Recent theoretical developments on electron removal from biological molecules interacting with bare and dressed helium beams Quinto, Michele Arcangelo; Champion, Christophe; Monti, Juan Manuel; Rivarola, Roberto Daniel Recent theoretical advances have enabled a deeper understanding of electron removal—including ionization, electron loss, and electron capture—from biologically relevant molecules under impact by helium projectiles in bare (He2+" role="presentation">, He+" role="presentation">) and neutral (He0" role="presentation">) states. To achieve biologically faithful predictions, state-of-the-art models have shifted focus from water-surrogate systems to DNA/RNA bases and amino acids—revealing substantial deviations in electron emission yields, localized energy deposition, and bond-breaking pathways. Employing and extending the Continuum Distorted Wave-Eikonal Initial State (CDW-EIS) framework to DNA/RNA nucleobases, this study provides differential and total cross sections for projectile energies ranging from tens of keV/u to several MeV/u.

Multilinguismo e diversidade de saberes na formação para a pesquisa acadêmica Barbiero, Ana Carolina Neumann; Pozzo, María Isabel Rita; Alvarez Estrada, Adrian Este artigo explora o aporte do multilinguismo e da diversidade de saberes em um contexto universitário fronteiriço, a partir de duas disciplinas ministradas por docentes ucranianos no Programa de Pós-graduação em Sociedade, Cultura e Fronteiras da Universidade Estadual do Oeste do Paraná (UNIOESTE). Desde 2022, o programa acolhe cientistas ucranianos com apoio da Fundação Araucária, promovendo um ambiente sociolinguístico plural. Realizado como estudo de caso participante, o trabalho combinou análise temática das notas de campo e dos documentos com uma análise descritiva dos metadados bibliográficos (língua e origem dos textos), integradas por meio de triangulação. Os resultados indicam que a presença de práticas multilíngues, a circulação de repertórios epistemológicos diversos e a ênfase na oralidade dos docentes ampliaram o repertório formativo dos alunos, apesar da sub-representação de textos em ucraniano e espanhol nas leituras sugeridas. Adotaram-se procedimentos de reflexão crítica (diário de campo e discussões interpares) para explicitar e mitigar vieses decorrentes do envolvimento de autores no programa. Conclui-se que a adoção de práticas multilíngues e de escolhas bibliográficas mais plurais favorece um ensino orientado à pesquisa que é mais inclusivo e epistemicamente diverso.; This article investigates the contribution of multilingualism and diverse knowledge in a borderland university setting, based on two courses taught by Ukrainian instructors in the Graduate Program in Society, Culture and Borders at the State University of Western Paraná (UNIOESTE). Since 2022, the program has hosted Ukrainian researchers with support from Fundação Araucária, fostering a plural sociolinguistic environment. Conducted as a participatory case study, the research combined thematic analysis of field notes and documentary materials with a descriptive analysis of bibliographic metadata (language and origin of texts), integrated through triangulation. Findings show that multilingual practices, the circulation of varied epistemological repertoires, and the prominence of instructors’ oral contributions broadened students’ formative repertoire, despite the underrepresentation of Ukrainian and Spanish texts among recommended readings. Critical reflexivity measures (field diary and peer discussions) were employed to surface and mitigate biases stemming from the authors’ involvement in the program. The study concludes that embracing multilingual practices and more plural bibliographic selections supports research-oriented teaching that is both more inclusive and epistemically diverse.

Sparse Approach to the Two-Weight Boundedness of Local Operators and Applications. Ramseyer, Mauricio Javier; Salinas, Oscar Mario; Sotto Rios, Juan Manuel; Toschi, Marisa Let Ω be a proper open subset of Rn. We provide sufficient conditions about local weights for the two-weight norm inequalities for local versions of the fractional maximal and the fractional integral operator acting on weighted Lebesgue spaces. The techniques applied, based on the use of Sparse operators, allow to get similar results to those known for the non-local versions, thus improving the known results for the local ones. As applications we obtain, in the first place, an a priori estimate for solutions of ∆^m(U) = f, in Ω, acting on weighted Sobolev spaces involving the distance to the boundary and different local weights. In the context of Schrödinger-type operators we also prove, as another application, the boundedness of the Riesz potential I^α_μ, where μ is a Radon measure on Rn.

Baseline assessment of mollusc assemblages from different intertidal rocky shores of Southern Patagonia Rumbold, Carlos Enrique; Martin, Juan Pablo; Pittaluga, Teresa Susana; Perroni, Mario Oscar; Sar, Alicia; Caminos, Carlos; Torres, Santiago Hernan Mollusc species are ecologically and economically important, acting as fishery resources, ecosystem engineers, bioindicators, and invasive species. However, their study in Southern Patagonian rocky shores remains limited. This research aimed to study the mollusc assemblages and to explore the effect of environmental variables (salinity regime, wave exposure and seasonality) and substrate characteristics (inclination and elevation) on community descriptors. A seasonal sampling was conducted at two sites in Bahía San Julián: one exposed to wave action (SJO) and one sheltered (SJI). Additionally, a sheltered estuarine site was studied in Río Gallegos (RGE). The results showed that at lower horizontal substrates species richness was highest in exposed marine environments (SJO: 7–19 spp.), followed by sheltered marine (SJI: 5–13 spp.) and estuarine environments (RGE: 2–8 spp.). Total density peaked in exposed-marine environments at upper substrates (SJO: 23,000–38,000 ind/m2) and was lowest at lower substrates (ca. 2200–13,000 ind/m2), considering both orientations (horizontal and vertical). A distinct composition of mollusc assemblages were determined between sheltered-estuarine (RGE) and marine environments (SJI and SJO), and between substrate characteristics. The explained variation of mollusc abundance, was attributed mainly to salinity regime (32.8%), followed by substrate elevation (14.7%), wave exposure (10.1%) and substrate inclination (9.0%). Suspension feeders were the dominant group in all study sites. Our findings suggest that species richness, density, and diversity of mollusc assemblages are synergistically determined by environmental variables and substrate characteristics. The present study provides essential information for developing marine biodiversity conservation programs in Southern Patagonia.

First Evidence of Holocene Rodent Parasites from the Argentine Puna: A Paleoparasitological Study of Coprolites from Alero Caído 1 Archaeological Site (Susques, Jujuy) Rodriguez, Valeria Alejandra de los Milagros; Tietze, Eleonor; Urquiza, Silvana Valeria; Beltrame, Maria Ornela This study presents the frst paleoparasitological investigation of rodent coprolites from theArgentine Puna, a high-altitude arid region of the Central Andes. Sixty-six coprolitesrecovered from the Alero Caído 1 archaeological site (Jujuy Province, Argentina) weremorphologically described and microscopically examined. The coprolites were recoveredfrom six stratigraphic levels (Levels 1?6), corresponding to Holocene occupations of the site.Three coprolite morphotypes were identifed. Fifteen samples (23%) were positive toparasitic remains. The parasite taxa found were: Trichuris sp., Paraspidodera sp., Helminthoxyssp., Monoecocestus sp., Viscachataenia quadrata, and Strongylus-type eggs. Morphologicaland parasitological evidence suggest that the coprolites originated from different rodenttaxa: myomorph rodents (Cricetidae) for Morphotype 1, and caviomorph rodents(Caviomorpha), particularly the mountain viscacha (Lagidium viscacia) and likelyOctodontidae species, for Morphotypes 2 and 3. These fndings extend the knowngeographic distribution of ancient parasites in South America and provide novel insightsinto rodent diversity, host?parasite relationships, and paleoecological conditions in highaltitude Andean environments. The results highlight the potential of rodent coprolites aspaleoecological archives for reconstructing faunal communities, biocultural interactions, andenvironmental dynamics in prehistoric Andean landscapes.

Coocurrencia de consumo de sustancias ilícitas y conductas antisociales en adolescentes: Estudio comparativo en países hispanohablantes; Co-occurrence of Illicit Substance Use and Antisocial Behaviors in Adolescents: A Comparative Study in Spanish-Speaking Countries Viano Tello, Consuelo María; Arbach, Karin; Bobbio, Antonella; Guibert, Micaela El consumo de sustancias y la conducta antisocial son comportamientos estrechamente relacionados y se han propuesto diversas teorías al respecto. Este estudio analizó la asociación entre diversos indicadores empíricos, derivados de las principales teorías explicativas, y la coocurrencia de consumo de sustancias ilícitas y conducta antisocial en 6169 adolescentes de Argentina, España, México y Venezuela, participantes del International Self-Report Delinquency Study. Mediante regresiones logísticas multivariadas, se exploró el efecto de los factores seleccionados en la muestra total y por país. Los factores contextuales (por ejemplo, consumo de sustancias en barrio y escuela) asociados a la coocurrencia entre consumo de sustancias y conductas antisociales variaron entre los países estudiados, mientras que el efecto de los factores personales (como el bajo autocontrol) mostró resultados consistentes. Los hallazgos pueden guiar el desarrollo de programas de prevención e intervención para distintos grupos, destacando aspectos aplicables a nivel transnacional y subrayando la necesidad de adaptar otros localmente.; Substance use and antisocial behavior are closely related behaviors, and various theories have proposed explanatory mechanisms to account for this association. This study analyzed the relationship between several empirical indicators, derived from major theoretical frameworks, and the co-occurrence of illicit substance use and antisocial behavior in 6,169 adolescents from Argentina, Spain, Mexico, and Venezuela, who participated in the International Self-Report Delinquency Study. Using multivariate logistic regressions, the effects of the theoretically selected indicators were explored in the total sample and by country. Contextual factors (e.g., substance use in neighborhoods and schools) associated with the co-occurrence of substance use and antisocial behavior varied across countries, whereas personal factors (e.g., low self-control) yielded more consistent results. The findings can inform the development of effective prevention and intervention programs for different groups, highlighting aspects that may be applied in several countries while underscoring the need to adapt others to each local context.

Bioética: La ética del primer cuarto del Siglo XXI; Bioethics: Ethics in the First Quarter of the 21st Century Sanz Ferramola, Ramon Alejandro; Mariñelarena-dondena, Luciana Se busca redefinir epistemológica y políticamente la bioética, tomando en consideración las transformaciones metafísicas a las que estamos asistiendo en los tiempos actuales. En este derrotero de redefinición, consideramos que se trata de investigar las condiciones por las cuales lo que es llegó a ser lo que es, y de ese modo planificar las coordenadas de lo porvenir. Para ello proponemos un seguimiento histórico de las condiciones contextuales en que aparece la bioética como un campo disciplinar de investigación y de transformación de realidades sociohistóricas. En tal recorrido vemos primero, las disputas epistemológicas e institucionales de la bioética en su origen, y el modo en que la bioética se incardina en los procesos de conciencia ecológica y del advenimiento del capitaloceno. Se propone suplantar la ética con una bioética, asentada en el principio precautorio, en la heurística del temor y en una ciencia posnormal alejada del poder y al servicio de la comunidad.; We attempt to redefine bioethics epistemologically and politically, taking into account the metaphysical transformations we are witnessing in the present day. On this road to redefinition, we believe that involves investigating the conditions by which what is came to be what it is, and thus plan the coordinates of the future. To this end, we propose a historical review of the contextual conditions in which bioethics emerged as a disciplinary field of research and transformation of socio-historical realities. In this becoming, we first see the epistemological and institutional disputes surrounding bioethics at its inception, and the way in which bioethics is embedded in the processes of ecological awareness and the advent of the capitalocene. It aims to replace ethics with bioethics, based on the precautionary principle, the heuristics of fear, and a post-normal science removed from power and at the service of the community.

Higher-order interaction analysis via hypergraph models for studying multidimensional neuroscience data Bilbao, Dalma Anahí; Aimar, Hugo Alejandro; Torterolo, Pablo; Mateos, Diego Martín Higher-Order Interaction (HOI) theory offers a powerful framework for capturing complex, non-linear relationships within multidimensional systems, moving beyond traditional pairwise graph methods to encompass multi-way interactions. This study applies HOI analysis, specifically using hypergraph theory, to explore intricate connectivity patterns in electrophysiological signals from neuroscience. Hypergraphs were constructed from connectivity data across various frequency bands, characterized through metrics such as spectral entropy, hyperedge centrality, and vertex centrality, and compared using spectral and centrality distance measures. Three distinct neurophysiological datasets were analyzed: intracranial EEG signals from rats during different sleep stages, scalp EEG data to distinguish between epilepsy types, and MEG recordings of seizure dynamics. The findings highlight the effectiveness of hypergraph-based HOI analysis in mapping neural dynamics across normal and pathological brain states. In sleep studies, it reveals distinct connectivity patterns between REM and NREM stages, while in epilepsy, it differentiates seizure types and stages, identifying spectral entropy as a potential marker for seizure onset. Notably, HOI analysis captures differences between primary and secondary generalized epilepsy, suggesting enhanced diagnostic accuracy. This approach provides a powerful tool for understanding complex neural interactions in high-dimensional data.

A finite element discretization of fractional problems using graded meshes Barrios, Melani; Lombardi, Ariel Luis; Penessi, Cecilia In this paper, we deal with the finite element approximation of a homogeneous Dirichlet boundary value problem for fractional powers of symmetric second--order elliptic operators on a two--dimensional domain $Omega$. We employ the diagonalization technique introduced in [Banjai, Melenk, Nochetto, Otárola, Salgado, Schwab, Foundations of Computational Mathematics (2019) 19: 901--962], which proposes a semi--discretization in the extended variable of a truncated Caffarelli--Silvestre extension. This approach decouples the problem into the solution of independent second--order reaction--diffusion equations in $Omega$, several of which extcolor{blue}{may} become singularly perturbed. For the case where $Omega=(0,1)^2$, we propose to approximate all the decoupled problems by bilinear finite elements over a unique layer adapted, suitably graded, rectangular mesh, which can be designed independently of the eventual singular perturbation parameters. We prove the convergence of the proposed scheme and show numerical examples confirming the theoretical results.

Combined Effects of Amikacin and Methylene Blue-Mediated Photodynamic Therapy on Pseudomonas aeruginosa Biofilms Mimicking Mono- and Polymicrobial Diabetic Foot Ulcer Infections Mariani, Florencia; Costilla, Celeste Rocío; Oppezzo, Oscar Juan; Galvan, Estela Maria Diabetic foot ulcer (DFU) infections frequently involve biofilm formation and exhibit limited responsiveness to conventional antibiotic therapy. In particular, Pseudomonas aeruginosa often participates in mono- and polymicrobial biofilms that display high tolerance to antimicrobial agents. This study evaluated the efficacy of methylene blue-mediated antimicrobial photodynamic therapy (aPDT), alone and in combination with antibiotics, against P. aeruginosa biofilms formed either as single-species or in mixed communities with Enterococcus faecalis, under conditions mimicking DFU infections. Macrocolony biofilms were challenged with amikacin alone (for single-species biofilms) or amikacin plus ampicillin (for mixed biofilms), aPDT, or sequential combinations of these treatments, and bacterial viability was quantified by colony-forming unit enumeration. Antibiotic treatment alone produced only modest reductions in P. aeruginosa viability, even at high concentrations, while aPDT using methylene blue was effective only at high photosensitizer concentrations. In contrast, sequential treatment with antibiotics followed by aPDT and a second antibiotic challenge resulted in a marked reduction in P. aeruginosa viability in both mono- and polymicrobial biofilms. Scanning electron microscopy revealed extensive structural damage in P. aeruginosa cells following combined treatments, whereas E. faecalis remained unaffected. Overall, our findings demonstrate that combining aPDT with antibiotics significantly enhances antibiofilm activity against P. aeruginosa, highlighting this approach as a promising alternative for the management of biofilm-associated DFU infections.

Teoría y praxis de la regularización de migrantes: un esquema y un caso para su comprensión dinámica y crítica; Theory and practice of migrant regularization: a framework and a case for its dynamic and critical understanding Penchaszadeh, Ana Paula; Linares, María Dolores La regularización es un proceso político complejo que determina, en gran medida y en múltiples niveles, la relación entre la población migrante y los Estados anfitriones. El presente artículo se propone, por un lado, ofrecer un modelo teórico-conceptual general para explicar el funcionamiento de las principales puertas de acceso a la regularidad de la población migrante residente; y, por otro lado, aplicar este esquema a la comprensión dinámica de la política de regularización de la población venezolana en la Argentina (2016-2024). La investigación adopta un enfoque procesual jurídico-político que combina el análisis de datos estadísticos oficiales, el relevamiento normativo y entrevistas a funcionarios clave para echar luz sobre el funcionamiento efectivo de las tres puertas de acceso a la regularidad para la población extranjera (vía migratoria, asilo y naturalización). El foco específico en la migración venezolana permite observar la implementación de una política de regularización (estandarizada y focalizada) sumamente efectiva, que ha priorizado la vía migratoria en detrimento del asilo y ha funcionado como trampolín para procesos de naturalización.; Regularization is a complex political process that shapes, to a large extent and across multiple levels, the relationship between migrant populations and host states. This article pursues a twofold objective. First, it proposes a general theoretical-conceptual model to explain the functioning of the main gateways to legal status for resident migrant populations. Second, it applies this framework to a dynamic analysis of regularization policies targeting the Venezuelan population in Argentina between 2016 and 2024. The study adopts a process-oriented legal-political approach that combines the analysis of official statistical data, a review of the relevant regulatory framework, and interviews with key public officials, in order to shed light on the effective operation of the three main pathways to legal status: migration channels, asylum, and naturalization. Focusing on Venezuelan migration allows us to observe the implementation of a highly effective regularization policy-standardized and targeted-which has prioritized the migration pathway over asylum and has operated as a springboard for subsequent naturalization processes.

Agreeing Language in Veterinary Endocrinology (ALIVE): Hypothyroidism, Hyperthyroidism, (Euglycaemic) Diabetic Ketosis/Ketoacidosis, and Diabetic Remission—A Modified Delphi-Method-Based System to Create Consensus Definitions Niessen, Stijn J. M.; Shiel, Robert; Wehner, Astrid; Campos, Miguel; Daminet, Sylvie; Fracassi, Federico; Graham, Peter; Korchia, Jérémie; Lathan, Patty; Leal, Rodolfo Olivera; Miceli, Diego Daniel; Mooney, Carmel T.; Perez Alenza, Maria de los Dolores; Peterson, Mark E.; Schoeman, Johan P. Companion animal endocrinology has benefited from international standardisation of disease terminology for diabetes mellitus, Cushing’s syndrome, and hypoadrenocorticism through Project Agreeing Language in Veterinary Endocrinology (ALIVE). A group of 14 experts and one chair convened for the third cycle of Project ALIVE, focusing on thyroid disease terminology. The cycle employed the modified Delphi approach from previous cycles, augmented by procedural refinements—such as inclusion of an off-site chair and stricter adherence to timelines —to improve efficiency and flexibility. Novel in this round was the integration of feedback from a previous cycle, which resulted in updated definitions for diabetes mellitus originally developed in ALIVE Cycle 1. Outcomes: A 100% consensus was achieved among panellists and 91.4–100% among 105 members of international veterinary endocrinology societies (32% of total memberships) over 78 thyroid-related terminology items and five revised definitions pertaining to diabetes mellitus. These standardised definitions are expected to facilitate clearer communication and education, enhance diagnostic consistency, support research comparability, and improve clinical care in feline and canine endocrine diseases.

Food and the Production of Urban Space: Reflections From Experiences in Latin American Cities Di Virgilio, Maria Mercedes This concluding chapter seeks to dialogue and integrate the evidence built from the set of studies in this volume that addresses the links between food and urban space in Latin America from different approaches, fields, and issues. As Latin American cities have evolved, they have done so in close relation to food production, distribution, and consumption. By integrating evidence from diverse studies and approaches, the paper offers a comprehensive and multidimensional view of how food shapes not only our cities but also our daily lives and social relations in Latin America. This approach invites a reconsideration of the role of food in urban planning and the quest for more equitable and sustainable cities.

Description of Eight New Species and Redescription of Known Species of Eccritotarsini of the Neella-Neoneella Complex (Heteroptera: Miridae: Bryocorinae) Minghetti, Eugenia; Montemayor Borsinger, Sara Itzel; Dellapé, Pablo Matías Eccritotarsini is the most diverse tribe of Bryocorinae, characterized by remarkable morphological heterogeneity andhighly variable general appearance, including the structure of male genitalia. Based on the results of a recent phylogeneticanalysis, which proposed new combinations and new genera, this contribution provides diagnoses and redescriptionsof the species included in the following genera: Adneella Carvalho, 960; Globicephalomiris Minghetti, Montemayor,and Dellapé, 2025; Laterocavocoris Minghetti, Montemayor, and Dellapé, 2025; Lelena Minghetti, Montemayor, andDellapé, 2025; Naelle Minghetti, Montemayor, and Dellapé, 2025; Neella Reuter, 908; Neoneella Costa Lima, 942;Proneella Carvalho, 960; and Puncticollus Minghetti, Montemayor, and Dellapé, 2025. Additionally, the following newspecies are diagnosed and described: Adneella tricolorata new species, Laterocavocoris pallida new species, Naelleyasuni new species, Neella dichroa new species, Neella majuscula new species, Neella nigricans new species, Neellapallidula new species, and Puncticollus tiputini new species.

Revisiting lactic acid isomer production by lactic acid bacteria: Assessing process parameters and feedstock selection Khawam, Jorge Nabil; Leonardi, Rodrigo Jorge; Benzzo, María Teresita; Coz, Alberto; Comelli, Raul Nicolas The demand for optically pure lactic acid (LA) is increasing due to its applications in the food, pharmaceutical, and biodegradable plastics industries. This study evaluated l- LA, d- LA, and dl- LA production using Lacticaseibacillus casei, L. coryniformis ATCC 25600, and Lactiplantibacillus plantarum, respectively, cultivated in laboratory- scale bioreactors with controlled pH and temperature. Agroindustrial byproducts, including sugarcane molasses, glucose- fructose syrup, and whey permeate, were compared with glucose as a reference substrate. Lacticaseibacillus casei reached the highest l- LA concentration in whey permeate (86 g L−1 in 24 h), with a yield of 1.07 g g−1 and maximum productivity of 4.70 g L−1 h−1, values higher than previously reported for lactose- based media. Lacticaseibacillus coryniformis ATCC 25600 achieved 70 g L−1 of d- LA from glucose- fructose syrup (95 g L−1 initial sugars) in 72 h, with complete sugar depletion, yield of 0.75 g g−1, and productivity of 1.95 g L−1 h−1. For dl- LA, L. plantarum produced 70 g L−1 in whey permeate within 48 h (87% sugar removal, yield 0.76 g g−1, productivity 1.44 g L- 1 h−1). Across all strains, whey permeate and syrup enabled the most efficient fermentations, whereas molasses showed potential but was limited by nitrogen content. These results highlight the feasibility of valorizing low- cost byproducts for optically pure LA production and provide kinetic and stoichiometric benchmarks to guide industrial process design.

Retroalimentaciones de IA en un seminario sobre revisión de capítulos de tesis; ai-Based Feedback in a Seminar on Reviewing Thesis Chapters; Feedback com inteligência artificial em um seminário sobre revisão de capítulos de teses Alvarez, Guadalupe; Difabio, Hilda Emilia La inteligencia artificial (ia) ha comenzado a incidir en la elaboración de textos, incluidos aquellos producidos en contextos universitarios. Por el momento, sin embargo, son escasos los estudios sobre las oportunidades y los desafíos que estas tecnologías plantean para la escritura académica y científica. Con el fin de contribuir a este campo de trabajo, este artículo de investigación comunica resultados preliminares de una investigación que se propone comprender, en el marco de una iniciativa pedagógica de posgrado, el alcance de actividades de retroalimentación con ia para la revisión de capítulos de tesis. Para ello, se desarrolla un estudio de casos múltiples con ocho estudiantes que participaron en un seminario virtual orientado a la enseñanza de la escritura de tesis en ciencias sociales y humanas. Se lleva a cabo un procedimiento cualitativo que considera múltiples fuentes —cuestionarios, registros de retroalimentación (incluidas las realizadas con ia) y relevamiento de cambios entre versiones iniciales y finales de capítulos—. El análisis muestra categorías asociadas al uso de sistemas inteligentes para la revisión de capítulos: generación de prompts, evaluación de respuestas de ia, edición del documento y decisión sobre el uso de las tecnologías. Se concluye que la ia generativa resulta potencialmente útil para la revisión textual, aunque implica limitaciones y riesgos, y requiere de formación específica para el nivel de posgrado.; Artificial Intelligence (ai) has begun to influence text production, including in university contexts. However, to date, few studies have explored the opportunities and challenges these technologies present for academic and scientific writing. This article aims to contribute to this emerging field by presenting preliminary findings from a study designed to understand, within a postgraduate pedagogical initiative, the role of ai-based feedback activities in the review of thesis chapters. A multiple case study was conducted involving eight students who took part in a virtual seminar on thesis writing in the Social Sciences and Humanities. A qualitative methodology was applied, drawing on multiple data sources: questionnaires, feedback records (including those generated with ai), and a comparison of initial and final versions of thesis chapters. The analysis identifies categories related to the use of intelligent systems in text revision: prompt generation, evaluation of ai responses, document editing, and decision-making around the use of these technologies. The study concludes that generative ai can be a potentially useful tool for text revision, but it also presents limitations and risks and requires specific training at the postgraduate level.; A Inteligência Artificial (ia) começou a influenciar a produção de textos, inclusive em contextos universitários. No entanto, ainda são escassos os estudos sobre as oportunidades e os desafios que essas tecnologias apresentam para a escrita acadêmica e científica. Com o objetivo de contribuir com esse campo em desenvolvimento, este artigo apresenta resultados preliminares de uma pesquisa que busca compreender, no âmbito de uma iniciativa pedagógica de pós-graduação, o alcance de atividades de feedback com ia na revisão de capítulos de tese. Foi desenvolvido um estudo de casos múltiplos com oito estudantes que participaram de um seminário virtual voltado ao ensino da escrita de teses nas Ciências Sociais e Humanas. Utilizou-se um procedimento qualitativo com diversas fontes de dados: questionários, registros de feedback (incluindo os gerados com ia) e análise comparativa entre versões iniciais e finais dos capítulos. A análise revelou categorias associadas ao uso de sistemas inteligentes na revisão textual: formulação de prompts, avaliação das respostas da ia, edição do documento e tomada de decisão sobre o uso das tecnologias. Conclui-se que a ia generativa é potencialmente útil para revisão textual, mas envolve limitações e riscos, exigindo formação específica no nível de pós-graduação.

Effects of newer veterinary macrolide antimicrobials on the CYP3A-dependent metabolism in cattle liver microsomes: potential Metabolic drug–drug interaction with monensin Ichinose, Paula; Munafó, Juan Pablo; Miró, María Victoria; Valente, Marcela; Moreno Torrejon, Laura; Larsen, Karen Elizabeth; Lanusse, Carlos Edmundo; Lifschitz, Adrian Luis; Virkel, Guillermo Leon Traditional macrolide antimicrobials are inhibitors of cytochrome P4503A (CYP3A) incattle liver. Monensin (MON), an ionophore with a narrow safety margin, undergoesCYP3A-dependent O-demethylation, and its incompatibility with macrolides is well recognized in livestock animals. This study evaluated the effects of newer macrolides—tilmicosin (TIL), tulathromycin (TUL), and gamithromycin (GAM)—on CYP3A-dependentmetabolism in bovine liver microsomes and examined how these drugs influence MONhepatic metabolism. Molecular docking studies were also performed to predict their interactions with CYP3A enzymes. The CYP3A-dependent enzyme activity, testosterone6β-hydroxylase, was inhibited in the presence of triacetyl-oleandomycin (used as a reference macrolide), as well as with MON. None of the other macrolides tested affectedthis enzymatic activity. All macrolides inhibited MON metabolism, but the extent of inhibition observed with triacetyl-oleandomycin was higher than that produced by TIL,TUL, and GAM. Molecular docking analyses indicated that triacetyl-oleandomycin andMON exhibited the highest binding affinities for the active site of CYP3A isozymes, compared with TIL, TUL, and GAM. The agreement between enzymatic data and in silico predictions indicates that TIL, TUL, and GAM are weaker inhibitors of CYP3A-mediatedMON metabolism. The modest reduction in MON hepatic metabolism caused by thesemacrolides—commonly used in cattle feedlots—suggests a low likelihood of clinicallyrelevant drug–drug interactions under typical dosing conditions.

Chitinozoans Butcher, Anthony; Camina, Sonia Clara Chitinozoans are Paleozoic marine organic-walled microfossils thought to be egg-cases of unknown animals. Some authors have also interpreted them to be the tests of a protistan organism. The bottle-, flask-, or urn-shaped vesicles are important for Ordovician through Devonian biostratigraphy. They have also been utilized to indicate paleoenvironmental and paleoclimate change.

Políticas sociales y acciones femeninas: un recorrido historiográfico posible para pensar la relación público privado: Argentina, provincia de Buenos Aires, primeras décadas del siglo XX de Paz Trueba, Yolanda Edith El nexo entre el Estado y los particulares de cara a la atención de necesidades sociales de amplio espectro, es un tema que, estimulado por las cuestiones del tiempo presente regresa una y otra vez al debate público cada cierto tiempo. Uno de esos momentos fue la vuelta de la democracia en Argentina en 1983, que generó un clima favorable al desarrollo de diversos campos de la historiografía nacional, entre ellos el que pensaba al Estado y su relación con la sociedad civil…

Effect of Water Availability on Radial and Height Growth of Nothofagus pumilio Magnin, Noel Amaru; Torres, Cristian Daniel; Villalba, Ricardo; Puntieri, Javier Guido Soil water availability is one of the most relevant environmental factors for plant growth. For Nothofagus pumilio, the most widely distributed temperate tree in the southern hemisphere, the effects of soil water availability on radial and height growth were analyzed by means of an open-air nursery experiment. In the present study, 5-year-old saplings growing under nursery field conditions were assigned to three irrigation treatments: no irrigation, intermediate irrigation, and high irrigation. The irrigation treatments were aimed at emulating three levels of rainfall —dry, mesic, and wet—occurring within the natural distribution of N. pumilio in north-western Patagonia. Increased water availability resulted in longer shoots with more internodes and taller plants with wider trunks. Also, higher soil moisture availability extended the period of trunk diameter growth. Although thegrowth of N. pumilio stands is strongly controlled by light availability, this study shows that microenvironmental differences in soil water induce differences in the length and diameter of the trunk. The effect of water availability would be more pronounced during the driest season of the year.