Alamandine, a protective component of the renin-angiotensin system, reduces cellular proliferation and interleukin-6 secretion in human macrophages through MasR–MrgDR heteromerization Rukavina Mikusic, Natalia Lucía; Silva, Mauro Gastón; Erra Diaz, Fernando Alberto; Pineda, Angélica M.; Ferragut, Fatima Eneida del Valle; Gomez, Karina Andrea; Mazzitelli, Luciana Romina; Gonzalez Maglio, Daniel Horacio; Nuñez, Myriam; Santos, Robson A.S.; Grecco, Hernan Edgardo; Gironacci, Mariela Mercedes Alamandine (ALA) exerts protective effects similar to angiotensin (Ang) (1-7) through Mas-related G protein-coupled receptor type D receptor (MrgDR) activation, distinct from Mas receptor (MasR). ALA induces anti-inflammatory effects in mice but its impact in human macrophages remains unclear. We aimed to investigate the anti-inflammatory effects of ALA in human macrophages. Interleukin (IL)-6 and IL-1β were measured by ELISA in human THP-1 macrophages and human monocyte-derived macrophages exposed to lipopolysaccharide (LPS). Consequences of MasR-MrgDR heteromerization were investigated in transfected HEK293T cells. ALA decreased IL-6 and IL-1β secretion in LPS-activated THP-1 macrophages. The ALA-induced decrease in IL-6 but not in IL-1β was prevented by MasR blockade and MasR downregulation, suggesting MasR-MrgDR interaction. In human monocyte-derived M1 macrophages, ALA decreased IL-1β secretion independently of MasR. MasR-MrgDR interaction was confirmed in THP-1 macrophages, human monocyte-derived macrophages, and transfected HEK293T cells. MasR and MrgDR formed a constitutive heteromer that was not influenced by ALA. ALA promoted Akt and ERK1/2 activation only in cells expressing MasR-MrgDR heteromers, and this effect was prevented by MasR blockade. While Ang-(1-7) reduced cellular proliferation in MasR -but not MrgDR- expressing cells, ALA antiproliferative effect was elicited in cells expressing MasR-MrgDR heteromers. ALA also induced an antiproliferative response in THP-1 cells and this effect was abolished by MasR blockade, reinforcing MasR-MrgDR interaction. MasR-MrgDR heteromerization is crucial for ALA-induced anti-inflammatory and antiproliferative responses in human macrophages. This study broaden our knowledge of the protective axis of the RAS, thus enabling novel therapeutic approaches in inflammatory-associated diseases.

Comment on De Rosa et al. Hearing Loss: Genetic Testing, Current Advances and the Situation in Latin America. Genes 2024, 15, 178 Elgoyhen, Ana Belen; Buonfiglio, Paula Inés; Dalamon, Viviana Karina The manuscript "Hearing Loss: Genetic Testing, Current Advances and the Situation in Latin America" by De Rosa et al. includes a comprehensive wealth of data that describe the state of the field in the Latin American region. A detailed demographic and economic landscape is presented, and provides insightful historical perspectives on key genetic advancements in hearing loss (HL) diagnosis. Nevertheless, the paper lacks important additional information concerning the current situation of genetic and genomic medicine in Latin American countries.

Engineering user-centered explanations to query answers in ontology-driven socio-technical systems Teze, Juan Carlos Lionel; Paredes, José Nicolás; Martinez, Maria Vanina; Simari, Gerardo The role of explanations in intelligent systems has in the last few years entered the spotlight as AI-based solutions appear in an ever-growing set of applications. Though data-driven (or machine learning) techniques are often used as examples of how opaque (also called black box) approaches can lead to problems such as bias and general lack of explainability and interpretability, in reality these features are difficult to tame in general, even for approaches that are based on tools typically considered to be more amenable, like knowledge-based formalisms. In this paper, we continue a line of research and development towards building tools that facilitate the implementation of explainable and interpretable hybrid intelligent socio-technical systems, focusing on features that users can leverage to build explanations to their queries. In particular, we present the implementation of a recently-proposed application framework (and make available its source code) for developing such systems, and explore user-centered mechanisms for building explanations based both on the kinds of explanations required (such as counterfactual, contextual, etc.) and the inputs used for building them (coming from various sources, such as the knowledge base and lower-level data-driven modules). In order to validate our approach, we develop two use cases, one as a running example for detecting hate speech in social platforms and the other as an extension that also contemplates cyberbullying scenarios.

Incidence of agroecological-based practices in urban vegetable gardens: effect on crop diversity and production levels de Paz, Manuel; Nabaes Jodar, Diego Nicolás; Ocariz, María Paula; Mantiñan, Camila; Raffo, Fernando; Garibaldi, Lucas Alejandro Agroecological-based practices (ABPs) play a vital role in urban vegetable gardens,enhancing the quality of life. However, factors driving ABP implementation and theirimpact on crop production and diversity are not fully understood. Our study assessedthe influence of socio-economic and environmental characteristics on ABP adoption,crop diversity, and totalTotal weight vegetable production in San Carlos de Bariloche,Argentina. Through interviews and a multi-model inference approach, we found thatABP implementation is tied to gardener experience and formative assets (e.g.,horticultural experience, specific trainingcapacitation). Crop diversity, integral to ABP,is affected by farming practices and farmer characteristics (Farm animals, Pollinator-friendlyFriendly pollinator practices, Experience, Additional training andEnvironmental knowledge). The Totaltotal weight produced was primarily influencedby the type of garden, the gardener´s experience and some ABPs. Long-standingcommercial and community objectives, and the use of farm animals and commercialseed led to greater production. Strengthening key drivers, such as farmer training,through public policies (e.g., income generation, financing, specific training, landaccess) can bolster the role of urban gardens in providing a healthy environment andpromoting food sovereignty.

Wearable Device Dataset from Induced Stress and Structured Exercise Sessions This original dataset contains physiological signals collected during structured acute stress induction and aerobic and anaerobic exercise sessions using a wearable device. Blood volume pulse, motion-based activity, skin temperature, and electrodermal activity were recorded with the Empatica E4, a research-grade wearable. The stress induction protocol involved math and emotional tasks designed to provoke stress responses, interleaved with rest periods. Self-reported stress levels were also recorded during this procedure. For the exercise sessions, distinct routines on a stationary bike were created for aerobic and anaerobic activities. The dataset includes records from 36 healthy volunteers for stress sessions, 30 for aerobic exercise, and 31 for anaerobic exercise. By examining the variations in physiological signals, the effects of these activities can be analyzed. This dataset is a valuable resource for research on stress and exercise detection and classification.

Catastro de cavidades de la zona de Malargüe La información que contiene este cuadro fue publicada en un medio de circulación acotada por la Federación Argentina de espeleología (FAdE) con sede en Malargüe. Es posible que en algunas localizaciones existan errores de coordenadas. este registro es útil a los fines de conocer cuantitativamente las cavernas y aleros identificados en el departamento de Malargüe. En el artículo "Malargüe (Argentina): extractivismo y disputa por bienes comunes" se aborda de forma secundaria la relevancia de la espeleología en el sur mendocino y su estrecha relación con la circulación de agua.

Plataformas petroleras costa este río Grande I (Malargüe) Relevamiento por medio de la herramienta Argenmap (IGN) de las plataformas petroleras existentes en el este del río Grande (Malargüe). Se midieron el perímetro y superficie de las plataformas y sus correspondientes centroides. Se contabilizaron un total de 571 plataformas (puede haber un límite de error en el conteo).

Plataformas petroleras zona Cerro Fortunoso (Malargüe) Relevamiento efectuado usando la herramienta de Argenmap (IGN) para contabilizar y medir las plataformas petroleras en el área de Cerro Fortunoso (Malargüe) en cercanías del área protegida provincial de La Payunia. Esta información se triangula con trabajo de campo donde se obtuvieron entrevistas con habitantes que crecieron en las inmediaciones y fotografías de la infraestructura que es parte de la actividad hidrocarburífera. En este lugar se contabilizaron (puede haber un límite de error) 234 plataformas. Se identifico su centroide y se midieron las superficies y perímetros.

Competitive ability of three native grass species during establishment Scarfó, María Cecilia; Rodriguez, Dana Aylen; Milano, Clara; Loydi, Alejandro Weed resistance is highly desirable in seed used for restoration. Therefore, assessing the competitiveness of target species during germination and establishment stages would help to plan effective restoration projects. Our study aims to assess the impact of competition in seedling establishment, height, leaf number, and aerial biomass of three native perennial forage grasses with different seed sizes. We conducted a competition experiment under greenhouse conditions with three native species Nassella longiglumis, N. tenuis and Piptochaetium napostaense), and one exotic annual species (Avena barbata). Two competition levels were established (with and without A. barbata) and two seeding densities for the perennial species were defined (15 and 30 seeds per pot). Established seedlings, leaf number, height and aerial biomass were measured. Seedling establishment was affected by competition only for N. tenuis. For all three species, N. longiglumis, with the larger seed size, was the least affected by competition. Competition reduced seedling biomass for all three species, with N. longiglumis, with the larger seed size, being the least affected. Increasing seeding density has little effect on the aerial biomass of the weed.The co-occurrence of native perennial species and the annual species A. barbata severely reduces growth, therefore it is important to implement management practices to control annual exotic species and effectively restore grassland ecosystems.

Fumonisins in infant cereals marketed as complementary food in Argentina Cendoya, Eugenia; Nichea, Maria Julia; Romero Donato, Cindy Johana; Zachetti, Vanessa Gimena Lourdes; Monge, Maria del Pilar; Ramirez, Maria Laura Infant cereals are typically the first foods introduced as complementary foods. Cereals used to elaborate complementary foods, such as wheat, maize and rice, are susceptible to mycotoxin contamination. Among mycotoxins, fumonisins have been epidemiologically associated, in humans, with oesophageal cancer, neural tube defects and stunting. Fumonisins have been found in maize and wheat grains in Argentina. In the present study, a survey was conducted to determine their occurrence in 82 wheat-based and multicereal-based infant cereal items collected from retail stores in Rio Cuarto, Argentina, using HPLC-MS. Of these samples, 84% showed FBs contamination with levels ranging from 0.05 to 992 μg/kg). Although FB1 was the most prevalent fumonisin, FB2 was found at higher levels. Most samples had levels below the limit of 200 μg/kg set for Argentinean cereal products for children. The outcome of this survey provides information on the naturally presence of fumonisin in infant cereal intended for children in Argentina, which can be helpful to consider relevant monitoring programmes.

Agroecological Aptitude of the Northeast of Formosa (Argentinean Subtropical Region) for Banana Production Assessed by Multiple Factor Analysis del Médico, Ana Paula; Vitelleschi, María Susana; Lavalle, Andrea Lina; Tenaglia, Gerardo Carlos; Pratta, Guillermo Raúl Banana (Musa spp.) is an important crop in the economies of many developing countries. In the north of Argentina, a subtropical region, banana plants grow in a suboptimal environment that limits yield because only one harvest per year is achieved. The objective of this work was to characterize the agroecological aptitude of Formosa, Argentina, for banana production through the behavior of three varieties of international use: Williams, Jaffa and Grand Naine, evaluated over five consecutive years. The three-way data analysis technique called Multiple Factor Analysis (MFA) was used for evaluating the varieties’ performances across cycles of production. The results allowed for inferring the existence of a genotype x environment interaction (GEI), corroborated by two-way factorial ANOVA. In order to determine how this suboptimal environment affected the development of each genotype of this perennial crop, Dual Multiple Factor Analysis (DMFA) was applied to jointly analyze the correlation structure between the traits that contributed to the performance of each variety in each year. The correlation structures between variables were different in each population and varied between years. All traits showed great variation between the years and genotypes, with the fruit peel thickness being the most discrepant throughout the years. However, Formosa appeared as a promising subtropical agroecological environment to produce banana because the varieties’ performances were acceptable for large-scale production systems. In addition to evaluating the adequate aptitude for cultivating banana in Formosa considering the significant effect of the GEIs, this research made a methodological contribution by proposing the use of three-way data analysis in Agronomy Science via MFA and DMFA.

An ultra-low noise fully-differential amplifier Spinelli, Enrique Mario; Haberman, Marcelo Alejandro A general-purpose instrumentation amplifier must be dc-coupled and has a differential input to handle both differential and single-ended input signals. It must also exhibit low input noise in both voltage and current to accommodate a wide range of signal source impedances. Additionally, having a differential output is desirable to allow direct connection to current high-resolution analog-to-digital converters (ADCs), which have differential inputs. There are commercially available devices with en voltage noise spectral densities as low as 1 nV/Hz−−−√ but present high current noise spectral densities in of a few pA/Hz−−−√ . On the other hand, there are also devices with in as low as a few fA/Hz−−−√ but presenting en around 10 nV/Hz−−−√ . To obtain low values of both en and in , a fully differential circuit topology combining discrete junction field transistors (JFETs) and operational amplifiers (OAs) is proposed. Design equations, stability analysis, and experimental results are presented. As an example, a fully differential instrumentation amplifier has been designed, built, and tested showing en<1 nV/Hz−−−√ at 1 kHz and in<10 fA/Hz−−−√ at 1 kHz. The proposed topology finds applications, such as front ends for measuring and testing instruments, industrial instrumentation, and audio circuits.

Neotectonics of the Magallanes-Fagnano fault system in Fuegian Patagonia based on high-resolution seismic profiles and geomorphic markers Restelli, Florencia Belen; Bran, Donaldo Mauricio; Almaraz, Fernando; Menichetti, M.; Lodolo, E.; Esteban, Federico Damián; Lozano, Jorge Gabriel; Tassone, Alejandro Alberto The Magallanes–Fagnano Fault System (MFFS), located at the southern tip of Patagonia, is part of the transform plate boundary between the Scotia and South American plates. Modern deformation along the fault system has been mostly studied on land, such as in the eastern region of Lago Fagnano. Furthermore, previous studies have primarily focused on the analysis of co-seismic deformation, while the long-term landscape response to neotectonics has not been addressed in detail. This work aims to identify and characterize active fault segments within the lake sediments and investigate the imprint of deformation in the surrounding landscape. To achieve this, we integrate high-resolution seismic profiles acquired in Lago Fagnano with a morphometric analysis of the hydrographic basin. These segments show subaqueous ruptures affecting the lacustrine sediments reaching the lake floor, indicating recent deformation episodes. Most of the recognized faults are sub-vertical or dip steeply (> 60°) to the south and show vertical offsets that range from 4 to 17 m. The morphometric analysis is consistent with the overall southward dip of the MFFS and indicates a hydrographic rejuvenation towards the north of the lake. In addition, the ruptures of the fault system can be correlated with the deformation observed on land, resulting in a ~ 150 km long segmented surface rupture zone that might be consistent with the rupture length estimated for the 1949 M7.5 earthquake doublet.

Comprender a Spinoza desde la intimidad de la lengua: Nota al margen de una nueva edición de la Ética Tatián, Diego La más reciente traducción de la Ética demostrada según el orden geométrico, realizada por Mario Caimi para la impresionante colección de clásicos de la editorial Colihue, constituye un acontecimiento para la filosofía en nuestra lengua y una enorme contribución para la comprensión de este libro singular. Se trata de una edición anotada, que cuenta con un extenso estudio preliminar donde su autor -a la manera de los trabajos clásicos de Martial Gueroult y Pierre Macherey en francés, o de Filippo Mignini en italiano- analiza minuciosamente el recorrido de proposiciones de cada una de las cinco partes de la obra.La tesis fundamental en la interpretación del libro mayor de Spinoza que desarrolla ese estudio -de ahora en más, un precioso instrumento de trabajo para investigadores a la vez que una introducción a la filosofía spinozista para quienes deseen iniciarse en ella-, consiste en que la Ética no es esencialmente un libro de ética sino de metafísica: una teoría de “lo que verdaderamente es”. El nombre de la obra habría sido adjudicado por los editores de las Opera posthuma y no por Spinoza mismo (quien en sus cartas, efectivamente, alude a ella como “mi filosofía”, pero nunca con el título bajo la que fue editada en 1677 apenas después de su muerte). En contraposición a un extendido arco de lecturas que incluye estudiosos tan diversos como Jonathan Bennett y Gilles Deleuze, el profesor Mario Caimi sostiene que el objetivo principal de este libro no es la búsqueda de la felicidad (Beatitudo) o la vida buena, sino la comprensión del fundamento y el ser de las cosas bajo el “aspecto de la eternidad”.

Hydrogeomorphological changes and the erosion-deposition impact in the San Francisco River Basin, Northwest Argentina: a multidecadal analysis Isuani, María Antonella; Georgieff, Sergio Miguel; Bustos, María Soledad Modifications of wetland and forest areas are studied, in particular, to establish to what extent they are sensitive to natural changes (e.g., increased precipitation and/or temperature) in addition to human activities (e.g., advancing agricultural frontier, deforestation, channelizations). The San Francisco River Basin (SFRB; 1,789 km2) is located in the Northwest of Argentina in the Geological Province of Nortwestern Pampean Ranges (Sierras Pampeanas Noroccidentales), between 27°40?S and 28°25?S, and 65°15?W and 65°45?W). In recent decades, agricultural development and management in the middle and lower SFRB generated rural channelizations (the largest of 10 km at the basin outlet between 2005-2015), drainage of wetland forests, deforestation of native dry forest since 1995 and changes in land use. In addition, a 200 mm increase in mean annual rainfall since 1972 and an increase in extreme hydrological events, are registered. These modifications produced changes in local base level, erosive processes of retreat and the development of new river channels from upstream, increasing flow velocities, flow rates, and sediment discharge. The intensified erosive processes resulted in four new river courses in the middle and lower basin, incorporating the SFRB into the Marapa river basin, changing from arheic to endorheic behaviour, and generating the contribution of liquid and solid flows to the system of which it is now a part. The aim of this study is to examine the development of the new hydrographic network within the SFRB between 1990 and 2018 and to calculate the solid and liquid discharges generated by the new network. The hydrographic network formed by the rivers El Abra, Ovanta, San Francisco and Suncho creek, was digitized in the open-source software QGIS 3.18.3 on the basis of the visual interpretation of satellite imagery. The lengths of the rivers were automatically calculated and exported to a spreadsheet to determine the downstream expansion of the river network. Measurements and sampling of water discharge and sediment load were performed monthly in the lower section of the SFRB. The float and crosssection method was used to quantify the flow rates, and the sediment samples were filtered, dried in an oven for 24 h and weighed on a precision balance to obtain the sediment concentration (C in mg/l). The study determined the generation of 102 km of new river channels in a 28 yr period. The hydrographic network had an annual sediment production of 82,138 t/yr and an annual discharge of 21,96 hm3, contributing to the Marapa river basin and generating an acceleration in the silting of the downstream Río Hondo reservoir. This work provides a basis for management and mitigation of erosion and flooding problems in the area.

El movimiento nutricionista internacional como libreto y su adopción en América Latina: las encuestas alimentarias en la década de 1930; O movimento internacional de nutrição como guia e sua implementação na América Latina: pesquisas de alimentação nos anos 1930; The international nutrition movement as a guide and its adoption in Latin America: food surveys in the 1930s Buschini, Jose Daniel Este artículo analiza una serie de encuestas alimentarias que tuvieron lugar en América Latina durante la década de 1930. Se argumenta que la realización de estas encuestas formó parte de un proceso más amplio, consistente en la participación de la región en la consolidación y expansión del movimiento nutricionista internacional, que entonces despuntaba. El trabajo hace foco en tres aspectos de esas encuestas, para mostrar de ese modo la conexión entre los desarrollos locales y globales.; Este artigo analisa uma série de pesquisas sobre alimentação realizadas na América Latina durante a década de 1930. Argumenta-se que a realização dessas pesquisas integra um processo mais amplo de participação da região na consolidação e expansão do então emergente movimento internacional de nutrição. O artigo se concentra em três aspectos dessas pesquisas para mostrar a relação entre o desenvolvimento local e global.; This study analyzes a series of food surveys that took place in Latin America during the 1930s. It argues these surveys belonged to a broader process consisting of the region participating in the consolidation and expansion of the then emerging international nutrition movement. This study focuses on three aspects of these surveys to show the connection between local and global developments.

Design of the tertiary optical system for the Large Latin American Millimeter Array radio telescope Rasztocky, Emiliano; Hampel, Matias Rolf; Reeves, Rodrigo; Lepine, Jacques R.D.; Romero, Gustavo Esteban Many modern radio telescopes employ an observational strategy that involves maximizing the use of their available spaces (cabins), outfitting them with various receivers at different frequencies to detect incoming signals from the sky simultaneously or individually. The Large Latin American Millimeter Array is a joint venture between Argentina and Brazil consisting of the installation and operation of a 12-m aperture Cassegrain telescope. It features three available cabins for instrumentation and plans to install six single-pixel heterodyne receivers, covering different bandwidths in the 30 to 950 GHz window of the electromagnetic spectrum, in its two lateral Nasmyth cabins at different phases of the project. Therefore, it is crucial not only to design a tertiary optical system that couples the antenna beam to those receivers but also to do it in a scalable way. The primary goal for the design is to simultaneously maximize the antenna efficiency while minimizing optical aberrations for all receivers, both fundamental aspects for the optimal functioning of cutting-edge astronomical instruments. We present the entire design process, starting from the quasi-optical approach based on the propagation of a fundamental Gaussian beam mode, continuing with the validation of the design based on physical optics simulations, and ending with a tolerance analysis of the system. As a result of this process, a frequency-independent tertiary optical system has been achieved for almost all the receivers, which is expected to provide high optical performance for the radio telescope.

A supervised data-driven spatial filter denoising method for speech artifacts in intracranial electrophysiological recordings Peterson, Victoria; Vissani, Matteo; Luo, Shiyu; Rabbani, Qinwan; Crone, Nathan E.; Bush, Alan; Richardson, R. Mark Neurosurgical procedures that enable direct brain recordings in awake patients offer unique opportunities to explore the neurophysiology of human speech. The scarcity of these opportunities and the altruism of participating patients compel us to apply the highest rigor to signal analysis. Intracranial electroencephalography (iEEG) signals recorded during overt speech can contain a speech artifact that tracks the fundamental frequency (F0) of the participant’s voice, involving the same high-gamma frequencies that are modulated during speech production and perception. To address this artifact, we developed a spatial-filtering approach to identify and remove acoustic-induced contaminations of the recorded signal. We found that traditional reference schemes jeopardized signal quality, whereas our data-driven method denoised the recordings while preserving underlying neural activity.

Selected farm-level crop protection practices in Europe and Argentina: Opportunities for moving toward sustainable use of pesticides Mark, Jennifer; Fantke, Peter; Soheilifard, Farshad; Alcon, Francisco; Contreras, Josefa; Abrantes, Nelson; Campos, Isabel; Baldi, Isabelle; Bureau, Mathilde; Alaoui, Abdallah; Christ, Florian; Mandrioli, Daniele; Sgargi, Daria; Pasković, Igor; Pasković, Marija Polić; Glavan, Matjaz; Hofman, Jakub; Harkes, Paula; Lwanga, Esperanza Huerta; Norgaard, Trine; Aparicio, Virginia Carolina; Schlünssen, Vivi; Vested, Anne; Silva, Vera; Geissen, Violette; Tamm, Lucius Extensive use of plant protection products (PPP) in the last decades contributes to negative impacts on ecosystems, animals and humans. For the strategies of PPP reduction and replacement of hazardous pesticides, farm-level data on agronomic management practices and crop protection applications are crucial. In this study, we strategically collected data for the 2021 season at the SPRINT project case study sites (CSS) in 10 European countries and Argentina, on perennial, arable and vegetable crops. Data collection included strategically selected farm and field data, pesticide records and farming practices. Results involved more than 1700 recorded PPP applications across various crops with more than 170 different active substances from PPP in organic, integrated pest management and conventional farming practices. We explored differences in application patterns (fungicides, insecticides, herbicides and non-PPP, e.g. adjuvants, growth regulators, and fertilizers) between and within crops, countries and farming systems and calculated the costs of PPP use. The pesticide dosages applied during the crop season varied up to a factor of 20 around recommended doses. Regarding the costs of PPPs use perennial crops had the highest costs per ha crop production area. Finally, we analysed the active substances applied in different farming systems in terms of their hazard statements. Our results shed light on how PPPs are used across different crop and farming types and will help elucidate how pesticide application patterns can be changed in the future. Finally, we highlighted non-PPP use practices which help to reduce dependency on PPP use. This might be used to support decision-making and policies within agricultural advisory/support systems.

Influencia de la calidad del agua y del abono sobre las fracciones orgánicas en suelos de La Pampa; Water quality and manure influence on organic fractions of La Pampa soils Huespe, Daiana Susana; Galantini, Juan Alberto; Baraldi, Luciano Martin; Alvarez, Cristian El uso de agua salina en sistemas hortícolas degrada el suelo y reduce la productividad. El objetivo de este estudio fue analizar cómo el agua de diferente calidad y la aplicación de abono orgánico afectan la productividad de lechuga (Lactuca sativa L.) y las fracciones de carbono orgánico en dos suelos de diferentes texturas característicos del centro de La Pampa. Se evaluó el cultivo de lechuga en dos suelos, uno arenoso y otro franco arenoso. El tratamiento principal se regó con agua de conductividad eléctrica de 1,0 (baja salinidad) y 2,0 (alta salinidad) dS m-1. Se fertilizó con una dosis de 100 kg N ha-1, usando tres combinaciones de las fuentes abono orgánico y urea: C0 (100:0), C2 (70:30) y C4 (40:60). Se evaluaron cuatro ciclos consecutivos durante los años 2020 y 2021. Se analizó: materia seca de raíces (MSR), aérea (MSA) y total (MST), la relación MSA/MSR, la eficiencia de uso del agua y la tasa de crecimiento. Se determinó el carbono orgánico (CO) total (COT) y el CO particulado (COP). Al evaluar el efecto acumulado se observó una interacción significativa entre el suelo de textura arenosa y el de textura franco arenosa (p<0,05). En el suelo arenoso el valor máximo de MST (1504 kg ha-1) se obtuvo con agua de CE de 1,0 dS m-1 con una disminución de 18% cuando se regó con agua con CE de 2,0 dS m-1. Mientras que, en el suelo franco arenoso el valor máximo de MST (1385 kg ha-1) se obtuvo con agua de 1,0 dS m-1 con una disminución de 54% cuando se regó con agua con CE de 2,0 dS m-1. En el suelo franco arenoso la aplicación de abono orgánico ayudó a mitigar el efecto del agua salina en las variables MST , MSA y MSR. Los cambios en el COP producidos por los tratamientos fueron diferentes en ambos suelos. Los índices de labilidad fueron más sensibles en el suelo arenoso para evidenciar cambios asociados al manejo. El índice de carbono orgánico fue sensible para evidenciar diferencias en el suelo franco arenoso. La textura del suelo condiciona la respuesta a la aplicación de agua y abono orgánico.; The use of saline water in horticultural systems degrades soil and reduces productivity. The objective of this study was to analyze how irrigation water quality and the application of organic manure affect lettuce (Lactuca sativa L.) productivity and organic carbon fractions in characteristic on two soils of different textures of central La Pampa province. Lettuce cultivation was evaluated in two soils, one sandy and one sandy loam soils. The main treatment was irrigation with water of contrasting electrical conductivity (CE): 1.0 (low salinity) and 2.0 (high salinity) dS m-1. Fertilization was carried out at a dose of 100 kg N ha-1, using three combinations of organic manure and urea sources: C0 (100:0), C2 (70:30) and C4 (40:60). Four consecutive cycles were evaluated during the years 2020 and 2021. The following variables were analyzed: root dry matter (MSR), aboveground dry matter (MSA) and total dry matter (MST), the MSA/MSR ratio, water use efficiency and growth rate. Total (COT) and particulate (COP) organic carbon were determined. When evaluating the cumulative effect, a significant interaction was observed between the sandy textured soil and the sandy loam soil (p < 0.05). In the sandy soil, the maximum MST value (1504 kg ha-1) was obtained under low salinity irrigation water, in comparison with a decrease of 18% when irrigated with water with an CE of 2.0 dS m-1. In contrast, in the sandy loam soil the maximum MST value (1385 kg ha-1) was obtained with low salinity water with a decrease of 54% when irrigated with water with CE of 2.0 dS m-1. In such soil, the application of organic manure helped mitigate the effect of saline water on the MST , MSA and MSR variables. The changes in the COP produced by the treatments were different in each soil. The lability indexes were more sensitive to management practices in the sandy soil. The organic carbon index was sensitive to show differences in sandy loam soil. Soil texture determines the response of lettuce to the application of water and organic manure.