Sindicador de canales de noticias

An ultra-low noise fully-differential amplifier

CONICET Digital -

An ultra-low noise fully-differential amplifier Spinelli, Enrique Mario; Haberman, Marcelo Alejandro A general-purpose instrumentation amplifier must be dc-coupled and has a differential input to handle both differential and single-ended input signals. It must also exhibit low input noise in both voltage and current to accommodate a wide range of signal source impedances. Additionally, having a differential output is desirable to allow direct connection to current high-resolution analog-to-digital converters (ADCs), which have differential inputs. There are commercially available devices with en voltage noise spectral densities as low as 1 nV/Hz−−−√ but present high current noise spectral densities in of a few pA/Hz−−−√ . On the other hand, there are also devices with in as low as a few fA/Hz−−−√ but presenting en around 10 nV/Hz−−−√ . To obtain low values of both en and in , a fully differential circuit topology combining discrete junction field transistors (JFETs) and operational amplifiers (OAs) is proposed. Design equations, stability analysis, and experimental results are presented. As an example, a fully differential instrumentation amplifier has been designed, built, and tested showing en<1 nV/Hz−−−√ at 1 kHz and in<10 fA/Hz−−−√ at 1 kHz. The proposed topology finds applications, such as front ends for measuring and testing instruments, industrial instrumentation, and audio circuits.

Neotectonics of the Magallanes-Fagnano fault system in Fuegian Patagonia based on high-resolution seismic profiles and geomorphic markers

CONICET Digital -

Neotectonics of the Magallanes-Fagnano fault system in Fuegian Patagonia based on high-resolution seismic profiles and geomorphic markers Restelli, Florencia Belen; Bran, Donaldo Mauricio; Almaraz, Fernando; Menichetti, M.; Lodolo, E.; Esteban, Federico Damián; Lozano, Jorge Gabriel; Tassone, Alejandro Alberto The Magallanes–Fagnano Fault System (MFFS), located at the southern tip of Patagonia, is part of the transform plate boundary between the Scotia and South American plates. Modern deformation along the fault system has been mostly studied on land, such as in the eastern region of Lago Fagnano. Furthermore, previous studies have primarily focused on the analysis of co-seismic deformation, while the long-term landscape response to neotectonics has not been addressed in detail. This work aims to identify and characterize active fault segments within the lake sediments and investigate the imprint of deformation in the surrounding landscape. To achieve this, we integrate high-resolution seismic profiles acquired in Lago Fagnano with a morphometric analysis of the hydrographic basin. These segments show subaqueous ruptures affecting the lacustrine sediments reaching the lake floor, indicating recent deformation episodes. Most of the recognized faults are sub-vertical or dip steeply (> 60°) to the south and show vertical offsets that range from 4 to 17 m. The morphometric analysis is consistent with the overall southward dip of the MFFS and indicates a hydrographic rejuvenation towards the north of the lake. In addition, the ruptures of the fault system can be correlated with the deformation observed on land, resulting in a ~ 150 km long segmented surface rupture zone that might be consistent with the rupture length estimated for the 1949 M7.5 earthquake doublet.

Comprender a Spinoza desde la intimidad de la lengua: Nota al margen de una nueva edición de la Ética

CONICET Digital -

Comprender a Spinoza desde la intimidad de la lengua: Nota al margen de una nueva edición de la Ética Tatián, Diego La más reciente traducción de la Ética demostrada según el orden geométrico, realizada por Mario Caimi para la impresionante colección de clásicos de la editorial Colihue, constituye un acontecimiento para la filosofía en nuestra lengua y una enorme contribución para la comprensión de este libro singular. Se trata de una edición anotada, que cuenta con un extenso estudio preliminar donde su autor -a la manera de los trabajos clásicos de Martial Gueroult y Pierre Macherey en francés, o de Filippo Mignini en italiano- analiza minuciosamente el recorrido de proposiciones de cada una de las cinco partes de la obra.La tesis fundamental en la interpretación del libro mayor de Spinoza que desarrolla ese estudio -de ahora en más, un precioso instrumento de trabajo para investigadores a la vez que una introducción a la filosofía spinozista para quienes deseen iniciarse en ella-, consiste en que la Ética no es esencialmente un libro de ética sino de metafísica: una teoría de “lo que verdaderamente es”. El nombre de la obra habría sido adjudicado por los editores de las Opera posthuma y no por Spinoza mismo (quien en sus cartas, efectivamente, alude a ella como “mi filosofía”, pero nunca con el título bajo la que fue editada en 1677 apenas después de su muerte). En contraposición a un extendido arco de lecturas que incluye estudiosos tan diversos como Jonathan Bennett y Gilles Deleuze, el profesor Mario Caimi sostiene que el objetivo principal de este libro no es la búsqueda de la felicidad (Beatitudo) o la vida buena, sino la comprensión del fundamento y el ser de las cosas bajo el “aspecto de la eternidad”.

Hydrogeomorphological changes and the erosion-deposition impact in the San Francisco River Basin, Northwest Argentina: a multidecadal analysis

CONICET Digital -

Hydrogeomorphological changes and the erosion-deposition impact in the San Francisco River Basin, Northwest Argentina: a multidecadal analysis Isuani, María Antonella; Georgieff, Sergio Miguel; Bustos, María Soledad Modifications of wetland and forest areas are studied, in particular, to establish to what extent they are sensitive to natural changes (e.g., increased precipitation and/or temperature) in addition to human activities (e.g., advancing agricultural frontier, deforestation, channelizations). The San Francisco River Basin (SFRB; 1,789 km2) is located in the Northwest of Argentina in the Geological Province of Nortwestern Pampean Ranges (Sierras Pampeanas Noroccidentales), between 27°40?S and 28°25?S, and 65°15?W and 65°45?W). In recent decades, agricultural development and management in the middle and lower SFRB generated rural channelizations (the largest of 10 km at the basin outlet between 2005-2015), drainage of wetland forests, deforestation of native dry forest since 1995 and changes in land use. In addition, a 200 mm increase in mean annual rainfall since 1972 and an increase in extreme hydrological events, are registered. These modifications produced changes in local base level, erosive processes of retreat and the development of new river channels from upstream, increasing flow velocities, flow rates, and sediment discharge. The intensified erosive processes resulted in four new river courses in the middle and lower basin, incorporating the SFRB into the Marapa river basin, changing from arheic to endorheic behaviour, and generating the contribution of liquid and solid flows to the system of which it is now a part. The aim of this study is to examine the development of the new hydrographic network within the SFRB between 1990 and 2018 and to calculate the solid and liquid discharges generated by the new network. The hydrographic network formed by the rivers El Abra, Ovanta, San Francisco and Suncho creek, was digitized in the open-source software QGIS 3.18.3 on the basis of the visual interpretation of satellite imagery. The lengths of the rivers were automatically calculated and exported to a spreadsheet to determine the downstream expansion of the river network. Measurements and sampling of water discharge and sediment load were performed monthly in the lower section of the SFRB. The float and crosssection method was used to quantify the flow rates, and the sediment samples were filtered, dried in an oven for 24 h and weighed on a precision balance to obtain the sediment concentration (C in mg/l). The study determined the generation of 102 km of new river channels in a 28 yr period. The hydrographic network had an annual sediment production of 82,138 t/yr and an annual discharge of 21,96 hm3, contributing to the Marapa river basin and generating an acceleration in the silting of the downstream Río Hondo reservoir. This work provides a basis for management and mitigation of erosion and flooding problems in the area.

El movimiento nutricionista internacional como libreto y su adopción en América Latina: las encuestas alimentarias en la década de 1930

CONICET Digital -

El movimiento nutricionista internacional como libreto y su adopción en América Latina: las encuestas alimentarias en la década de 1930; O movimento internacional de nutrição como guia e sua implementação na América Latina: pesquisas de alimentação nos anos 1930; The international nutrition movement as a guide and its adoption in Latin America: food surveys in the 1930s Buschini, Jose Daniel Este artículo analiza una serie de encuestas alimentarias que tuvieron lugar en América Latina durante la década de 1930. Se argumenta que la realización de estas encuestas formó parte de un proceso más amplio, consistente en la participación de la región en la consolidación y expansión del movimiento nutricionista internacional, que entonces despuntaba. El trabajo hace foco en tres aspectos de esas encuestas, para mostrar de ese modo la conexión entre los desarrollos locales y globales.; Este artigo analisa uma série de pesquisas sobre alimentação realizadas na América Latina durante a década de 1930. Argumenta-se que a realização dessas pesquisas integra um processo mais amplo de participação da região na consolidação e expansão do então emergente movimento internacional de nutrição. O artigo se concentra em três aspectos dessas pesquisas para mostrar a relação entre o desenvolvimento local e global.; This study analyzes a series of food surveys that took place in Latin America during the 1930s. It argues these surveys belonged to a broader process consisting of the region participating in the consolidation and expansion of the then emerging international nutrition movement. This study focuses on three aspects of these surveys to show the connection between local and global developments.

Design of the tertiary optical system for the Large Latin American Millimeter Array radio telescope

CONICET Digital -

Design of the tertiary optical system for the Large Latin American Millimeter Array radio telescope Rasztocky, Emiliano; Hampel, Matias Rolf; Reeves, Rodrigo; Lepine, Jacques R.D.; Romero, Gustavo Esteban Many modern radio telescopes employ an observational strategy that involves maximizing the use of their available spaces (cabins), outfitting them with various receivers at different frequencies to detect incoming signals from the sky simultaneously or individually. The Large Latin American Millimeter Array is a joint venture between Argentina and Brazil consisting of the installation and operation of a 12-m aperture Cassegrain telescope. It features three available cabins for instrumentation and plans to install six single-pixel heterodyne receivers, covering different bandwidths in the 30 to 950 GHz window of the electromagnetic spectrum, in its two lateral Nasmyth cabins at different phases of the project. Therefore, it is crucial not only to design a tertiary optical system that couples the antenna beam to those receivers but also to do it in a scalable way. The primary goal for the design is to simultaneously maximize the antenna efficiency while minimizing optical aberrations for all receivers, both fundamental aspects for the optimal functioning of cutting-edge astronomical instruments. We present the entire design process, starting from the quasi-optical approach based on the propagation of a fundamental Gaussian beam mode, continuing with the validation of the design based on physical optics simulations, and ending with a tolerance analysis of the system. As a result of this process, a frequency-independent tertiary optical system has been achieved for almost all the receivers, which is expected to provide high optical performance for the radio telescope.

A supervised data-driven spatial filter denoising method for speech artifacts in intracranial electrophysiological recordings

CONICET Digital -

A supervised data-driven spatial filter denoising method for speech artifacts in intracranial electrophysiological recordings Peterson, Victoria; Vissani, Matteo; Luo, Shiyu; Rabbani, Qinwan; Crone, Nathan E.; Bush, Alan; Richardson, R. Mark Neurosurgical procedures that enable direct brain recordings in awake patients offer unique opportunities to explore the neurophysiology of human speech. The scarcity of these opportunities and the altruism of participating patients compel us to apply the highest rigor to signal analysis. Intracranial electroencephalography (iEEG) signals recorded during overt speech can contain a speech artifact that tracks the fundamental frequency (F0) of the participant’s voice, involving the same high-gamma frequencies that are modulated during speech production and perception. To address this artifact, we developed a spatial-filtering approach to identify and remove acoustic-induced contaminations of the recorded signal. We found that traditional reference schemes jeopardized signal quality, whereas our data-driven method denoised the recordings while preserving underlying neural activity.

Selected farm-level crop protection practices in Europe and Argentina: Opportunities for moving toward sustainable use of pesticides

CONICET Digital -

Selected farm-level crop protection practices in Europe and Argentina: Opportunities for moving toward sustainable use of pesticides Mark, Jennifer; Fantke, Peter; Soheilifard, Farshad; Alcon, Francisco; Contreras, Josefa; Abrantes, Nelson; Campos, Isabel; Baldi, Isabelle; Bureau, Mathilde; Alaoui, Abdallah; Christ, Florian; Mandrioli, Daniele; Sgargi, Daria; Pasković, Igor; Pasković, Marija Polić; Glavan, Matjaz; Hofman, Jakub; Harkes, Paula; Lwanga, Esperanza Huerta; Norgaard, Trine; Aparicio, Virginia Carolina; Schlünssen, Vivi; Vested, Anne; Silva, Vera; Geissen, Violette; Tamm, Lucius Extensive use of plant protection products (PPP) in the last decades contributes to negative impacts on ecosystems, animals and humans. For the strategies of PPP reduction and replacement of hazardous pesticides, farm-level data on agronomic management practices and crop protection applications are crucial. In this study, we strategically collected data for the 2021 season at the SPRINT project case study sites (CSS) in 10 European countries and Argentina, on perennial, arable and vegetable crops. Data collection included strategically selected farm and field data, pesticide records and farming practices. Results involved more than 1700 recorded PPP applications across various crops with more than 170 different active substances from PPP in organic, integrated pest management and conventional farming practices. We explored differences in application patterns (fungicides, insecticides, herbicides and non-PPP, e.g. adjuvants, growth regulators, and fertilizers) between and within crops, countries and farming systems and calculated the costs of PPP use. The pesticide dosages applied during the crop season varied up to a factor of 20 around recommended doses. Regarding the costs of PPPs use perennial crops had the highest costs per ha crop production area. Finally, we analysed the active substances applied in different farming systems in terms of their hazard statements. Our results shed light on how PPPs are used across different crop and farming types and will help elucidate how pesticide application patterns can be changed in the future. Finally, we highlighted non-PPP use practices which help to reduce dependency on PPP use. This might be used to support decision-making and policies within agricultural advisory/support systems.

Influencia de la calidad del agua y del abono sobre las fracciones orgánicas en suelos de La Pampa

CONICET Digital -

Influencia de la calidad del agua y del abono sobre las fracciones orgánicas en suelos de La Pampa; Water quality and manure influence on organic fractions of La Pampa soils Huespe, Daiana Susana; Galantini, Juan Alberto; Baraldi, Luciano Martin; Alvarez, Cristian El uso de agua salina en sistemas hortícolas degrada el suelo y reduce la productividad. El objetivo de este estudio fue analizar cómo el agua de diferente calidad y la aplicación de abono orgánico afectan la productividad de lechuga (Lactuca sativa L.) y las fracciones de carbono orgánico en dos suelos de diferentes texturas característicos del centro de La Pampa. Se evaluó el cultivo de lechuga en dos suelos, uno arenoso y otro franco arenoso. El tratamiento principal se regó con agua de conductividad eléctrica de 1,0 (baja salinidad) y 2,0 (alta salinidad) dS m-1. Se fertilizó con una dosis de 100 kg N ha-1, usando tres combinaciones de las fuentes abono orgánico y urea: C0 (100:0), C2 (70:30) y C4 (40:60). Se evaluaron cuatro ciclos consecutivos durante los años 2020 y 2021. Se analizó: materia seca de raíces (MSR), aérea (MSA) y total (MST), la relación MSA/MSR, la eficiencia de uso del agua y la tasa de crecimiento. Se determinó el carbono orgánico (CO) total (COT) y el CO particulado (COP). Al evaluar el efecto acumulado se observó una interacción significativa entre el suelo de textura arenosa y el de textura franco arenosa (p<0,05). En el suelo arenoso el valor máximo de MST (1504 kg ha-1) se obtuvo con agua de CE de 1,0 dS m-1 con una disminución de 18% cuando se regó con agua con CE de 2,0 dS m-1. Mientras que, en el suelo franco arenoso el valor máximo de MST (1385 kg ha-1) se obtuvo con agua de 1,0 dS m-1 con una disminución de 54% cuando se regó con agua con CE de 2,0 dS m-1. En el suelo franco arenoso la aplicación de abono orgánico ayudó a mitigar el efecto del agua salina en las variables MST , MSA y MSR. Los cambios en el COP producidos por los tratamientos fueron diferentes en ambos suelos. Los índices de labilidad fueron más sensibles en el suelo arenoso para evidenciar cambios asociados al manejo. El índice de carbono orgánico fue sensible para evidenciar diferencias en el suelo franco arenoso. La textura del suelo condiciona la respuesta a la aplicación de agua y abono orgánico.; The use of saline water in horticultural systems degrades soil and reduces productivity. The objective of this study was to analyze how irrigation water quality and the application of organic manure affect lettuce (Lactuca sativa L.) productivity and organic carbon fractions in characteristic on two soils of different textures of central La Pampa province. Lettuce cultivation was evaluated in two soils, one sandy and one sandy loam soils. The main treatment was irrigation with water of contrasting electrical conductivity (CE): 1.0 (low salinity) and 2.0 (high salinity) dS m-1. Fertilization was carried out at a dose of 100 kg N ha-1, using three combinations of organic manure and urea sources: C0 (100:0), C2 (70:30) and C4 (40:60). Four consecutive cycles were evaluated during the years 2020 and 2021. The following variables were analyzed: root dry matter (MSR), aboveground dry matter (MSA) and total dry matter (MST), the MSA/MSR ratio, water use efficiency and growth rate. Total (COT) and particulate (COP) organic carbon were determined. When evaluating the cumulative effect, a significant interaction was observed between the sandy textured soil and the sandy loam soil (p < 0.05). In the sandy soil, the maximum MST value (1504 kg ha-1) was obtained under low salinity irrigation water, in comparison with a decrease of 18% when irrigated with water with an CE of 2.0 dS m-1. In contrast, in the sandy loam soil the maximum MST value (1385 kg ha-1) was obtained with low salinity water with a decrease of 54% when irrigated with water with CE of 2.0 dS m-1. In such soil, the application of organic manure helped mitigate the effect of saline water on the MST , MSA and MSR variables. The changes in the COP produced by the treatments were different in each soil. The lability indexes were more sensitive to management practices in the sandy soil. The organic carbon index was sensitive to show differences in sandy loam soil. Soil texture determines the response of lettuce to the application of water and organic manure.

“Yo escuché hablar a Borges”: Una experiencia desde la historia oral

CONICET Digital -

“Yo escuché hablar a Borges”: Una experiencia desde la historia oral Favero, Bettina Este artículo resume la experiencia del proyecto de investigación “Las conferencias de Borges”, dirigido por la doctora Mariela Blanco. A partir del año 1949, Jorge Luis Borges comenzó a dictar conferencias y clases en distintas ciudades del país, llegando a un público que en muchas ocasiones no lo había leído. Así, el Borges de la escritura se transformó en un Borges “oral” que, con su forma de hablar, sus tonos de voz y sus gestos, llegó a un público más amplio y se hizo, de alguna manera, más humano...

Modulation optimization when using a splitter pump after the first dimension in comprehensive two- dimensional liquid chromatography

CONICET Digital -

Modulation optimization when using a splitter pump after the first dimension in comprehensive two- dimensional liquid chromatography Acquaviva, Agustín; Castells, Cecilia Beatriz Marta The rapid growth in the use of two dimensional liquid chromatography (2D-LC) applied to the analysis of moderately to highly complex mixtures, has been fueled by continuous improvements in performance and robustness of the instrument components, as well as the ease-of-use of software necessary for controlling the 2D-LC instrument hardware, and analysis of the large data files that result from this type of work.This work has focused on the evaluation of the performance of an online full comprehensive mode (LC×LC), when an active modulation is implemented using a flow splitter pump placed after the 1D effluent. Two different types of splitting pumps were evaluated: a binary ultra-high pressure liquid chromatography (UHPLC) pump and a high precision syringe pump. We analyzed the performance (reproducibility in peak area and retention times and the 2D peak dispersion) as a function of the location of the active pump Before or After the modulation valve, and the influence of connecting tubes (based on internal diameter and length) necessary between the interface, waste, and the splitting pump. The effect on the flow direction on the filling and flushing of the injection loops at the modulation valve was also analyzed for each pump.In this study, we demonstrate that flow-splitting LCxLC assembly can be performed using either a UHPLC binary pump or a simple syringe pump. Flow splitting after the first dimension is a straightforward strategy to: (i) independently select the 1D column and flow rates with respect to the second dimension; (ii) consciously dilute the eluate according to the solvent characteristics of the second dimension, thereby avoiding 2D peak distortions; and (iii) adapt the injected amount to the second column according to the relative concentration of the components in a complex sample. However, careful consideration of the system setup is necessary. It is demonstrated how experimental results can be significantly affected in terms of peak broadening and reproducibility if optimization of the interface is not taken into account.In addition, under the optimized conditions, the reproducibility in peak area and dispersion in the 2D dimension were evaluated as a function of the amount of sample transferred in terms of percentage of filled loop

Cobaltabis(Dicarbollide) [o-COSAN]− for Boron Neutron Capture Therapy of Head and Neck Cancer: Biodistribution and Irradiation Studies in an Experimental Oral Cancer Model

CONICET Digital -

Cobaltabis(Dicarbollide) [o-COSAN]− for Boron Neutron Capture Therapy of Head and Neck Cancer: Biodistribution and Irradiation Studies in an Experimental Oral Cancer Model Palmieri, Mónica Alejandra; Monti Hughes, Andrea; Trivillin, Verónica Andrea; Garabalino, Marcela Alejandra; Ramos, Paula Sofia; Thorp, Silvia Inés; Curotto, Paula; Pozzi, Emiliano C. C.; Nuez Martínez, Miquel; Teixidor, Francesc; Viñas, Clara; Schwint, Amanda Elena Boron neutron capture therapy (BNCT) is a tumor-selective particle radiotherapy that combines preferential boron accumulation in tumors and neutron irradiation. Based on previous studies in tumor-bearing mice, this study evaluated the biodistribution of the sodium salt of cobaltabis(dicarbollide) (Na[3,3´-Co(C2B9H11)2], abbreviated as Na[o-COSAN]) in the hamster cheek pouch oral cancer model and the Na[o-COSAN]/BNCT therapeutic effect on tumors and induced radiotoxicity. The synthesis and comprehensive characterization of 10B-enriched trimethylammonium salt of nido-[7,8-C210B9H12]-o-carborane, along with the cesium and sodium salts of [o-10COSAN] cobaltabis(dicarbollide) are reported here for the first time.Methods: Hamsters bearing tumors were injected with Na[o-COSAN] (7.5 mg B/kg) and euthanized at different time-points after injection (30 min, 2, 3, 5, and 18 h post-administration) to evaluate boron uptake in different tissues/organs. Based on these results, tumor-bearing animals were treated with Na[10B-o-COSAN]/BNCT (7.5 mg B/kg b.w., 3 h), prescribing 5 Gy total in absorbed dose to the precancerous tissue surrounding tumors, i.e., the dose-limiting tissue.Results: Na[o-10COSAN] exhibited no toxicity. Although biodistribution studies employing Na[o-COSAN] have shown low absolute boron concentration in the tumor (approx. 11 ppm), Na[o-10COSAN]/BNCT induced a high and significant therapeutic effect on tumors versus the control group (cancerized, untreated animals). Moreover, only half of the animals exhibited severe mucositis in the precancerous dose-limiting tissue after BNCT, which resolved completely at 21 days after irradiation.Conclusions: Na[o-10COSAN] would be potentially useful to treat head and neck cancer with BNCT.

Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research

CONICET Digital -

Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research Salgueiro, María Jimena; Portillo, Mariano Gastón; Tesán, Fiorella; Nicoud, Melisa Beatriz; Medina, Vanina Araceli; Moretton, Marcela Analía; Chiappetta, Diego Andrés; Zubillaga, Marcela Beatriz Background: Previous studies employing polymeric micelles and molecular imaging for in vivo nanosystem characterization have led to the development of radionanoprobes (RNPs) designed for diagnosing and monitoring therapeutic interventions in preclinical oncology research, specifically within breast and colon cancer models. These models exhibit high GLUT1 expression on tumor cells and VEGFR expression on the tumor vasculature. We aimed to enhance the tumor-targeting specificity of these RNPs by functionalizing micelles with glucose and bevacizumab. The choice of 99mTc to label the nanoprobes is based on its availability and that direct labeling method is a widespread strategy to prepare radiopharmaceuticals using cold reagents and a 99Mo/99mTc generator. Soluplus® is an attractive polymer for synthesizing micelles that also allows their functionalization. With all the above, the objective of this work was to design, develop and characterize nanoprobes based on polymeric micelles and radiolabeled with 99mTc for the characterization of biological processes associated to the diagnosis, prognosis and monitoring of animal models of breast and colon cancer in preclinical research using molecular images.Results: Four RNPs (99mTcTc-Soluplus®, 99mTcTc-Soluplus®+TPGS, 99mTcTc-Soluplus®+glucose and 99mTcTc-Soluplus®+bevacizumab) were produced with high radiochemical purity (>95% in all cases) and stability in murine serum for up to 3 hours. The RNPs maintained the 100 nm size of the Soluplus® polymeric micelles even when they were functionalized and labeled with 99mTc. The image acquisition protocol enabled the visualization of tumor uptake in two cancer experimental models using the assigned RNPs. In vivo biological characterization showed signal-to-background ratios of 1.7 ± 0.03 for [99mTc]Tc-Soluplus®+TPGS, 1.8 ± 0.02 for [99mTc]Tc-Soluplus®, and 2.3 ± 0.02 for [99mTc]Tc-Soluplus®+glucose in the breast cancer model, and 1.8 ± 0.04 for [99mTc]Tc-Soluplus® and 3.7 ± 0.07 for [99mTc]Tc-Soluplus®+bevacizumab in the colon cancer model. Ex vivo biodistribution, showed that the uptake of the tumors, regardless of the model, is <2% IA/g while the blood activity concentration is higher, suggesting that the enhanced permeability and retention effect (EPR) would be one of the mechanisms involved in imaging tumors in addition to the active targeting of RNPs.Conclusions: Soluplus®-based polymeric micelles provide a promising nanotechnological platform for the development of RNPs. The functionalization with glucose and bevacizumab enhances tumor specificity enabling effective imaging and monitoring of cancer in animal models.

Spatial and temporal composition of herbaceous vegetation in Geoffroea decorticans (Gill. Ex Hook. & Arn.) Burkart. thickets

CONICET Digital -

Spatial and temporal composition of herbaceous vegetation in Geoffroea decorticans (Gill. Ex Hook. & Arn.) Burkart. thickets Rauber, Ruth Bibiana; Arroyo, D.; Cendoya, Maria Alicia In the Central Semiarid Region of Argentina, the native woody species Geoffroea decorticans has increased in range and density, probably due to overgrazing. The aim of this work was to evaluate the floristic and functional composition of the herbaceous vegetation along time in grazed sites, within thickets of G. decorticans, and compared to grasslands. We registered the cover of each herbaceous species in different locations within thickets and in the natural grassland, at each season for two years, from autumn 2021 to summer 2023. Indicator species of grasslands were found to be mostly palatable native perennials, resulting more homogeneous than those of thickets. Moreover, the mean cover of palatable species was higher in grasslands than in thickets. Consequently, grasslands confer stability and food resource for livestock. Woody thickets would exhibit a decreased stratification from the center to the edge, that would give rise to niche opportunities and biodiversity reservoirs. Temporal variability in floristic composition indicated differences between grasslands and thickets over time, which decreased in spring, probably by homogenization by grazing in winter. The temporal variability of functional composition showed a cyclical variability in all locations that decreased in spring in all cases.

From livestock farming to amateur Botany in the Rio de la Plata: the case of the uruguayan Mariano B. Berro (1838–1919)

CONICET Digital -

From livestock farming to amateur Botany in the Rio de la Plata: the case of the uruguayan Mariano B. Berro (1838–1919) García, Susana Valeria This paper focuses on the formation of an herbarium and the botanical exchanges conducted by a Uruguayan landowner, Mariano B. Berro (1838–1919), by analysing his archive deposited in the National Archives of Uruguay, which has been neglected as a source for the history of science. This case illustrates the relationship between animal husbandry and the observation and collection of local vegetation, especially the identification of forage plants. In particular, this paper analyses the correspondence between Berro and the Swiss pharmacist and landowner Teodoro Stuckert (1852–1932), who settled in the province of Córdoba, Argentina. Both of them began to assemble botanical collections in the 1890s, and maintained an intense correspondence for nearly 20 years, which provides insights into the practices of a vocational botanist from a rural area in the Rio de la Plata and the role of the network created to exchange specimens, data, and publications within South America as well as with Europe.

Participación del protofeminismo en el proyecto de Estado-nación : Una hipótesis teórico-política (1852-1878)

CONICET Digital -

Participación del protofeminismo en el proyecto de Estado-nación : Una hipótesis teórico-política (1852-1878); Protofeminism’s Participation in the National State Project: A Theoretical-Political Hypothesis (1852-1878) Losiggio, Daniela El presente artículo se propone analizar la participación que tuvo el pensamiento protofeminista de periodistas, maestras y escritoras del siglo XIX argentino en el proyecto de Estado-nación. Partimos de la hipótesis de que Educación popular (1849) de Domingo Faustino Sarmiento constituye un texto fundante de la formación del Estado-nación argentino y que, tanto el libro como la implementación de su programa, se encontraban en diálogo con estas producciones de mujeres.; This article maintains that the proto-feminist thought of journalists and educators of the Argentine XIX century had a relative participation in the founding of the NationState; more specifically, in the popular education project of Sarmiento. To achieve that goal, we rely on women’s history studies. They allow us to shed new light on the canonical interpretations that, within political theory, reflect on the origin of the Argentine State.

Distritos económicos y renovación urbana en el sur de la ciudad de Buenos Aires

CONICET Digital -

Distritos económicos y renovación urbana en el sur de la ciudad de Buenos Aires; Economic Districts and Urban Renewal in the south of Buenos Aires city Arqueros Mejica, Maria Soledad; Goicoechea, María Eugenia; Vazquez, Diego Ezequiel; Fassina, Rosario Este artículo indaga en las transformaciones producidas en el entorno de los distritos económicos del sur de la ciudad de Buenos Aires, Argentina, (2008-2019) en el marco de las estrategias de renovación urbana y la propia trayectoria del territorio. Para ello se relevaron 780 lotes y distintas fuentes documentales (normativas, proyectos y programas). Los resultados de la investigación dan cuenta de fuertes diferencias vinculadas a la trayectoria del proceso de urbanización, las intervenciones públicas y las inversiones en el espacio, poniendo de relieve los diversos efectos de la política en el territorio.; This paper focuses on the urban changes in the surroundings of economic districts in the south of the city of Buenos Aires, Argentina, (2008-2019), within the framework of urban renewal strategies and the territory’s trajectory. For this purpose, we surveyed 780 lots and different documentary sources (regulations, projects and programs). The results of the analysis show strong differences linked to the trajectory of the urbanization process, public policies and investments in space, highlighting the various effects of politics in the territory.

Fiberwise criteria for twisted forms of algebraic structures

CONICET Digital -

Fiberwise criteria for twisted forms of algebraic structures Gille, P.; Pianzola, Arturo We provide a criterion for certain algebraic objects overJacobson schemes to be forms of each other based on theirbehaviour at closed fibres. This criterion permits to answer aquestion related to current and affine Kac-Moody Lie algebrasthat I. Burban had asked the authors.

Supplementary material for: Escherichia coli biogenic synthesized iron oxide nanoparticles: characterization, microbicidal and keratinocyte cellular effects

CONICET Digital -

Supplementary material for: Escherichia coli biogenic synthesized iron oxide nanoparticles: characterization, microbicidal and keratinocyte cellular effects Excel file containing data from experimental assays. Data from the assays are included: MTT, neutral red, crystal violet, production of reactive species (by NBT and DCFDA), wound healing, activity of the enzymes SOD, CAT and GST, and GSH content.

Alcances y cambios de la deuda de hogares en Bahía Blanca

CONICET Digital -

Alcances y cambios de la deuda de hogares en Bahía Blanca; Scope and changes in household debt in Bahía Blanca Cantamutto, Francisco J. El presente artículo presenta los hallazgos en torno a la dinámica de ingresos y deudas de los hogares de Bahía Blanca, Argentina. El estudio de la situación financiera de los hogares ha cobrado relevancia de los últimos años. Desde la agenda de los organismos internacionales de crédito, la agenda de la inclusión financiera es presentada como un instrumento para la lucha contra la pobreza. Sin embargo, los resultados no parecen tan lineales. El financiamiento en los hogares muestra diferencia según la situación socio-económica de los hogares, mostrando diferentes fuentes, motivos y usos. En este artículo se discute esta situación a partir de información cuantitativa recopilada entre 2020 y 2023, período que atraviesa diferentes fases del ciclo económico nacional. Se encuentran impactos diferenciales, que abren la puerta a suponer que la deuda para los hogares esconde situaciones de vulnerabilidad de derechos básicos.; This article presents the findings regarding the dynamics of income and debt of households in Bahía Blanca, Argentina. The study of the financial situation of households has gained relevance in recent years. From the agenda of international credit organizations, the financial inclusion agenda is presented as an instrument for the fight against poverty. However, the results do not seem so linear. Financing in households shows differences depending on the socioeconomic situation of the households, showing different sources, reasons and uses. This article discusses this situation based on quantitative information collected between 2020 and 2023, a period that goes through different phases of the national economic cycle. Differential impacts are found, which open the door to assuming that household debt hides situations of vulnerability of basic rights.

Páginas

Suscribirse a Facultad de Ciencias Químicas de la Universidad Nacional de Córdoba agregador