Sufficient dimension reduction for a novel class of zero-inflated graphical models Koplin, Eric Lionel; Forzani, Liliana Maria; Tomassi, Diego Rodolfo; Pfeiffer, Ruth M. Graphical models allow modeling of complex dependencies among components of a random vector. In many applicationsof graphical models, however, for example microbiome data, the data have an excess number of zero values. Wepresent new pairwise graphical models with distributions in an exponential family, that accommodate excess numbersof zeros in the random vector components. First we characterise these multivariate distributions in terms of univariateconditional distributions. We then model predictors that arise from such a pairwise graphical model with excess zerosas a function of an outcome, and derive the corresponding first order sufficient dimension reduction (SDR). That is,we find linear combinations of the predictors that contain all the information for the regression of the outcome as afunction of the predictors. We estimate the SDR using pseudo-likelihood with a hierarchical penalty that accounts forthe graphical model structure, for variable selection, by allowing interactions only for variables that are associatedwith outcome also through main effects. This method yields consistent estimators of the reduction and can be appliedto continuous or categorical outcomes. We then illustrate our methods by studying normal, Poisson and truncatedPoisson graphical models with excess zeros in simulations and by analyzing microbiome data from the AmericanGut Project. Our models provided robust variable selection and the Poisson zero-inflation pairwise graphical modelresulted in predictive performance that was equal or better than that obtained from applying other available methodsfor the analysis of microbiome data.

Validity and Reproducibility of an Electronic Food Frequency Questionnaire in Argentinian Adults Gili, Rocio Victoria; Leeson, Sara; Carlino, Belén; Contreras Guillen, Ismael Alejandro; Xutuc, Daniel; Martins, Marcia Cristina Teixeira; Díaz, María del Pilar; Segovia-siapco, Gina; Oliveira Da Silva Pacheco, Sandaly; Pacheco, Fabio Juliano This study aimed to validate a semiquantitative electronic food frequency questionnaire (eFFQ) in estimating the intake of a comprehensive list of nutrients and bioactive compounds among adults from six regions of Argentina using multiple 24 h dietary recall (24HR) as a reference. A total of 163 adults completed two administrations of the eFFQ and four 24HRs. The paired t-test/Wilcoxon signed-rank test, Spearman/Pearson correlations, cross-classification, weighted kappa statistics, and Bland–Altman plots were employed to determine relative validity. To determine reproducibility, intraclass correlations (ICC), cross-classification, and weighted kappa statistics were calculated. For relative validity, crude correlations ranged from 0.15 to 0.57; energy adjustment and de-attenuation slightly improved most of these correlations. In cross-classification analysis, agreements within one quintile adjacent to exact agreement (EA ± 1) ranged from 52.2% to ~74%; extreme misclassifications were < 7%. For reproducibility, the crude ICC ranged from 0.29 to 0.85, showing moderate to good correlations for most nutrients. Cross-classification analysis showed agreement levels for the EA ± 1 quintile of 70.6% to 87.7%. Weighted kappa values ranged from 0.21 to 0.62. The results show that this eFFQ is relatively valid in ranking adults according to their nutrient intake and has an acceptable reproducibility, yet it slightly overestimates the intake of most nutrients.

Young Plasma Rejuvenates Blood DNA Methylation Profile, Extends Mean Lifespan, and Improves Physical Appearance in Old Rats Chiavellini, Priscila; Lehmann, Marianne; Gallardo, Maria D.; Canatelli Mallat, Martina; Pasquini, Diana Camila; Zoller, Joseph A.; Gordevicius, Juozas; Girard, Mauricio; Lacunza, Ezequiel; Hereñú, Claudia Beatriz; Horvath, Steve; Goya, Rodolfo Gustavo There is converging evidence that young blood conveys cells, vesicles, and molecules able to revitalize function and restore organ integrity in old individuals. We assessed the effects of young plasma on the lifespan, epigenetic age, and healthspan of old female rats. Beginning at 25.6 months of age, a group of 9 rats (group T) was intraperitoneally injected with plasma from young rats until their natural death. A group of 8 control rats of the same age received no treatment (group C). Blood samples were collected every other week. Survival curves showed that from age 26 to 30 months, none of the group T animals died, whereas the survival curve of group C rats began to decline at age 26 months. Blood DNAm age versus chronological age showed that DNAm age in young animals increased faster than chronological age, then slowed down, entering a plateau after 27 months. The DNAm age of the treated rats fell below the DNAm age of controls and, in numerical terms, remained consistently lower until natural death. When rats were grouped according to the similarities in their differential blood DNA methylation profile, samples from the treated and control rats clustered in separate groups. Analysis of promoter differential methylation in genes involved in systemic regulatory activities revealed specific GO term enrichment related to the insulin-like factors pathways as well as to cytokines and chemokines associated with immune and homeostatic functions. We conclude that young plasma therapy may constitute a natural, noninvasive intervention for epigenetic rejuvenation and health enhancement.

Regulación de intermediarios de Internet: Análisis de los Foros Latinoamericanos de Gobernanza (2018-2021); Internet intermediaries’ regulation: Analysis of the Latin American Governance Forums (2018-2021); Regulamentação de intermediários da Internet: Análise dos Fóruns de Governança Latino-Americanos (2018-2021) Bizberge, Ana; Mastrini, Guillermo Néstor Este artículo analiza la regulación de intermediarios en los Foros de Gobernanza de Internet de América Latina entre 2018 y 2021, desde la perspectiva de las políticas públicas de comunicación. Se indagan los temas, actores y su posicionamiento sobre los derechos humanos y la libertad de expresión a partir de la revisión de videos y relatorías de los foros. El artículo concluye que el abordaje de derechos humanos se desplaza de la libertad de expresión hacia la privacidad. El trabajo busca contribuir a la comprensión de los debates emergentes sobre regulación de Internet en la región.; This article analyzes Internet intermediaries’ regulation in the Latin American Governance Forums between 2018-2021 with the approach of public policy in communications. The topics, actors and their position on human rights and freedom of expression are examined based on the review of videos and reports of the forums. The article concludes that the human rights approach shifts from freedom of expression to privacy. The paper aims to make a contribution to the understanding of the emerging debates on Internet regulation in the region.; Este artigo analisa a regulação dos intermediários nos Fóruns Latino-Americanos de Governança da Internet entre 2018 e 2021, sob a perspectiva das políticas públicas de comunicação. Os temas, atores e sua posição sobre direitos humanos e liberdade de expressão são investigados a partir da análise de vídeos e reportagens dos fóruns. O artigo conclui que a abordagem dos direitos humanos muda da liberdade de expressão para a privacidade. O trabalho busca contribuir para a compreensão dos debates emergentes sobre a regulação da Internet na região.

El concepto de amor y lo político en la ética política kantiana; The concept of love and the political in Kantian political ethics Quiroga, Noelia Eva El propósito de este trabajo es ofrecer una lectura ético-política del amor en la ética de la virtud kantiana contenida en la Religión dentro de los límites de la mera Razón y en la Metafísica de las Costumbres. Para ello, en primer lugar, estudiaré el problema que presenta el amor propio entendido como un posible obstáculo para el amor hacia los demás, con quienes interactuamos. En segundo lugar, estudiaré cómo la idea de amor práctico en la ética de la virtud kantiana, da lugar, en el ámbito de la relación con los otros, al deber de amar al prójimo y contribuir con su felicidad. Finalmente, estudiaré cómo la ética política kantiana, encarnada en la idea de la comunidad ética, expresa una ética del amor que permite contrarrestar el exceso de amor propio.; The purpose of this work is to offer an ethical-political reading of love in the Kantian virtue ethics expressed in Religion within the Boundaries of Mere Reason and in The Metaphysics of Morals. To this end, in the first place, I will study the problem that self-love presents, understood as a possible obstacle to love towards others with whom we interact. Secondly, I will study how the idea of practical love, in Kantian virtue ethics, gives rise in the realm of relationships with others to the duty to love one’s neighbor and contribute to his happiness. Finally, I will study how the Kantian political ethics, embodied in the idea of the ethical community, expresses an ethics of love that allows to counteract the excess of self-love.

Producción y reproducción de discursos sexo-generizados a través de la cultura física oficial: Consecuencias en la formación de profesionales en Educación Física en Argentina (1937-1939); The production and reproduction of sex-gendered discourses through official physical culture: Consequences in the training of professionals in physical education in Argentina (1937-1939) Boyezuk, Agustina; Galak, Eduardo La propuesta de este escrito es interpretar la construcción de discursos sexo-generizados que orbitaron la educación de los cuerpos y las sensibilidades en la cultura física oficial en argentina, a través de analizar la institucionalización de la Educación Física en un momento bisagra de la disciplina a finales de la década de 1930. Se trata de un contexto reformista en el que emerge el segundo Instituto Nacional, producto de la creación de la Dirección General de Educación Física en 1938 que instaura modificaciones estructurales para la disciplina. Se parte como hipótesis que el proyecto educativo de cultura física estuvo atravesado por un conjunto de modificaciones macro políticas estatales características del segundo cuarto del siglo XX argentino, que generaron una nueva organización institucional de los procesos de escolarización (Puiggrós, 1996; Scharagrodsky & Southwell, 2007), lo cual se reflejó en un cambio de paradigma que se materializó en esas dos instituciones estatales que abordaron respectivamente la formación y el ejercicio profesional. Más allá de haber reproducido prácticas, saberes y discursos que estaban en tensión por aquellos años, estos establecimientos funcionaron como dispositivos político-estetizantes que configuraron sentidos sexo-generizados, reproduciendo una gramática de lo corporal (Galak, 2020) y contribuyendo en la construcción de sensibilidades que asociaron a los modos de hacer particulares modos de ser (Chihuailaf Vera, Mujica Johnson & Concha López, 2022). Para ello se analizan un conjunto de documentos oficiales, principalmente los Boletines del Ministerio de Justicia e Instrucción Pública (Argentina, 1938-1939) y los Registros de Clasificación, cuadernos de los institutos de formación profesional donde figuraban las notas de evaluación.; This paper aims to interpret the construction of sex-gendered discourses that orbited the education of bodies and sensibilities in physical culture in Argentina by analysing the institutionalisation of Physical Education at a turning point in the discipline at the end of the 1930s. In the reformist context, the second National Institute emerged as a new establishment dedicated to professionalisation. This was a result of the creation of the General Directorate of Physical Education in 1938, which introduced structural modifications to the discipline. The educational project of physical culture in Argentina during the second quarter of the 20th century was influenced by a set of state macro-political modifications. These modifications led to a new institutional organisation of schooling processes, as noted by Puiggrós (1996), and Scharagrodsky & Southwell (2007). This change of paradigm was reflected in two state institutions that dealt with training and professional practice. In addition to reproducing practices, knowledge, and discourses that were in tension during that time, these establishments functioned as political aesthetic devices that created meanings related to sex, reproducing a bodily grammar (Galak, 2020) and contributing to the construction of sensibilities that associated specific ways of being with particular ways of doing. To achieve this, it is analysed a set of official documents, including the Boletines of the Ministry of Justice and Public Instruction (Argentina, 1938-1939) and the Registros de Clasificación, qualification notebooks used by higher education institutes to record grades.

Becoming a Multilatina: strategic capabilities as necessary conditions for the internationalization of Latin American firms Hermans, Michel; Borda Reyes, Armando; Newburry, William; Cordova Chea, Carlos; Finchelstein, Diego; Gonzalez Perez, Maria Alejandra; Montoya, Miguel; Velasco, Gerardo; Velez Campo, Juan Purpose This study aims to challenge the generic interpretation of Multilatinas as Latin American firms that have been able to internationalize because of highly competitive strategic capabilities. The authors test whether capabilities that international business researchers commonly associate with internationalization are necessary at different stages of the internationalization process to better understand the extent to which emerging market (EM) firms need to develop them. Design/methodology/approach International business research suggests a positive association between strategic capabilities and firm internalization. However, it remains unclear what specific capabilities are necessary and when they are necessary. These questions are particularly important in the context of the internationalization of firms from emerging economies, such as Latin America. The authors apply necessary condition analysis (NCA) on a sample of Latin American firms at different internationalization stages to test what strategic capabilities represent necessary conditions for becoming a Multilatina. Findings The findings suggest that only a few strategic capabilities are necessary for Latin American firms to become “Multilatinas”. While entrepreneurial orientation and marketing and sales capabilities represent necessary conditions, EM firms may internationalize even though other capabilities are developed to a lesser extent. The authors reflect on how shifts in local markets and technology drive the emergence of different types of Multilatinas. Research limitations/implications Measuring strategic capabilities across multiple EM firms implies a risk that firm-specific aspects are not fully captured. While the authors focused on the comparative competitive strength of capabilities and took great care to minimize measurement error, the authors acknowledge possible bias. Also, while NCA does not require a minimum sample size, findings from our sample of firms from four countries may not generalize to the region or other EMs. Originality/value As a relatively new statistical technique, the use of NCA has spread rapidly. To the best of the authors’ knowledge, the linkage between organizational capabilities and firm internationalization has not been tested from a necessary conditions perspective yet. The reflections on the “Multilatina” concept based on the notion of EM firms as configurations of strategic capabilities inform current debates on EM multinational enterprises.

New co-products from an endangered tree species: Araucaria angustifolia (bertol.) kuntze Sequin, Christian Javier; Perusset, Sergio Andres; Trossero, Julia Adriana; Aceñolaza, Pablo Gilberto Araucaria angustifolia is a notable tree species distributed in the Atlantic forest of central-eastern South America. It has been considered acritically endangered species. Due to competition from other land uses, including agriculture and Pinus plantations, A. angustifolia has lostdistribution and plantation area. This study aims to investigate new co-products of A. angustifolia waste products that can be used to preventagricultural diseases. Brown spot is the most common foliar disease of soybeans and is caused by Septoria glycines. In this work, we evaluated theantifungal activity of plant tissue-derived compounds against S. glycines. The ethyl acetate extract of A. angustifolia leaves showed antifungalactivity and was analyzed by HPLC-PDA and GC-MS. The results show two compounds as the principal constituents of antifungal activity. Bothcompounds showed a base peak at m/z 79.08, but they could not be identified by comparison with GC-MS spectral libraries. However, peaks atm/z 91 and 119 indicate that both compounds may contain aromatic structures. As a result of this study, we found that A. angustifolia can be usedto obtain reliable antifungal compounds against S. glycines.

"La Geografía" en el centro Buzai, Gustavo Daniel El presente artículo de reflexión se centra en la Geografía Artística (Kunstgeographie), la cual se preocupa principalmente “por la localización, además de por la cronología, al estudiar las características o rasgos determinantes del arte y la arquitectura” (Da Costa Kaufmann, 1999:12). La indagación realizada muestra curiosidad por la escultura La Geografía que, de acuerdo a las consultas que pude realizar en el ámbito geográfico, su existencia pasa inadvertida y más desconocido aún es el lugar de privilegio de su localización, sitio y posición de gran simbolismo en el espacio urbano de Buenos Aires.; This reflection article is focused on Artistic Geography (Kunstgeographie), which is mainly concerned "with location, in addition to chronology, when studying the characteristics or determining features of art and architecture" (Da Costa Kaufmann , 1999:12). The investigation carried out shows curiosity about the sculpture La Geografía (The Geography) which, according to the consultations that I was able to make in the geographical area, its existence goes unnoticed and even more unknown is the privileged place of its location, site and position of great symbolism in the urban space of Buenos Aires.

Primera experiencia de implantación de radiotransmisores en la víbora Bothrops alternatus; First radiotransmitters implantation experience in the viper Bothrops alternatus Vera, David Gustavo; Clausse, María; Nejamkin, Pablo; Almaraz, Karen; Berkunsky, Igor La radiotelemetría se ha convertido en una herramienta valiosa para estudiar la ecología espacial y reproductiva de las serpientes. Diferentes metodologías han sido utilizadas para colocar radiotransmisores en serpientes, incluida la colocación externa con cinta adhesiva, la ingestión forzada y la aplicación de pegamento en la piel, aunque presentan limitaciones y efectos negativos en las serpientes, como la pérdida de los transmisores o la alteración del comportamiento alimentario. En el presente trabajo se presenta el primer caso de implantación de radiotransmisores en la especie Bothrops alternatus en la Argentina. Se utilizaron dos ejemplares de yarará grande B. alternatus capturados de la naturaleza. Se siguió un procedimiento basado en trabajos anteriores con adaptaciones específicas propias para tratar serpientes venenosas. Los ejemplares fueron anestesiados con isoflurano, con soporte de oxígeno durante toda la cirugía. En cada ejemplar se realizó una incisión de 2 cm de longitud, se dividió el músculo y se accedió a la cavidad celómica. El radiotransmisor, previamente esterilizado, se colocó en esta cavidad y su antena se tunelizó bajo la piel hacia la parte superior del cuerpo. Posteriormente, se suturaron los planos musculares y la piel con material estéril. La cirugía fue exitosa en ambos especímenes, con una duración de aproximadamente 30 minutos y una recuperación rápida después de la anestesia. Los radiotransmisores emitieron señales que se captaron a distancias de hasta 500 metros en el campo, lo que permitió rastrear el movimiento de las serpientes durante un período de 10 días. Sin embargo, se observó que la duración de la batería de los transmisores fue menor de lo esperado, lo que limitó el seguimiento a largo plazo. Este trabajo representa una contribución significativa al campo de la radiotelemetría en serpientes en la Argentina, proporcionando un protocolo detallado y exitoso para la implantación de radiotransmisores en serpientes venenosas.; Radio telemetry has become a valuable tool for studying the spatial and reproductive ecologyof snakes. Various methodologies have been used to attach radio transmitters to snakes, including external placement with adhesive tape, forced ingestion, and skin glue application. Still, these methods have limitations and negative effects on snakes, such as transmitter loss or alterations in feeding behavior. This study presents the first case of radio transmitter implantation in the species Bothrops alternatus in Argentina. Two large venomous snakes B. alternatus specimens, were captured from the wild. A procedure was followed based on previous work with specific adaptations for venomous snakes. The specimens were anesthetized with isoflurane and provided with oxygen throughout the surgery. A 2 cm incision was made in each specimen, the muscle was divided, and access to the celomic cavity was obtained. The previously sterilized radio transmitter was placed in this cavity, and its antenna was tunneled under the skin towards the upper body. Subsequently, the muscle layers and skin were sutured with sterile material. The surgery was successful in both specimens, lasting approximately 30 minutes, with rapid recovery post-anesthesia. The transmitters emitted signals detected at distances of up to 500 meters in the field, allowing tracking of the snakes’ movements over 10 days. However, it was observed that the transmitter battery life was shorterthan expected, limiting long-term monitoring. This work represents a significant contribution to the field of snake radio telemetry in Argentina, providing a detailed and successful protocol for radio transmitter implantation in venomous snakes.

Electrochemical synthesis of donor-acceptor triazine based polymers with halochromic and electrochromic properties Renfige Rodriguez, Yone Melisa; Gonzalez Lopez, Edwin Javier; Macor, Lorena Paola; Solis, Claudia Alejandra; Durantini, Javier Esteban; Morales, Gustavo Marcelo; Otero, Luis Alberto; Durantini, Edgardo Néstor; Heredia, Daniel Alejandro; Gervaldo, Miguel Andres Two triazine monomers substituted with aromatic α,β unsaturated ketones (chalcones) as connecting arms, holding triphenylamine or carbazole ending groups, were by the first time synthesized using commercial and inexpensive starting materials in just two steps. Triphenylamine and carbazole groups were strategically introduced in order to allow electrochemical polymerization and redox activity of the obtained films. The chalcone, together with the triphenylamine or carbazole outer groups, give rise to the formation of a donor-acceptor systems, allowing the generation of photoinduced intramolecular charge transfer (ICT) electronic transitions and providing basic sites for protonation. Because of the star-like chemical structure of the used triazine, electrochemical polymerization of these monomers conducted to the formation of hyperbranched structures. The polymeric materials exhibited not only electrochromic properties but also showed a halochromic behavior. Spectroelectrochemical studies of the films showed different colorations in the three redox states (neutral, semioxidized and fully oxidized). The color changes are fast and easily detected by the naked eye. Electrochemical parameters such as optical contrast, coloration efficiency, optical memory, and long-term stability for both films were obtained and compared. A quasi-solid window-type electrochromic device was assembled using the electrogenerated polymer with the best electrochromic performance and stability. Moreover, the triphenylamine based polymer showed reversible color changes upon acid-base vapor exposure cycles, demonstrating that this polymer can be used not only in electrochromic devices but also in acid vapor sensors.

Diversity response of necrophagous dipteran communities and their functional groups to an anthropization gradient Dufek, Matias Ignacio; Larrea, Dario Daniel; Damborsky, Miryam Pieri; Mulieri, Pablo Ricardo The anthropization process exerts a profound effect on ecosystems, causing alterations in biodiversity, habitat structure, and species composition, ultimately disrupting the delicate balance of natural environments. The aim of the present study was to explore the ecological dynamics of necrophagous Sarcophagidae and Calliphoridae flies along an anthropization gradient. This research investigated alpha and beta diversity patterns to unravel the impact of human-induced environmental changes on these insect communities and also assesses the dynamics of functional groups in relation to their impact on medical and forensic fields. Five distinct habitats, ranging from urban to forested areas, were surveyed in two Departments in the Province of Chaco, Argentina. Necrophagous flies were collected using van Someren-Rydon canopy traps across three seasons. Two main functional groups were analyzed: oviparous flies (Calliphoridae) and larviparous flies (Sarcophagidae). Results indicated a significant negative correlation between Sarcophagidae species richness and anthropization, whereas Calliphoridae showed increased abundance in highly anthropized sites. The combined assemblage of Calliphoridae+Sarcophagidae exhibited significant relationships across all community parameters evaluated. Beta diversity analysis revealed turnover as the main process shaping dipteran communities along the anthropization gradient, with spatial species replacement dominating. This underscores the importance of interspecific spatial segregation in dipteran community composition. In conclusion, this study enhances our understanding of the ecological adaptations of necrophagous dipterans to anthropogenic disturbances. The observed shifts in diversity and abundance have implications for forensic investigations and public health, emphasizing the need for nuanced monitoring and conservation strategies. This research contributes valuable insights into the intricate ecological interactions of these insect communities within changing ecosystems.

Loss of function in somatostatin receptor 5 has no impact on the growth of medaka fish due to compensation by the other paralogs Boan, Agustín Fernando; Delgadin, T. H.; Canosa, Luis Fabian; Fernandino, Juan Ignacio Somatic growth in vertebrates is regulated endocrinologically by the somatotropic axis, headed by the growth hormone (GH) and the insulin growth factor-I (IGF-I). Somatostatin (Sst), a peptide hormone synthesized in the hypothalamus, modulates GH actions through its receptors (Sstr). Four Sstr subtypes (Sstr 1–3 and 5) have been identified in teleosts. However, little is known about whether they have a specific function or tissue expression. The aim of this study was to determine the role of sstr2 and sstr5 in the growth of the medaka (Oryzias latipes). The assessed expression pattern across diverse tissues highlighted greater prevalence of sstr1 and sstr3 in brain, intestine and muscle than in pituitary or liver. The expression of sstr2 was high in all the tissues tested, while sstr5 was predominantly expressed in the pituitary gland. A CRISPR/Cas9 sstr5 mutant with loss of function (sstr5-/-) was produced. Assessment of sstr5-/- indicated no significant difference with the wild type regarding growth parameters such as standard length, body depth, or peduncle depth. Furthermore, the functional loss of sstr5 had no impact on the response to a nutritional challenge. The fact that several sstr subtypes were upregulated in different tissues in sstr5-/- medaka suggests that in the mutant fish, there may be a compensatory effect on the different tissues, predominantly by sstr1 in the liver, brain and pituitary, with sstr2 being upregulated in pituitary and liver, and sstr3 only presenting differential expression in the brain. Analysis of the sstr subtype and the sstr5-/- fish showed that sstr5 was not the only somatostatin receptor responsible for Sst-mediated Gh regulation.

Biotic and abiotic factors acting on community assembly in parallel anaerobic digestion systems from a brewery wastewater treatment plant Spatola Rossi, Tatiana; Gallia, Mateo; Erijman, Leonardo; Figuerola, Eva Lucia Margarita Anaerobic digestion is a complex microbial process that mediates the transformation of organic waste into biogas. The performance and stability of anaerobic digesters relies on the structure and function of the microbial community. In this study, we asked whether the deterministic effect of wastewater composition outweighs the effect of reactor configuration on the structure and dynamics of anaerobic digester archaeal and bacterial communities. Biotic and abiotic factors acting on microbial community assembly in two parallel anaerobic digestion systems, an upflow anaerobic sludge blanket digestor (UASB) and a closed digester tank with a solid recycling system (CDSR), from a brewery WWTP were analysed utilizing 16S rDNA and mcrA amplicon sequencing and genome-centric metagenomics. This study confirmed the deterministic effect of the wastewater composition on bacterial community structure, while the archaeal community composition resulted better explained by organic loading rate (ORL) and volatile free acids (VFA). According to the functions assigned to the differentially abundant metagenome-assembled genomes (MAGs) between reactors, CDSR was enriched in genes related to methanol and methylamines methanogenesis, protein degradation, and sulphate and alcohol utilization. Conversely, the UASB reactor was enriched in genes associated with carbohydrate and lipid degradation, as well as amino acid, fatty acid, and propionate fermentation. By comparing interactions derived from the co-occurrence network with predicted metabolic interactions of the prokaryotic communities in both anaerobic digesters, we conclude that the overall community structure is mainly determined by habitat filtering.

Materia orgánica en sedimentos submareales dentro del Puerto de la ciudad de Mar del Plata Estos resultados de materia orgánica expresados como mg C orgánico /g muestra, realizado por triplicado y promediado en las muestras correspondientes a la desembocadura del Aº Del Barco, tomadas durante un muestreo estacional realizado en el periodo 2019-2020.

El gobierno del Frente de Todos, o el fracaso de la búsqueda del consenso imposible; The Frente de Todos Government, or the Failure of the Search for the Impossible Consensus Cantamutto, Francisco J. Este artículo analiza la llegada al gobierno de la Argentina del Frente de Todos en 2019, como parte de un segundo ciclo de gobiernos progresistas o populares en la región. Tras la experiencia neodesarrollista del kirchnerismo, el país experimentó un gobierno con políticas neoliberales (con la coalición Cambiemos) que lo sumió en una crisis severa, a la cual se sumó la generada por la pandemia. El gobierno del Frente de Todos prometió generar un proceso de crecimiento con redistribución, pero no pudo realizarlo. Este artículo, basado en una mirada de economía política, argumenta a que la razón de fondo está en el énfasis consensual del gobierno, que buscó eludir intenciones refundacionales propias de una parte de la coalición, a saber, el propio kirchnerismo. La intención de acordar incluso con los ganadores del período previo limitó las posibilidades de actuar en pos de un proceso redistributivo o de cambio estructural, limitando así los márgenes de acción. Ante la falta de resultados económicos, pero también en los sesgos de la gestión de la pandemia, creció en la oposición una crítica de derecha radical, que modificó el escenario político.; This article analyzes the arrival of the Frente de Todos government in Argentina in 2019, as part of a second cycle of progressive or popular governments in the region. After the neo-developmentalist experience of Kirchnerism, the country experienced a government with neoliberal policies (with the Cambiemos coalition) that plunged it into a severe crisis, to which was added the one generated by the pandemic. The government of the Frente de Todos promised to generate a process of growth with redistribution, but was unable to do so. This article, based on a political economy perspective, argues that the underlying reason lies in the government’s consensual emphasis, which sought to avoid the re-foundational intentions of one part of the coalition, namely Kirchnerism itself. The intention of agreeing even with the winners of the previous period limited the possibilities of acting in pursuit of a redistributive process or structural change, thus limiting the margins for action. Faced with the lack of economic results, but also in the biases of the management of the pandemic, a radical right-wing criticism grew in the opposition, which modified the political scenario.

Harmonic complex structures and special hermitian metrics on products of Sasakian manifolds Andrada, Adrián Marcelo; Tolcachier, Alejandro It is well known that the product of two Sasakian manifolds carries a 2-parameter family of Hermitian structures (J_(a,b), g_(a,b)). We show in this article that the complex structure J_(a,b) is harmonic with respect to g_(a,b) , i.e. it is a critical point of the Dirichlet energy functional. Furthermore, we also determine when these Hermitian structures are locally conformally Kähler, balanced, strong Kähler with torsion, Gauduchon or k-Gauduchon (k ≥ 2). Finally, we study the Bismut connection associated to (J_(a,b), g_(a,b)) and we provide formulas for the Bismut-Ricci tensor Ric^B and the Bismut-Ricci form ρ^B . We show that these tensors vanish if and only if each Sasakian factor is η-Einstein with appropriate constants and we also exhibit some examples fulfilling these conditions, thus providing new examples of Calabi-Yau with torsion manifolds.

Machine learning models predict the emergence of depression in Argentinean college students during periods of COVID-19 quarantine López Steinmetz, Lorena Cecilia; Sison, Margarita; Zhumagambetov, Rustam; Godoy, Juan Carlos; Haufe, Stefan Introduction: The COVID-19 pandemic has exacerbated mental health challenges, particularly depression among college students. Detecting at-risk students early is crucial but remains challenging, particularly in developing countries. Utilizing data-driven predictive models presents a viable solution to address this pressing need. Aims: 1) To develop and compare machine learning (ML) models for predicting depression in Argentinean students during the pandemic. 2) To assess the performance of classification and regression models using appropriate metrics. 3) To identify key features driving depression prediction. Methods: A longitudinal dataset (N = 1492 college students) captured T1 and T2 measurements during the Argentinean COVID-19 quarantine. ML models, including linear logistic regression classifiers/ridge regression (LogReg/RR), random forest classifiers/regressors, and support vector machines/regressors (SVM/SVR), are employed. Assessed features encompass depression and anxiety scores (at T1), mental disorder/suicidal behavior history, quarantine sub-period information, sex, and age. For classification, models’ performance on test data is evaluated using Area Under the Precision-Recall Curve (AUPRC), Area Under the Receiver Operating Characteristic curve, Balanced Accuracy, F1 score, and Brier loss. For regression, R-squared (R2), Mean Absolute Error, and Mean Squared Error are assessed. Univariate analyses are conducted to assess the predictive strength of each individual feature with respect to the target variable. The performance of multi- vs univariate models is compared using the mean AUPRC score for classifiers and the R2 score for regressors. Results: The highest performance is achieved by SVM and LogReg (e.g., AUPRC: 0.76, 95% CI: 0.69, 0.81) and SVR and RR models (e.g., R2 for SVR and RR: 0.56, 95% CI: 0.45, 0.64 and 0.45, 0.63, respectively). Univariate models, particularly LogReg and SVM using depression (AUPRC: 0.72, 95% CI: 0.64, 0.79) or anxiety scores (AUPRC: 0.71, 95% CI: 0.64, 0.78) and RR using depression scores (R2: 0.48, 95% CI: 0.39, 0.57) exhibit performance levels close to those of the multivariate models, which include all features. Discussion: These findings highlight the relevance of pre-existing depression and anxiety conditions in predicting depression during quarantine, underscoring their comorbidity. ML models, particularly SVM/SVR and LogReg/RR, demonstrate potential in the timely detection of at-risk students. However, further studies are needed before clinical implementation.

Zygosporium palaeogibbum sp. nov. (Xylariales, Ascomycota) associated with Cinnamomum Schaeff. (Lauraceae) leaves from the Siwalik (Middle Miocene) of eastern Himalaya Mahato, Sumana; Bianchinotti, Maria Virginia; Kundu, Sampa; Khan, Mahasin Ali Well-preserved remains of a mitosporic fungus were found on leaf cuticles of Cinnamomum sp. (Lauraceae) recovered from the lower Siwalik (Chunabati Formation; Middle Miocene) sedimentary stratum of Darjeeling foothills of eastern Himalaya. Based on the characteristic features (solitary vesicular conidiophores arising directly from a superfcial mycelium and strongly curved, darkly pigmented, ovoid to pyriform vesicles with 1–3 celled stalk cells), it is here proposed as a new fossilspecies, Zygosporium palaeogibbum sp. nov. The in situ evidence of Z. palaeogibbum in appreciable numbers on the host leaf cuticles suggests the probable existence of a host-specifc saprophytic relationship in the Darjeeling sub-Himalaya’s ancient warm humid tropical climate during the time of deposition. This conclusion on past climate is in agreement with published qualitative, quantitative, and palaeomycological climatic data obtained from the study of megafossil plant remains from the same fossil locality.

SolNet dataset: Descriptors obtained by Tomato Analyzer in a publicly available images dataset on the SolNetwork website A set of tomato fruit images publicly available was downloaded from SolNetwork. The images were analyzed with the Tomato Analyzer (version 2.0) which is a computer vision-based program that permits the semi-automated and objective measurement of 47 fruit shape, size, and colour descriptors obtained from the longitudinal and latitudinal section of tomato A total of 1424 images, representing 368 tomato accessions, and 41 morphological attributes, were analyzed. The dataset includes as well, four categorical shape features, one for each shape classification system available in tomato.