Una Europa a la medida de Japón: un estudio sobre la construcción del discurso jesuita en la misión japonesa en la segunda mitad del siglo XVI; Europe shaped for the Japanese: analyzing the jesuit discourse in the Japanese mission in the second half of the 16th century Hoyos Hattori, Paula El presente artículo propone un estudio de la imagen de Europa que los jesuitas construyeron de manera deliberada durante la misión japonesa y procuraron divulgar entre los feligreses de la reciente iglesia de Japón. Para ello, trabajaremos con una colección de cartas redactadas desde allí, impresa en Évora en 1598 y otros documentos jesuitas: el Sumario de las cosas de Japón (1583), un informe del Visitador de la Compañía en Asia, Alessandro Valignano; De missione legatorum (1590), un diálogo latino atribuido al jesuita Duarte de Sande; y las instrucciones redactadas por el mismo Valignano para guiar a distancia la primera embajada de Japón a Europa. Nos demoraremos en dos estrategias comunicativas que buscaban legitimar el lugar preeminente de Europa a nivel mundial: el desarrollo de seminarios para conformar un clero nativo y la planificación de esa embajada de cuatro jóvenes japoneses, nobles y conversos, enviada a Roma en 1582.; This paper analyzes the image of Europe portrayed in the Jesuit documents written from the Japanese mission. This image was deliberately made and disclosed by the missioners among the new Japanese Christians. For this goal, the paper deals with different Jesuit sources: (i) a collection of letter published in Évora in 1598; (ii) the Sumario de las cosas de Japón (1583), written by the Visitor of the Society of Jesus in Japan, Alessandro Valignano; (iii) the latin dialogue De missione legatorum (1580), written by Duarte de Sande S.J.; (iv) Valignano’s Instructions for the Embassy.

Psicoanálisis y educación: lo imposible versus la razón evaluadora; Psychoanalysis and education: about the impossible versus the evaluative reason Giuliano, Facundo El deseo de este artículo es profundizar la reflexión ético-política en torno al vínculo entre psicoanálisis y educación pudiendo enseñar, desde una perspectiva interpretativa, las principales tensiones y contradicciones de lo que podría llamarse los mecanismos psíquicos de la razón evaluadora. Esto supone ubicarse en torno a lo imposible para explorar y problematizar, entre otros asuntos, algunos aportes de Freud en relación con las pulsiones y de Lacan en relación con el no-saber, el conocimiento y la verdad, que dan lugar a lo in-evaluable.; The desire of this article is to deepen the ethical-political reflection around the link between psychoanalysis and education, being able to teach, from an interpretative perspective, for the main tensions and contradictions of what we called the psychic mechanisms of the evaluative reason. This involves locating around the impossible to explore and problematize, among other issues, some contributions of Freud in relation to the drives and Lacan in relation to not knowing, knowledge and truth, which gives rise to the unevaluable.

Resistencia a metales pesados y antimicrobianos en cepas de enterococos aisladas de cerdos del Valle Inferior del Río Chubut - Argentina; Resistance to heavy metals and antimicrobial in enterococci strains isolated from pigs of Valle Inferior del Río Chubut - Argentina Vallejo, Marisol; Gil, Marianela Soledad; Parada, Romina Belén; Marguet, Emilio Rogelio El objetivo de este trabajo fue determinar la presencia de factores de virulencia, resistencia a metales pesados y antibióticos en 65 cepas de Enterococcus aisladas del contenido fecal de cerdos, recolectadas en el Valle Inferior del Río Chubut. La producción de exopolisacáridos fue el factor de virulencia más frecuente y se detectó en 45 cepas, mientras que la actividad de gelatinasa se presentó en una sola cepa; el mismo resultado se obtuvo para la actividad hemolítica. La prueba en agar reveló que 25 cepas presentaron resistencia a zinc (≥12 mM) mientras que 64 exhibieron resistencia intermedia a cobre (4-12 mM). Todas las cepas seleccionadas en función de su resistencia al zinc exhibieron resistencia a tetraciclina, dos de ellas a vancomicina y solo una a teicoplanina. Todas las cepas seleccionadas resultaron sensibles a la ampicilina. Mediante PCR se obtuvo la amplificación del gen tetM en 22 cepas que mostraron resistencia a la tetraciclina. Los resultados obtenidos en este estudio evidenciarían el uso generalizado de zinc y tetraciclina como promotores de crecimiento en la alimentación de cerdos. Esta práctica ejerce una presión selectiva en especies bacterianas animales y contribuye a la propagación de la resistencia a los antibióticos.; The objective of this work was to determine the presence of virulence factors, heavy metal resistance and antibiotic in 65 Enterococcus strains isolated from fecal content of pigs, collected in the Valle Inferior del Río Chubut. Exopolysaccharides production was the most frequent virulence factor and was detected in 45 strains, while gelatinase activity was displayed by only one strain; same result was obtained for hemolytic activity. Agar plates test revealed that 25 strains were resistant to zinc (≥12 mM) while 64 strains exhibited intermediate copper resistance (4-12 mM). All strains selected on the basis of their resistance to zinc exhibited resistance to tetracycline, two of them resistance to vancomycin and only one resistance to teicoplanin. All strains selected were sensitive to ampicillin. PCR techniques allowed the amplification of tetM gen in 22 strains among the 25 that showed resistance to tetracycline. The results obtained in this study would evidence the widespread usage of zinc and tetracycline as growth promoters in pig feeding. This practice exerts selective pressure in animal bacterial species and contributes to the spread of antibiotic resistance.

¿Qué ocurre cuando un programa de gobierno se transforma progresivamente en un monstruo deseable?: Recordando la dimensionalidad múltiple del Programa Conectar Igualdad; What happens when a government programme transforms itself into a desirable monster?: A recollection on the multiple dimensions of the Connecting Equality Programme Seijo, Gustavo Luis; Calamari, Marina Laura; Fidmay, Paloma; Ozono, Maximiliano Eduardo Este artículo centra su interés en el análisis del Programa Conectar Igualdad que ha distribuido netbooks entre estudiantes y profesores de escuelas argentinas. Se propone indagar en este trabajo acerca del carácter multi-dimensional de este programa de gobierno. Implica esto que el Conectar Igualdad es un programa que buscaba, inicialmente, reducir la brecha digital y mejorar el acceso a tecnologías de información y comunicación. El proceso de implementación del Conectar Igualdad ha incorporado también objetivos educativos, políticos, industriales y de infraestructura de forma sostenida a esta iniciativa original. Este artículo aborda precisamente este modo de conformación progresiva que ha adoptado el Programa Conectar Igualdad e intenta pensar implicancias para la gestión futura de este tipo de iniciativas de política pública.; This study addresses the Connecting Equality Programme (CEP) which has been delivering netbooks among students and teachers of Argentinian schools. This article explores the multi-dimensional nature of this government programme. The analysis claims that, in similar fashion to the ‘One Laptop per Child’ programme, the CEP aimed at reducing the digital gap by improving the access to information and communication technology in Argentina. However, and in stark contrast to the One Laptop per Child programme, the implementation process of the CEP highlights the progressive incorporation of educational, political, infrastructural and industrial objectives aside from the aforementioned reduction of the digital gap. Therefore, this study addresses the progressive incorporation of many dimensions and objectives within the frame of a single government programme and suggests a number of future managerial implications for this type of public policy initiative.

Celdas en cuña para refractometría: criterios de selección de materiales y parámetros; Wedge cells for refractometry: materials and parameters selection criteria Vázquez, Patricia María Elena; Oreglia, Eduardo Victor; Ciocci Brazzano, Ligia; Veiras, Francisco Ezequiel; Matteo, Claudia Leda; Sorichetti, Patricio Aníbal Este trabajo presenta criterios de selección de materiales y parámetros de celdas en cuña para refractometría en el rango visible. Estas celdas consisten en dos prismas de ángulo recto enfrentados, que definen una cavidad con forma de cuña entre ellas, en la que se coloca la muestra cuyo índice de refracción se desea medir. Éste se determina a partir de la desviación de un haz luminoso que atraviesa la celda. Este modelo para fines de ingeniería tiene en cuenta la geometría de la celda y los índices de refracción del material de la celda y de la muestra. A partir de allí realizamos el cálculo numérico y trazado de rayos correspondiente al sistema óptico. También proponemos ajustes polinómicos para simplificar el tratamiento numérico, como complemento de las ecuaciones completas. Estos polinomios dan el índice de refracción de la muestra como una función explícita del ángulo de deflexión. Se incluye además el análisis de los errores de la aproximación.; This work presents the materials and parameters selection criteria of wedge cells for refractometry in the visible range. These cells consist of two right angle prisms facing each other, defining a wedge-shaped cavity where the sample is placed. The refractive index of the sample is determined from the deviation of a light beam that traverses the cell. This model for engineering purposes includes the cell geometry and the refractive indexes of the cell material and the sample. We perform the numerical calculation and ray tracing of the optical system. We also propose polinomial fitting functions in order to simplify the numerical treatment, and as a complement to the complete set of equations. These polynomials give the refractive index of the sample as an explicit function of the deviation angle. An analysis of the approximation errors is also given.

Gestión de la demanda en las redes inteligentes. Perspectiva y control desde el usuario y la distribuidora; Demand management in smart networks. Perspective and control of users and suppliers Bragagnolo, Sergio Nicolás; Vaschetti, Jorge Carlos; Magnago, Fernando; Gomez Targarona, Juan Carlos de Jesus El objetivo de este artículo es desarrollar el concepto de gestión de la demanda en relación a los tipos de control existentes y presentar un ejemplo simple de optimización de la demanda para evaluar las potencialidades de un control híbrido. Se presenta una breve introducción, detallando el conocimiento actual en gestión de demanda, se desarrolla el concepto de control directo e indirecto sobre la demanda, se identifica, y se elabora una tabla con las cargas residenciales. Se modelan dos residencias que podrán modificar su carga ante un esquema de precios dados y un objetivo de no concentración de la demanda fijados por la distribuidora, obteniendo una correcta optimización y dispersando las cargas de diferente forma en la segunda ronda. Se concluye que una intervención de la distribuidora puede mejorar la distribución de la demanda por la aleatoriedad del algoritmo genético sin comprometer la privacidad del usuario.; The article aims is to develop the demand side management concept in relation to existing control types. It also aims to providing a simple example of demand optimization to evaluate the potentialities of a hybrid control. A brief introduction is presented detailing the state of the art. Then, the direct and indirect control over demand was discussed, the types of loads were described, and a table with the residential loads was prepared. Two residences were modeled, which could modify their load before a given price scheme and a non-concentration objective set by the distributor. This resulted in obtaining a correct optimization and distributing of the loads in a different way in the second round. It is concluded that an intervention of the distributor can improve the distribution of the demand by the randomness of the genetic algorithm without compromising user privacy.

Context-specific functions of Notch in Drosophila blood cell progenitors Blanco Obregón, Dalmiro Manuel; Katz, Maximiliano Javier; Durrieu, Lucía; Gándara, Lautaro; Wappner, Pablo Drosophila Larval hematopoiesis takes place at the lymph gland, where myeloid-like progenitors differentiate into Plasmatocytes and Crystal Cells, under regulation of conserved signaling pathways. It has been established that the Notch pathway plays a specific role in Crystal Cell differentiation and maintenance. In mammalian hematopoiesis, the Notch pathway has been proposed to fulfill broader functions, including Hematopoietic Stem Cell maintenance and cell fate decision in progenitors. In this work we describe different roles that Notch plays in the lymph gland. We show that Notch, activated by its ligand Serrate, expressed at the Posterior Signaling Center, is required to restrain Core Progenitor differentiation. We define a novel population of blood cell progenitors that we name Distal Progenitors, where Notch, activated by Serrate expressed in Lineage Specifying Cells at the Medullary Zone/Cortical Zone boundary, regulates a binary decision between Plasmatocyte and Crystal Cell fates. Thus, Notch plays context-specific functions in different blood cell progenitor populations of the Drosophila lymph gland.

Mirá cómo luchamos: Reflexiones sobre la acción de repudio a Darthés en Brasil; Look how we fight: Analysis on the action of repudiation to Darthés in Brazil Camezzana, María Daniela Desde el 3 de junio de 2015, se multiplicaron las actuaciones colectivas que interpelan los modos establecidos de producir lo cotidiano, abriendo nuevas preguntas sobre el lugar del cuerpo en las prácticas políticas callejeras y la posibilidad de construir la hospitalidad (López, 2019) necesaria para reunir diversas formas de existencia dentro del movimiento feminista. En este sentido, el presente trabajo se propone analizar la acción que realizaron residentes argentinas en San Pablo, Brasil, bajo el lema "El repudio a Juan Darthés cruza fronteras" cuando tomaron conocimiento del viaje del actor acusado de violación a dicha ciudad tras la conferencia de prensa que brindó el Colectivo Actrices Argentinas. Entendiendo que la misma marcó un hito en la causa feminista argentina, se abordará como un espacio liminal que habilita una lectura en tanto producto mediático y otra como acontecimiento situado en un marco de enunciación mayor que las actrices venían construyendo con sus anteriores apariciones. En segundo lugar, no solo se considerarán las imágenes, consignas y otros elementos significantes utilizados durante la acción realizada en la Avenida Paulista sino que se tendrán en cuenta a partir de las impresiones que relatan las participantes en la entrevista de campo, lo que quedó resonando en “el cuerpo” afectado en la experiencia y las repercusiones recibidas luego de la irrupción callejera. A modo de conclusión, se consignarán también las instancias de negociación con las participantes que posibilitaron la construcción de una noción compartida de los riesgos “palpables” en el contexto local. A partir de la cual se repensaron los sentidos de agencia social empleados a priori en otros artículos sobre performances.; Since June 3, 2015, collective actions that question the established ways of producing the daily life, opening new questions about the place of the body in street political practices and the possibility of building the hospitality necessary to gather various forms of existence inside the feminist movement. In this sense, the present work intends to analyze the action carried out by Argentine residents in São Paulo, Brazil, under the slogan "The repudiation of Juan Darthés crosses borders" when they took knowledge about the trip of the actor accused of rape after the conference press provided by the Actresses Argentinas Collective. Understanding that it marked a milestone in the Argentine feminist cause, it will be approached as a liminal space that enables a reading as a media product and another as an event inscribed in a framework of greater enunciation that the actresses had been building with their previous appearances. Secondly, not only will the images, slogans and other significant elements used during the action carried out on Avenida Paulista be considered, also be taken into account the impressions of the participants expressed in the interview, which resonated in " the body” affected by the experience and the repercussions received after the street performance. By way of conclusion, the negotiation instances with the participants that made possible the construction of a common notion of “feel” risks in the local context will also be included. From which the senses of social agency used a priori in other articles on performances were reviewed.

El rol protagónico de la Confederación Obrera Regional Argentina en la huelga general del Centenario, mayo de 1910; The leading role of the Argentine Regional Workers Confederation in the Centennial general strike, May 1910 Belkin, Alejandro Marcelo El año 1910 constituye un momento clave en la historia argentina por el Centenario de la Revolución de mayo y un punto de inflexión en la historia del movimiento obrero argentino por la huelga general y la represión. En este artículo nos propusimos indagar en la estrategia del sindicalismo revolucionario local hacia la huelga general del Centenario. En ese marco, examinamos el rol desempeñado por la Confederación Obrera Regional Argentina en los sucesos que derivaron en la medida de fuerza. Asimismo, analizamos las diferentes respuestas elaboradas por el movimiento obrero ante los distintos tipos de protestas, el amplio apoyo a las luchas de carácter económico y el escaso respaldo a la lucha política. Hemos utilizado diversos tipos de fuentes, publicaciones políticas y gremiales, diarios comerciales y documentos oficiales; The year 1910 constitutes a key moment in Argentine history for the Centennial of the May Revolution and a turning point in the history of the Argentine labour movement due to the general strike and repression. This article aim to investigate the strategy of the local revolutionary unionism, towards the Centennial general strike. In this context, we examine the role played by the Argentine Regional Workers Confederation in the events that led to the force measure. Likewise, we analyze the different responses prepared by the labour movement to the different types of protests, the broad support for economic struggles and the scant support for the political struggle. We have used various types of sources, political and union publications, business journals and official documents.

Distribution of the organic anion transporters Oat1 and Oat3 between renal membrane microdomains in obstructive jaundice Nosetto, Evangelina Cecilia; Campagno, Romina Valeria; Torres, Adriana Mónica; Brandoni, Anabel Relation between the renal function and the membrane environment where the organic anion transporters Oat1 and Oat3 are localized is scarce. The aim of this study was to examine the Oat1 and Oat3 distribution in different cellular fractions under physiological conditions as well as the effects of extrahepatic cholestasis on membrane distribution of both proteins. Besides, the potential role of jaundice serum on the Oat1 and Oat3 expression in suspensions of renal tubular cells was evaluated. Cellular and membrane fractions of renal cortex were obtained from control rats to evaluate Oat1 and Oat3 protein expressions. Other rats were subjected to bile duct ligation (BDL) or Sham operation to determine the membrane distribution of Oat1 and Oat3 between lipid raft domains (LRD) and non-LRD. Incubation of renal cortical cells with serum from Sham and BDL were also performed to study Oat1 and Oat3 protein expressions. In physiological conditions, Oat1 and Oat3 were concentrated in LRD. The pathology induced a shift of Oat1 from LRD to non-LRD, while Oat3 showed no changes in its distribution. In cells exposed to BDL serum, Oat1 protein expression in membranes significantly increased. For Oat3, no difference between groups was observed. The Oat1 redistribution to non-LRD in BDL could be favoring the increase in renal transport of organic anions previously observed. This change was specific to Oat1. The in vitro experiment allows to conclude that some component present in BDL serum is responsible for the alterations observed in Oat1 expression in cortical membranes.

Nuevo financiamiento nacional para vivienda: características e implementación de préstamos hipotecarios UVA en Rosario; New national financing for housing: characteristics and implementation of the UVA mortgage loans in Rosario Barenboim, Cintia Ariana Uno de los mayores problemas que tiene Argentina es la dificultad del acceso a la vivienda propia para los sectores medios. Si bien los créditos hipotecarios pueden ser una solución, no han tenido una gran participación, representando solo el 1,5% del PBI en el 2012. En respuesta, ese mismo año se lanzó el “Programa Pro.Cre.Ar” limitado parcialmente por el nuevo gobierno en 2016 que crea otro sistema de financiamiento basado en la “Unidad de Valor Adquisitivo” (UVA), actualizado con el Coeficiente de Estabilización de Referencia regido por el índice general de inflación. En este contexto el objetivo principal del artículo radica en analizar el nuevo sistema de financiamiento público UVA para obtener una vivienda propia en Rosario. La metodología es descriptiva, centrada en el análisis de contenido de documentos escritos (investigaciones, artículos periodísticos, documentos oficiales) y realización de entrevistas semi- estructuradas. Los resultados muestran que en sus comienzos no tuvo problemas, las cuotas eran bajas (similares a la de un alquiler) y los bancos públicos tuvieron mayor protagonismo pero desde el 2018 con la acelerada inflación, la devaluación de la moneda, los consecuentes incrementos de las UVA y tasas fijas hicieron que la demanda se redujera, prácticamente no habiendo solicitudes. Los resultados muestran que en sus comienzos no tuvo problemas, las cuotas eran bajas (similares a la de un alquiler) y los bancos públicos tuvieron mayor protagonismo pero desde el 2018 con la acelerada inflación, la devaluación de la moneda, los consecuentes incrementos de las UVA y tasas fijas hicieron que la demanda se redujera, prácticamente no habiendo solicitudes.; One of the biggest problems that Argentina has is the difficulty of access to own housing for the middle sectors. Although mortgage loans can be a solution, have not had a large participation, representing only 1.5% of GDP in 2012. In response, that same year the "Pro.Cre.Ar Program" was partially launched, which was then limited by the new government in 2016 that creates another financing system based on the "Purchase Value Unit" (UVA), updated with the Reference Stabilization Coefficient governed by the general inflation index. In this context, the main objective of the article is to analyze the new UVA public financing system to obtain a home of its own in Rosario. The methodology is descriptive, focused on the content analysis of written documents (research, journalistic articles, official documents) and semi-structured interviews. The results show that in its beginnings it did not have problems, the quotas were low (similar to that of a rent) and the public banks had greater protagonism but since 2018 with the accelerated inflation, the devaluation of the currency, the consequent increases of the UVA and fixed rates caused the demand to be reduced, with practically no requests.

A new abelisauroid (Dinosauria: Theropoda) from the Huincul Formation (lower Upper Cretaceous, Neuquén Basin) of Patagonia, Argentina Baiano, Mattia Antonio; Coria, Rodolfo Anibal; Cau, Andrea A new ceratosaurian theropod dinosaur, Huinculsaurus montesi gen. et sp. nov., is described here. This taxon is based on the last three dorsal vertebrae and the first and second sacral vertebrae found in association at Aguada Grande, Neuquén Province, Argentina. Although fragmentary, Huinculsaurus shows a unique mix of features which differentiates it from all other theropods, including the sympatric abelisaurid Ilokelesia, and is diagnosed by prezygapophyseal articular facets twice longer than wide, anterior centroparapophyseal lamina strongly developed as an extensive lateral lamina in the posterior dorsal vertebrae, pneumatic foramina located ventrally to the postzygodiapophyseal lamina in the posterior dorsal vertebrae, posteriorly tapering postzygapophysis pointed posteriorly, and an accessory lamina bisecting the parapophyseal centrodiapophyseal fossa in the posterior dorsal neural arches. Phylogenetic analyses recovered Huinculsaurus as most closely related to the Late Jurassic Elaphrosaurus than to other Cretaceous abelisauroids, suggesting the persistence of the elaphrosaurine lineage in South America up to the early Late Cretaceous.

Pasado y presente en la obra de Natalio Botana: Lecturas de un historiador de la libertad, el poder y la historia. Conversaciones con Fernando Rocchi (EDHASA 2019); Past and present in the work of Natalio Botana: readings of a historian of freedom, power and history. Conversations with Fernando Rocchi (EDHASA 2019) Bragoni, Elsa Beatriz El artículo reflexiona sobre el reciente libro de Natalio Botana en el que traza su propia biografía intelectual en conexión con la historia política contemporánea. Escoge algunos nudos fundamentales (legitimidad – gobierno limitado- federalismo – partido político) con el propósito de puntualizar interrogantes, conceptos y procedimientos de investigación que gravitaron en la renovación de la historiografía política del siglo XIX argentino y latinoamericano.; This article reflects on Natalio Botana´s recent book in which he traces his own intellectual biography in connection with contemporary political history. It selects fundamental key issues (legitimacy - limited government - federalism - political party) with the purpose of clarifying questions, concepts and research procedures that weighed on the renewal of political historiography of the 19th century in Argentina and Latin America.

Trielectrode plasma reactor for water treatment Giuliani, Leandro Estanislao; De Angelis, L.; Díaz Bukvic, Gema; Zanini, Matías; Minotti, Fernando Oscar; Errea, María Inés; Grondona, Diana Elena Water pollution due to emerging organic pollutants, such as agrochemicals, has become a topic of growing interest worldwide. The increase of pollutants in aquatic systems stimulated the development of new strategies for water remediation. Plasma technology is an advanced oxidation process which has proved to be an efficient method for organic matter degradation. In this work, a novel design of a trielectrode plasma reactor based on a dielectric barrier discharge extended to a third electrode operated in ambient air is presented. The water to be treated flows through a gutter with low impedance and far from the electrodes connected to the voltage sources. The reactor operates in ambient air, and it does not rely on the use of expensive inert gases. The design of the reactor is easily scalable. The performance of the reactor, in terms of the removal efficiency and the energy yield, was tested in an aqueous solution of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), one of the most widely used around the world. The reactor presents a good efficiency in the removal of the herbicide 2,4-D and values of energy yield of about 240 mg/kW h.

Quadratic helicity and cosmological magnetic fields Akhmet'ev, Peter; Cirilo, Diego Julio; Smirnov, Alexandr In this work, the quadratic helicity χB(2) is discussed from the physical and topological points of view. We show, after the introduction of a mathematical description of the properties of helicity and quadratic helicity in the context of standard dynamo equations, examples of the importance of these high invariants in cosmological scenarios. These scenarios consider extensions of the standard model and extensions of GR.

Physics of in vitro magnetofection. Effect of magnetic transport and redistribution of nanoparticles Arciniegas Vaca, Magda Lorena; Pasquevich, Gustavo Alberto; Mykhaylyk, Olga; Mele, Nicolás Germán; Goya, Rodolfo Gustavo; Sanchez, Francisco Homero A comprehensive study of relevant aspects of the physics behind in vitro magnetic assisted transfection, or magnetofection is presented. Magnetofection experiments were performed as a function of culture-magnet distance for a fixed time of 30 min, as a function of time for a fixed separation of about 1 mm, and under special geometries chosen to elucidate the relative effects of gravitational and magnetic forces. It is shown that under appropriate conditions, in vitro magnetofection can be performed with almost equal easiness in any desired space direction, even against gravity. Redistribution of magnetic nanoparticles in a colloid, with an initial uniform distribution, was studied with the same experimental setup used in magnetofection experiments, as a function of time, and as a function of culture-magnet relative position. It was found that magnetic nanoparticles tend to arrange into concentrated regions with ring or circle shapes, and that final distribution depends strongly on relative position. Cellular uptake of magnetic nanoparticles was estimated for standard magnetofection and for no applied magnetic field experiments. A consistent description of results is given by comparing magnetofection efficiency, nanoparticles uptake and redistribution experiments. The results presented here constitute novel information that will contribute to gaining deeper understanding of how magnetofection proceeds and how can be improved. They impact directly on in vivo procedures, providing conceptual tools to optimize setup geometry and magnetic field application time.

El papel del análisis financiero en la identificación de las incertidumbres sobre empresa en marcha; The role of financial analysis in identifying uncertainties about going concern Briozzo, Anahi Eugenia; Albanese, Diana Ester; Pullés, Yanina; Di Rocco, Paula El objetivo de este trabajo es analizar empíricamente la relación de los ratios financieros y las características de la empresa, con la inclusión de un párrafo de énfasis por la incertidumbre sobre empresa en marcha en el informe del auditor. Se estudian las firmas que realizan oferta pública de sus acciones en los mercados de valores de Argentina. El análisis estadístico se realiza en dos etapas: análisis bivariado con tests no paramétricos y análisis multivariado empleando una regresión probit. Los resultados del análisis bivariado muestran que la antigüedad, la razón corriente y los ratios de endeudamiento están significativamente asociados con la incertidumbre de empresa en marcha. En el análisis multivariado son relevantes con efecto negativo el margen sobre ventas y la antigüedad, mientras que el ratio de endeudamiento muestra un efecto positivo.; The aim of this work is to empirically analyze the relationship of financial ratios and firm characteristics with the inclusion of an emphasis paragraph for uncertainty related to the going concern assumption in the auditor’s report. The firms that make public offers of their shares in the stock markets of Argentina are studied. Statistical analysis is carried out in two stages: bivariate analysis with non-parametric tests, and multivariate analysis using a probit regression. The results of the bivariate analysis show that the age of the firm, current ratio, and solvency ratios are significantly associated with the uncertainty of a going concern. In the multivariate analysis, the margin on sales and the age of the firm are relevant, with a negative effect on the likelihood of the firm having a report with an emphasis on uncertainty of a company in progress, while the debt ratio shows a positive effect.

Tulio Halperin Donghi y sus contextos, 1962 Viale, Adrián Mariano Introducción a la reedición del artículo de Tulio Halperin Donghi: "Historia y larga duración: examen de un problema".

A new megaflora (leaves and reproductive structures) from the Huancané Formation (Lower Cretaceous), Peru Martinez, Leandro Carlos Alcides; Pacheco Huacallo, Edgar; Pujana, Roberto Roman; Padula, Horacio We describe fossil leaves and reproductive structures remains from the Lower Cretaceous of Peru. A great part of the plant fossils are very well preserved, and they come from three different stratigraphic levels of the Huancane Formation in a single locality close to Cusco City. The fossil flora is dominated by Brachyphyllum, Cupressinocladus, Podozamites, leaves assigned to the Araucariaceae and Araucarites Presl. Other leaf fossil-genera found are: Weichselia, Sagenopteris, Sphenopteris, and Pachypteris. This fossil assemblage is consistent with the age inferred for the Huancane Formation, which was based on biostratigraphic and isotopic studies. The plant assemblage suggests a forest canopy dominated by conifers, with an understore composed by ferns (Weichselia) and putative pteridosperms. These new data increase the knowledge of the palaeofloristic composition of the Cretaceous flora of Peru, contribute to the fossil record of South America, and particularly to the palaeoflora near equatorial regions.

Data of ureagenesis from ammonia, glutamine and alanine, and mitochondrial aquaporin-8 expression in thioacetamide-treated hepatocytes Capiglioni, Alejo Matías; Alvarez, María de Luján; Marinelli, Raul Alberto We present data about the synthesis of urea from different substrates, i.e., free ammonia, glutamine and alanine in primary cultured rat hepatocytes treated or untreated with the model hepatotoxic agent thioacetamide (TAA). We also provide data about the expression of mitochondrial aquaporin-8 (mtAQP8), a hepatocyte channel protein which facilitates ammonia diffusion into mitochondria to supply the urea cycle. Ammonia-derived ureagenesis was significantly inhibited by about 30% while that from the both amino acids resulted unaffected in TAA-treated hepatocytes. Protein expression of mtAQP8 was decreased by about 80% after TAA treatment. These data can be useful for the understanding of the mechanisms of drug-induced hepatic dysfunction.