The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives Gargiulo, Ernesto; Giordano, Mirta Nilda; Niemann, Carsten U.; Moussay, Etienne; Paggetti, Jérôme; Morande, Pablo Elías Hairy cell leukemia (HCL) is an incurable, rare lymphoproliferative hematological malignancy of mature B cAlthough first line therapy with purine analogues leads to positive results, almost half of HCL patients relapse after 5-10 years, and standard treatment may not be an option due to intolerance or refractoriness. Proliferation and survival of HCL cells is regulated by surrounding accessory cells and soluble signals present in the tumor microenvironment, which actively contributes to disease progression. In vitro studies show that different therapeutic approaches tested in HCL impact the tumor microenvironment, and that this milieu offers a protection affecting treatment efficacy. Herein we explore the effects of the tumor microenvironment to different approved and experimental therapeutic options for HCL. Dissecting the complex interactions between leukemia cells and their milieu will be essential to develop new targeted therapies for HCL patients.

Promoting spontaneous analogical transfer by idealizing target representations Trench, Juan Maximo; Tavernini, Lucía Micaela; Goldstone, Robert L. Recent results demonstrate that inducing an abstract representation of target analogs at retrieval time aids access to analogous situations with mismatching surface features (i.e., the late abstraction principle). A limitation of current implementations of this principle is that they either require the external provision of target-specific information or demand very high intellectual effort. Experiment 1 demonstrated that constructing an idealized situation model of a target problem increases the rate of correct solutions compared with constructing either concrete simulations or no simulations. Experiment 2 confirmed that these results were based on an advantage for accessing the base analog, and not merely an advantage of idealized simulations for understanding the target problem in its own terms. This target idealization strategy has broader applicability than prior interventions based on the late abstraction principle because it can be achieved by a greater proportion of participants and without the need to receive target-specific information. We present a computational model, SampComp, that predicts successful retrieval of a stored situation to understand a target based on the overlap of a random, but potentially biased, sample of features from each. SampComp is able to account for the relative benefits of base and target idealization, and their interaction.

Chemical Profile and Biological Potential of Hornodermoporus martius (Agaricomycetes) from Paraguay Campi Gaona, Michelle Geraldine; Mancuello, Claudia; Ferreira, Francisco; Ferreira, Williams; Maubet, Yanine; Cristaldo, Enzo; Vantrate, Braulio; Benítez, Darío; Granados, Alejandro Manuel; Robledo, Gerardo Lucio To further knowledge of the biological activity of native neotropical fungal species, this study aimed to determine the chemical composition and microbiological activity of Hornodermoporus martius. Ethanol, hexane, diethyl ether, and ethyl acetate fractions and the water residue were analyzed and resulted in a total phenolic compound content between 13 and 63 mg of gallic acid equivalents per gram of crude extract. The total antioxidants ranged between 3 and 19 mg of ascorbic acid equivalents per gram of crude extract, and the percentage of antioxidant activity was determined to be between 6 and 25%. A preliminary profile of compounds is provided for the first time for the species; the results from the nonpolar fraction showcased the presence of saturated and unsaturated acids, fatty alcohol, sterols, and cis-vaccenic acid. Our findings also revealed antimicrobial properties from compounds within the hexane and diethyl ether fractions at concentrations of 1 mg mL–1, which inhibited the growth of certain gram-positive and gram-negative bacteria. For the first time in academic literature, our work analyzed and documented the chemical characteristics and microbial properties of H. martius, suggesting potential for medicinal applications.

Usos medicinales y alimenticios de flora introducida en el Chaco Seco argentino: Contrastes entre el conocimiento local y el científico; Medicinal and nutritional uses of flora introduced in the Argentine Dry Chaco: Contrasts between local and scientific knowledge Manzano García, Jessica; Jiménez Escobar, Néstor David; Martínez, Gustavo Javier; Luján, María Claudia Las especies introducidas generan preocupación mundial debido a que en muchos casos manifiestan su potencialidad como invasoras. Sin embargo, poco se conoce su importancia sociocultural e interacción biocultural. Por medio de entrevistas abiertas y semiestructuradas, caminatas guiadas y observación participante se indagó sobre los principales usos y las valoraciones culturales de las plantas biogeográficamente introducidas en localidades del Chaco Seco (Catamarca y Córdoba). Se documentaron un total de 53 especies, 18 con uso medicinal y 40 alimenticias. Los tratamientos más recurrentes corresponden a trastornos digestivos y afecciones respiratorias; en las alimenticias se destacan aquellas de consumo directo. La mayoría de taxones con aplicaciones terapéuticas locales, coinciden con estudios teóricos sobre principios activos y sus efectos curativos. Finalmente, se concluye que, el origen biogeográfico de las especies es independiente de las valoraciones culturales mientras sean potencialmente aprovechables, además de reconocer que los conocimientos etnobotánicos basados en la experiencia fundamentan los usos encontrados desde la academia.; Introduced species generate worldwide concern due to in many cases manifest their potential as invasive as invasives. However, little is known about its sociocultural importance and biocultural interaction. Through open and semi-structured interviews, guided walks and participant observation, the main uses and cultural valuations of biogeographically introduced plants in localities of the Dry Chaco (Catamarca and Córdoba) were investigated. A total of 53 species were documented, 18 with medicinal use and 40 for food. The most recurrent treatments correspond to digestive disorders and respiratory conditions; in food, those for direct consumption stand out. Most taxa with local therapeutic applications coincide with theoretical studies on active principles and their curative effects. Finally, it is concluded that the biogeographic origin of the species is independent of the cultural valuations as long as they are potentially usable, in addition to recognizing that ethnobotanical knowledge based on experience supports the uses found from the academy.

El Patrimonio cultural de la humanidad, el derecho al servicio de la creación de un común global; Cultural Heritage: law in the service of the creation of a global commons Levrand, Norma Elizabeth El proceso de reconocimiento y consolidación del patrimonio histórico y artístico se desarrolló en el ámbito jurídico sub-nacional hasta mediados del siglo XX.La destrucción y los despojos producidos por la II Guerra Mundial alertaron a la comunidad internacional sobre la necesidad de establecer un régimen jurídico que resguarde los bienes culturales. Desde entonces, diversos organismos internacionales y regionales, entre los que se destaca la Organización de las Naciones Unidas para la Educación, la Ciencia y la Cultura (UNESCO, por sus siglas en inglés), han elaborado un conjunto de documentos internacionales dedicados a tal fin. Este trabajo propone un análisis de los dispositivos jurídicos presentes en los principales instrumentos normativos internacionales, focalizado a aquellos que posibilitaron crear y gobernar el patrimonio cultural como un bien común global. En particular se examinan la Convención del Patrimonio Mundial, Cultural y Natural, que cumple 50 años de vigencia y la Convención para la Salvaguarda del Patrimonio Cultural Inmaterial, ambas adoptadas en el marco de la UNESCO.; The process of recognition and consolidation of historical and artistic heritage developed at the sub-national legal level until the middle of the 20th century. The destruction and destruction caused by World War II alerted the international community to the need to establish a legal regime to protect cultural property. Since then, a number of international and regional organizations, including the United Nations Educational, Scientific and Cultural Organization (UNESCO), have produced a series of international documents to this end. This paper proposes an analysis of the legal mechanisms present in the main international normative instruments, focusing on those that have made it possible to create and govern cultural heritage as a global common good. In particular, it examines the World Cultural and Natural Heritage Convention, which has been in force for 50 years, and the Convention for the Safeguarding of the Intangible Cultural Heritage, both adopted within the framework of UNESCO.

Uncovering aquatic diversity patterns in two Patagonian glacial lakes: does habitat heterogeneity matter? Miserendino, Maria Laura; Epele, Luis Beltran; Brand, Cecilia; Uyua, Noelia Mariel; Santinelli, Norma Herminia; Sastre, Alicia Viviana Glacially-influenced lakes are responding to global warming, improving our understanding of these threatened ecosystems is globally imperative especially at southern hemisphere areas like Patagonia. We compared environmental parameters, phytoplankton and littoral benthic macroinvertebrates at two lakes fed by retreating glaciers: El Antiguo (proglacial) and Bagillt (glacial). Our prediction was that differences in water temperature, nutrients, food resources and spatial heterogeneity will modulate aquatic diversity facets. Harsher environmental conditions were recorded at the proglacial lake, including colder water, lower availability of allochthonous resources, and lower pH; but no differences existed in total suspended solids, chlorophyll a, and nutrients. The phytoplankton community (23 taxa) was dominated by Coscinodiscophyceae and Fragilariophyceae at El Antiguo, whereas at Bagillt (20 taxa) Bacillariophyceae and Zygnemathophyceae were the richest groups. The glacial lake included aquatic insects, amphipods, leeches, and mollusks, exhibiting a significantly higher invertebrate richness than the proglacial lake (33 and 8 taxa, respectively). The latter was dominated by Podonominae and Diamesinae (Chironomidae, Diptera). The turnover component of within lakes beta diversity was consistently higher at Bagillt than at El Antiguo. Long-term approaches could clarify whether the expected compositional changes recorded in the northern hemisphere’s aquatic communities correspond to southern hemisphere patterns.

Las lógicas de la diplomacia económica instrumental en las relaciones internacionales contemporáneas (2017-2022); The logics of instrumental economic diplomacy in contemporary international relations (2017-2022) Zelicovich, Julieta En el marco de las transformaciones del orden internacional un fenómeno con creciente ocurrencia es el de la subordinación de los flujos comerciales y financieros a metas no económicas. El objetivo de este trabajo es comprender las características de ese uso instrumental de las relaciones económicas internacionales en el período reciente (2017-2022). Se argumenta que en estos años se produjo un despliegue de la diplomacia económica instrumental, apoyado en discursos que postulan un vínculo necesario entre la política económica, la seguridad internacional y la política estratégica; y en la ampliación de las competencias de los gobiernos para intervenir sobre los flujos económicos. El artículo revisa los debates conceptuales en torno a diplomacia económica instrumental y geoeconomía; para buscar sistematizar los rasgos de estas prácticas y proceder a su estudio empírico. Se analizan tres casos claves: EEUU, China y Unión Europea. De las regularidades identificadas se desprende una agenda de investigación.; Amid the transformations of the international order, the subordination of commercial and financial flows to non-economic goal is a phenomenon with increasing occurrences. The objective of this work is to understand the characteristics of this instrumental use of international economic relations in the recent period (2017-2022). It is argued that in these years there has been a deployment of instrumental economic diplomacy, supported both by discourses that postulate a necessary link between economic policy, international security and strategic policy; and by the expansion of the capacity of governments to intervene in the economic flows. The article reviews the conceptual debates around instrumental economic diplomacy and geoeconomics; to seek to systematize the features of these practices and proceed to their empirical study. Three key cases are analyzed: the USA, China and the European Union. A research agenda emerges from the identified regularities.

AI in User Interface Design and Evaluation Grigera, Julián; Espada, Jordan Pascual; Rossi, Gustavo Héctor Designing and evaluating user interfaces is a complex task. The current focus on user experience (UX) demands user-centered processes that take considerable time and resources, and thus collide with the fast-paced agile methodologies that currently dominate the industry. In this context, academia and industry have proposed the automation of different tasks in the design and evaluation user interfaces (UIs) like prototyping and user testing. Artificial intelligence (AI) techniques such as machine learning have been a considerable help to achieve this. The articles featured in this special issue describe original proposals in the use of AI for UI and user behavior evaluation.

A new species of land planarian (Platyhelminthes: Tricladida: Geoplanidae) from the Amazonian lowlands, Peru Negrete, Lisandro Hector Luis; Vega Tuesta, Leyli; Brusa, Francisco Notogynaphallia urku sp. nov. is here described from the north-east region of Peru, in the Amazonian lowlands. Specimens of the new species are flattened, up to 120 mm long, and characterised by their dorsal colouration consisting of a median band of melon yellow, on which run two irregular longitudinal stripes formed by tiny jet black dots; cephalic region with two para-median stripes forming a ‘V’; two green beige lateral bands with jet black pigment covering a large part of these bands, in the form of large circular or irregular spots that reach the posterior end of the body; marginal stripes with antique pink pigment; ventral surface ivory with antique pink margins, except for the cephalic region, whose margins are jet black. This species represents the second record of Notogynaphallia in Peru and exhibits some similarities regarding external features and internal anatomy to species found in Paraguay and Argentina, with which it is compared.

Tritrichomonas foetus Cell Division Involves DNA Endoreplication and Multiple Fissions Iriarte, Lucrecia Soledad; Martínez, Cristian Iván; de Miguel, Natalia; Cóceres, Verónica Mabel Tritrichomonas foetus and Trichomonas vaginalis are extracellular flagellated parasites that inhabit animals and humans, respectively. Cell division is a crucial process in most living organisms that leads to the formation of 2 daughter cells from a single mother cell. It has been assumed that T. vaginalis and T. foetus modes of reproduction are exclusively by binary fission. However, here, we showed that multinuclearity is a phenomenon regularly observed in different T. foetus and T. vaginalis strains in standard culture conditions. Additionally, we revealed that nutritional depletion or nutritional deprivation led to different dormant phenotypes. Although multinucleated T. foetus are mostly observed during nutritional depletion, numerous cells with 1 larger nucleus have been observed under nutritional deprivation conditions. In both cases, when the standard culture media conditions are restored, the cytoplasm of these multinucleated cells separates, and numerous parasites are generated in a short period of time by the fission multiple. We also revealed that DNA endoreplication occurs both in large and multiple nuclei of parasites under nutritional deprivation and depletion conditions, suggesting an important function in stress nutritional situations. These results provide valuable data about the cell division process of these extracellular parasites.

Design, Synthesis, Characterization, and Evaluation of the Anti-HT-29 Colorectal Cell Line Activity of Novel 8-Oxyquinolinate-Platinum(II)-Loaded Nanostructured Lipid Carriers Targeted with Riboflavin Boztepe, Tugce; Scioli Montoto, Sebastián; Gambaro, Rocío Celeste; Ruiz, María Esperanza; Cabrera, Silvia; Alemán, José; Islan, German Abel; Castro, Guillermo Raul; Leon, Ignacio Esteban Colorectal cancer is occasionally called colon or rectal cancer, depending on where cancer begins to form, and is the second leading cause of cancer death among both men and women. The platinum-based [PtCl(8-O-quinolinate)(dmso)] (8-QO-Pt) compound has demonstrated encouraging anticancer activity. Three different systems of 8-QO-Pt-encapsulated nanostructured lipid carriers (NLCs) with riboflavin (RFV) were investigated. NLCs of myristyl myristate were synthesized by ultrasonication in the presence of RFV. RFV-decorated nanoparticles displayed a spherical shape and a narrow size dispersion in the range of 144–175 nm mean particle diameter. The 8-QO-Pt-loaded formulations of NLC/RFV with more than 70% encapsulation efficiency showed sustained in vitro release for 24 h. Cytotoxicity, cell uptake, and apoptosis were evaluated in the HT-29 human colorectal adenocarcinoma cell line. The results revealed that 8-QO-Pt-loaded formulations of NLC/RFV showed higher cytotoxicity than the free 8-QO-Pt compound at 5.0 µM. All three systems exhibited different levels of cellular internalization. Moreover, the hemotoxicity assay showed the safety profile of the formulations (less than 3.7%). Taken together, RFV-targeted NLC systems for drug delivery have been investigated for the first time in our study and the results are promising for the future of chemotherapy in colon cancer treatment.

Endophytic Trichoderma strains increase soya bean growth and promote charcoal rot control Larran, Silvina; Simon, Maria Rosa; Santamarina, María Pilar; Roselló Caselles, Josefa; Consolo, Verónica Fabiana; Perello, Analia Edith Charcoal rot, caused by Macrophomina phaseolina (Tassi) Goid., is one of the world's most serious diseases because it reduces yield and seed quality. Nowadays, biological control is an environment-friendly option for controlling plant diseases. The goals of this study were to (i) test eight endophytic Trichoderma spp. strains as biocontrol agents against M. phaseolina and (ii) further investigate two selected strains showing good behaviour against the pathogen. Pathogen-antagonist interactions were studied in dual culture, and the morphological alterations of M. phaseolina mycelia in the interaction zone were examined by light microscopy. Trichoderma strains were applied to soya bean seeds by a seed coating technique. Their bioprotective effects were assessed by in vitro and in vivo assays to evaluate radicle length, the germination percentage and the presence of typical charcoal rot symptoms in seedlings. Two Trichoderma strains were selected and they were molecularly identified as T. harzianum species complex. Their antagonistic ability against M. phaseolina was evaluated under different water availability conditions. The mechanisms used by these two endophytic strains against the pathogen were evaluated by cryo-scanning electron microscopy. The results showed that all eight Trichoderma strains successfully performed biocontrol activity against M. phaseolina by reducing colony growth and causing morphological alterations in the mycelia of M. phaseolina. All endophytes improved seed germination and radicle length, and reduced typical symptoms and disease progression on seedlings. Water availability in the medium impacted on fungal growth. At 0.995 ɑw, all the fungi grew more and faster. At 0.95 ɑw M. phaseolina grew more than the Trichoderma strains, while the pathogen grew slightly more at 0.98 ɑw than the Trichoderma strains. However, both selected Trichoderma strains grew larger and faster than the pathogen at 0.995 ɑw. The mechanisms involved in pathogen control revealed by the light and cryo-scanning microscopy studies included competition for nutrients or space and direct mycoparasitism. All the endophytic Trichoderma strains were antagonistic against M. phaseolina, however our study allowed us to select two Trichoderma strains with good potential to be included for charcoal rot management.

Determinación de variables morfométricas en glándulas endometriales en los días 30 y 70 de la gestación en porcinos; Morphometric variables determination in porcine endometrial glands at 30 and 70 gestation days Fiorimanti, Mariana Rita; Cristofolini, Andrea Lorena; Gomez, Keisy Pabla; Barbeito, Claudio Gustavo; Merkis, Cecilia Inés Se determinaron las variables morfológicas, número, área de lumen y altura celular de las glándulas endometriales de la cerda gestante en una etapa temprana de 30 días y en una media tardía al día 70. Se obtuvieron muestras placentarias de 30 y 70 días de gestación, provenientes de frigoríficos de Río Cuarto (Córdoba, Argentina). Parte de las placentas fueron procesadas mediante la técnica para microscopía óptica convencional y destinados al análisis digital de la morfometría glandular. Otra parte fue procesada por la técnica de microscopía electrónica convencional para la técnica de MOAR. Se detectó un número significativamente mayor de glándulas endometriales en el día 30 de gestación respecto del día 70. El área de lumen glandular fue significativamente mayor al día 70 respecto del día 30 de gestación. La altura celular fue significativamente mayor en el día 30 de gestación. La técnica de MOAR permitió visualizar con mayor detalle el epitelio glandular y diferenciar células ciliadas de secretoras. En la gestación temprana, el crecimiento glandular es activo, hay numerosas glándulas y moderada actividad secretora. En la gestación media tardía, las glándulas endometriales no aumentan en número, pero sí en actividad secretora acompañando las crecientes demandas metabólicas del feto en desarrollo.; Morphological variables, number, lumen area and cell height of the endometrial glands of the pregnant sow were determined at an early stage of 30 days and in a late average at day 70. Placental samples of 30 and 70 days of gestation were obtained from slaughterhouses from Río Cuarto, (Córdoba, Argentina). Part of the placentas were processed using the conventional optical microscopy technique and destined for digital analysis of glandular morphometry. Another part was processed by the conventional electron microscopy technique for the MOAR technique. A significantly higher number of endometrial glands was detected on day 30 of gestation compared to day 70. The glandular lumen area was significantly greater on day 70 compared to day 30 of gestation. Cell height was significantly higher on day 30 of gestation. The MOAR technique allowed visualizing the glandular epithelium in greater detail and differentiating ciliated from secretory cells. In early gestation, glandular growth is active, with numerous glands and moderate secretory activity. In late mid-gestation, the endometrial glands would not increase in number, but in secretory activity, accompanying the increasing metabolic demands of the developing fetus.

Wild pigs and their widespread threat to biodiversity conservation in South America la Sala, Luciano Francisco; Burgos, Julian Mariano; Caruso, Nicolás; Bagnato, Camilo Ernesto; Ballari, Sebastián A.; Guadagnin, Demetrio L.; Kindel, Andreas; Etges, Matheus; Merino, Mariano Lisandro; Marcos, Andrea; Skewes, Oscar; Schettino, Daniella; Perez, Andres Maximiliano; Condorí, Walter Ezequiel; Tammone Santos, Agostina; Carpinetti, Bruno Nicolás; Zalba, Sergio Martín Wild pigs, including wild boar (Sus scrofa) and feral domestic pig (Sus scrofa domestica), are associated with negative impacts in their native and introduced ranges. We compiled wild pig occurrence reports and utilized Maximum Entropy modelling to predict their potential distribution in ecoregions overlaying Argentina, Brazil, Bolivia, Chile, Uruguay and Paraguay. An analysis of their observed and potential distributions was carried out in relation to four biodiversity hotspots and 3766 protected areas to estimate the number of units and percent area currently and potentially invaded. Among biodiversity hotspots, Atlantic Forest, Cerrado, and Chilean Winter Rainfall-Valdivian Forests included 44.7% of wild pig records. The proportion of suitable area was 85% in Atlantic Forest, 61.3% in Cerrado, 37.5% in Chilean Winter Rainfall-Valdivian Forests, and 5.6% in Tropical Andes. The number of protected areas with known wild pig presence was led by Uruguay (100%), followed by Chile (20.3%), Argentina (15.8%), Paraguay (9.5%), Bolivia (6.5%), and Brazil (4.7%). The proportion of protected areas with predicted wild pig presence was highest in Uruguay (100%), followed by Paraguay (72.6%), Brazil (58.0%), Argentina (57.4%), Chile (42.2%), and Bolivia (35.9%). Our work represents the first assessment of wild pig potential distribution in South America and highlights the potentially devastating impacts of wild pigs on the regional biodiversity and national conservation targets, especially at mega-diverse areas. We present a dynamic web application that can be readily consulted by scientists, managers and decision makers to improve wild pig control and risk mitigation actions in the study region.

Two new species of the ant-like spider genus Fluda Peckham & Peckham, 1892 from Bolivia with first reports of potential ant models for the genus and a novel ant-resembling behavior (Araneae: Salticidae, Simonellini) Perger, Robert; Rubio, Gonzalo Daniel In this work, the results of a survey for species of Fluda Peckham & Peckham, 1892 in primary forest in five Bolivian forest ecoregions are reported. Fluda dauca sp. nov. is described from Southwest Amazon forest and F. thuruampara sp. nov. from Bolivian Yungas forest. Fluda perdita (Peckham & Peckham, 1892) is reported from Bolivia for the first time. Both new species exhibited polymorphic mimicry; dark females of both species resembled the turtle ant Cephalotes pusillus (Klug, 1824) and dark males of F. thuruampara sp. nov. the carpenter ant Camponotus sanctaefidei Dalla Torre, 1892. Orange males and females of F. dauca sp. nov. are likely mimics of Camponotus latangulus Roger, 1863. Males of Fluda may compensate lower mimetic accuracy by the broadened femora I, resembling an ant head in lateral view and ant mandibles when moving the face towards a potential threat. As in other Simonellini, the turnover of Fluda species between the South American superregions suggests that significant shifts in seasonality and related conditions are major factors triggering speciation in the tribe Simonellini.

Reproductive and vegetative phenology of the micro endemic Stachytarpheta cassiae (Verbenaceae) Guimarães, Gesline Ferreira; Soares, Michellia Pereira; dos Santos, Renata Moreira; dos Santos, Fabíola Mendes; Ashworth, Lorena; Negreiros, Daniel; Aguilar, Ramiro; Fernandes, Geraldo Wilson Afonso The flora of the Brazilian rupestrian grasslands represents a hotspot of species richness and endemisms. Stachytarpheta cassiae (Verbenaceae), is a micro endemic species, from which nothing is known. Here, we quantified the activity and intensity of vegetative and reproductive phenophases throughout 12 months and tested for their seasonality and their relationship with local climatic variables. Both vegetative and reproductive phenophases were continuous. No seasonality was observed in the vegetative phenophases and none of them was influenced by climatic variables. Only flower buds and mature fruits’ intensities showed seasonality in February (rainy season) and July (dry season), respectively. Accordingly, increased temperature and humidity combined explained increased production of flower buds whereas decreased rainfall explained increased mature fruits. Higher intensity in flower buds may respond to similar climatic conditions as other species in the community. However, S. cassiae is much different as it continues producing flowers continuously. Higher intensity of mature fruits in the dry season is expected as their seeds are abiotically dispersed. Due to constant flower and leaf production, S. cassia may be a key species for the conservation of many vertebrate and invertebrate species and for maintaining the biogeochemical functioning of the impoverished soils of the rupestrian grasslands.

Ver el tiempo: la imagen óptico-sonora pura y su vinculación con el tiempo Aión en Gilles Deleuze; To see the time: the pure optical-sound image and its link with the Aion in Gilles Deleuze Matti, Felipe Andres Este trabajo tiene como objetivo investigar el vínculo entre la imagen óptico-sonora pura y el Aión. Para ello, se propone como hipótesis principal la situación óptica-sonora pura es el puntapié inicial para adquirir una imagen directa del tiempo. En efecto, dicha imagen sería la del Aión, base del tiempo cronológico. La situación óptico-sonora pura describe el momento en el que ya no hay percepción seguida de acción, dando lugar a la percepción de la interioridad del tiempo fundamental. Por lo tanto, se sostiene aquí que lo visto en la imagen óptico-sonora pura es el tiempo Aión o tiempo del acontecimiento.; : This paper aims to investigate the link between the pure optical-sound image and the Aion. For this purpose, it is proposed as a main hypothesis that the pure optical-sound situation is the starting point for acquiring a direct image of time. Indeed, this image would be that of the Aion, the basis of chronological time. The pure optical-sound situation describes the moment in which there is no longer perception followed by action, giving rise to the perception of the interiority of fundamental time. Therefore, it is argued here that what is seen in the pure optical-sound image is the Aion time or time of the event.

Cómo lidiar con el rechazo de un manuscrito científico Gracia, Guadalupe; Grande Ratti, Maria Florencia A raíz de un proyecto de investigación clínica, aprovechamos la oportunidad para normalizar el rechazo de un manuscrito científico ante su envío a revistas científicas arbitradas e indexadas. Comentamos lecciones aprendidas de nuestra experiencia, haciendo hincapié sobre los pasos para seguir a fin de superar satisfactoriamente el proceso editorial y alcanzar una publicación.

Tensiones productivas de un archivo teatral audiovisual: reflexiones a partir de una experiencia de gestión e investigación; Productive tensions of an audiovisual theatrical archive: reflections from a management and research experience Girotti, Bettina Inés; Brownell, Pamela El presente artículo parte de la experiencia que venimos realizando desde el Grupo de Estudio sobre Teatro contemporáneo, política y sociedad en América Latina (IIGG-UBA), con la creación y gestión de un archivo de registros audiovisuales dedicados a la temática delgrupo. Se trata del Fondo Documental Teatro y Política en América Latina (TyPAL), radicado en el Archivo Audiovisual del Instituto deInvestigaciones Gino Germani, y en esta ocasión, en el marco de la convocatoria de un dossier dedicado a temáticas de archivo vinculadas al arte y la literatura, nos interesa abordar algunas de las tensiones productivas que surgen del trabajo con el archivo y que están en gran medida concentradas en su definición como archivo teatral audiovisual. Estructuramos estas reflexiones en torno de algunos binomios que condensan esas tensiones productivas –investigación teatral/archivo; lo teatral/lo audiovisual; analógico/digital; archivos personales/archivos institucionales– y que nos permiten analizar algunas de los circunstancias específicas y discusiones conceptuales en las que se enmarca el TyPAL y que permiten abordar cuestiones propias de la investigación en artes escénicas en el contexto del creciente interés archivístico extendido en la cultura contemporánea.; This paper presents the experience of the research group on Contemporary Theater, Politics and Society in Latin America (IIGGUBA) with the creation and management of an archive that collects videos connected to the group’s subject. It is called TyPAL (Teatro y Política en América Latina) and it is hosted as a fonds inside the Audiovisual Archive of the Gino Germani Research Institute at the University of Buenos Aires. Within the framework of this issue’s dossier, we aim to approach some of the productive tensions that emerge when working with the archive, and that are connected to its definition as an audiovisual theatrical archive. We organized our reflections on a series of pairings that condense these productive tensions ‒theatrical research/archive; theatrical/ audiovisual; analogical/digital; personal archives /institutional archives‒ and that allowed us to analyze some of the specific circumstances and conceptual discussions in which the TyPAL is framed and that let us address issues of performing arts research in the context of the growing archival interest widespread in contemporary culture.

Acute and chronic physical activity improves spatial memory in an immersive virtual reality task Ramírez Butavand, Daniela; Rodríguez, María Florencia; Cifuentes, Maria Virginia; Miranda, Magdalena; Garcia Bauza, Cristian Dario; Bekinschtein, Pedro Alejandro; Ballarini, Fabricio Matias Physical activity benefits both fitness and cognition. However, its effect on long-term memory is unclear. In this study, we evaluated the effect of acute and chronic exercise on long-term spatial memory for a new virtual reality task. Participants were immersed in the virtual environment and navigated a wide arena that included target objects. We assessed spatial memory in two conditions (encoded targets separated by a short or long distance) and found that 25 min of cycling after encoding — but not before retrieval — was sufficient to improve the long-term memory retention for the short, but not for the long distance. Furthermore, we found that participants who engaged in regular physical activity showed memory for the short-distance condition whereas controls did not. Thus, physical activity could be a simple way to improve spatial memories.