Antifibrotic effects of pioglitazone at low doses on the diabetic rat kidney are associated with the improvement of markers of cell turnover, tubular and endothelial integrity, and angiogenesis Toblli, Jorge Eduardo; Cao, Gabriel Fernando; Giani, Jorge Fernando; Angerosa, Margarita; Dominici, Fernando Pablo; Gonzalez Cadavid, Nestor F. BACKGROUND/AIMS: Pioglitazone and other thiazolidinediones are renoprotective in diabetic nephropathy at doses that normalize glycemia, presumably as a consequence of glycemic control. However, low doses of pioglitazone that did not normalize glycemia in rat models of type 2 diabetes prevented tubulointerstitial fibrosis and glomerulosclerosis through counteracting inflammation, oxidative stress, cell cycle arrest, and fibrosis. The current work tested whether this low-dose treatment also reduces other fibrosis and inflammation factors in the diabetic kidney and prevents tubular cell loss, endothelial damage, and abnormal angiogenesis. METHODS: ZDF fa/fa rats (ZDF) were fed for 4 months chow with 0.001% pioglitazone, and the untreated ZDF and the non-diabetic lean Zucker rats (LZR) received regular chow. Proteinuria, creatinine clearance, blood pressure, and renal quantitative histopathology markers were determined. RESULTS: Correction of renal function in ZDF by pioglitazone, occurring with a glycemia >250 mg/dl, was accompanied by normalization of the renal levels of connective tissue growth factor and fibronectin (fibrosis), TNF-α, interleukin-6 and MCP-1 (inflammation), megalin (tubular cells), the PCNA/caspase-3 ratio (positive cell turnover), VEGF (abnormal angiogenesis), and the ratio between eNOS and iNOS (endothelial dysfunction). CONCLUSION: This supports mechanisms for the renoprotective effects of pioglitazone in diabetes additional to glycemic control.

Las tensiones internas del pluralismo moral; The internal tensions of moral pluralism Lariguet, Guillermo Claudio En este trabajo admito como hipó- tesis de trabajo filosófico que el pluralismo moral podría ser una mejor opción frente al monismo moral (aunque se pueda reconocer que, al final, los argumentos de uno y otro lado no puedan ser concluyentes). A partir de esta hipótesis de trabajo, caracterizo cuáles son las notas principales que definen un pluralismo —especialmente moral— de carácter «razonable». Sostengo que estas notas definitorias, que forman parte de las premisas de partida del pluralismo razonable, podrían comportar consecuencias que el propio pluralista no estaría fácilmente dispuesto a aceptar: en particular, un fuerte relativismo moral, un particularismo moral fuerte y una fragmentación de valores que podría derivar en desintegración moral. El seguimiento de estas posibles consecuencias, a su vez, depende de cuánta presión conceptual sobre las notas definitorias del pluralismo razonable ejerza el análisis conceptual preferido por el filósofo.; In this present work, I state, as a philosophical hypothesis of work, that moral pluralism could be a better option when it is confronted with monism (although it could be recognized that the arguments of both sides are not conclusive). From the point of view of this hypothesis, I attempt to characterize the main conceptual features of a «reasonable» pluralism In addition, I maintain that the possible implications of these features can imply some unacceptable consequences for the reasonable pluralist; in particular, some kind of moral particularism, some kind of moral relativism and some kind of fragmentation of values. In this last case the other consequence could be a so called «moral disintegration». My point is that these consequences depend on some sort of «conceptual pressure» exerted by different strategies designed by philosophers in their analysis of the concept of a reasonable pluralism.

Oligodendrocyte responses to buprenorphine uncover novel and opposing roles of μ-opioid- and nociceptin/orphanin FQ receptors in cell development: Implications for drug addiction treatment during pregnancy Eschenroeder, Andrew C.; Vestal Laborde, Allison A.; Sanchez, Emilse Silvina; Robinson, Susan E.; Sato Bigbee, Carmen Although the classical function of myelin is the facilitation of saltatory conduction, this membrane and the oligodendrocytes, the cells that make myelin in the central nervous system (CNS), are now recognized as important regulators of plasticity and remodeling in the developing brain. As such, oligodendrocyte maturation and myelination are among the most vulnerable processes along CNS development. We have shown previously that rat brain myelination is significantly altered by buprenorphine, an opioid analogue currently used in clinical trials for managing pregnant opioid addicts. Perinatal exposure to low levels of this drug induced accelerated and increased expression of myelin basic proteins (MBPs), cellular and myelin components that are markers of mature oligodendrocytes. In contrast, supra-therapeutic drug doses delayed MBP brain expression and resulted in a decreased number of myelinated axons. We have now found that this biphasic-dose response to buprenorphine can be attributed to the participation of both the mu-opioid receptor (MOR) and the nociceptin/orphanin FQ receptor (NOP receptor) in the oligodendrocytes. This is particularly intriguing because the NOP receptor/ nociceptin system has been primarily linked to behavior and pain regulation, but a role in CNS development or myelination has not been described before. Our findings suggest that balance between signaling mediated by (a) MOR activation and (b) a novel, yet unidentified pathway that includes the NOP receptor, plays a crucial role in the timing of oligodendrocyte maturation and myelin synthesis. Moreover, exposure to opioids could disrupt the normal interplay between these two systems altering the developmental pattern of brain myelination.

Estudio de los efectos angiogénicos de materiales biocerámicos vítreos de tercera generación Haro Durand, Luis Alberto; Gongora, Adrian Daniel; Gómez, Martin Carlos; Porto Lopez, Jose Manuel; Boccaccini, Aldo R.; Zago, María Paola; Baldi, Alberto; Gorustovich Alonso, Alejandro Adrian El proceso angiogénico es crítico para la reparación y regeneración de tejidos. El objetivo del presente estudio in vitro fue evaluar los efectos pro-angiogénicos de los productos iónicos de disolución del vidrios bioactivos del sistema SiO2-CaO-Na2-O-P2O5 (45S5) y modificado por boro (45S5.2B) sobre células endoteliales humanas. En comparación al control, las células estimuladas con los productos iónicos de disolución del vidrio 45S5.2B evidenciaron mayor capacidad de proliferación, migración y nivel de expresión de citoquinas IL6 y bFGF. La actividad pro-angiogénica observada, señala que el vidrio bioactivo 45S5.2B tendría potencial aplicación en diferentes estrategias de medicina regenerativa e ingeniería de tejidos que requieran un alto grado de vascularización.

Viviendas bioclimaticas en Tapalque: sistema de climatización por muros acumuladores de calor (mac): resultados preliminares Discoli, Carlos Alberto; Viegas, Graciela Melisa; San Juan, Gustavo Alberto Se presenta el desarrollo de sistemas de climatización para invierno conformados por muros acumuladores de calor (MAC) y el análisis comparado de diferentes tecnologías. Los sistemas se diseñaron para climatizar prototipos de viviendas bioclimáticas emplazados en Tapalqué, provincia de Buenos Aires (36° 21´ Lat. Sur, 60° 61´ Long. Oeste). Están incluidos en la fachada norte del prototipo y conformados por una masa de acumulación compuesta por piezas apilables industrializadas construidas con dos tecnologías de hormigón, macizas y mixtas que incorporan vainas de PVC llenas con agua tratada. Están cubiertas con una vidriera de simple vidrio con protección nocturna. Se presentan los diseños tecnológicos, las etapas de industrialización, fabricación y montaje. Se realizaron simulaciones de los sistemas incorporados a la vivienda y mediciones en laboratorio. Las simulaciones registraron una mayor performance en locales con muros acumuladores mixtos. Las mediciones en banco de ensayo corroboraron una diferencia de 2°C en las temperaturas registradas en el interior de los locales.

Insulin modifies aging-related inhibition of 1-stearoyl, 2-achidonoylglycerol phosphorylation in rat synaptic terminals Zulian, Sandra Edith; Ilincheta, Monica Graciela; Giusto, Norma Maria The purpose of the present study was to analyze diacylglycerol kinase (DAGK) activity in synaptic terminals from cerebral cortex (CC) and hippocampus (Hp) from adult (3-4 month-old) and aged (26-28 month-old) rats. The effect of insulin through DAGK activity on synaptosomes from adult and aged rats was also analyzed under conditions favoring saturated or unsaturated phosphatidic acid (PA) formation, using exogenous di-palmitoil glycerol (DPG) or 1-stearoyl-2-arachidonoylglycerol (SAG) as substrates. Results showed that the enzymatic activity preferentially uses 1-stearoyl-2-arachidonoylglycerol (SAG) as substrate, thus indicating the presence of -type DAGK. A significant decrease in DAGK activity transforming SAG into PA was also observed in both tissues from aged rats. Western Blot detection of DAGK showed that enzyme content undergoes no changes with aging. [3H]inositol incorporation into phosphoinosites was also analyzed to evaluate the role of DAGK in their synthesis. Data obtained from 3H-inositol incorporation into phosphoinositides revealed that in synaptosomes from aged rats phosphatidylinositol (PI) synthesis is lower than in adult animals. Interestingly, in the presence of SAG, PI synthesis was restored to adult values. DAGK activity over SAG was more highly stimulated by insulin in CC and Hp synaptosomes of aged rats with respect to adult rats. On the other hand, insulin exerted a stimulatory effect on PI and phosphatidylinositol 4 phosphate (PI(4)P) synthesis in synaptosomal CC from aged rats. Taken together, our findings indicate that in aged rats insulin triggers a stimulatory mechanism that reverts the diminished synaptosomal ability to synthesize arachidonoyl phosphatidic acid (20:4 PA). The recovery of this PA species indicates that insulin positively regulates phosphoinositide synthesis.

A data-driven, two-temperature solar model with Alfven waves van der Holst, B.; Manchester IV, W. B.; Frazin, R. A.; Vasquez, Alberto Marcos; Tóth, G.; Gombosi, T. I. We have developed a new three-dimensional magnetohydrodynamic (MHD) solar wind model coupled to the Space Weather Modeling Framework (SWMF), that solves for the different electron and proton temperatures. The collisions between the electrons and protons are taken into account as well as the anisotropic thermal heat conduction of the electrons. The solar wind is assumed to be accelerated by the Alfv en waves. In this paper, we do not consider the heating of closed magnetic loops and helmet streamers, but do address the heating of the protons by the Kolmogorov dissipation of the Alfv n waves in open field line regions. The inner boundary conditions for this solar wind model are obtained from observations and an empirical model. The Wang-Sheeley-Arge model is used to determine the Alfv n wave energy density at the inner boundary. The electron density and temperature at the inner boundary are obtained from the differential emission measure tomography applied to the extreme ultraviolet images of the STEREO A and B spacecraft. This new solar wind model is validated for solar minimum Carrington rotation 2077 (November 20 through December 17, 2008). Due to the very low activity during this rotation, this time period is suitable for comparing the simulated Corotating Interaction Regions (CIRs) with in-situ ACE/WIND data. Although we do not capture all magnetohydrodynamic variables perfectly, we do find that the time of occurance and the density of CIRs are better predicted than by our previous semi-empirical wind model in the SWMF that was based on a spatially reduced adiabatic index to account for the plasma heating.

La reforma del Estado en la provincia de Córdoba en el tiempo inmediatamente posterior a la crisis del 2001: ¿Qué hay de nuevo? Manzo, Alejandro Gabriel El presente trabajo pretende reflexionar en torno al destino del “neoliberalismo” luego de la crisis del 2001. A tal fin realiza un análisis comparativo entre dos procesos de reformas estatales en la provincia de Córdoba: uno primero, activado en 1999 bajo los auspicios del Banco Mundial y del Banco Interamericano de Desarrollo y, otro segundo, puesto en marcha en el 2004 por el nuevo equipo del gobernador De La Sota. Se cierra el artículo con una mirada crítica sobre este último proceso.; This article pretends to analyze the destiny of “neoliberalism” after the crisis of 2001. To such purpose it realizes a comparative analysis between two State Reforms policies in the province of Córdoba: the first one, activated in 1999 under the patronages of the World Bank and the Inter-American Development Bank and, the second one, constructed in 2004 by the new administration of De La Sota. The article concludes with a critical view of the last mentioned process.

Agents That Learn What Argument to Select In Argumentation-Based Negotiations Monteserin, Ariel José; Amandi, Analia Adriana Argument selection is considered the essence of the strategy in argumentation-based negotiation. An agent, which is arguing during a negotiation, has to decide what arguments are the best to persuade the opponent. In fact, in each negotiation step, the agent must select an argument from a set of candidate arguments by applying some selection criterion. For this task, the agent observes some factors of the negotiation context, for instance trust in the opponent, expected utility, among others. Usually, argument selection mechanisms are defined statically. However, as the negotiation context varies from a negotiation to another, defining a static selection mechanism it is not useful. For this reason, we present in this paper a novel approach to personalize argument selection mechanisms in the context of argumentation-based negotiation. The selection mechanism defines a set of preferences that determine how preferable it is to utter an argument in a given context. Our approach maintains a hierarchy of preferences in order to learn new preferences and update the existing ones as the agent experience increases. We tested this approach in a simulated multiagent system and obtained promising results.

Trypanosoma cruzi I genotypes in different geographical regions and transmission cycles based on a microsatellite motif of the intergenic spacer of spliced-leader genes Cura, Carolina Inés; Mejía Jaramillo, Ana M.; Duffy, Tomás; Burgos, Juan Miguel; Rodriguero, Marcela Silvina; Cardinal, Marta Victoria; Kjos, Sonia; Gurgel Gonçalves, Rodrigo; Blanchet, Denis; De Pablos, Luis M.; Tomasini, Nicolás; Da Silva, Alexandre; Russomando, Graciela Mabel; Cuba Cuba, Cesar A.; Aznar, Christine; Abate, Teresa; Levin, Mariano Jorge; Osuna, Antonio; Gurtler, Ricardo Esteban; Diosque, Patricio; Solari, Aldo; Triana Chávez, Omar; Schijman, Alejandro Gabriel The intergenic region of spliced-leader (SL-IR) genes from 105 Trypanosoma cruzi I (Tc I) infected biological samples, culture isolates and stocks from 11 endemic countries, from Argentina to the USA were characterised, allowing identification of 76 genotypes with 54 polymorphic sites from 123 aligned sequences. On the basis of the microsatellite motif proposed by Herrera et al. (2007) to define four haplotypes in Colombia, we could classify these genotypes into four distinct Tc I SL-IR groups, three corresponding to the former haplotypes Ia (11 genotypes), Ib (11 genotypes) and Id (35 genotypes); and one novel group, Ie (19 genotypes). Genotypes harbouring the Tc Ic motif were not detected in our study. Tc Ia was associated with domestic cycles in southern and northern South America and sylvatic cycles in Central and North America. Tc Ib was found in all transmission cycles from Colombia. Tc Id was identified in all transmission cycles from Argentina and Colombia, including Chagas cardiomyopathy patients, sylvatic Brazilian samples and human cases from French Guiana, Panama and Venezuela. Tc Ie gathered five samples from domestic Triatoma infestans from northern Argentina, nine samples from wild Mepraia spinolai and Mepraia gajardoi and two chagasic patients from Chile and one from a Bolivian patient with chagasic reactivation. Mixed infections by Tc Ia + Tc Id, Tc Ia + Tc Ie and Tc Id + Tc Ie were detected in vector faeces and isolates from human and vector samples. In addition, Tc Ia and Tc Id were identified in different tissues from a heart transplanted Chagas cardiomyopathy patient with reactivation, denoting histotropism. Trypanosoma cruzi I SL-IR genotypes from parasites infecting Triatoma gerstaeckeri and Didelphis virginiana from USA, T. infestans from Paraguay, Rhodnius nasutus and Rhodnius neglectus from Brazil and M. spinolai and M. gajardoi from Chile are to our knowledge described for the first time.

Justicia caballeresca en América Lastra, Silvia Cristina El subconsciente imaginario de los hispano-indianos, sin duda alguna, fue fuertemente configurado por la lectura y la audición de la narrativa caballeresca hispánica de los siglos XVI y XVII. Pero, aún hoy, es materia de conjetura la incidencia paratextual del discurso caballeresco no sólo como estímulo a la emulación de hazañas y vivencias maravillosas –la mirabilia–, sino como configurador y propulsor de un código regenerador-perfectivo en torno de una específica idea de la justicia.; Reading and listening to 16th and 17th century Hispanic chivalric stories undoubtedly configured the imaginary subconscious of HispanicIndians. But even today, we wonder about the paratextual influence of chivalric discourse not only as a factor for the emulation of prowesses and marvellous experiences –mirabilia–, but also as the configuring factor of a perfectiveregenerating code around a specific idea of justice.

Consejeros del príncipe: Intelectuales y populismo en la Argentina de hoy; Counselors to the prince: Intellectuals and populism in today’s Argentina Palermo, Vicente Antonio Este artículo abordará la relación entre intelectuales públicos y política en la Argentina durante las gestiones de Néstor Kirchner y Cristina Fernández de Kirchner tomando en cuenta principalmente a Ernesto Laclau, por una parte, y al grupo de intelectuales Carta Abierta, por otra. Tanto Ernesto Laclau como el núcleo de Carta Abierta mantuvieron intensos vínculos con ambos presidentes así como una vigorosa participación expresada en debates, presencia en los medios y declaraciones. Esta participación, así como los vínculos con los presidentes, que se intensificaron a partir del conflicto entre el gobierno nacional y los sectores agropecuarios en 2008, fueron intensa y directamente políticos, puesto que se proponían incidir en la configuración político cultural argentina y en las decisiones de actores políticos comenzando por los propios presidentes.; In this article we will address the relationship between public intellectuals and Argentinean politics during the mandates of Néstor Kirchner and Cristina Fernández de Kirchner taking mainly into account Ernesto Laclau, on the one hand, and the group of intellectuals Carta Abierta, on the other hand. Both Ernesto Laclau and Carta Abierta group maintained intense links with both presidents as well as a strong participation showed in debates, presence on the media and statements. This participation, as well as links with presidents, that were intensified after the conflict between the national government and the agricultural and livestock sectors in 2008, were intensively and directly political, since they intended to have a bearing on the Argentinean political-cultural composition and on the decisions of political actors, starting by the presidents themselves.

Alcances y limitaciones del derecho a la vivienda: Los asentamientos Rodrigo Bueno y la Aldea Gay y los programas de recuperación de terrenos; The Scope And Limitations Of The Right To Housing: Rodrigo Bueno And Aldea Gay Settlements And Land Recovery Yacovino, María Paula En este artículo, nos preguntaremos acerca de los contenidos y matices que adquiere el derecho a la vivienda en el accionar de algunas agencias estatales de la ciudad de Buenos Aires, en un contexto caracterizado por mecanismos de planificación urbana que provilegian la lógica del urban design por sobre el urban plannig característico de la ciudad moderna (amendola 2000). Para ello, abordaremos los vínculos que ciertas agencias estatales establecen con los pobladores de algunos espacios habitacionales de la pobreza en la ciudad de Buenos Aires, deteniéndonos en el papel del Estado como productor de problemas y clasificaciones sociales. Examinaremos, en particular, la relación entre los "nuevos asentamientos" y las agencias del Estado, a partir del analisis de dos programas estatales que involcuran sendos espacios urbanos en proceso de recualificación: el Programa de Recuperación de Terrenos de la Reserva Ecológica Cosatnera Sur y el Programa de Recuperación de Terrenos del Parque Natural de la Ciudad Universitaria. Veremos cómo el reconocimiento constitucional del derecho a la vivienda es reinterpretado en cada caso de acuerdo a los proyectos urbanos en marcha para las áreas en cuestión y a la capacidad de presión de los sectores involucrados.; In this article, the contents and nuances of the right to housing in the operation of state agencies in the city of Buenos Aires within a context characterized by mechanisms of urban development that prioritize urban design over urban planning of the modern city are discussed. In so doing, the links that certain State agencies establish with the local inhabitants of impoverished housing in Buenos Aires are examined, attending to the role of the State as a producer of social problems and classifications. In particular, the relations between "new settlements" and State agencies are examined by analyzing two State programs regarding urban spaces that are being reclassified: the land recovery programs of the Costanera Sur Ecological Reserve and the Ciudad Universitaria Natural Park. As is seen, the constitutional acknowledgement of the right to housing is reinterpreted in each case, according to the ongoing urban projects in each area and pressure from of the different sectors involved.

O país do futuro, visto da Argentina Palermo, Vicente Antonio Se trata de una discusión a la luz de las trayectorias históricas de ambos países, de aspecto de la cultura política brasileña, y de las percepciones argentinas sobre Brasil, su presente y su futuro.; Como o Brasil é percebido por seu vizinho mais próximo? Que imagens projeta? Qual é a percepção sobre seu futuro? A partir da análise das trajetórias históricas, expressões da cultura política de ambos os países e alguns textos significativos, o artigo identifica traços fundamentais do Brasil – a continuidade do Estado, a persistência da desigualdade, a suposta cordialidade de seu povo – que ajudam a entender a imagem do Brasil que prevalece na Argentina, o que, por sua vez, permite definir melhor a ideia que os próprios argentinos têm de seu país.

Potentiation of omega-3 fatty acid antidepressant-like effects with low non-antidepressant doses of fluoxetine and mirtazapine Laino, Carlos Horacio; Fonseca, Cristina; Sterin, Norma Beatriz; Slobodianik, Nora; Reines, Analia Gabriela Despite the advances in psychopharmacology, the treatment of depressive disorders is still not satisfactory. Side effects and resistance to antidepressant drugs are the greatest complications during treatment. Based on recent evidence, omega-3 fatty acids may influence vulnerability and outcome in depressive disorders. The aim of this study was to further characterize the omega-3 antidepressant-like effect in rats in terms of its behavioral features in the depression model forced swimming test either alone or in combination with antidepressants fluoxetine or mirtazapine. Ultimately, we prompted to determine the lowest dose at which omega-3 fatty acids and antidepressant drugs may still represent a pharmacological advantage when employed in combined treatments. Chronic diet supplementation with omega-3 fatty acids produced concentration-dependent antidepressant-like effects in the forced swimming test displaying a behavioral profile similar to fluoxetine but different from mirtazapine. Fluoxetine or mirtazapine at antidepressant doses (10 and 20 mg/kg/day, respectively) rendered additive effects in combination with omega-3 fatty acid supplementation (720 mg/kg/day). Beneficial effects of combined treatment were also observed at subeffective doses (1 mg/kg/day) of fluoxetine or mirtazapine, since in combination with omega-3 fatty acids (720 mg/kg/day), antidepressants potentiated omega-3 antidepressant-like effects. The antidepressant-like effects occurred in the absence of changes in brain phospholipid classes. The therapeutic approach of combining omega-3 fatty acids with low ineffective doses of antidepressants might represent benefits in the treatment of depression, especially in patients with depression resistant to conventional treatments and even may contribute to patient compliance by decreasing the magnitude of some antidepressant dose-dependent side effects.fluence vulnerability and outcome in depressive disorders. The aim of this study was to further characterize the omega-3 antidepressant-like effect in rats in terms of its behavioral features in the depression model forced swimming test either alone or in combination with antidepressants fluoxetine or mirtazapine. Ultimately, we prompted to determine the lowest dose at which omega-3 fatty acids and antidepressant drugs may still represent a pharmacological advantage when employed in combined treatments. Chronic diet supplementation with omega-3 fatty acids produced concentration-dependent antidepressant-like effects in the forced swimming test displaying a behavioral profile similar to fluoxetine but different from mirtazapine. Fluoxetine or mirtazapine at antidepressant doses (10 and 20 mg/kg/day, respectively) rendered additive effects in combination with omega-3 fatty acid supplementation (720 mg/kg/day). Beneficial effects of combined treatment were also observed at subeffective doses (1 mg/kg/day) of fluoxetine or mirtazapine, since in combination with omega-3 fatty acids (720 mg/kg/day), antidepressants potentiated omega-3 antidepressant-like effects. The antidepressant-like effects occurred in the absence of changes in brain phospholipid classes. The therapeutic approach of combining omega-3 fatty acids with low ineffective doses of antidepressants might represent benefits in the treatment of depression, especially in patients with depression resistant to conventional treatments and even may contribute to patient compliance by decreasing the magnitude of some antidepressant dose-dependent side effects.fluoxetine or mirtazapine. Ultimately, we prompted to determine the lowest dose at which omega-3 fatty acids and antidepressant drugs may still represent a pharmacological advantage when employed in combined treatments. Chronic diet supplementation with omega-3 fatty acids produced concentration-dependent antidepressant-like effects in the forced swimming test displaying a behavioral profile similar to fluoxetine but different from mirtazapine. Fluoxetine or mirtazapine at antidepressant doses (10 and 20 mg/kg/day, respectively) rendered additive effects in combination with omega-3 fatty acid supplementation (720 mg/kg/day). Beneficial effects of combined treatment were also observed at subeffective doses (1 mg/kg/day) of fluoxetine or mirtazapine, since in combination with omega-3 fatty acids (720 mg/kg/day), antidepressants potentiated omega-3 antidepressant-like effects. The antidepressant-like effects occurred in the absence of changes in brain phospholipid classes. The therapeutic approach of combining omega-3 fatty acids with low ineffective doses of antidepressants might represent benefits in the treatment of depression, especially in patients with depression resistant to conventional treatments and even may contribute to patient compliance by decreasing the magnitude of some antidepressant dose-dependent side effects.file similar to fluoxetine but different from mirtazapine. Fluoxetine or mirtazapine at antidepressant doses (10 and 20 mg/kg/day, respectively) rendered additive effects in combination with omega-3 fatty acid supplementation (720 mg/kg/day). Beneficial effects of combined treatment were also observed at subeffective doses (1 mg/kg/day) of fluoxetine or mirtazapine, since in combination with omega-3 fatty acids (720 mg/kg/day), antidepressants potentiated omega-3 antidepressant-like effects. The antidepressant-like effects occurred in the absence of changes in brain phospholipid classes. The therapeutic approach of combining omega-3 fatty acids with low ineffective doses of antidepressants might represent benefits in the treatment of depression, especially in patients with depression resistant to conventional treatments and even may contribute to patient compliance by decreasing the magnitude of some antidepressant dose-dependent side effects.ficial effects of combined treatment were also observed at subeffective doses (1 mg/kg/day) of fluoxetine or mirtazapine, since in combination with omega-3 fatty acids (720 mg/kg/day), antidepressants potentiated omega-3 antidepressant-like effects. The antidepressant-like effects occurred in the absence of changes in brain phospholipid classes. The therapeutic approach of combining omega-3 fatty acids with low ineffective doses of antidepressants might represent benefits in the treatment of depression, especially in patients with depression resistant to conventional treatments and even may contribute to patient compliance by decreasing the magnitude of some antidepressant dose-dependent side effects.fluoxetine or mirtazapine, since in combination with omega-3 fatty acids (720 mg/kg/day), antidepressants potentiated omega-3 antidepressant-like effects. The antidepressant-like effects occurred in the absence of changes in brain phospholipid classes. The therapeutic approach of combining omega-3 fatty acids with low ineffective doses of antidepressants might represent benefits in the treatment of depression, especially in patients with depression resistant to conventional treatments and even may contribute to patient compliance by decreasing the magnitude of some antidepressant dose-dependent side effects.fits in the treatment of depression, especially in patients with depression resistant to conventional treatments and even may contribute to patient compliance by decreasing the magnitude of some antidepressant dose-dependent side effects.

Picasso alquimista: Una lectura de "Las Meninas"; Alchemist Picasso: a Reading of "Las Meninas" Lucero, Guadalupe Este texto presenta una lectura de la serie Las meninas según Velázquez que Picasso realizó en 1957, articulada en tres momentos: 1) revisión de las interpretaciones clásicas de Las Meninas, que poco después de la aparición de la serie picassiana se reactivan en torno al clásico texto de Michel Foucault que preludia Las palabras y las cosas; 2) presentación de la serie a la luz de una dialéctica de la falsificación y 3) análisis del vínculo forma-contenido a partir de la problematización de la noción misma de "variación", buscando algunas resonancias con la lógica musical de la variación. Consideramos que la radicalidad del ejercicio picassiano se encuentra en el centro de lo que se le reprocha: su potencia falsificante.; The objective of this essay is to reflect on Picasso's Las meninas según Velázquez, painted in 1957. We have chosen three moments to develop our thesis: in the first place, we will develop a critical revisión of the classical lectures on Las Meninas since Foucault published his essay in Les mots et les choses (1966); secondly, and taking as a starting point Rosalind Krauss' essay on Picasso, The Picasso Papers, we will read the series as a dialectic of fake and falsification, and finally we will analyze the relationship between form and content through the problem-posing of musical variation. We would like to point out that what is revolutionary in Picasso's series is indeed their fake power.

Notas acerca de los sentidos del fracaso escolar Lucero, Cristian; Viamonte Leme, Lourdes Notas acerca de los sentidos del fracaso escolar es un ensayo que, como su nombre lo indica, está compuesto por algunas notas en las que se propone revisar de qué manera y desde qué posición teórica e ideológica se ha analizado la situación del fracaso escolar en América Latina.En su desarrollo se reconsideran las bases sobre las cuales se estableció el proyecto educativo de la modernidad y su relación con las distintas culturas y la forma en la que se procesaron dentro de la escuela.Otra de las notas desarrolla una mirada acerca de que manera la igualdad educativa derivó en diversidad y como la concepción, que en la Argentina se tiene este concepto, genera una clausura de las oportunidades de inclusión social.Durante el trabajo se hace expresa referencia a las teorías que miran al fracaso colocando el acento en el sujeto y a aquellas que lo hacen en el proceso socio histórico que genera el fracaso. Finalmente, se ensaya una relación entre los resultados que obtienen los estudiantes en las evaluaciones nacionales (para el caso argentino) e internacionales y el rol de las políticas en la generación del fracaso escolar.

Post- Filosofía y ''psicobiografías'': Rorty, Derrida y la escritura filosófica Acosta, Jazmín Anahí Siguiendo a Derrida, Rorty propone visualizar la práctica filosófica en la “era post-Filosófica” como una praxis escrita (Rorty, 1991). Según la formulación propuesta en “El progreso del pragmatista” (1992), ésta habrá de visualizarse como una forma de la escritura autobiográfica. A la luz del deconstruccionismo derrideano, y asumiendo la defensa rortyana de la “cultura post-Filosófica” como una “cultura literaria”, esta comunicación aborda los intrincados derroteros que, según Geoffrey Bennington (1996) imbrican filosofía, escritura y vida.; Following Derrida‟s steps, Rorty conceptualizes the philosophical practicing in the post-philosophical era as a written praxis (Rorty, 1991). According to Rorty (“The Pragmatist‟s Progress”, 1992), this praxis should be understood as a kind of autobiographical writing. In the light of Derridian deconstruction and assuming the Rortyan defense of a “Post-Philosophical Culture” as a “Literary Culture”, this paper deals with a series of complex issues which, from the point of view of Geoffrey Bennington (1996), link Philosophy, Writing and Life.

Riesgo y Equidad Laplacette, Graciela Ines; Paolino, Melisa Delia; Suárez, Natalia Se presenta una sistematización de la discusión realizada por las integrantes del grupo Equidad y Salud en relación al concepto de equidad y su vinculación con la salud. Se analiza la historia del concepto de riesgo en la epidemiología y su relación con la temática de equidad en salud. Desde una mirada crítica del concepto de riesgo se presentan algunos de sus aspectos históricos, las limitaciones del paradigma de riesgo y la vinculación del concepto de riesgo con las concepciones de salud y equidad.

Humanidad como fin, justificación de principios kantianos de justicia y diferencia deontológica: una teoría kantiana de la acción para los fundamentos del argumento contractualista-constructivista político Marey, Macarena El objetivo de este artículo es exponer un paso argumental para una justificación kantiana de la aplicación jurídico-política del principio de la humanidad que sea plenamente compatible con la tesis de la diferencia deontológica entre ética y derecho. Dicho paso se ubica en el nivel metaético de justificación de los principios de justicia en el marco del contrato originario. Específicamente, mi tesis interpretativa consiste en que este nivel se inicia con una teoría de la acción por la cual la descripción de los rasgos de los agentes o personas que participan de él resulta compatible con el “hecho del pluralismo”.; The aim of this paper is to develop a step within the justificatory argumentation that bases the juridical-political application of the principle of humanity in a way that makes it fully compatible with the thesis of the deontological distinction between ethics and law. This step belongs to the metaethical level that serves to justify Kant’s principles of justice within the original contract. Specifically, my interpretative thesis holds that this level begins with a theory of action by which the description of the agents or persons that participate in the contract is fully compatible with the fact of pluralism.