Inmunoterapia en cáncer. Perspectivas actuales, desafíos y nuevos horizontes; Immunotherapy in cancer. Current prospects, challenges and new horizons D'alotto Moreno, Tomas; Blidner, Ada Gabriela; Girotti, Maria Romina; Maller, Sebastian Matias; Rabinovich, Gabriel Adrián La activación del sistema inmunológico en pacientes con cáncer ha sido un objetivo histórico en el campo de la oncología. En las últimas décadas, nuestro entendimiento de la respuesta inmunológica antitumoral ha promovido el desarrollo de novedosas estrategias terapéuticas dando como resultado un cambio de paradigma en el tratamiento del cáncer. La utilización de agentes bloqueantes de puntos de chequeo del sistema inmunológico como PD-1/PD-L1 y CTLA-4, de agonistas de moléculas co-estimuladoras como CD137 y OX-40 y la transferencia adoptiva de células T antitumorales modi cadas genéticamente han generado importantes bene cios clínicos, re ejados en respuestas objetivas y duraderas, en enfermos sin tratamientos convencionales disponibles. Sin embargo, un gran número de pacientes no responde a dichas terapias generando resistencia o sufriendo recaídas de la enfermedad debido a la aparición de circuitos inhibitorios o compensatorios. La combinación racional de estrategias terapéuticas permite eliminar mecanismos de resistencia, mientras que la identi cación de biomarcadores predictivos facilita la selección de pacientes respondedores a dichos tratamientos. Recientes ensayos clínicos y estudios pre-clínicos permiten vislumbrar un escenario optimista con importantesdesafíos en la implementación de estrategias de inmunoterapia en cáncer.; Recent under-standing of the mechanisms that control immune system homeostasis and orchestrate antitumor responses has prompted the development of novel immunotherapeutic modalities. These include antibodies that target immune checkpoints such as PD-1/PD-L1 and CTLA-4, agonistic antibodies of costimulatory molecules such as CD137 and OX-40 and the adoptive transfer of genetically-modified antitumor T cells. However, a large number of patients do not respond to these therapies and develop resistance as a result of activation of compensatory circuits. Rational combination of immunotherapeutic modalities will help overcome resistance and will increase the number of patients who will benefit from these treatments. Moreover, identification of predictive biomarkers will allow selection of patients responding to these treatments. Emerging clinical trials and pre-clinical studies have shown exciting results anticipating new horizons in the design and implementation of cancer immunotherapeutic modalities

Prediction of regional agro-industrial wastes characteristics by thermogravimetric analysis to obtain bioenergy using thermal process Saffe Pinto, María Alejandra; Fernandez Brizuela, Anabel Alejandra; Mazza, German Delfor; Rodriguez, Rosa Ana The use of energy from biomass is becoming more common worldwide. This energy source has several benefits that promote its acceptance; it is bio-renewable, non-toxic and biodegradable. To predict its behavior as a fuel during thermal treatment, its characterization is necessary. The experimental determination of ultimate analysis data requires special instrumentation, while proximate analysis data can be obtained easily by using common equipment but, the required time is high. In this work, a methodology is applied based on thermogravimetric analysis, curves deconvolution and empirical correlations for characterizing different regional agro-industrial wastes to determine the high heating value, the contents of moisture, volatiles matter, fixed carbon, ash, carbon, hydrogen, oxygen, lignin, cellulose and hemicellulose. The obtained results are similar to those using standard techniques, showing the accuracy of proposed method and its wide application range. This methodology allows to determine the main parameters required for industrial operation in only in one step, saving time.

A singular nitric oxide synthase with a globin domain found in Synechococcus PCC 7335 mobilizes N from arginine to nitrate Correa Aragunde, Maria Natalia; Foresi, Noelia Pamela; del Castello, Fiorella Paola; Lamattina, Lorenzo The enzyme nitric oxide synthase (NOS) oxidizes L-arginine to NO and citrulline. In this work, we characterise the NOS from the cyanobacteria Synechococcus PCC 7335 (SyNOS). SyNOS possesses a canonical mammalian NOS architecture consisting of oxygenase and reductase domains. In addition, SyNOS possesses an unusual globin domain at the N-terminus. Recombinant SyNOS expressed in bacteria is active, and its activity is suppressed by the NOS inhibitor L-NAME. SyNOS allows E. coli to grow in minimum media containing L-arginine as the sole N source, and has a higher growth rate during N deficiency. SyNOS is expressed in Synechococcus PCC 7335 where NO generation is dependent on L-arginine concentration. The growth of Synechococcus is dramatically inhibited by L-NAME, suggesting that SyNOS is essential for this cyanobacterium. Addition of arginine in Synechococcus increases the phycoerythrin content, an N reservoir. The role of the novel globin domain in SyNOS is discussed as an evolutionary advantage, conferring new functional capabilities for N metabolism.

Cattle decrease plant species diversity in protected humid temperate savanna Batista, William B.; Mochi, Lucia Sol; Biganzoli, Fernando Question: Is domestic cattle an appropriate surrogate for fire in a protected humid temperate savanna? Study area: El Palmar Grande de Colón (31°52' S, 58°17' W), Argentina. Methods: We surveyed dense Butia yatay palm savannas in two neighboring protected areas, El Palmar National Park (EPNP), under cattle exclusion since 1970 with sporadic burning; and La Aurora Wildlife Refuge (LAWR), under moderate cattle density, and not burnt since 1997. In each area, we randomly selected ten dense savanna stands, established 500 m2 plots and undertook floristic survey in spring and summer to produce exhaustive plant-species lists. We statistically compared the two samples in terms of: local and global diversities; compositional heterogeneity among stands; mean similarity to a historical record from the area; overall species composition; and abundance and numbers of species with different growth habits and origins. Results: Differences between our samples are clear-cut. Savannas at EPNP have significantly increased local and global species richness and exhibit decreased similarities with the historical record. They have a novel understory, with significantly increased abundances and species numbers of fire-resistant grassland shrubs and fire-sensitive trees, and a groundcover with significantly increased richness of subshrub and perennial graminoid species. Savannas at LAWR have virtually no woody understory, and exhibit a groundcover dominated by an impoverished suite of perennial grasses, with significantly increased abundances and numbers of annual and of exotic species. Conclusions: Our results suggest that large-scale, long-term cattle exclusion and sporadic fires have resulted in changes in the structure and composition of the savanna vegetation leading to increased plant species diversity. Apparently, conservation of these humid savannas in protected areas requires periodic fire, while domestic cattle are a poor alternative for maintaining their plant species diversity.

Cretaceous intraplate contraction in Southern Patagonia: A far-field response to changing subduction dynamics? Gianni, Guido Martin; Navarrete Granzotto, César Rodrigo; Liendo, Ingrid Florencia; Díaz, Marianela Ximena Yasmin; Gimenez, Mario Ernesto; Encinas, Alfonso; Folguera Telichevsky, Andres The origin, extent, and timing of intraplate contraction in Patagonia are among the least understood geological processes of southern South America. Particularly, the intraplate Deseado fold-thrust belt (FTB), located in the Patagonian broken foreland (47°–48°300 S), is one of the most enigmatic areas. In this belt, time constraints on tectonic events are limited and synorogenic deposits have not been documented so far. Furthermore, the driving mechanism for intraplate contraction remains unknown. In this study, we carried out a structural and sedimentological analysis. We report the first syntectonic deposits in this area in the Baqueró (Aptian) and Chubut (Cenomanian/Campanian) groups and a newly found unit referred to as the Albian beds (109.9 ± 1.5 Ma). Thus, several contractional stages in late Aptian, Albian, and Cenomanian-Campanian are then inferred. We suggest that the Deseado FTB constituted the southernmost expression of the early Patagonian broken foreland in Cretaceous times. Additionally, we analyzed the spatiotemporal magmatic arc behavior as a proxy of dynamic changes in the Andean subduction during determined stages of intraplate contraction. We observe a significant arc broadening from ~121 to 82 Myr and magmatic quiescence after ~67 Ma. This is interpreted as a slab shallowing to flattening process. Far-field tectonic forces would have been produced by increased plate coupling linked to the slab flattening as indirectly indicated by the correlation between Cretaceous arc expansion and intraplate contraction. Finally, the tectonic evolution of the Deseado FTB favors studies supporting inception of Andean shortening since Cretaceous times.

El Fondo para la Investigación Científica y Tecnológica (FONCyT) anuncia los resultados del proceso de adjudicación para la convocatoria RC 2018 mediante Resolución N°035/18.

El Fondo Tecnológico Argentino (FONTAR) anuncia los resultados del proceso de reconsideración para la convocatoria ANR 4800 2017 C2 mediante Resolución de Directorio N°410, 411 y 412/18.

El Fondo Tecnológico Argentino (FONTAR) anuncia los resultados del proceso de evaluación y reconsideración para la convocatoria ANR P+L 2017 C2 mediante Resolución de Directorio N°413, 414 y 419/18.

El Fondo Tecnológico Argentino (FONTAR) anuncia los resultados del proceso de reconsideración para la convocatoria ANR SOCIAL 2017 C2 mediante Resolución de Directorio N°415 y 416/18.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia los resultados del proceso de evaluación para las convocatorias ANR Fonsoft 2017 C1 y C2 mediante Resolución de Directorio N°256, 306, 309, 357, 363, 366 y 389/18.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia los resultados del proceso de evaluación para la convocatoria Becas Jóvenes Profesionales TIC 2017 mediante Resolución de Directorio N°327, 362, 365 y 387/18.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia los resultados del proceso de evaluación y reconsideración de la ventanilla Crédito Exporta 2014 mediante Resolución de Directorio N°305, 390 y 392/18.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia los resultados de los procesos de evaluación y reconsideración para la convocatorias Emprendedores FONSOFT 2016 y 2017 C1 y C2 mediante Resolución de Directorio N°245, 248, 328, 313, 360, 308, 359, 361, 386, y 388/18.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia los resultados del proceso de evaluación para la convocatoria ANR Empresa Joven 2017 C1 y C2 mediante Resolución de Directorio N°307, 338, 358, 364, 384/18.

Petrología y potencial económico de las pegmatitas ubicadas al norte del batolito de Renca, provincia de San Luis, Argentina; Petrology and economic potential of pegmatites located at the north of Renca batholith, San Luis province, Argentina Wul, Julieta Gisele El objetivo principal de esta tesis es el estudio de las relaciones petrológicas entre las pegmatitas y las rocas circundantes localizadas al norte del batolito de Renca, provincia de San Luis, para establecer los vínculos con el magma parental que las habría originado. Otro objetivo de esta tesis es clasificar a las pegmatitas de la región e inferir su potencial metalogenético en base a estudios mineralógicos y geoquímicos. El área de estudio está localizada en el sector centro-este de la Sierra de San Luis, en donde afloran rocas del Complejo Metamórfico Conlara de edad ediacárica-cámbrica representadas por una secuencia de esquistos bandeados, esquistos de grano fino y en menor proporción, bancos de esquistos turmalínicos y turmalinitas. En el área también aflora una suite de granitos de tipo S de edades estimadas cámbrico-ordovícicas conformada por el Plutón La Tapera, el granito Los Alanices y el granito El Peñón. Afloran también los batolitos de Renca y Las Chacras-Potrerillos de edades devónicas. Por último, a lo largo de la fractura de carácter regional denominada Bajo de Véliz-San Felipe-El Morro aflora un conjunto de rocas máficasultramáficas denominado Las Cañas cuya edad se estima que estaría relacionada a procesos famatinianos. Las pegmatitas estudiadas forman parte del grupo Villa Praga-Las Lagunas, perteneciente al distrito pegmatítico Conlara. Se han relevado pegmatitas alojadas en el Complejo Metamórfico Conlara de signatura LCT (Li, Cs, Ta) y también de signatura NYF (Nb, Y, F) alojadas en el batolito de Las Chacras-Potrerillos. Se trata de pegmatitas graníticas, concordantes y discordantes con la roca de caja y son de mineralogía simple compuesta por cuarzo, microclino, albita y muscovita como minerales principales y berilo, turmalina, granate, apatita y circón como minerales accesorios, en algunos casos se encuentra espodumeno y columbita. La mayoría de los cuerpos estudiados presentan zonación donde puede observarse las siguientes zonas: núcleo, intermedia, externa y de borde. Se emplearon todos los criterios geológicos disponibles en esta tesis incluyendo estudios geoquímicos en muscovita y feldespato de las pegmatitas para clasificarlas y se las agrupó en clase elementos raros, subclase REL-Li (Elementos Raros-Litio), tipos berilo y complejo, y estériles a las pegmatitas de la familia LCT y en clase elementos raros, subclase REL-REE (Elementos Raros-Tierras Raras), tipo allanita-monacita a la única pegmatita estudiada de la familia NYF. El análisis de esta información permitió obtener resultados acerca del grado de fraccionamiento de las pegmatitas. Si bien los hallazgos de mineralizaciones de Nb-Ta y de espodumeno son escasos en estas pegmatitas, algunas de ellas presentan características compatibles con este tipo de mineralización que ya ha sido descripta en pegmatitas de áreas cercanas que presentan características similares a las estudiadas en esta tesis. El estudio de difracción de rayos X sobre feldespato indicó elevado grado de ordenamiento y triclinicidad, compatible con microclino bajo. En algunos casos, se observó que el más bajo grado de triclinicidad obtenido en feldespato se correspondería con pegmatitas de menor volumen y morfología de diques. El resultado de análisis petrográficos, químicos (EPMA: microanálisis con sonda de electrones) y de isótopos de boro (SIMS: espectrometría de masa de iones secundarios) en turmalina de pegmatitas NYF y LCT, granito Los Alanices, esquistos con turmalinas y turmalinitas del Complejo Metamórfico Conlara permitieron clasificar a la turmalina dentro de la serie chorlo-dravita y estudiar sus variaciones composicionales químicas e isotópicas dentro de cada cristal. El contenido de boro que llevó a la cristalización de turmalina en las pegmatitas estudiadas se relacionaría con la fusión parcial de los metasedimentos del Complejo Metamórfico Conlara. Datos químicos e isotópicos indican que dichas rocas serían la fuente de los leucomonzogranitos y monzogranitos muscovítico-biotítico de los cuales derivarían los líquidos pegmatíticos. El aporte de boro a ese fundido granítico original provendría de las micas que intervinieron en las reacciones de fusión parcial y probablemente también de reacciones involucrando turmalina. Las condiciones de P y T necesarias para fusión parcial se alcanzaron en un nivel cortical no expuesto. La presencia de rocas máficas de probable edad ordovícica como el gabro de las Cañas podría indicar una posible fuente de calor. Las edades de enfriamiento de las pegmatitas LCT sugieren una historia de enfriamiento común con el encajante metamórfico. La relación del emplazamiento/deformación indica que estas pegmatitas son sin a tardío cinemáticas respecto de D3, un evento de plegamiento y desarrollo de foliación de edad ordovícica temprana.; The main objective of this thesis was focused on the study of petrology relations between pegmatites and surrounding rocks located at the north of Renca batholith, San Luis province, to establish connections with the parental magma that originated them. Other important aim of this thesis is oriented to classify and infer the metallogenic potential of those pegmatites through mineralogical and geochemical studies. The area of study is located at the center-east part of Sierra de San Luis. Rock outcrops here belong to the Conlara Metamorphic Complex of ediacaran-cambrian ages represented by sequences of banded schists, fine grained schists and in less proportion layers of tourmaline schists and tourmalinites. Also in this area there are outcrops of S-type granites of cambricordovicic estimated ages, composed by La Tapera Pluton, Los Alanices granite and El Peñón granite. Moreover, granites of devonic ages are located in the area, they are Renca and Las Chacras-Potrerillos batholiths. Additionally, along the regional strip denominated Bajo de Véliz-San Felipe-El Morro there is an outcrop of mafic-ultramafic rocks named Las Cañas, whose age is unknown but is estimated to be related to famatinian processes. The studied pegmatites belong to the Villa Praga-Las Lagunas group, Conlara pegmatitic distirct. Pegmatites of LCT (Li, Cs, Ta) signature located in the Conlara Metamorphic Complex and pegmatites with NYF (Nb, Y, F) signature from Las Chacras-Potrerillos batholiths were sampled. This set of pegmatites is granitic and it is concordant and discordant with the host rock. They have simple mineralogy composed by quartz, microcline, albite and muscovite as main minerals. Accessory minerals are beryl, tourmaline, garnet, apatite and zircon, in some cases there are spodumene and columbite. Most of these pegmatites have zonation with a core, intermediate, wall and border zone. All available geological features including muscovite and feldspar geochemistry were carried out in these pegmatites to classify them, and they were grouped in rare elements class, RELLi subclass (Rare Elements-Lithium), beryl and complex type and barren for pegmatites of LCT petrogenetic family and in rare elements class, REL-REE (Rare Elements-Rare Earth) subclass, allanite-monacite type, to the only pegmatite of NYF petrogenetic family analyzed. This information was useful to infer the fraccionation of the pegmatites. To the moment it is scarce the Nb-Ta and spodumene mineralization in these pegmatites, but some of them have compatible characteristics with this kind of minerals that have been described in others pegmatites near this area. The X ray diffraction carried out in feldspars indicate a high ordering degree and triclinicity, compatible with low microcline. In some cases, it was observed that the lowest degree of triclinicity obtained in feldspar would correspond with pegmatites of smaller volume and dike morphology. Petrographic, chemical (EPMA: electron microprobe analyzer) and isotopic (SIMS: secondary ion mass spectrometry) analyses carried out in tourmaline from NYF and LCT pegmatites, Los Alanices granite, tourmaline schist and tourmalinite from Conlara Metamorphic Complex led to study compositional and isotopic variations in each crystal. They were grouped as belonging to the schorl-dravite series according to the chemical composition. The boron content that led the crystallisation of tourmaline in the pegmatites studied would be related to the partial fusion of metasediments of the Conlara Metamorphic Complex. Chemical and isotopic data indicate that these rocks would be the source of the muscoviticbiotitic leucomonzogranites and monzogranites from which pegmatitic liquids would derivate. The contribution of boron to that original granite melt would come from the micas that participated in the partial fusion reactions and probably also from reactions involving tourmaline. The P and T conditions necessary for partial melting were achieved at a nonexposed cortical level. The presence of mafic rocks of probable ordovician ages such as the gabbro de las Cañas could indicate a possible heat source. The cooling ages of the LCT pegmatites suggest a common cooling history with the metamorphic host rocks. The relation of the emplacement/deformation indicates that these pegmatites are syn to post kinematic with respect to D3, an early folding and foliation development event of the early ordovician age.

Paisajes agrarios del segundo milenio de la era en el sector norte del Valle de Tafí (Tucumán, Argentina); Agrarian landscape of the second millennium in the northern area of Tafi Valley (Tucumán, Argentina) Franco Salvi, Valeria Leticia; Molar Becchio, Rocío María Este artículo se propone discutir los resultados de investigaciones arqueológicas realizadas en el sector Norte del valle de Tafí, enfocándonos específicamente en evidencias de las actividades agrícolas correspondientes a la primera mitad del segundo milenio de la Era Cristiana. Durante este período el paisaje agrario se transforma segregándose del sector de viviendas, lo que ha generado diversas explicaciones en la literatura arqueológica del Noroeste Argentino. Hemos llegado a la conclusión preliminar de que el valle adquiere una lógica espacial que es propia de este período en la región, pero que no habría sido originada por los factores que la arqueología tradicional suele atribuirle, esto es, la presión demográfica, conflictos o cambios ambientales.; This paper proposes to discuss the results of archaeological research carried out in the northern sector of the Tafi valley, specifically focusing on evidences corresponding to the first half of the Second Millennium of the Christian Age. During this period, the agrarian landscape is segregating of household area which has generated several explanations in the archaeological literature of the Northwest Argentina. We came to the preliminary conclusion that the valley acquires a spatial logic, typical of this period in the region, but would not have been caused by factors that traditional archaeology usually attribute, this are population pressure, conflict or environmental changes.

Towards a situated ethics of care: Some moral dilemmas around aspects of care in an unequal society Faur, Eleonor Carol; Tizziani, Ania This article analyses moral dilemmas around aspects of care from gender and class perspectives. Based on quantitative data and qualitative research for the surrounding area of Buenos Aires, we probe how contemporary women and men in Argentina organise, experience and perceive the relationship between working life and their responsibilities for caring for family members. A situated ethics of care, as explored in the article, reinforces the notion that care is always contextual – it can only be understood within a social and political milieu – and presents distinctions among subjects that hold unequal positions in class and gender hierarchies.

Temáticas, geografías y debates en el campo de la pedagogía de la alternancia; Topics, geographies and discussions in the field of pedagogy of alternation Miano, María Amalia; Lara Corro, Erik Said En este artículo mapeamos la producción teórica elaborada en los últimos siete años sobre la pedagogía de la alternancia, con el fin de exponer un estado del conocimiento actual en este ámbito. Metodológicamente, el mapeo siguió dos ejes: (a) la agrupación semántica de las producciones de acuerdo con las temáticas recurrentes para dar cuenta de qué se ha estudiado y los tipos de producciones, y (b) el agrupamiento con un enfoque geográfico para reconstruir la cantidad de producciones y temáticas recurrentes por país. Nuestros resultados muestran que este campo de investigación aloja perspectivas muy diversas e incluso contrapuestas, entre las que pueden identificarse los polos "pedagogía de la alternancia y emancipación" y "pedagogía de la alternancia y sujeción".; We map the theoretical production elaborated in the last seven years on the Pedagogy of Alternation, in order to expose a state of current knowledge in this field. The mapping followed two axes: (a) the semantic grouping of the productions according to the recurrent themes to account for what has been studied and the types of productions, and (b) the grouping with a geographic focus to reconstruct the quantity of productions and recurrent themes by country. The analysis shows that the field of pedagogy of alternation has diverse and opposing perspectives, in which highlight the poles “pedagogy of alternation and emancipation” and “pedagogy of alternation and subjection”

Liftings of Jordan and super Jordan planes Andruskiewitsch, Nicolas; Angiono, Iván Ezequiel; Heckenberger, Istvan We classify pointed Hopf algebras with finite Gelfand-Kirillov dimension whose infinitesimal braiding has dimension 2 but is not of diagonal type, or equivalently is a block. These Hopf algebras are new and turn out to be liftings of either a Jordan or a super Jordan plane over a nilpotent-by-finite group.

Electrical effective parameters of the grains and the Montgomery's method in Bi 1.65Pb 0.35Sr 2Ca 2.5Cu 3.5O y ceramics Cruz García, A.; Fernández Gamboa, J. R.; Altshuler, E.; Jardim, R. F.; Vázquez Robaina, Odin; Muné, P. In this paper we have applied the Montgomery's measurement method to Bi 1.65Pb 0.35Sr 2Ca 2.5Cu 3.5O y ceramic samples, to study the behavior of the grains? electrical effective parameters, such as: intrinsic effective anisotropy, t= ρc/ ρa b, the slope of the linear part in the temperature dependence of the ab-planes resistivity, Aa b= Δρa b/ ΔT, the weak links resistivity, ρw l, and the orientation probability of the grains? a-axes along a certain preferential direction, γx a. Here, ρa b, ρc and T are the main values of the resistivitity tensor and the measurement temperature, respectively. The samples were pressed uniaxially at three different compacting pressures and extracted from the pellets by cutting an slab along the cylinder axis. Samples cut in this way, exhibit almost an isotropic behavior in the transport properties. Moreover, the sample extracted from the pellet compacted at 488 MPa exhibits the best inter and intragranular properties. The effective intrinsic anisotropy of its grains has the lowest value in the sample set. These results can be used in the fabrication of this superconducting material for certain applications.