos”; Schiller’s Formative Project in the Briefe über “Don Carlos” Napoli, Santiago Juan El artículo intenta analizar un texto teórico de Friedrich Schiller, las Briefe über “Don Carlos” (Cartas sobre “Don Carlosˮ). El objetivo principal que se propone es dar cuenta de una de las problemáticas centrales que atraviesan la obra: la educación del estadista. Para ello ha sido necesario el abordaje de dicha fuente desde el punto de vista de su autonomía respecto de la pieza teatral a la que hace referencia, Don Carlos, Infant von Spanien, representada y publicada el año anterior. Las Briefe über “Don Carlos”, más que una defensa contra los críticos dramáticos, constituyen un ensayo de gran complejidad filosófica, marcado por la intención de mostrar la formación de un gobernante promisorio. Asimismo, la obra exhibe un proyecto de ciudadano delineado por Schiller para su propia época.; The article intends to examine Friedrich Schiller’s theoretical text, the Briefe über “Don Carlos” (Letters upon “Don Carlos”). The main objective it proposes is to show one of the main questions throughout the work: the education of a statesman. In order to accomplish that, it has been necessary to approach to the mentioned source from the point of view of its autonomy with regard to the play to which it refers, Don Carlos, Infant von Spanien, represented and published the previous year. The Briefe über “Don Carlos”, rather than a defense against drama critics, constitute an essay with a great philosophical complexity, characterized by the purpose of showing the formation of a future political leader. Likewise, the work exhibits an outline of a citizen created by Schiller for his own period.

Regulation of NADPH oxidase NOX4 by delta iodolactone (IL-δ) in thyroid cancer cells Thomasz, Lisa; Oglio, Andrea Romina; Salvarredi, Leonardo Andres; Perona, Marina; Rossich, Luciano Esteban; Copelli, Silvia Beatriz; Pisarev, Mario Alberto; Juvenal, Guillermo Juan Introduction: Iodine is not used only by the thyroid to synthesize thyroid hormones but also directly influences a number of thyroid parameters such as thyroid proliferation and function. Several iodinated lipids, biosynthesized by the thyroid, were postulated as intermediaries in the action of iodide. Among these, iodolactone (IL-δ) and 2-iodohexadecanal (2-IHDA) have shown to inhibit several thyroid parameters. The antiproliferative effect of IL-δ is not restricted to the thyroid gland. IL-δ exhibits anti-tumor properties in breast cancer, neuroblastoma, glioblastoma, melanoma and lung carcinoma cells suggesting that IL-δ could be used as a chemotherapeutic agent. Moreover in a colon cancer cell line (HT-29), IL-δ induced cell death, and this effect was mediated by reactive oxygen species (ROS) generation. The aim of the present study was to analyze the sources of reactive oxygen species induced by IL-δ and to explore the contribution of ROS induced by IL-δ on cell proliferation and apoptosis. Methodology and results: Cancer thyroid follicular (WRO) and papilar (TPC-1) cells lines were treated with IL-δ. Proliferation and apoptosis was analyzed. IL-δ caused a significant loss of cell viability on WRO and TPC-1 cells in a concentration dependent manner and induced apoptosis after 3 h of treatment. Furthermore, IL-δ (10 μM) increased ROS production (39% WRO and 20% TPC-1). The concomitant treatment of WRO and TPC-1 cells with Trolox or NAC plus IL-δ abrogated the augment of ROS induced by IL-δ exposure. Additionally Trolox and NAC reversed the effect of IL-δ on cell proliferation and apoptosis. Only in WRO cells IL-δ upregulates NADPH oxidase NOX4 expression, and siRNA targeted knock-down of NOX4 attenuates ROS production, apoptosis (p < 0.05) and the inhibitory effect of IL-δ on cell proliferation and PCNA expression (p < 0.05). Conclusions: The antiproliferative and pro-apoptotic effect of IL-δ is mediated by different mechanisms and pathway involving different sources of ROS generation depending on the cellular context.

Galactic perturbations on the population of wide binary stars with exoplanets Correa Otto, Jorge Alfredo; Gil Hutton, Ricardo Alfredo Aims. The aim of this work is to study the dynamical effects of the Galaxy on binary star systems with physical and orbital characteristics similar to those of the population of known wide binary stars with exoplanets. As secondary goal we analyse the possible consequences on the stability of a hypothetical planetary system orbiting one of the stellar components. Methods. We numerically reproduced the temporal evolution of a sample of 3 × 105 binary star systems disturbed by the Galactic potential and passing stars in an environment similar to the solar neighbourhood. Results. Our results show that the dynamical evolution of the population of wide binary stars with exoplanets in the solar neighbourhood is modelled by the process of disruption of binary star systems induced by the Galaxy. We found that this process depends mainly on the separation between both stars, whereas it is almost independent of the initial orbital configuration. Moreover, our calculations are in agreement with the results of previous works regarding the indirect influence of the Galaxy on the stability of planetary systems in wide binary stars. However, the effects on the planetary region show a dependence on the initial configuration of binary stars. Finally, we obtain an indirect test of the impulse approximation model for dynamical studies of binary star systems.

Extreme cold events in South America analyzed from a GFDL model perspective: comparison between CMIP3 and CMIP5 climate scenarios Muller, Gabriela Viviana; Rabelo Da Rocha Repinaldo, Cintia; Araneo, Diego Christian This paper deals with the future change projections of extreme cold events in relation to historical climate simulations, based on the comparison between two versions of the GFDL model, CMIP3 and CMIP5, in three regions of southeastern South America where these events are frequent. To this end, the compositions of up to five extreme events below 0 °C at 850 hPa were considered. They were derived from daily data collected from May to September of the NCEP/NCAR reanalysis and GFDL Coupled Atmospheric and Oceanic Global Circulation Model. The study periods run from 1961 to 1990 and from 2081 to 2100 for the most critical scenarios: A2 (GFDL-CM2) and RCP8.5 (GFDL-CM3). Sea level pressure, temperature, and wind were analyzed at 850 hPa and wind also at 250 hPa, for each of the areas under study, representing tropical (Area 1) and subtropical (Area 2 and Area 3) latitudes. The ability of the model to simulate the historical climate, represented by the reanalysis, increased as latitude decreased, CM3 version being better for subtropical latitudes than CM2. Depending on GFDL model version, temperature was higher or lower than those shown by the reanalysis in the tropical latitudes. In contrast, at subtropical latitudes, both versions of the model present lower values. An increase in mean temperature is expected in the future in the three areas, mainly at tropical latitudes (Area 1) according to both versions of the model, which is in line with the results reported by other global models. In Area 2, a further increase in temperature is projected in CM3 version, while, for Area 3, the greatest projection is in CM2 version. Changes are expected for the future climate, primarily explained by the configuration of the circulation fields, such as in the case of the subtropical areas in CM2, whose pattern is more related to that typically associated with radiative cooling, rather than the advective cooling shown in the historical climate. This result is in contrast with the results of the CM3 version, which displays a pattern associated with cold air advection from the south for both the historical and future climate. As regards the tropical area, both versions of the model reveal a considerable reduction in the number of extreme cold events.

Tamizaje del cáncer de mama: certezas y controversias Luthy, Isabel Alicia El cáncer de mama es globalmente el de mayor incidencia en mujeres, con estimaciones de entre 1.7 y 2.4 millones de casos anuales según diferentes fuentes1, 2. También es globalmente la principal causa de muerte por cáncer con unas 523 000 muertes anuales2. Según información del Instituto Nacional del Cáncer de la Argentina, en el año 2012 (último dato disponible) se registraron alrededor de 20 000 nuevos casos de cáncer de mama (que representa el 32.2% de los cánceres en mujeres), mientras que en 2016 se registraron 5645 fallecimientos de mujeres (19.4% de las muertes por cáncer considerando solamente ese sexo) y 45 de hombres por esta enfermedad. Probablemente estas cifras se encuentren subestimadas. Se publicaron una serie de trabajos que pusieron en duda la conveniencia del tamizaje del cáncer de mama, fundamentalmente debido al sobrediagnóstico y el consecuente sobretratamiento (revisado en4). Si se impone esta política tan contraria al concepto de medicina preventiva, ¿no veremos aumentar nuevamente las tasas de mortalidad que se mantenían constantes, aunque la incidencia seguía incrementándose?

El Fondo para la Investigación Científica y Tecnológica (FONCyT) anuncia los resultados del proceso de procesabilidad de la convocatoria PICT 2017.

El organismo dedicado a promover el financiamiento de proyectos para la generación de conocimiento y la mejora de los sistemas productivos participó del encuentro de nanotecnología más grande de Latinoamérica.

La Agencia Nacional de Promoción Científica y Tecnológica participó de la 15° Feria Internacional de Productos, Equipos y Servicios para la Salud que se realizó del 27 al 29 de septiembre en el Centro de Exposiciones de Costa Salguero.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia el resultados del proceso de reconsideracion y evaluacion para la convocatoria Emprendedores FONSOFT 2016 C2 mediante Resolución de Directorio N°504 y 510/17.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia los resultados del proceso de evaluación del llamado ANR Capacitación Fonsoft mediante la resolución nº 499/17 del Directorio de la Agencia.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia el resultado del proceso de evaluación para las convocatorias ANR Empresa Joven FONSOFT 2016 C1 y C2 mediante Resolución de Directorio N°503,508 y 509/17.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia los resultados del proceso de reconsideración y evaluación para la convocatoria ANR FONSOFT 2015 C2 y 2016 C1 y c2 mediante Resolución de Directorio N°494,500,501,502,511 y 512/17.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia el resultados del proceso de reconsideracion para la convocatoria Becas Jóvenes Profesionales TIC 2016 mediante Resolución de Directorio N°498 y 505/17.

Seminal plasma proteins modify the distribution of sperm subpopulations in cryopreserved semen of rams with lesser fertility Ledesma, Alba; Zalazar, Lucia; Fernández Alegre, Estela; Hozbor, Federico Andrés; Cesari, Andreina; Martínez Pastor, Felipe Any physiological mechanism involved in sperm selection and semen improvement has effects on heterogeneous sperm populations. This is mainly due to the fact that sperm populations within a single ejaculate have considerable heterogeneity for many variables, such as motility which is meaningful in terms of understanding how some sperm cells possess fertility advantages as compared with other cells. In the present research, initially there was a multivariate and clustering analysis used to assess sperm motility data from cryopreserved ram semen to identify subpopulations and compare the distribution of these clusters between rams with lesser and greater fertility. There were four classifications made of sperm subpopulations (clusters): CL1 fast/linear/progressive sperm; CL2 fast/non-linear sperm; CL3 very fast/linear sperm with vigorous beating and CL4 slow/non-linear sperm. Rams with greater fertility had a lesser proportion of sperm considered as “hyperactivated” (CL2) and a greater proportion of slow and non-linear sperm (CL4) than sperm of rams with lesser fertility. In addition, the effects were assessed for the capacity of seminal plasma (SP) and interacting SP proteins (iSPP) that were present during different seasons of the year to improve the distribution of sperm within subpopulations of semen from rams with lesser fertility. The iSPP and SP were obtained by artificial vagina (AV) and electroejaculation (EE) during breeding and non-breeding seasons and added to thawed semen. All the aggregates had a significant effect on the distribution of sperm subpopulations and effects differed among seasons of the year and depending on collection method used. Even though, future studies are needed to assess the contribution of each subpopulation on ram sperm fertility, it is important that a multivariate analysis be used to evaluate the effect of a treatment on sperm quality variables.

La Agencia Nacional de Promoción Científica y Tecnológica (ANPCYT), a través del Fondo para la Investigación Científica y Tecnológica (FONCyT) llama, en forma conjunta con la Universidad Pedagógica Provincial (UNIPE), a la presentación de proyectos de Investigación Científica y Tecnológica para la adjudicación de subsidios a grupos de investigadores formados y activos de la Universidad Pedagógica Provincial orientados a áreas de interés común con el co-financiador.

El titular de la Agencia Nacional de Promoción Científica y Tecnológica realizó dos charlas de difusión ante referentes del sector privado y público de la localidad chubutense.

Autoridades del organismo internacional y del Fondo Argentino Sectorial visitaron la compañía biotecnológica del Grupo Insud.