Las formas de la vitalidad en la recepción de una obra teatral; Forms of vitality in the reception of a theater work Nudler, Alicia Clara; Jacquier, María de la Paz; Español, Silvia Ana En el artículo se describe un estudio empírico realizado con espectadores de una obra deteatro-danza, cuyo objetivo fue explorar la captación de formas de la vitalidad (Stern, 1985 y2010). El estudio se caracteriza por un diseño complejo que implicó (a) la puesta en escenade una obra teatral, (b) la conformación de un estímulo novedoso a partir de la obra, y (c)la creación de tareas a ser realizadas por los espectadores al finalizar la función. La obra a laque asistieron los espectadores/participantes fue Dibaxu del director Hugo Aristimuño. Elestímulo creado fue la proyección de dos fragmentos de la obra filmados en vivo en una delas funciones. Las tareas fueron cuatro: dos tareas no-verbales, originales y novedosas, y dosverbales. Se describen los rasgos particulares de la obra, el proceso de creación del estímulo ylas tareas creadas. Se presentan los resultados de la tarea verbal que consistió en la selecciónde palabras descriptoras de formas de la vitalidad para caracterizar los fragmentos seleccionados de la obra presenciada. Se comentan luego los desafíos metodológicos del estudiode la recepción de espectáculos en vivo, se realizan comparaciones con otros trabajos delcampo, y se resalta la virtud del diseño que permitió crear un estímulo breve que conserva,sin embargo, las cualidades de la obra completa. Finalmente, se discute la contribución de lainvestigación realizada tanto al estudio de las formas de la vitalidad como a los estudios depúblicos de teatro y danza de orientación cognitiva.; This article describes an empirical study conducted with spectators of a theater-dance piece with the goal of exploring the reception of forms of vitality (Stern, 1985 and 2010). The study entails a complex design including a) the production of a live performance; b) the creation of an original stimulus based on the play; c) the design of tasks to be carried by spectators after the show. The performance attended by the spectators/participants was Dibaxu by theater director Hugo Aristimuño. The stimulus was the projection of two excerpts of the play recorded during one of the live performances. The tasks were four: two non-verbal tasks, original and innovative, and two verbal ones. The specific traits of the performance, the process of creation of the stimulus and the tasks carried by participants are described. The results are presented of the verbal task consisting in the selection by participants of forms of vitality words to describe the excerpts. The article also discusses the challenges of studying the reception of live performances, establishes comparisons with other studies in the field, and points to the advantage of designing a short stimulus which nevertheless retains some of the qualities of the whole performance. Finally, it discusses the contribution of the study to the knowledge of forms of vitality and to cognitively oriented research on dance and theater audiences.

Presencia de Aspergillus flavus en lotes de maíz de Santiago del Estero, norte de Córdoba y este de Tucumán Barontini, Javier Miguel; Druetta, Marcelo Alberto; Luna, Ivana Natasha; Torrico Ramallo, Ada Karina; Chulze, Sofia Noemi; Giménez, María de la Paz Argentina se encuentra entre los líderes mundiales en producción de maíz, ocupando el sexto lugar como productor y oscila entre el tercero y cuarto como exportador. En la campaña 2018/19, el país produjo alrededor de 57 millones de toneladas. La región conformada por la provincia de Santiago del Estero, este de Tucumán y norte de Córdoba es responsable de entre 10 y 20 % de la producción nacional, dependiendo de los factores climáticos propios de cada ciclo agrícola.

Impresión 3D en tecnología farmacéutica: MESO PP® un proceso simplificado de obtención de formas farmacéuticas sólidas Barberis, Maria Eugenia; Real, Juan Pablo; Palma, Santiago Daniel La manufactura aditiva, más comúnmente conocida como impresión 3D (I3D) es a todas luces una herramienta que está impactando en muchos campos de la producción (1). La I3D es un proceso que permite crear objetos sólidos a partir de modelos digitales prediseñados, añadiendo el material capa por capa hasta lograr la forma alojada en un archivo digital. Con sólo modificar el diseño y adaptando el archivo de base, es posible crear estructuras geométricas diferenciadas en tamaño y forma, usando exactamente la misma impresora (2, 3).La tecnología de I3D ha sido incorporada hace más de 30 años. Su inventor, Charles Hull, fue quien solicitó la patente del primer aparato destinado a manufactura aditiva en el año 1984.Hull diseñó su primera impresora 3D basada en esterolitografía la cual estuvo comercialmente disponible en el 1988 (4, 5). Desde entonces hasta la actualidad, han aparecido distintos procesos de I3D que utilizan procesos diferentes, velocidades de impresión y resoluciones diferenciales, como así también, diversos materiales. La tecnología farmacéutica ha puesto foco y atención en este tipo de procesos.

Reversals of Reforestation Across Latin America Limit Climate Mitigation Potential of Tropical Forests Schwartz, Naomi B.; Aide, T. Mitchell; Graesser, Jordan; Grau, Hector Ricardo; Uriarte, María Carbon sequestration through tropical reforestation and natural regeneration could make an important contribution to climate change mitigation, given that forest cover in many tropical regions increased during the early part of the 21st century. The size of this carbon sink will depend on the degree to which second-growth forests are permanent and protected from re-clearing. Yet few studies have assessed permanence of reforestation, especially not at a large spatial scale. Here, we analyzed a 14-year time series (2001–2014) of remotely sensed land-cover data, covering all tropical Latin America and the Caribbean, to quantify the extent of second-growth forest permanence. Our results show that in many cases, reforestation in Latin America and the Caribbean during the early 21st century reversed by 2014, limiting carbon sequestration. In fact, reversals of reforestation, in which some or all gains in forest cover in the early 2000s were subsequently lost, were ten times more common than sustained increases in forest cover. Had reversals of reforestation been avoided, forests could have sequestered 0.58 Pg C, over four times more carbon than we estimate was sequestered after accounting for impermanence (0.14 Pg), representing a loss of 75% of carbon sequestration potential. Differences in the prevalence of reforestation reversals across countries suggest an important role for socio-economic, political, and ecological context, with political transitions and instability increasing the likelihood of reversals. These findings suggest that national commitments to reforestation may fall short of their carbon sequestration goals without provisions to ensure long-term permanence of new forests.

Difusión de proyectos de investigación en institutos de formación docente: el caso de un simposio en el sur mendocino Di Marco, María Elisa; Pérez, María de Los Ángeles; García, Gastón César El presente estudio de caso refiere la realización de un Simposio de Investigación Educativa elaborado en el sur de Mendoza para difundir a la comunidad educativa los diferentes proyectos que fueron realizando los docentes de los Institutos de Formación Docente de la jurisdicción mencionada. En este sentido, el trabajo se estructura de la siguiente manera: primero, se ilustra la situación de la investigación educativa en el Nivel Superior enfatizando su importancia en Argentina, especialmente en el sur de Mendoza, junto con algunas consideraciones generales sobre cómo se comunican los resultados de los proyectos dentro de la misma institución; y segundo, una descripción del simposio junto con los resultados extraídos de encuestas realizadas a los docentes participantes, tanto en la inscripción como en la evaluación del evento. A modo de conclusión se realizan algunas reflexiones sobre la necesidad de generar este tipo de espacios para responder a las necesidades de difusión y comunicación de los proyectos de investigación docente en comunidades educativas.; This case study is about the execution of a symposium about education investigation made in southern Mendoza to dissemination the different projects that were carried out by teachers in the teacher training colleges in the jurisdiction before mentioned among the education community. In this sense this study is structured as follows: first, the situation of the education investigation in the southern Mendoza is illustrated emphasizing its importance in Argentina, especially in the south of Mendoza, together with some general considerations about how project results are communicated within the same institution; second, a description of the symposium along with the results taken form surveys made to participating teachers, not only in their registration but also in the event examination. Conclusions will be drawn about some reflections about the need to create this kind of space to reach to the need of spread and communication of the teacher investigation projects in education communities.

Fractional and integer stages of lithium ion-graphite systems: The role of electrostatic and elastic contributions Gavilán Arriazu, Edgardo Maximiliano; Hümöller, Juan Martin; Pinto, Oscar Alejandro; De Mishima, B. A. López; Leiva, Ezequiel Pedro M.; Oviedo, Oscar Alejandro In the present work, we analyze the hot topic of integer and fractional stages of lithium-ion batteries by using Monte Carlo simulations. While fractional stages have been demonstrated through several experimental, simulation and theoretical measurements, in other experimental techniques, such as electrochemical ones, there is no evidence for them. In previous work, we have analyzed the thermodynamics and kinetics of lithium-ion intercalation using a potential based on empirical parameterization, where multiple stages (integer and fractional) were found and analyzed. The present simulations suggest that if we consider repulsive elastic interactions in addition to electrostatic ones, the Hamiltonian symmetry is broken and there is no evidence for fractional stages. The physical origin of these repulsive interactions is assigned to the increasing graphite layer separation during lithium-ion intercalation. In the light of these simulations, selected experimental data are revisited, validating the presented novel parameterization. The parametrization used here can be used for other kinds of intercalation compounds, such as those involving Na or K.

Análisis preliminar de diatomeas holocénicas del sitio arqueológico para Yacu 1, Santiago del Estero- Argentina; Análisis preliminar de diatomeas holocenicas del sitio arqueológico para Yacu 1, Santiago del Estero- Argentina Perez Pincheira, Egly Veronica; Leon, Diego Catriel En el presente trabajo se presentan los resultados preliminares del análisis de diatomeas recuperadas en dos cuadrículas en el sitio arqueológico Para Yacu 1, Santiago del Estero-Argentina. La temporalidad relativa de estas biomineralizaciones, correspondiente al holoceno, se estableció a partir de su asociación a restos de cerámica prehispánica. Estos estudios permitieron inferir dos situaciones microambientales: 1) condiciones de humedad coincidentes con un cuerpo de agua y 2) momentos de desecación. Este último estado habría permitido el asentamiento humano recurrente en este espacio.; This paper presents the preliminary results of the analysis of diatoms recovered in two grids at the archaeological site Para Yacu 1, Santiago del Estero-Argentina. The relative temporality of these biomineralizations, corresponding to the Holocene, refers from their association to pre-Hispanic potery remains. These studies allowed two microenvironmental situations to be inferred: 1) moisture conditions coincident with a body of water and 2) moments of drying. The latter state would have allowed recurrent human settlement in this space.

Glaciomarine sequence stratigraphy in the Mississippian Río Blanco Basin, Argentina, southwestern Gondwana: Basin analysis and palaeoclimatic implications for the Late Paleozoic Ice Age during the Tournaisian Ezpeleta, Miguel; Rustán, Juan José; Balseiro, Diego; Davila, Federico Miguel; Dahlquist, Juan Andrés; Vaccari, Norberto Emilio; Sterren, Andrea Fabiana; Prestianni, Cyrille; Cisterna, Gabriela Adriana; Basei, Miguel The Late Paleozoic Ice Age (LPIA) has been well recorded in the uppermost Mississippian?Pennsylvanian of Gondwana. Nevertheless, little is known about the temporal and geographic dynamics, particularly during the early Mississippian. We report on exceptional Tournaisian glaciomarine stratigraphic sections from central Argentina (Río Blanco Basin). Encompassing c. 1400 m, these successions contain conspicuous glacigenic strata with age constraints provided bypalaeontological data and U/Pb detrital zircon age spectra. A variety of marine, glaciomarine and fan-deltaic environments indicate relative sea-level variations mainly associated with tectonism and repetitive cycles of glacial activity. Provenance analysis indicates a source from the Sierras Pampeanas basement located to the east. Fifteen sequences were grouped into threedepositional models: (1) Transgressive Systems Tracts (TST) to Highstand Systems Tracts (HST) sequences unaffected by glacial ice; (2) Lowstand Systems Tracts (LST) to TST and then to HST with glacial influence; and (3) non-glacial Falling-Stage Systems Tracts (FSST) to TST and HST. The glacial evidence indicates that the oldest Mississippian glacial stage of the LPIA in southwestern Gondwana is constrained to the middle Tournaisian. In contrast with previous descriptions of Gondwanan coeval glacial records, our sequence analysis confirms complex hierarchical climate variability, rather than a single episode of ice advance and retreat.

Increased expression of autophagy protein LC3 in two patients with progressing chronic lymphocytic leukemia Arroyo, Daniela Soledad; Rodríguez, Cecilia Inés; Bussi, Claudio; Manzone Rodriguez, Clarisa; Sastre, Darío; Heller, Viviana; Stanganelli, Carmen Graciela; Slavutsky, Irma Rosa; Iribarren, Pablo Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia in the western hemisphere. It is characterized by a clonal proliferation of a population of CD5+ B lymphocytes that accumulate in the secondary lymphoid tissues, bone marrow, and blood. Some CLL patients remain free of symptoms for decades, whereas others rapidly become symptomatic or develop high-risk disease. Studying autophagy, which may modulate key protein expression and cell survival, may be important to the search for novel prognostic factors and molecules. Here, we applied flow cytometry technology to simultaneously detect autophagy protein LC3B with classical phenotypical markers used for the identification of tumoral CLL B cell clones. We found that two patients with progressing CLL showed increased expression of the autophagy protein LC3B, in addition to positive expression of CD38 and ZAP70 and unmutated status of IGHV. Our data suggest that activation of autophagy flux may correlate with CLL progression even before Ibrutinib treatment.

Early eocene spore and pollen assemblages from the laguna del hunco fossil lake beds, patagonia, argentina Barreda, Viviana Dora; Zamaloa, María del Carmen; Gandolfo, María A.; Jaramillo, Carlos; Wilf, Peter Premise of research. The early Eocene Laguna del Hunco (LH) fossil site, northwestern Chubut Province, Argentina, holds one of the best-preserved and most diverse paleofloras worldwide. The paleoflora comprises ferns, gymnosperms, and flowering plants. Despite the rapidly growing knowledge of its macrofossil record, little is known about the site’s palynological content. Herein, we present the first dispersed spore-pollen assemblages recovered from LH. Methodology. Palynological samples were collected from seven stratigraphic levels of the Tufolitas de LH (Huitrera Formation), of which six yielded palynomorphs. We determine the botanical affinities of fossil morphotypes and provide systematic descriptions of some taxa. In addition, we establish similarities between LH and other Patagonian Eocene localities, and we compare palynological and prior megafloral records from LH. Pivotal results. We identify 56 spore and pollen species and 28 plant families, of which eight (Cyatheaceae, Schizaeaceae, Polypodiaceae, Asteraceae, Chloranthaceae, Nothofagaceae, Rubiaceae, and Ulmaceae) are reliably reported from the site for the first time. Among other Eocene Patagonian palynofloras, the LH assemblage is similar to Pampa de Jones/Nahuel Huapi Este and Confluencia. Conclusions. The LH spore-pollen assemblages augment the plant fossil record for this significant Eocene locality by incorporating new taxa (e.g., Asteraceae, with one morphotype that represents the oldest record of the family in Patagonia). The new data also reinforce the presence of plant families previously reported from macrofossils, such as Juglandaceae, with pollen grains similar to those of the Engelhardia-Alfaroa group, and Fagaceae (Castaneoideae), complementing the macrofossil record of leaves and reproductive structures.

Economías sexoafectivas: significados, prácticas y relaciones en tensión en contextos petroleros de la Patagonia Argentina; Sexual-affective economies: meanings, practices, and relationships in tension in oil industry contexts of Argentine Patagonia Cabrapan Duarte, Melisa Gisel En este artículo, se analiza la configuración de las economías sexoafectivas en torno a la prostitución en contextos petroleros de la Patagonia argentina. Además, se estudian las diferentes dinámicas conyugales y familiares entre hombres y mujeres que se vincularon sexoafectivamente a través del mercado sexual o fuera de él, y que desenvuelven y sostienen económicamente sus vidas en contextos dependientes de la actividad hidrocarburífera. El objetivo es, a partir de las experiencias y discursos de diferentes actores, indagar en cómo se construye y significa la cotidianidad de esos relacionamientos, y el modo en que se expresan las tensiones entre la sexualidad, el afecto y la economía.; This article analyses the conformation of the sexual-affective economies around prostitution in oil industry contexts of Argentine Patagonia. Likewise, it studies different conjugal and family dynamics, between men and women that were involved sexual-affectively through the sex-trade context or outside of it, and who developed and sustained their lives in a local economy that is dependent on the oil and gas industry. The purpose is, based on the experiences and discourses of different actors, to analyze hoy everyday life is built in those relationships, what do they mean and how the tensions between sexuality, affection, and the economy are expressed.

Influencia del método de dispersión en el fraccionamiento físico de un suelo de Argentina central; Four dispersion methods, typically applied to soil physical fractionation protocols, were compared in a Mollisol from mountain grasslands from central Argentina. The proportion of coarse and fine soil fractions obtained after dispersion was significantly different. Considering that mineral fractions after dispersion using glass beads did not differ from granulometric analysis, this method achieved better results than sonication or shaking with chemical dispersant for evaluated soils. Pestoni, Sofía; Gallardo, Norma; Pérez Harguindeguy, Natalia; Kowaljow, Esteban Se compararon cuatro métodos de dispersión de suelos, ampliamente utilizados en protocolos de fraccionamiento físico, sobre un Molisol de pastizales montañosos del centro de Argentina. La proporción de las fracciones fina y gruesa del suelo varió significativamente entre métodos. Debido a que las fracciones minerales post dispersión con bolitas de vidrio no difirieron del resultado del análisis granulométrico, este método mostró los mejores resultados, por sobre la sonicación y el agitado con dispersante químico, para los suelos evaluados.

Crustal seismicity in the Andean Precordillera of Argentina using seismic broadband data Venerdini, Agostina Lia; Alvarado, Patricia Monica; Ammirati, Jean Baptiste; Podesta Di Santo, Marcos Gaston; López, Luciana; Fuentes, Facundo; Linkimer, Lepolt; Beck, Susan In this study, we analyze 100 crustal Precordilleran earthquakes recorded in 2008 and 2009 by 52 broadbandseismic stations from the SIEMBRA and ESP, two temporary experiments deployed in the Pampeanflat slabregion, between the Andean Cordillera and the Sierras Pampeanas in the Argentine Andean backarc region.In order to determine more accurate hypocenters, focal mechanisms and regional stress orientations, werelocated 100 earthquakes using the JHD technique and a local velocity model. The focal depths of our relocatedevents vary between 6 and 50 km. We estimated local magnitudes between 0.4≤ML≤5.3 and momentmagnitudes between 1.3≤Mw≤5.3. Focal mechanisms were determined from new hypocenter relocations andfirst motion P-wave polarities. Our solutions exhibit a majority of the earthquakes with reverse faulting me-chanism. Regional stress tensor from the inversion of P- and T-axis orientations, shows a maximum stress axis(σ1) almost horizontal with a strike of 85° and a minimum stress axis (σ3) almost vertical.We correlate this small-to-moderate magnitude seismicity with the presence of large basement structuresbeneath the Iglesia-Calingasta Basin in the west and the Eastern Precordillera in the east. The nucleation of deepearthquakes beneath the Iglesia Basin could be related to the presence of a major ramp accommodating thecrustal shortening between the Frontal Cordillera and the Precordillera. The crustal seismicity beneath thePrecordillera seems to correlate with west-dipping structures rooting deep into the Cuyania basement suggestinga thick-skinned basement deformation system beneath the Precordillera and its shallow thin-skinned fold andthrust belt.

Delayed Bilateral Teleoperation of the Speed and Turn Angle of a Bipedal Robot Moya, Viviana; Slawiñski, Emanuel; Mut, Vicente Antonio This paper proposes a shared control scheme which aims to achieve a stable control of the speed andturn of a bipedal robot during a delayed bilateral teleoperation. The strategy allows to get a delay-dependent damping value that must be injected to assure a bounded response of the hybrid system,while simultaneously, the human operator receives a force feedback that help him to decrease thesynchronism error. Furthermore, a test where a human operator handles the walking of a simulatedbipedal robot, to follow a curve path in front of varying time delay, is performed and analyzed.

Canonical transient receptor potential 6 channel deficiency promotes smooth muscle cells dedifferentiation and increased proliferation after arterial injury Smith, Andrew H.; Priya, Bhanu Priya; Driscoll, Erin C.; Chaudhuri, Pinaki; Birnbaumer, Lutz; Rosenbaum, Michael A.; Graham, Linda M. Objective Previous studies showed the benefit of canonical transient receptor potential 6 (TRPC6) channel deficiency in promoting endothelial healing of arterial injuries in hypercholesterolemic animals. Long-term studies utilizing a carotid wire-injury model were undertaken in wild-type (WT) and TRPC6-/- mice to determine the effects of TRPC6 on phenotypic modulation of vascular smooth muscle cells (SMC) and neointimal hyperplasia. We hypothesized that TRPC6 was essential in the maintenance or reexpression of a differentiated SMC phenotype and minimized luminal stenosis following arterial injury. Methods The common carotid arteries (CCA) of WT and TRPC6-/- mice were evaluated at baseline and 4 weeks after wire injury. At baseline, CCA of TRPC6-/- mice had reduced staining of MYH11 and SM22, fewer elastin lamina, luminal dilation, and wall thinning. After carotid wire injury, TRPC6-/- mice developed significantly more pronounced luminal stenosis compared with WT mice. Injured TRPC6-/- CCA demonstrated increased medial/intimal cell number and active cell proliferation when compared with WT CCA. Immunohistochemistry suggested that expression of contractile biomarkers in medial SMC were essentially at baseline levels in WT CCA at 28 days after wire injury. By contrast, at 28 days after injury medial SMC from TRPC6-/- CCA showed a significant decrease in the expression of contractile biomarkers relative to baseline levels. To assess the role of TRPC6 in systemic arterial SMC phenotype modulation, SMC were harvested from thoracic aortae of WT and TRPC6-/- mice and were characterized. TRPC6-/- SMC showed enhanced proliferation and migration in response to serum stimulation. Expression of contractile phenotype biomarkers, MYH11 and SM22, was attenuated in TRPC6-/- SMC. siRNA-mediated TRPC6 deficiency inhibited contractile biomarker expression in a mouse SMC line. Conclusions These results suggest that TRPC6 contributes to the restoration or maintenance of arterial SMC contractile phenotype following injury. Understanding the role of TRPC6 in phenotypic modulation may lead to mechanism-based therapies for attenuation of IH. Clinical Relevance After endovascular intervention and open vascular surgery, vascular smooth muscle cells (VSMC) undergo a coordinated reprogramming of gene expression to facilitate arterial healing. Down regulation of VSMC-specific contractile biomarkers (eg, SM22 and MYH11) and induction of pathways that promote cell proliferation, migration, and matrix synthesis are hallmarks of this phenotypic switch. Dysregulated phenotypic switching leads to the development of neointimal hyperplasia and vascular restenosis. Identifying pathways that regulate or constrain VSMC phenotypic modulation, therefore, has the potential to decrease neointimal hyperplasia and improve outcomes after vascular intervention. In this study, we demonstrate that depletion of the non-voltage-gated cation channel TRPC6 promotes phenotypic switching and loss of contractile biomarkers in systemic arterial VSMC. TRPC6-/- mice developed significantly more pronounced luminal stenosis compared with wild-type mice after carotid wire injury. These results suggest that TRPC6 contributes to the restoration or maintenance of contractile phenotype in VSMC after injury. Understanding the role of TRPC6 in phenotypic switching may lead to mechanism-based therapies to mitigate restenosis.

Escuelas rurales de alternancia y cogestión: Un análisis sociolingüístico y etnográfico de las tomas de decisiones en el Consejo de Administración; Alternation Rural Schools and Co-management: A Sociolinguistic and Ethnographic Framework to Analyzing Decision Making at the Board Miano, María Amalia; Lara Corro, Erik Said; Heras, Ana Inés Realizamos un análisis sociolingüístico y etnográfico de las interacciones que tienen lugar entre los miembros de un Consejo de Administración de una escuela rural de alternancia. Este Consejo está formado por padres y madres de los estudiantes, egresados y docentes que se reúnen para tomar decisiones sobre la gestión de la escuela. Se trata de actores que ocupan lugares diferenciados en la estructura organizacional y que portan recursos materiales, culturales y simbólicos diversos. A través del análisis de las interacciones sostenemos que los procesos de tomas de decisión exceden los temas vinculados a la gestión de lo escolar para abarcar las situaciones de vida de las familias que habitan en el medio rural. Estos procesos implican para los Consejeros el aprendizaje de una competencia comunicativa vinculada a ejercer una práctica de escucha, ponderación, debate y seguimiento de la decisión alcanzada.; We present a sociolinguistic and ethnographic analysis of interactions taking place at the Board of a rural school run by the pedagogy of alternance model. The members of the Board are the students´ family, teachers, the principal and alumni, who meet in order to make decisions together. In as much as these members occupy different and differential positions in the school, their material and symbolic resources are diverse. Our analysis shows that the processes entailed in making decisions relate not only to the specific issues brought to discussion but also to several other situations connected to the way in which the members of the rural community live. Therefore, making decisions at the Board involves developing a specific communicative competence related to learning to listen, ponder alternatives, engage in debate, and follow up with the decision taken as a collective.

Territorializar la extensión universitaria: diálogo de saberes y co-construcción de conocimiento Valente Ezcurra, Dana; Girado, Agustina; Migueltorena, Alejandro En el presente artículo abordamos las discusiones implicadas en la territorialización de la universidad, profundizando en el rol de la extensión universitaria y la función social del conocimiento. Estas reflexiones se han nutrido de las experiencias de trabajo realizadas colectivamente en el marco de distintos proyectos de extensión, que permitieron articular diversas intervenciones y acciones vinculadas al Acceso Justo al Hábitat y el Derecho a la Ciudad en Tandil (Buenos Aires, Argentina) desde el año 2013 a la actualidad. Con el objetivo de relacionar diversos enfoques y prácticas es que nos preguntamos cómo territorializar la universidad; atendiendo a las respuestas que suscita este interrogante la estructura argumental se ordena en tres apartados. El primero de ellos aborda los debates en torno a las perspectivas desde las que se conceptualiza la Extensión Universitaria y su función social, profundizando en sus implicancias respecto a la construcción de territorios y territorialidades. El segundo, recupera la función social del conocimiento, discutiendo los requerimientos ontológicos, epistemológicos y metodológicos exigidos para el diálogo de saberes y la co-construcción de conocimiento. Finalmente, compartimos algunas reflexiones situadas sobre nuestras experiencias de trabajo, pretendiendo contribuir a la construcción de prácticas integrales, que desde el territorio y junto a organizaciones sociales avancen en la transformación de las desigualdades con un horizonte de justicia social y espacial.

Trayectorias y dinámicas de adultos/as mayores: curso de vida y alimentación en diálogo; Trajectories and food dynamics of Elderly People: food as life story Abraham, Maria Daniela; Huergo, Juliana; Butinof, Mariana Argentina atraviesa un proceso de transición demográfica avanzada, ya que los/as Adultos Mayores (AM) alcanzan el 15,1% de la población. Ello pone en tensión el lugar de las/os AM en la sociedad, sus condiciones de acceso y resolución de necesidades, entre ellas la alimentación. En este trabajo se postula que hablar de la alimentación, de los alimentos, es hablar de los/as AM, de la historia de vida de estas personas que se va escribiendo entre sustancias y circunstancias que hacen a actividades tan cotidianas como el cocinar y el comer. Así, se planteó como objetivo, indagar acerca de la categoría trayectorias y dinámicas alimentarias (TyDA) de los/as AM de la Ciudad de Córdoba-Argentina, para establecer diálogo(s) posible(s) entre alimentación y curso de vida.Se realizó una investigación con posicionamiento epistemológico mixto entre paradigma interpretativista y crítico; con triangulación metodológica cuali-cuantitativa. Etapa cuantitativa: muestra no probabilística por cuotas según nivel de instrucción (n=384); incluyendo a AM de Córdoba y gran Córdoba que integran espacios participativos. Se implementó un cuestionario semiestructurado. Etapa cualitativa: muestra intencional (n=10) a partir del muestro anterior. Se realizaron observaciones participantes, bitácora de campo y entrevistas. Participaron 384 AM, edad promedio de 72 años (DE=7), 79% mujeres y 21% varones. Las TyDA, siguiendo una idea de proceso que se construye y reconstruye constantemente, fueron abordadas desde: a) Etapa de la vida b) Sistema Alimentario y c) Alimentos identificadores. Reconstruir la historia de la comida de los/as AM propicia el reencuentro con la propia historia (infancia, juventud, adultez, vejez). Esta matriz de sentido es una invitación a repensar los abordajes en materia de políticas públicas destinados a este grupo poblacional; que genera cambios demográficos tanto a nivel macrosocial (cultura, economía, mercado de trabajo, sistemas políticos) pero especialmente en la experiencia de vida de los y las AM.; Argentina is going through an advanced demographic transition process, as the Elderly (E) reach 15.1% of the population. This puts in strain the place of the E in society, their conditions of access and resolution of needs, including food. In this work it is postulated that to talk about food is to talk about the E, about the life story of these people that is being written among substances and circumstances resulting from daily activities such as cooking and eating. Thus, the objective was to research on trajectories and food dynamics (T&FD) of the E living in Cordoba City, Argentina, to establish possible dialogue(s) between food and life course. An investigation with mixed epistemological positioning between interpretive and critical paradigm was carried out; with qualitative quantitative methodological triangulation. Quantitative stage: non-probabilistic sample according to level of instruction (n=384); including the E from Cordoba and great Cordoba that integrate participatory spaces. A semistructured questionnaire was implemented. Qualitative stage: intentional sample (n=10) resulting from the previous sample. Participant observations, field log and interviews were made. 384 participated, average age of 72 years old (SD=7), 79% women and 21% men. The T&FD, following a process idea that is constantly constructed and reconstructed, were approached from: a) Life stage b) Food System and c) Food identifiers. Reconstructing the history of the food of the E favors the connection with their own life story (childhood, youth, adulthood, old age). This matrix of meaning is an invitation to rethink public policy approaches for this population group, which generates demographic changes at a macrosocial level (culture, economy, labor market, political systems) but especially in the life experience of these E.

HoSeIn: A Workflow for Integrating Various Homology Search Results from Metagenomic and Metatranscriptomic Sequence Datasets Rozadilla, Gastón; Moreiras Clemente, Jorgelina; Mccarthy, Cristina Beryl Data generated by metagenomic and metatranscriptomic experiments is both enormous and inherently noisy. When using taxonomy-dependent alignment-based methods to classify and label reads, the first step consists in performing homology searches against sequence databases. To obtain the most information from the samples, nucleotide sequences are usually compared to various databases (nucleotide and protein) using local sequence aligners such as BLASTN and BLASTX. Nevertheless, the analysis and integration of these results can be problematic because the outputs from these searches usually show inconsistencies, which can be notorious when working with RNA-seq. Moreover, and to the best of our knowledge, existing tools do not criss-cross and integrate information from the different homology searches, but provide the results of each analysis separately. We developed the HoSeIn workflow to intersect the information from these homology searches, and then determine the taxonomic and functional profile of the sample using this integrated information. The workflow is based on the assumption that the sequences that correspond to a certain taxon are composed of:1)sequences that were assigned to the same taxon by both homology searches;2)sequences that were assigned to that taxon by one of the homology searches but returned no hits in the other one.

Rab Proteins: Insights into Intracellular Trafficking in Endometrium Leiva, Natalia Lorena; Nolly, Mariela Beatriz; Ávila Maniero, Mariángeles; Losinno, Antonella Denise; Damiani, Maria Teresa Rab proteins belong to the Ras superfamily of small monomeric GTPases. These G proteins are the main controllers of vesicular transport in every tissue, among them, the endometrium. They are in charge of to the functional subcellular compartmentalization and cargo transport between organelles and the plasma membrane. In turn, intracellular trafficking contributes to endometrial changes during the menstrual cycle, secretion to the uterine fluid, and trophoblast implantation; however, few reports analyze the role of Rab proteins in the uterus. In general, Rab proteins control the release of cytokines, growth factors, enzymes, hormones, cell adhesion molecules, and mucus. Further, the secretion of multiple compounds into the uterine cavity is required for successful implantation. Therefore, alterations in Rab-controlled intracellular transport likely impair secretory processes to the uterine fluid that may correlate with abnormal endometrial development and failed reproductive outcomes. Overall, they could explain recurrent miscarriages, female infertility, and/or assisted reproductive failure. Interestingly, estrogen (E2) and progesterone (P) regulate gene expression of Rab proteins involved in secretory pathways. This review aims to gather information regarding the role of Rab proteins and intracellular trafficking in the endometrium during the different menstrual phases, and in the generation of a receptive stage for embryo implantation, modulated by E2 and P. This knowledge might be useful for the development of novel reproductive therapies that overcome low implantation rates of assisted reproductive procedures.