DNA repair kinetic of hydrogen peroxide and UVA/B induced lesions in peripheral blood leucocytes from xeroderma pigmentosum patients and healthy subjects Prieto Gonzalez, Elio A.; Mudry, Marta Dolores; Palermo, Ana María The objective of the present work was to study the fine kinetics of DNA repair in xeroderma pigmentosum (XP) syndrome, a complex disorder linked to a deficiency in repair that increases cancer susceptibility. The repair process was evaluated by the comet assay (CA) in cells from 2 XP patients and 9 controls exposed to UVA/B (UVA 366/UVB 280 nm) and H2 O2 (150 µM) at temperatures of 4, 15, and 37°C. Samples were taken at 2-min intervals during the first 10 min to analyze the “fine kinetics” repair during the initial phase of the curve, and then at 15, 20, 25, 30, 45, 60, and 120 min. CA evaluation of DNA repair activity points to BER/NER initiation in the first 30 min with both inductors at 37°C and 15°C, but final comet length showed differences according to treatment. Repair kinetics during 120 min showed a good correlation with clinical features in both XP patients. Differences in final comet length were less pronounced in XP cells treated with H2 O2 than with UVA/B, probably because the peroxide produces mainly base oxidation but less bulky lesions; UVA/B generates a mixture of both. These findings reinforce the value of CA in testing in DNA repair ability or exposure monitoring

Probing the µνSSM with light scalars, pseudoscalars and neutralinos from the decay of a SM-like Higgs boson at the LHC Ghosh, Pradipta; Lopez, Daniel Elbio; Mitsou, Vasiliki A.; Muñoz, Carlos; Ruiz de Austri, Roberto The “µ from ν” supersymmetric standard model (µνSSM) can accommodate the newly discovered Higgs-like scalar boson with a mass around 125 GeV. This model provides a solution to the µ-problem and simultaneously reproduces correct neutrino physics by the simple use of right-handed neutrino superfields. These new superfields together with the introduced R-parity violation can produce novel and characteristic signatures of the µνSSM at the LHC. We explore the signatures produced through two-body Higgs decays into the new states, provided that these states lie below in the mass spectrum. For example, a pair produced light neutralinos depending on the associated decay length can give rise to displaced multi-leptons/taus/jets/photons with small/moderate missing transverse energy. In the same spirit, a Higgs-like scalar decaying to a pair of scalars/pseudoscalars can produce final states with prompt multi-leptons/taus/jets/photons.

Traveling planetary wave activity from mesopause region airglow temperatures determined by the Network for the Detection of Mesospheric Change (NDMC) Reisin, Esteban Rodolfo; Scheer, Jurgen; Dyrland, M. E.; Sigernes, F.; Deehr, C. S.; Schmidt, C.; Höppner, K.; Bittner, M.; Ammosov, P. P.; Gavrilyeva, G. A.; Stegman, J.; Perminov, V. I.; Semenov, A. I.; Knieling, P.; Koppmann, R.; Shiokawa, K.; Lowe, R. P.; López González, M. J.; Rodríguez, E.; Zhao, Y.; Taylor, M. J.; Buriti, R. A.; Espy, P. J.; French, W. J. R.; Eichmann, K. U.; Burrows, J. P.; von Savigny, C. The global distribution of  traveling planetary wave (PW)  activity in the mesopause region is estimated for the first time from ground-based airglow measurements. Monthly and total mean climatologies of  PW power are determined from rotational temperatures measured at 19 sites from 78ºN to 76°S which contribute to the Network for the Detection of Mesospheric Change (NDMC). Wave power is expressed as the standard deviation of nocturnal mean temperature around the seasonal temperature variation. The results from 20ºN confirm the SABER traveling PW proxy by Offermann et al. (2009) at two altitudes. Most sites between 69°S and 69°N show total mean traveling PW activity of about 6 K, and only some high latitude sites have considerably higher activity levels. At the two tropical sites, there is practically no seasonal variation of PW activity. At 70% of the midlatitude sites, the seasonal variation is moderate for most of the year, but it is quite appreciable at all high latitude sites. Results about traveling PW activity at 87 km and 95 km available from several sites signal similar behavior at both altitudes. The total mean climatological results here obtained have further been used to separate the traveling PW contribution from the superposition of wave types contained in OH rotational temperature fluctuations measured by the SCIAMACHY instrument on Envisat. A narrow equatorial wave activity maximum is probably caused by gravity waves, while a tendency towards greater activity at higher northern latitudes may be due to stationary planetary waves.

How Can Active Region Plasma Escape into the Solar Wind from Below a Closed Helmet Streamer? Mandrini, Cristina Hemilse; Nuevo, Federico Alberto; Vasquez, Alberto Marcos; Démoulin. P.; Van Driel Gesztelyi, L.; Baker, D.; Culhane, J. l.; Cristiani, Germán Diego; Pick, M. Recent studies show that active-region (AR) upflowing plasma, ob- served by the EUV-Imaging Spectrometer (EIS), onboard Hinode, can gain access to open field-lines and be released into the solar wind (SW) via magnetic- interchange reconnection at magnetic null-points in pseudo-streamer configu- rations. When only one bipolar AR is present on the Sun and it is fully covered by the separatrix of a streamer, such as AR 10978 in December 2007, it seems unlikely that the upflowing AR plasma can find its way into the slow SW. However, signatures of plasma with AR composition have been found at 1 AU by Culhane et al. (2014) apparently originating from the West of AR 10978. We present a detailed topology analysis of AR 10978 and the surrounding large-scale corona based on a potential-field source-surface (PFSS) model. Our study shows that it is possible for the AR plasma to get around the streamer separatrix and be released into the SW via magnetic reconnection, occurring in at least two main steps. We analyse data from the Nan ̧cay Radioheliograph (NRH) searching for evidence of the chain of magnetic reconnections proposed. We find a noise storm above the AR and several varying sources at 150.9 MHz. Their locations suggest that they could be associated with particles accelerated during the first- step reconnection process and at a null point well outside of the AR. However, we find no evidence of the second-step reconnection in the radio data. Our results demonstrate that even when it appears highly improbable for the AR plasma to reach the SW, indirect channels involving a sequence of reconnections can make it possible.

Linking Up to Development? Global Value Chains and the Making of a Post-Washington Consensus Werner, Marion; Bair, Jennifer; Fernández, Víctor Ramiro Over the last decade, the global value chain (GVC) approach, with its associated notions of chain governance and firm upgrading, has proliferated as a mode of analysis and of intervention amongst development institutions. This article examines the adoption and adaptation of GVCs at four multilateral agencies in order to understand the purchase of value chain approaches within the development field. Mixing GVC perspectives with other theoretical influences and applied practices, these institutions deploy value chain frameworks to signal a new generation of policies that promise both to consolidate, and to advance beyond, the market fundamentalism of the Washington Consensus. To achieve this, value chain development frameworks craft interventions directed toward various constellations of firm and non-firm actors as a ‘third way’ between state-minimalist and state-coordinated approaches. The authors identify key adaptations of the GVC framework including an emphasis on value chain governance as an instrument to correct market failure in partnership with state and development agencies, and upgrading as a de facto tool for poverty reduction. They find that efforts are ongoing to construct a ‘post’ to the Washington Consensus and that the global value chain is enabling this process by providing a new language and new object of development intervention: ‘the chain’ and the local–global linkages that comprise it.

Treatment with LPS plus INF-γ induces the expression and function of muscarinic acetylcholine receptors, modulating NIH3T3 cell proliferation: participation of NOS and COX Español, Alejandro Javier; Maddaleno, M. O.; Lombardi, Maria Gabriela; Cella, Maximiliano; Martinez Pulido, Paola; Sales, Maria Elena BACKGROUND AND PURPOSE: LPS and IFN-γ are potent stimuli of inflammation, a process in which fibroblasts are frequently involved. We analysed the effect of treatment with LPS plus IFN-γ on the expression and function of muscarinic acetylcholine receptors in NIH3T3 fibroblasts with regards to proliferation of these cells. We also investigated the participation of NOS and COX, and the role of NF-κB in this process. EXPERIMENTAL APPROACH: NIH3T3 cells were treated with LPS (10 ng·mL(-1)) plus IFN-γ (0.5 ng·mL(-1)) for 72 h (iNIH3T3 cells). Cell proliferation was evaluated with MTT and protein expression by Western blot analysis. NOS and COX activities were measured by the Griess method and radioimmunoassay respectively. KEY RESULTS: The cholinoceptor agonist carbachol was more effective at stimulating proliferation in iNIH3T3 than in NIH3T3 cells, probably due to the de novo induction of M3 and M5 muscarinic receptors independently of NF-κB activation. iNIH3T3 cells produced higher amounts of NO and PGE2 than NIH3T3 cells, concomitantly with an up-regulation of NOS1 and COX-2, and with the de novo induction of NOS2/3 in inflamed cells. We also found a positive feedback between NOS and COX that could potentiate inflammation. CONCLUSIONS AND IMPLICATIONS: Inflammation induced the expression of muscarinic receptors and, therefore,stimulated carbachol-induced proliferation of fibroblasts. Inflammation also up-regulated the expression of NOS and COX-2, thus potentiating the effect of carbachol on NO and PGE2 production. A positive crosstalk between NOS and COX triggered by carbachol in inflamed cells points to muscarinic receptors as potential therapeutic targets in inflammation.

Available Chlorine in household bleaches by using a new and easy spectrophotometric method Caucino, Florencia ; Calderón, Ruth ; Montes Spinsanti, Gimena ; Ciolino, Andrés Eduardo In this communication, an alternative method to determine the "available chlorine" in household bleach, based on the reaction of a known quantity of bleach with a standardized CuSO4.5H2O aqueous solution is proposed. The alkaline media of the bleach can promote the formation of both hydroxyl cupric sulfate and cupric hydroxide, which form a solid mixture that can be separated by filtration. Since the [Cu(H2O)6]2+(aq) complex has a maximum of absorbance at 815 nm, the remaining [Cu(H2O)6]2+(aq) complex in solution after the addition of thebleach can be obtained by spectrophotometric analysis. By using these measurements and the stoichiometry of the process, the "available chlorine" concentration in the household bleach can be easily estimated, in a fast and reliable fashion. The values obtained for different samples of commercial household bleaches by using this methodology were compared with those obtained with the standard sodium thiosulfate titration method. The differences between the values obtained, considering the titration method as the true value, were less than 2 %. Consequently, the spectrophotometric method presented in this communication offers the possibility of comparing the results with other well-established methods, and combines elegantly stoichiometry calculations and spectrophotometry measurements in one laboratory activity.

Morphological comparison of wild, farmed and hybrid specimens of two South American silversides, Odontesthes bonariensis and Odontesthes hatcheri Crichigno, Sonia Alejandra; Shohei Hattori, Ricardo; Strussmann, Carlos Augusto; Cussac, Victor Enrique In this study, body shape of hybrid and presumptive introgressed South American silversides was studied. Body shape of O. bonariensis and O. hatcheri from wild populations and farmed stocks was compared to provide basic information on the effects of fish farming on morphometric parameters. Subsequently, wild presumptive introgressed individuals and artificially hybridized farmed individuals were morphologically analysed to assess the effects of hybridization on the same parameters. Most farmed purebred individuals were shorter and higher than their wild counterparts, which is probably due to the favourable growth conditions compared to the wild habitat. However, the results evidenced that purebred individuals were more slender than both hybrid (farmed) fish and introgressed (wild) fish. Further studies on the growth performance of hybrid Odontesthes will be required in order to assess whether the combination of hybridization and sterilization could produce, under farming conditions, growth performances which satisfy the requirements of aquaculture.

Defining photometric peculiar type Ia Supernovae González Gaitán, S.; Hsiao, E. Y.; Pignata, G.; Förster, F.; Gutiérrez, C. P.; Bufano, F.; Galbany, L.; Folatelli, Gaston; Phillips, M. M.; Hamuy, M.; Anderson, J. P.; de Jaeger, T. We present a new photometric identification technique for SN 1991bg-like type Ia supernovae (SNe Ia), i.e., objects with light curve characteristics such as later primary maxima and the absence of a secondary peak in redder filters. This method is capable of selecting this sub-group from the normal type Ia population. Furthermore, we find that recently identified peculiar sub-types such as SNe Iax and super-Chandrasekhar SNe Ia have photometric characteristics similar to 91bg-like SNe Ia, namely, the absence of secondary maxima and shoulders at longer wavelengths, and can also be classified with our technique. The similarity of these different SN Ia sub-groups perhaps suggests common physical conditions. This typing methodology permits the photometric identification of peculiar SNe Ia in large upcoming wide-field surveys either to study them further or to obtain a pure sample of normal SNe Ia for cosmological studies.

Planar Normal Sections on Isoparametric Hypersurfaces and the infinity laplacian Barros, Julio; Sanchez, Cristian Urbano The present article is devoted to present a new characterization of the Cartan isoparametric hypersurfaces in terms of properties of the polynomial, that determines the algebraic set of planar normal sections on the homogeneous isoparametric hypersurfaces in spheres. We show that Cartan isoparametric hypersurfaces are the only homo- geneous isoparametric hypersurfaces in spheres for which the Innity Laplacian of the polynomial that denes the algebraic set of planar normal sections is the polynomial multiplied by the squared norm of the tangent vector. Since it is required for our work, we also give these polynomials for all homogeneous isoparametric hypersurfaces in spheres.

Inflation as a White Hole explosion from a 5D vacuum Bellini, Mauricio; Anabitarte, Mariano Using a new kind of 5D Ricci-flat canonical metric, we obtain by a static foliation an effective 4D Schwarzschild – de Sitter hypersurface. We examine some particular initial conditions that could be responsible for the inflationary expansion of the early universe, which could be driven by the explosion of a white hole (WH). The zeroth-order spectrum outside the WH describes quantum fluctuations, which for a scale invariant power spectrum, can be expressed in terms of the cosmological constant, or the square mass of the WH.

Screening concentration of E1, E2 and EE2 in sewage effluent and surface waters of the "Pampas" region and the "Río de la Plata" estuary (Argentina) Valdés, María Eugenia; Marino, Damian Jose Gabriel; Wunderlin, Daniel Alberto; Somoza, Gustavo Manuel; Ronco, Alicia Estela; Carriquiriborde, Pedro Concentrations of estrone (E1), 17β-estradiol (E2) and 17α-ethinylestradiol (EE2) were investigated for the first time in sewage effluents and receiving waters of the “Río de la Plata” estuary and neighboring areas by means of LC–MS/MS. E2 and EE2 were ubiquitous in the evaluated sewage effluent samples showing concentrations ranging between 122–631 and 65–187 ng/L, respectively. In surface waters, these estrogens were only detected in the “Girado” stream (Chascomús) at 369 and 43 ng/L, respectively. No significant relationship was found among the size of the served population and the concentration of the estrogens in the sewage effluent. The detection of these estrogens in receiving waters was dependent on the dilution capacity of the system. The studied estrogens were undetectable at the La Plata City water supply station. Conversely, concentrations found at the “Girado” stream indicate a potential ecotoxicological risk of these estrogens to the local aquatic biota.

Indole acetic acid is responsible for protection against oxidative stress caused by drought in soybean plants: the role of heme oxygenase induction López Lecube, Manuel; Noriega, Guillermo Osvaldo; Santa Cruz, Diego Mario; Tomaro, Maria Lujan; Batlle, Alcira Maria del C.; Balestrasse, Karina Beatriz Objectives This study was focused on the role of indole acetic acid (IAA) in the defense against oxidative stress damage caused by drought in soybean plants and to elucidate whether heme oxygenase-1 (HO-1) and nitric oxide (NO) are involved in this mechanism. IAA is an auxin that participates in many plant processes including oxidative stress defense, but to the best of our knowledge no information is yet available about its possible action in drought stress. Methods To this end, soybean plants were treated with 8% polyethylene glycol (PEG) or 100 µM IAA. To evaluate the behavior of IAA, plants were pretreated with this compound previous to PEG addition. Lipid peroxidation levels (thiobarbituric acid reactive substances (TBARS)), glutathione (GSH) and ascorbate (AS) contents, catalase (CAT), superoxide dismutase (SOD), and guaiacol peroxidase (POD) activities were determined to evaluate oxidative damage. Results Drought treatment (8% PEG) caused a significant increase in TBARS levels as well as a marked decrease in the non-enzymatic (GSH and AS) and enzymatic (CAT, SOD, and POD) antioxidant defense systems. Pre-treatment with IAA prevented the alterations of stress parameters caused by drought, while treatment with IAA alone did not produce changes in TBARS levels, or GSH and AS contents. Moreover, the activities of the classical enzymes involved in the enzymatic defense system (SOD, CAT, and POD) remained similar to control values. Furthermore, this hormone could enhance HO-1 activity (75% with respect to controls), and this increase was positively correlated with protein content as well as gene expression. The direct participation of HO-1 as an antioxidant enzyme was established by performing experiments in the presence of Zn-protoporphyrin IX, a well-known irreversible inhibitor of this enzyme. It was also demonstrated that HO-1 is modulated by NO, as shown by experiments performed in the presence of an NO donor (sodium nitroprusside), an NO scavenger (2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide), or an NO synthesis inhibitor (N-nitro-l-arginine methyl ester, NAME). Discussion It is concluded that IAA is responsible, at least in part, for the protection against oxidative stress caused by drought in soybean plants through the modulation of NO levels which, in turn, enhances HO-1 synthesis and activity.

Sistema biorremediador para tratamiento de suelos y/o aguas contaminadas Scotti, Adalgisa; Godeas, Alicia Margarita; Silvani, Vanesa Analia La presente se refiere a un sistema biorremediador para tratamiento de suelos y/o aguas contaminadas. El sistema está formado por una planta hiperacumuladora, un hongo formador de micorrizas arbusculares y la coenzima metálica Cinc (Zn), desarrollados en un sustrato compuesto con cenizas volcánicas, absorbiendo metales pesados y radiosótopos en suelos y aguas contaminadas. A causa de la contaminación de suelos y aguas por metales pesados resulta de interés disponer de mecanismos de simbiosis, sinergia de metales, estimulación enzimática etc. que permitan aumentar la capacidad de biorremediación del sistema para disponer como herramientas de captación de metales en la fitorremediación. Las ventajas de la presente sobre otros sistemas consisten en: la obtención de mayores coeficientes de bioacumulación y una mayor eficiencia del sistema

Engineered chimeras reveal the structural basis of hexacoordination in globins: A case study of neuroglobin and myoglobin Boron, Carlos Ignacio; Capece, Luciana; Pennacchietti, Francesca; Wetzler, Diana Elena; Bruno, Stefano; Abbruzzetti, Stefania; Chisari, Lucía; Luque, F. Javier; Viappiani, Cristiano; Marti, Marcelo Adrian; Estrin, Dario Ariel; Nadra, Alejandro Daniel Background Myoglobin (Mb) and neuroglobin (Ngb) are representative members of pentacoordinated and bis-histidyl, hexacoordinated globins. In spite of their low sequence identity, they show surprisingly similar three-dimensional folds. The ability of Ngb to form a hexacoordinated bis-histidyl complex with the distal HisE7 has a strong impact on ligand affinity. The factors governing such different behaviors have not been completely understood yet, even though they are extremely relevant to establish structure-function relationships within the globin superfamily.

Impact of upstream and downstream constraints on a signaling module's ultrasensitivity Altszyler Lemcovich, Edgar Jaim; Ventura, Alejandra; Colman Lerner, Alejandro Ariel; Chernomoretz, Ariel Much work has been done on the study of the biochemical mechanisms that result in ultrasensitive behavior of simple biochemical modules. However, in a living cell, such modules are embedded in a bigger network that constrains the range of inputs that the module will receive as well as the range of the module’s outputs that network will be able to detect. Here, we studied how the effective ultrasensitivity of a modular system is affected by these restrictions. We use a simple setup to explore to what extent the dynamic range spanned by upstream and downstream components of an ultrasensitive module impact on the effective sensitivity of the system. Interestingly, we found for some ultrasensitive motifs that dynamic range limitations imposed by downstream components can produce effective sensitivities much larger than that of the original module when considered in isolation.

Una estrategia didáctica para la formación de educadores de salud en Brasil: la indagación dialógica problematizadora; A teaching strategy for education in health in Brazil: dialogic problematizing inquiry; Uma estratégia didática para a formação de educadores em saúde no Brasil: a indagação dialógica problematizadora de Longhi, Ana Lia Teresita; Bermudez, Gonzalo Miguel Angel; Dubeux Abensur, Patricia Lima; Ruiz Moreno, Lidia El trabajo presenta una propuesta didáctica para la formación docente de profesionales del área de la salud denominada “Indagación Dialógica Problematizadora” (IDP) y probada en el espacio curricular “Formación didáctico-pedagógica en salud” del Centro de Desarrollo de la Enseñanza Superior en Salud (CEDESS), Universidad Federal de San Pablo. La misma se diseñó en el marco de un proyecto binacional entre Brasil y Argentina, y se desarrolló en formato presencial y virtual. La implementación de IDP permitió generar una dinámica comunicacional coherente con el posicionamiento constructivista y posibilitar un cambio en las formas comunicativas del docente y de los alumnos, guiadas desde la problematización de situaciones cercanas a las experiencias de los mismos. La implementación de esta innovación educativa fue coherente con los cambios curriculares derivados de las actuales políticas de salud para Brasil.; O trabalho apresenta uma proposta didática para a formação docente de profissionais da área da saúde denominada “Indagação Dialógica Problematizadora” (IDP), que foi avaliada no espaço curricular “Formação didático-pedagógica em saúde”, formato presencial e virtual, oferecida pelo Centro de Desenvolvimento do Ensino Superior em Saúde (Cedess), Universidade Federal de São Paulo. A experiência realizou-se no contexto de um projeto binacional entre Brasil e Argentina. A implementação da IDP permitiu gerar uma dinâmica comunicativa coerente com o posicionamento construtivista e possibilitou uma mudança nas formas comunicativas, do docente e dos alunos, guiadas a partir da problematização de situações relacionadas às experiências dos pós-graduandos. A implementação desta inovação educativa foi coerente com as mudanças curriculares derivadas das atuais políticas de saúde e educação no Brasil.; This paper presents a teaching strategy for education of health professionals called “Dialogic Problematizing Inquiry” (DPI), which was evaluated in the course “Teaching Methodology in Health Education”, promoted by the Development of Higher Education in Health Center, at Federal University of Sao Paulo. It was designed in the framework of a bilateral project between Brazil and Argentina, and was developed in presencial and virtual format. The implementation of DPI generated a communication dynamic that was coherent with a constructivist perspective and enabled a change in teacher and students communication manners, which were guided by close-to-student-problematizing situations. The implementation of this teaching innovation was consistent with the curriculum changes stemming from current health policies in Brazil.

Triptan partition in model membranes Wood, Irene; Pickholz, Mónica Andrea In this work, we report a molecular dynamics simulations study of protonated triptans, sumatriptan and naratriptan, in a fully hydrated bilayer of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidyl-choline (POPC). The simulations were carried out at two concentrations for each drug. Our results show partition between the lipid head-water interphase and water phase for both triptans, with increasing access to the water phase with increasing concentrations. The triptans were stabilized at the interphase through different specific interactions with the POPC bilayer such as hydrogen bonds, salt bridges, and cation-π. Besides, sumatriptan and naratriptan protonated molecules have no access to the hydrophobic region of the bilayer at the studied conditions. Similar results were found for both drugs, however protonated naratriptan shows slightly higher affinity for the water phase. This behavior was attributed to the bulky lateral amino group in its structure under the studied conditions (drugs were originally placed at the water phase). This work represents a first insight to the comprehensive understanding of triptan partition in model membranes.

“En cada pueblo un nombre” : Trayectorias, prácticas y saberes de migrantes africanos de la región subsahariana en Argentina; “In every village a name” : Paths, practices and knowledge of African migrants from the Sub-Saharan region in Argentina; “Em cada vila, um nome” : Trajetórias, práticas e conhecimento dos migrantes africanos da região sub-saariana, na Argentina Morales, Orlando Gabriel Este artículo se basa en resultados de una aproximación etnográfica a migrantes africanos de la región subsahariana -en su mayoría senegaleses- radicados en las ciudades de La Plata y Buenos Aires (Argentina). En particular, delibero sobre experiencias de circulación migratoria en un espacio transnacional, de inserción en redes sociales y de producción-puesta en juego de saberes específicos atinentes a la situación de migración. En este marco, sostengo que los migrantes deben ser concebidos como agentes con competencias para (re)elaborar concepciones acerca del espacio, la movilidad y la sociabilidad, pese a su condición de vulnerabilidad social.; This article is based on results of an ethnographic approach to sub-Saharan African migrants – where most Senegalese – living in the cities of La Plata and Buenos Aires (Argentina). It presents reflections on experiences of transnational migratory circulation, social networking integration, and production and execution of specific knowledge on the situation of migration. In this context, I argue that migrants should be conceived as agents with competencies to develop and rework the conceptions of space, mobility and sociability, despite their social vulnerability.; Este artigo é baseado em resultados de uma abordagem etnográfica de migrantes da África Subsaariana – especialmente Senegal – com sede nas cidades de La Plata e Buenos Aires (Argentina). Ele apresenta reflexões sobre experiências de migração transnacional, integração de redes sociais, produção e execução de conhecimento específico sobre a situação da migração. Neste contexto, defendo que os migrantes devem ser pensados como agentes que têm competência para desenvolver e reformular concepções de espaço, mobilidade e sociabilidade, apesar de sua vulnerabilidade social.

Autonomía y descentralización en la construcción del Estado argentino (1860-1940): Por una historia política de los conceptos jurídico-administrativos Casagrande, Agustín Elías Taking as a starting point a critical position against the uses of the words autonomy and autarchy in Altamira´s works in 1950, this essay focuses on the semantic that the administrative law poured into them during the XX century and the problems and political implications which that involved. Nevertheless, that methodological suggestion called for a deeper reconstruction based on the question of how the displacement of the semantics of those two concepts occurred and which was the bond between that change and the building of the National State. To do that, in this work it was taken as a prolific example the experience of the State-nation building in Argentina during 1860-1940, to witness the role the Administrative Law played in it. That task required not only a contextualization but, at the same time, a consideration about the way in which discourses and political power were related. Therefore this work undertakes a parallel study on the education of lawyers ?the creation of the Administrative Law chair at the University of Buenos Aires; the link between the State and the social question that allowed the consolidation of the first; and finally, a textual study of the concept of autonomy and autarchy in the administrative and constitutional literature written at that time.