Pensar con sonidos: Los universos musicales en El Trino del Diablo de Daniel Moyano; Thinking with Sounds: Musical Universes in El Trino del Diablo by Daniel Moyano López, Irene Noemí La música ocupa un lugar predominante en la producción literaria de Daniel Moyano. Su escritura entrama en diversos planos –semántico, formal, ideológico- referencias y procedimientos provenientes del discurso musical construyendo un espacio textual complejo. Consideramos por ello que a través de su estudio es posible colaborar en la reflexión acerca de las múltiples formas de producción de sentido que se generan en el diálogo entre lenguajes artísticos, en este caso entre música y literatura. En este trabajo realizamos una lectura de El trino del diablo para mostrar las formas en que el universo narrativo de la novela se configura a través de la incorporación de mitos y concepciones acerca de la música y los intérpretes, incidiendo en la construcción de espacios de pertenencia y marcos de referencia cultural e identitaria. Asimismo, la lectura en torno a la textualización de prácticas, valores y referencias musicales constituye una forma posible de conocimiento y comprensión del mundo político y social de los años 1970 en Argentina.; Music plays a major role in Daniel Moyano's literary production. References and procedures coming from musical discourse are interwoven in his writing creating a complex textual space in various planes –semantic, formal, and ideological. Therefore, we consider that studying his writing allows us to contribute to the considerations about the multiple ways of sense production created in the dialog between artistic languages, in this case, between music and literature. In this paper, we do a reading of El trino del diablo* in order to show the ways in which the narrative universe of the novel takes shape by means of the incorporation of myths and conceptions about music and interpreters, influencing the construction of areas of membership and cultural and identity frames of reference. Likewise, reading taking into consideration the textualization of practices, values, and musical references is a possible way of knowing and understanding the political and social world of the 1970s in Argentina.

Sex morphs and invasiveness of a fleshy-fruited tree in natural grasslands from Argentina Amodeo, Martín Raúl; Zalba, Sergio Martín Invasiveness has usually been studied as a species-level attribute; nevertheless, phenotypic differences between individuals in a population can lead to significant variations in colonization ability. In this paper, we analyse the potential effects of sex morphs of Prunus mahaleb, a gynodioecius fleshy-fruited tree, on its invasiveness in natural grasslands in the southern Argentine Pampas. We assessed the abundance of both hermaphrodite and female plants and compared their fecundity, propagule size and germination response. We found that the females were less abundant in the invasive populations studied, apparently since the beginning of the colonization. However, our results demonstrated that at the present time females do not show any fecundity reduction, which clearly shows that P. mahaleb has established an effective interaction with generalist pollinators which compensates for the apparent disadvantage of females. Fruit set showed a wider range of variability over time in the females than in the hermaphrodites, which could be the consequence of greater susceptibility to changes in the activity of pollinators. We found no evidence of a female benefit due to reallocation of resources or better outcrossed progeny considering propagule size and germination. We discuss the relative importance of sex morphs and interactions at different stages of the invasion process.

When sperm meets egg: the spark of new life Wozniak, Katherine Lynn; Luque, Guillermina Maria; Ahn, Soo Hyun Activation following fertilization reawakens the quiescent egg and inhibits polyspermy. Oscillating cytoplasmic Ca2+ concentrations ([Ca2+ ]) during egg activation are a highly conserved event that have persisted through the course of evolution. For example, fertilization in the starfish Asterina miniata results in two Ca2+ -dependent processes in the fertilized egg.

Improving the water resistance of epoxy–anhydride matrices by the incorporation of bentonite Capiel, Guillermina; Uicich, Julieta; Alvarez, Vera Alejandra; Montemartini, Pablo Ezequiel Epoxy-anhydride based polymers are commonly used as a matrix in pipeline systemsexposed to water during their in-service life. Water absorption at moderatetemperatures and/or at long exposure times could lead to irreversible hydrolysisreaction decreasing considerably the polymer overall performance. A strategy toenhance the barrier properties of epoxy resins is to add nano-fillers to traditional matrices. In this work, we added bentonite and chemically modified bentonite to this purpose. Water absorption of the resulting materials at three different temperatures (22°C, 80 °C and 93 °C) was studied and simultaneously, the evolution during the immersion tests of glass transition temperature and flexural modulus was recorded.Long-term gravimetric results showed that composites with chemically modified bentonite produce a delay on the hydrolysis of epoxy-anhydride matrix, which is a relevant result, due to the tough application and uses of the system, from the technological point of view.

Spatial and temporal variation in volatile composition suggests olfactory division of labor within the trap flowers of Aristolochia gigantea Martin, Kyle R.; More, Marcela; Hipólito, Juliana; Charlemagne, Shaniece; Schlumpberger, Boris O.; Raguso, Robert A. The olfactory components of floral advertisement can be complex, often showing dynamic patterns of emission and chemical composition that may reflect diverse functions related to pollination. In this study we investigated the spatial and temporal variation of volatile production in the distinctive kettle trap flowers of the Neotropical pipevine Aristolochia gigantea (Aristolochiaceae). These flowers show unusual complexity in scent chemistry and floral morphology in addition to conspicuous changes in scent at distinct stages during floral ontogeny. In this study, volatiles were collected from separate stages in development (bud, female, male, wilted flower), and from different functional units (limb, black ring, yellow disk, utricle, nectary) within each stage. Our results document a strikingly complex and dynamic floral scent composition for A. gigantea. Female stage floral emissions are dominated by sweet lemon-scented citronella-like compounds including (E)- and (Z)-citral, citronellol and citronellal, and at the same time include smaller amounts of pungent, brood-site associated volatiles such as dimethyl disulfide, 2-heptanone, and 3-methyl-1-butanol. Volatile emissions plummet one day later in male stage flowers, except for increased production of monoterpenoids and sesquiterpenoids, including a burst of linalool within the floral chamber. Volatiles emitted from wilted flowers resemble the vegetative background as soon as 48 h post anthesis. Multidimensional scaling revealed unexpected differentiation of volatile emissions across spatial units of the complex flower (e.g. within vs. outside of the trap), as well as at different stages of sexual expression as flowers matured. These results suggest that protogynous kettle trap flowers or inflorescences utilize a chemical division of labor, in concert with visual and tactile cues, to choreograph pollinator behavior such that female and male floral functions are optimized.

Model selection: Using information measures from ordinal symbolic analysis to select model sub-grid scale parameterizations Pulido, Manuel Arturo; Rosso, Osvaldo A. The use of information measures for model selection in geophysical models with subgrid parameterizations is examined.} Although the resolved dynamical equations of atmospheric or oceanic global numerical models are well established, the development and evaluation of parameterizations that represent subgrid-scale effects  pose a big challenge. For climate studies, the parameters or parameterizations are usually selected according to a root-mean-square error criterion, that measures the differences between the model state evolution and observations along the trajectory. However, inaccurate initial conditions and systematic model errors contaminate root-mean-square error measures. In this work, information theory quantifiers, in particular Shannon entropy, statistical complexity and Jensen-Shannon divergence, are evaluated as measures of the model dynamics. An ordinal analysis is conducted using the Bandt-Pompe symbolic data reduction in the signals. The proposed ordinal information measures are examined in the two-scale Lorenz´96 system. By comparing the two-scale Lorenz´96 system signals with a one-scale Lorenz´96 system with deterministic and stochastic parameterizations, we show that information measures are able to select the correct model and to distinguish the parameterizations including the degree of stochasticity that results in the closest model dynamics to the two-scale Lorenz´96 system.

Draft genome sequence of lactobacillus curvatus FLEC03, a meat-borne isolate from beef carpaccio packaged in a modified atmosphere Teran, Lucrecia Cecilia; Coeuret, Gwendoline; Raya, Raul Ricardo; Champomier-Vergès, Marie-Christine; Chaillou, Stéphane In this study, we present the draft genome sequence for Lactobacillus curvatus FLEC03. This strain was isolated from beef carpaccio packaged in a modified atmosphere. The draft genome will contribute to understanding the role of L. curvatus strains in food products (fermentation, biopreservation, or spoilage) through comparative genomics with other strains.

Alternative splicing switches: Important players in cell differentiation Fiszbein, Ana; Kornblihtt, Alberto Rodolfo Alternative splicing (AS) greatly expands the coding capacities of genomes by allowing the generation of multiple mature mRNAs from a limited number of genes. Although the massive switch in AS profiles that often accompanies variations in gene expression patterns occurring during cell differentiation has been characterized for a variety of models, their causes and mechanisms remain largely unknown. Here, we integrate foundational and recent studies indicating the AS switches that govern the processes of cell fate determination. We include some distinct AS events in pluripotent cells and somatic reprogramming and discuss new progresses on alternative isoform expression in adipogenesis, myogenic differentiation and stimulation of immune cells. Finally, we cover novel insights on AS mechanisms during neuronal differentiation, paying special attention to the role of chromatin structure.

Marcadores moleculares de la progresión tumoral asociados a cadherina epitelial en cáncer de próstata y de vejiga Mencucci, Maria Victoria Cadherina Epitelial (CadE) es una glicoproteína transmembrana que cumple un rol fundamental en la adhesión intercelular. La pérdida de CadE es clave en la Transición Epitelio Mensenquimal (TEM); las células pierden capacidad adhesiva y ganan comportamiento mótil e invasivo, posibilitando la progresión tumoral a través de la invasión local de los tejidos y la metástasis a distancia.En el Cáncer de Próstata (CP) y el Cáncer de Vejiga (CV) se han reportado alteraciones en la expresión/función(es) de CadE y de otras moléculas relacionadas a la TEM, pero los estudios no son concluyentes. Asimismo, existen moléculas relacionadas a CadE y a la progresión y agresividad tumoral que aún no han sido estudiadas en estos tumores. Específicamente, Disadherina (Dys) se ha encontrado sobreexpresada en numerosos tumores sólidos y asociada a la metástasis, no habiendo antecedentes en CP. Asimismo, Efrina-B1 ha sido relacionada a la desregulación de B-catenina y la agresividad tumoral, pero no hay antecedentes de su expresión en CV. El presente estudio ha caracterizado la expresión de CadE y otros marcadores de la TEM en CP y CV. Asimismo, por primera vez describe la expresión de Dys en CP y Efrina-B1 en CV y las asocia a la progresión y agresividad tumoral de estos tumores.

Dinámicas de construcción de subjetividades políticas y epistémicas en dispositivos pedagógicos de formación política. Un estudio en movimientos populares multisectoriales del Área Metropolitana de Buenos Aires (2011-2015) Palumbo, María Mercedes La Tesis Doctoral denominada "Dinámicas de construcción de subjetividades políticas y epistémicas en dispositivos de formación política. Un estudio en movimientos populares multisectoriales en el Área Metropolitana de Buenos Aires (2011-2015)" se propuso interpretar las dinámicas de construcción de subjetividades políticas y epistémicas en dispositivos pedagógicos de formación política destinados a militantes de base en movimientos populares multisectoriales pertenecientes al Área Metropolitana de Buenos Aires en el período 2011-2015. Por un lado, se exploraron los procesos de construcción de subjetividades epistémicas en relación a los saberes y conocimientos (la trama epistémica) en circulación en los talleres de formación, los sujetos portadores de saberes y conocimientos y las tensiones en torno a la visibilización, socialización, resignificación y diálogo de saberes al interior de los dispositivos de formación política. Por otro lado, se indagaron las dinámicas de construcción de subjetividades políticas en cuanto a los relatos sobre los tránsitos subjetivos operados en las prácticas políticas cotidianos y el reforzamiento en el marco de los talleres del saber hablar y el poner el cuerpo en tanto habilidades políticas centrales para las prácticas políticas. Finalmente, se abordó el carácter multisectorial de los movimientos populares expresado en los talleres como un aspecto clave en cuanto potencia y tensiona las dinámicas de construcción de subjetividades políticas y epistémicas.

Cohesive Properties of Cu-X and Ni-X (In, Sn) Intermetallics: Ab Initio Systematics, Correlations and “Universality” Features Bertoldi, Dalía Surena; Ramos, Susana Beatriz; Gonzalez Lemus, Nasly Vanessa; Fernandez Guillermet, Armando Jorge This paper reports an analysis of the systematics of cohesive properties and equation-of-state parameters for a large number of stable, metastable and hypothetical binary MeaXb type phases formed by Me = Cu, Ni with X = In, Sn. To this aim, an ab initio database previously developed by the authors using spin polarized density-functional-theory calculations, using the VASP code, is adopted. The work involves the volume (V0), Wigner–Seitz radius, bulk modulus (B0) and cohesive energy (Ecoh) of the phases. At the outset of the paper it is shown that these properties can be studied as functions of the average group number (AGN), i.e., the weighted average of the number of valence electrons involved in the VASP calculations. Moreover, the cohesive energy density (CED), defined as Ecoh/V0, is shown to correlate very well with the AGN variable and with B0. These striking regularities are given two complementary interpretations. First, a general microscopic picture of the variations of cohesion is developed by studying the evolution of the contributions of the d- and p-electrons to their electronic density of states. In this way the effects of the hybridization of d- and p-electrons, and the filling up of bonding and anti-bonding states is highlighted. Next, a thermodynamic analysis based on the classical approach developed by Rose, Ferrante, Smith and collaborators is performed. It is concluded that the correlation involving CED and B0 is a manifestation of a significant degree of “universality” in the variation of the cohesive properties with the Wigner–Seitz radius of these compounds.

Intramyocardial gene silencing by interfering RNA Brea, María Soledad; Morgan, Patricio Eduardo; Perez, Nestor Gustavo RNAi is a widely used methodology for gene silencing. The action mechanism of siRNA molecules has been well studiedin recent years, and the technique has been optimized in terms of safety and effectiveness. Cardiovascular diseases havea high incidence in the current population, and despite of the extensive research, safe and efficient therapeutics have notyet been found, which is reflected by 17.1 million people who die each year for this cause. In this context, siRNAs arebeing considered a therapeutic tool to regulate the expression of genes involved in the generation of these pathologies.The efficacy of siRNAs entry to cardiomyocytes, the safety of the delivery process and the degree of silencing achievedare main aspects before consider it as a cardiovascular disease therapy. Presently, we will give a brief outline of thecurrent understanding of the RNAi mechanism and the delivery system to the heart. We describe the use of lentivirus fora functional silencing of cardiac proteins in the study of a pathophysiological process, the slow force response to cardiacstretch.

Fuentes documentales para el estudio del clima en la región sur-austral de Chile (40º S a 51º S) durante los últimos siglos.; Documentary sources to study the climate in the far south region of Chile (40º - 51º S) during the last centuries Prieto, Maria del Rosario; Solari, María Eugenia; Crouchet, Juana; Larroucau, Andres Frente a la importancia que han adquirido durante los últimos años los estudios climáticos, sumado a la necesidad de encontrar nuevas fuentes que permitan elaborar registros cada vez más completos e integrados sobre el clima del pasado, complementando así lo que ya se está haciendo a través del estudio de anillos de árboles, testigos de hielo y sedimentos lacustres, se ha considerado que la documentación histórica, generada a partir de la llegada de los españoles al continente sudamericano, puede entregar valiosa información sobre diversos fenómenos meteorológicos, permitiendo elaborar registros temporales más extensos de dichos eventos. Es por ello que en este trabajo se describen las principales fuentes documentales para la reconstrucción del clima en la región sur de Chile (40° S a 51º S) durante los últimos 450 años, dando cuenta de la forma en que se generaron, el tipo de información que pueden entregar y los lugares donde se conservan. Los registros climáticos provienen de crónicas, relatos de viajeros, informes de las autoridades de los gobiernos locales, naturalistas y científicos, entre otros, y que han sido conservados y publicados en archivos públicos, diarios y revistas, así como mapas antiguos, fotografías, dibujos y otros soportes gráficos más recientes. Esta investigación formó parte de una serie de proyectos interdisciplinarios cuyo objetivo fue estudiar la historia ambiental y los cambios climáticos ocurridos en esa región desde distintas perspectivas paleoclimáticas, tales como la dendrocronología y la glaciología.; Given the importance that climatologic studies have acquired in the last few years, plus the need to find new sources that allow creating a registry ever more complete and integrated about the climate in the past, complementing what is already being done through the study of tree rings, ice cores and lake sediments, it has been considered that historic documentation, generated since the arrival of the Spaniards to the south American continent, can provide valuable information about diverse meteorological phenomena, allowing for the creation of longer temporary registries about such events. Hence this work describes and analyzes the main documentary sources for the reconstruction of the climate in the southern region of Chile (40 to 51º S) during the last 450 years; accounting for the way they were generated, the type of information they can provide and the places where they are conserved. The climatic registries come from chronicles, travelers’ accounts, reports from the authorities of local governments, naturalists and scientists, among others, that have been conserved and published in public archives, newspapers and magazines; as well as antique maps, photographs, paintings and other more recent graphic formats. This investigation was part of a series of interdisciplinary projects whose objective was to study the environmental history and the climate changes occurred in that region from different paleoclimatic perspectives, such as dendrochronology and glaciology.

Stenocercus doellojuradoi Arzamendia, Vanesa; Fitzgerald, L.; Giraudo, Alejandro Raul; Kacoliris, Federico Pablo; Montero, Ricardo; Pelegrin, Nicolas; Scrocchi Manfrini, Gustavo Jose; Williams, Jorge Daniel This species is classified as Near Threatened because it is sensitive to deforestation and disappears from deforested areas. Throughout the Gran Chaco, deforestation is taking place at alarming rates, and deforestation in the Chaco is predicted to continue into the future. This lizard's extent of occurrence exceeds 20,000 km2, but the rate of population decline is believed to be high and, while unquantified, may approach the level for listing as Vulnerable under criterion A.

Liolaemus ditadai Pelegrin, Nicolas; Abdala, Cristian Simón This species is listed as Data Deficient because it is known only from a few specimens, and there are nodata on population size and trends and the extent to which apparent threats may affect it. However, theonly known population is restricted to a small area and more research is needed to better determine itspopulation status and threats

Tropidurus melanopleurus Abdala, Cristian Simón; Arzamendia, Vanesa; Fitzgerald, L.; Giraudo, Alejandro Raul; Kacoliris, Federico Pablo; Montero, Ricardo; Pelegrin, Nicolas; Scrocchi Manfrini, Gustavo Jose; Williams, Jorge Daniel Listed as Least Concern in view of the relatively large extent of occurrence, large number of locations, probable large population size, apparently stable trend, and lack of major threats.

Diplolaemus darwinii Abdala, Cristian Simón; Arzamendia, Vanesa; Firzgerald, L.; Giraudo, A.; Kacoliris, Federico Pablo; Montero, Ricardo; Pelegrin, Nicolas; Scrocchi Manfrini, Gustavo Jose; Williams, Jorge Daniel; Vidal Mejía, Diana Marcela; Tala, Charif; Ortiz, Juan Carlos; Núñez, Hernán; Garin, Carlos; Avilés, R.; Mella Ávila, Jorge; Núñez, Jorge; Sallabery, Nicole; Victoriano, Pedro Diplolaemus darwinii is listed as Least Concern in view of its wide distribution, and because it is unlikelyto be impacted by any major threat.

Ética e historia: una mirada desde la ética discursiva; Ethics and history: a look from the discursive ethics; Ética e história: uma visão de ética do discurso Scivoletto, Gonzalo Martín El siguiente trabajo se propone analizar la relación entre la ética discursiva y la historia, a partir de la reconstrucción realizada por Karl-Otto Apel en las Mercier Lectures de 1999 (Lovaina). Se intentará mostrar cómo la ética discursiva se encuentra entrelazada con las tres dimensiones del tiempo histórico. La relación con el pasado apunta al posicionamiento respecto de la situación moral e institucional “heredada” por la tradición (eticidad sustancial). La relación con el presente se refiere a la “situación humana”, entendida esta como un proceso evolutivo-cultural (desde la hominización hasta el presente) y como un “momento” o situación particular dentro de ese proceso. Finalmente, la relación con el futuro alude a la capacidad de la ética de orientar la historia humana hacia un horizonte normativo, en tanto ideal regulativo.; This work aims to analyze the relationship between discursive ethics and history, based on the reconstruction by Karl-Otto Apel in the 1999 in Mercier Lectures (Leuven). It attempts to show how discursive ethics is intertwined with the three dimensions of historical time. The relationship with the past points to the positioning regarding the moral and institutional situation “inherited” by tradition (substantial ethics). The relationship with the present refers to the “human situation”, understood as an evolutionary-cultural process (from hominization to the present) and as a “moment” or particular situation within that process. Finally, the relationship with the future alludes to the ability of ethics to guide human history towards a normative horizon, as a regulative ideal.; O seguinte artigo propõe analisar a relação entre a ética do discurso e história, desde a reconstrução realizada por Karl-Otto Apel nas Mercier Lectures de 1999 (Lovaina). Ele tentará mostrar como a ética do discurso se encontra entrelaçada com as três dimensões do tempo histórico. A relação com o passado aponta ao posicionamento sobre a situação moral e institucional “herdada” pela tradição (ética substancial). A ligação com o presente refere-se à “situação humana”, entendida como um processo evolutivo-cultural (a partir da hominização presente) e como um “momento” ou situação particular dentro daquele processo. Finalmente, a relação com o futuro se refere à capacidade da ética para orientar a história humana para um horizonte normativo, enquanto ideal regulador.

El Modelo de Crédito Parcial aplicado a la escala Distorsión del Big Five Questionnaire; The Partial Credit Model applied to the Lie Scale of the Big Five Questionnaire Abal, Facundo Juan Pablo; Lozzia, Gabriela Susana; Auné, Sofía Esmeralda; Attorresi, Horacio Felix Se aplicó el Modelo de Crédito Parcial (MCP) de la Teoría de Respuesta al Ítem al análisis de ítems de la adaptación española escala Distorsión del Big Five Questionnaire. Esta escala evalúa la tendencia de los individuos a ofrecer un perfil distorsionado. Participaron 1592 adultos de población general (55% sexo femenino). El análisis de los datos se realizó con Winsteps. El ajuste del MCP fue adecuado para todos los ítems; no obstante, un porcentaje considerable de evaluados no presentó un patrón de respuestas acorde a las expectativas del modelo. Cinco ítems presentaron inversiones en el orden esperable para los valores estimados de parámetros de umbral. Los resultados revelaron las debilidades que presenta la escala y orientan sobre posibles modificaciones futuras.; The Partial Credit Model (PCM) of the Item Response Theory was applied to the Spanish Lie Scale adaptation of the Big Five Questionnaire. The scale measures individuals’ tendency to provide a distorted profile. The sample comprised 1592 adults from the general population (55% females). All analyses were performed by means of Winsteps software. The PCM exhibited satisfactory goodness-of-fit for all items. However, a considerable proportion of respondents had incongruent response patterns which were not in agreement with the model’s expectations. Five items presented inversions in the order expected for the estimated values of threshold parameters. These findings show the scale weaknesses and yield useful information to guide possible changes in future research.

Miradas antropológicas respecto de la ocurrencia de suicido de jóvenes en la ciudad de Bahía Blanca, Argentina (2010- 2013); Anthropological approach to the ocurrence of young men suicide at Bahia Blanca city, Argentina (2010-2013) Noceti, Maria Belen; Eliosoff, Dévora Isolda Desde una perspectiva antropológica se caracteriza el fenómeno del suicidio. Se presentan antecedentes etnográficos en el tratamiento del fenómeno desarrollado a lo largo de la historia de la Antropología como disciplina científica. Empíricamente se presentan resultados de una investigación en torno a suicidios de jóvenes varones ocurridos durante el periodo 2010 al 2013, en Bahía Blanca, Argentina. La muerte acontece como parte de un diálogo entre el suicida y sus referentes; resulta medio por el que los jóvenes manifiestan malestar en relación al lugar que ocupan en la red de relaciones en la que se encuentran inmersos. El suicidio consiste en un acto perlocutorio en medio de una contienda dialógica ante el reclamo por tal malestar. El diálogo es interrumpido impestivamente por la muerte del joven, que la perpetra ante la imposibilidad de generar algún tipo de estrategias argumentativas para sostener su reclamo frente a sus otros significantes. El comportamiento de estos otros, a posteriori del acto fatal, evidencia que el suicida mediante la destrucción de la persona física logra preservar la persona social. Se propone la necesidad de generar políticas de prevención del suicidio donde la muerte sea resignificada, a fin de generar contraargumentos que neutralicen al suicidio como reacción.