Stilobezzia Kieffer (Diptera: Ceratopogonidae) from the Brazilian Amazon: three new species, redescription of S. (Stilobezzia) maculata Lane and new records da Silva, Irene M.; Ferreira Keppler, Ruth L.; Cazorla, Carla Gisela Three new species of Stilobezzia Kieffer, 1911 are described and illustrated from the Brazilian Amazon, two in the nominotypical subgenus Stilobezzia: S. (Stilobezzia) brasiliensis n. sp. and S. (Stilobezzia) campinaranensis n. sp., and one in the subgenus Acanthohelea: S. (Acanthohelea) medialuna n. sp. We also redescribe and re-illustrate S. (Stilobezzia) maculata Lane based on the examination of type material and additional specimens. In addition, S. (Eukraiohelea) proxima Cazorla & Felippe-Bauer, S. (Eukraiohelea) quasielegantula Cazorla & Felippe-Bauer, S. (Stilobezzia) chaconi Macfie, S. (Stilobezzia) glauca Macfie, and S. (Stilobezzia) maculata are recorded for the first time from the state of Amazonas, northern Brazil. The number of Stilobezzia species in Brazilian Amazon increases from 11 to 19.

In Vitro Studies of Pegylated Magnetite Nanoparticles in a Cellular Model of Viral Oncogenesis: Initial Studies to Evaluate Their Potential as a Future Theranostic Tool Principe, Gabriel; Lezcano, Virginia Alicia; Tiburzi, Silvina Mabel; Miravalles, Alicia Beatriz; Rivero, Paula Sofia; Montiel Schneider, María Gabriela; Lassalle, Verónica Leticia; González Pardo, María Verónica Magnetic nanosystems represent promising alternatives to the traditional diagnostic and treatment procedures available for different pathologies. In this work, a series of biological tests are proposed, aiming to validate a magnetic nanoplatform for Kaposi’s sarcoma treatment. The selected nanosystems were polyethylene glycol-coated iron oxide nanoparticles (MAG.PEG), which were prepared by the hydrothermal method. Physicochemical characterization was performed to verify their suitable physicochemical properties to be administered in vivo. Exhaustive biological assays were conducted, aiming to validate this platform in a specific biomedical field related to viral oncogenesis diseases. As a first step, the MAG.PEG cytotoxicity was evaluated in a cellular model of Kaposi’s sarcoma. By phase contrast microscopy, it was found that cell morphology remained unchanged regardless of the nanoparticles’ concentration (1–150 µg mL−1). The results, arising from the crystal violet technique, revealed that the proliferation was also unaffected. In addition, cell viability analysis by MTS and neutral red assays revealed a significant increase in metabolic and lysosomal activity at high concentrations of MAG.PEG (100–150 µg mL−1). Moreover, an increase in ROS levels was observed at the highest concentration of MAG.PEG. Second, the iron quantification assays performed by Prussian blue staining showed that MAG.PEG cellular accumulation is dose dependent. Furthermore, the presence of vesicles containing MAG.PEG inside the cells was confirmed by TEM. Finally, the MAG.PEG steering was achieved using a static magnetic field generated by a moderate power magnet. In conclusion, MAG.PEG at a moderate concentration would be a suitable drug carrier for Kaposi’s sarcoma treatment, avoiding adverse effects on normal tissues. The data included in this contribution appear as the first stage in proposing this platform as a suitable future theranostic to improve Kaposi’s sarcoma therapy.

¿El ciudadano que resiste o el sujeto que obedece? Tensiones entre la resistencia y la obediencia en la filosofía de Spinoza; The citizen who resists or the subject who obeys: Tensions between resistance and obedience in Spinoza’s philosophy Rozenberg, Antonio David; Ricci Cernadas, Gonzalo El presente artículo analiza la relación entre obediencia y resistencia en el pensamiento de Baruch Spinoza. El mismo parte de la afirmación hecha por Laurent Bove de que la resistencia es el principio de la libertad política y no la obediencia. Para demostrar la relación contingente y no necesaria que existe entre los términos sustanciales de los cuales trata este artículo, dividimos el mismo en tres partes. La primera parte analiza a la resistencia desde la relación entre deseo e ingenium. La segunda parte se centra en el problema de la obediencia a partir de la figura del súbdito y su relación con el Estado. La tercera y última parte analiza las formas de libertad política en el pensamiento de Spinoza y da cuenta de cómo en la relación entre obediencia y resistencia no implica necesariamente la prioridad de la segunda sobre la primera.; This article analyzes the relationship between obedience and resistance in the thought of Baruch Spinoza. To demonstrate the contingent and not necessary relationship that exists between the terms, the author divides the ar ticle into three par ts. The first par t analyzes resistance from the rela-tionship between desire and ingenium. The second par t focuses on the problem of obedience from the figure of the subject and his relationship with the State. The third and final part analyzes the forms of political freedom in Spinoza’s thought and shows how the relationship bet ween obedience and resistance does not necessarily imply the priority of the second over the first.

Cannabidiol repairs behavioral and brain disturbances in a model of fetal alcohol spectrum disorder Gasparyan, Ani; Navarro, Daniela; Navarrete, Francisco; Austrich Olivares, Amaya; Scoma, Ernest R.; Hambardikar, Vedangi D.; Acosta, Gabriela Beatriz; Solesio, María E.; Manzanares, Jorge Fetal alcohol spectrum disorder (FASD) includes neuropsychiatric disturbances related to gestational and lactational ethanol exposure. Available treatments are minimal and do not modulate ethanol-induced damage. Developing animal models simulating FASD is essential for understanding the underlying brain alterations and searching for efficient therapeutic approaches. The main goal of this study was to evaluate the effects of early and chronic cannabidiol (CBD) administration on offspring exposed to an animal model of FASD. Ethanol gavage (3 g/kg/12 h, p.o.) was administered to C57BL/6 J female mice, with a previous history of alcohol consumption, between gestational day 7 and postnatal day 21. On the weaning day, pups were separated by sex, and CBD administration began (30 mg/kg/day, i.p.). After 4–6 weeks of treatment, behavioral and neurobiological changes were analyzed. Mice exposed to the animal model of FASD showed higher anxiogenic and depressive-like behaviors and cognitive impairment that were evaluated through several experimental tests. These behaviors were accompanied by alterations in the gene, cellular and metabolomic targets. CBD administration normalized FASD model-induced emotional and cognitive disturbances, gene expression, and cellular changes with sex-dependent differences. CBD modulates the metabolomic changes detected in the hippocampus and prefrontal cortex. Interestingly, no changes were found in mitochondria or the oxidative status of the cells. These results suggest that the early and repeated administration of CBD modulated the long-lasting behavioral, gene and protein alterations induced by the FASD model, encouraging the possibility of performing clinical trials to evaluate the effects of CBD in children affected with FASD.

A century of parasitology in fisheries and aquaculture Timi, Juan Tomas; Buchmann, Kurt Fish parasitological research associated with fisheries and aquaculture has expanded remarkably over the past century. The application of parasites as biological tags has been one of the fields in which fish parasitology has generated new insight into fish migration and stock assessments worldwide. It is a well-established discipline whose methodological issues are regularly reviewed and updated. Therefore, no concepts or case-studies will be repeated here; instead, we summarize some of the main recent findings and achievements of this methodology. These include the extension of its use in hosts other than bony fishes; the improvements in the selection of parasite tags; the recognition of the host traits affecting the use of parasite tags; and the increasingly recognized need for integrative, multidisciplinary studies combining parasites with classical methods and modern techniques, such as otolith microchemistry and genetics. Archaeological evidence points to the existence of parasitic problems associated with aquaculture activities more than a thousand years ago. However, the main surge of research within aquaculture parasitology occurred with the impressive development of aquaculture over the past century. Protozoan and metazoan parasites, causing disease in domesticated fish in confined environments, have attracted the interest of parasitologists and, due to their economic importance, funding was made available for basic and applied research. This has resulted in a profusion of basic knowledge about parasite biology, physiology, parasite-host interactions, life cycles and biochemistry. Due to the need for effective control methods, various solutions targeting host-parasite interactions (immune responses and host finding), genetics and pharmacological aspects have been in focus.

Modelling relative abundance of Oligoryzomys flavescens, an Orthohantavirus reservoir, in an endemic hantavirus pulmonary syndrome zone Vadell, María Victoria; Gonzalez Fischer, Carlos Maria; Codesido, Mariano; Carbajo, Anibal Eduardo; Bilenca, David Norberto; Gomez Villafañe, Isabel Elisa Hantavirus pulmonary syndrome (HPS) is a zoonotic emerging infectious disease caused by New World orthohantaviruses (family Hantaviridae) hosted by rodents of the family Cricetidae. In Argentina, one of its main hosts is the sigmodontine rodent Oligoryzomys flavescens, a widely distributed mouse of the Pampas, Delta and Espinal ecoregions of central-east Argentina. Because the abundance of the reservoir and its proportion in the rodent community affects both virus prevalence and human exposure risk, its estimation throughout its known geographical distribution is of key importance for the design of public health strategies to prevent HPS. The aim of this study was therefore to model the relative abundance of O. flavescens in most of the Pampas ecoregion within Buenos Aires Province, Argentina, where hantavirus pulmonary syndrome is endemic. To do this we used owl-pellet samples collected between 2006 and 2008 from 51 sites distributed throughout most of Buenos Aires province. Mammalian prey in each pellet was identified to the lowest possible taxonomic level by examination of the skulls, dentaries and molars. We modelled the frequency of O. flavescens found in each sample as a function of climatic, environmental, and topographic data of each site. The two best models were applied to a Geo referential Information System to build maps of estimated frequency (as a proxy of relative abundance) within Buenos Aires province. Estimated relative abundance of O. flavescens in Buenos Aires province was significantly associated with annual mean temperature, annual precipitation and presence of freshwater bodies, and varied among sub-regions, with the Inland and Rolling Pampas being the regions with highest frequencies. Knowing in which areas O. flavescens abundance is expected to be higher can be used to concentrate limited sanitary efforts in those areas that are most needed in order to reduce transmission and increase detection.

A New Carleman Inequality for a Linear Schrödinger Equation on Some Unbounded Domains Sanchez Fernandez de la Vega, Constanza Mariel; de Teresa, Luz; Torres, Pablo Andres This article presents a new Carleman inequality for a linear Schrödinger equation which is suitable for both bounded and unbounded domains. We characterize the conditions on the auxiliary function necessary to obtain the global inequality. The novelty of this result is the construction of the auxiliary function on some unbounded domains and for a corresponding valid control region ω. As a consequence, we prove some results on the controllability of a linear Schrödinger equation on unbounded domains.

Tripartite networks show that keystone species can multitask Timóteo, Sérgio; Albrecht, Jörg; Rumeu, Beatriz; Norte, Ana C.; Traveset, Anna; Frost, Carol M.; Marchante, Elizabete; López Núñez, Francisco A.; Peralta, Guadalupe; Memmott, Jane; Olesen, Jens M.; Costa, José M.; da Silva, Luís P.; Carvalheiro, Luísa G.; Correia, Marta; Staab, Michael; Blüthgen, Nico; Farwig, Nina; Hervías Parejo, Sandra; Mironov, Sergei; Rodríguez Echeverría, Susana; Heleno, Ruben Keystone species are disproportionately important for ecosystem functioning. While all species engage in multiple interaction types with other species, keystone species importance is often defined based on a single dimension of their Eltonian niche, that is, one type of interaction (e.g. keystone predator). It remains unclear whether the importance of keystone species is unidimensional or if it extends across interaction types. We conducted a meta-analysis of tripartite interaction networks examining whether species importance in one dimension of their niche is mirrored in other niche dimensions, and whether this is associated with interaction outcome, intimacy or species richness. We show that keystone species importance is positively associated across multiple ecological niche dimensions, independently of abundance, and find no evidence that multidimensionality of keystone species is influenced by the explanatory variables. We propose that the role of keystone species extends across multiple ecological niche dimensions, with important implications for ecosystem resilience and conservation. Read the free Plain Language Summary for this article on the Journal blog.

Tan spot of wheat: Can biological control interact with actual management practices to counteract this global disease? Reynoso, Agustina; Sautua, Francisco; Carmona, Marcelo Anibal; Chulze, Sofia Noemi; Palazzini, Juan Manuel Tan spot is a devastating foliar disease of wheat caused by Pyrenophora tritici-repentis, a necrotrophic ascomycete, which causes considerable yield losses worldwide. To control this disease, an integrated management plan must be implemented by the combination of different tools such as the use of wheat varieties with resistance to Tan spot, crop rotation, tillage systems, balanced fertilization and fungicide application. However, there are increasing worldwide restrictions related to the use of chemical products due to environmental and human risks, aggravated by the fact that consumers are demanding food produced in a more environmentally-friendly way. These facts encouraged producers and scientists to exploit the use of native beneficial microorganisms to control phytopathogens of wheat, that can be used as a tool to control Tan spot. This review focuses on the combination of microorganisms with different management practices to produce wheat in a more sustainable way.

Datos y medidas de cerámica entera decorada procedente de colecciones varias de la quebrada de La Cueva (Jujuy, Argentina) Datos y medidas de la cerámica entera decorada procedente de distintas colecciones museográficas de la quebrada de La Cueva (Jujuy, Argentina). Dichas colecciones son: Muniz Barreto (Museo de Ciencias Naturales de La Plata), Casanova-Gatto y Medenica (Museo Etnográfico de Buenos Aires e Instituto Interdisciplinario Tilcara -Universidad de Buenos Aires-), y Basílico (Museo Arqueológico Provincia de Jujuy).

Serie de precipitaciones mensuales Pinamar: Período 2017-2022 Se presentan los registros mensuales de precipitaciones registrados por la estación meteorológica perteneciente a la Munipalidad de Pinamar. La instalación y mantenimiento de la misma se encuentra dentro de los alcances previstos en el convenio de cooperación entre el Dr. Rodrigues Capitulo, Leandro (UNLP-CONICET) y el Municipio de Pinamar.

Registro de Conductividades Eléctricas (Salinidad) en Perforación de Monitoreo de Interfase Agua Dulce-Salada: Pinamar Se muestran los registros obtenidos a partir de un sensor automático de niveles y conductividad eléctrica (Salinidad) de una perforación de monitoreo de la interfase agua dulce-salada ubicada la Localidad de Pinamar.

Hilbert modular forms of half-integral weight These files are the result of using the main result from "Nicolás Sirolli and Gonzalo Tornaría, Effective construction of Hilbert modular forms of half-integral weight" for computing the central values twisted L-series attached to Hilbert modular forms.

Área afectada por incendios forestales en el área serrana de la Región Metropolitana de Córdoba (1999-2022) Archivo vectorial tipo shape que muestra los polígonos correspondientes a las áreas afectadas por incendios forestales en el área serrana de la Región Metropolitana de Córdoba (entre 1999 y 2022). Incluye el área de Sierras Chicas, Valle de Punilla y Valle de Paravachasca. El relevamiento se realizó manualmente según áreas afectadas identificadas en imágenes Landsat 5 y 8 obtenidas entre julio y diciembre.

Análisis filogenético de cepas de Camarosporium sp. en Atriplex undulatum del Salitral de la Vidriera Conjunto de datos del análisis filogenético, 4 alineamientos de las secuencias de cuatro genes (ITS, LSU, SSU y TEF1) de 26 especies del banco de datos genéticos junto con tres cepas propias y una matriz concatenada con 3 de los 4 genes.

Alteraciones en la memoria de crías de ratas expuestas a Flúor durante la gestación y la lactancia Daily exposure to fluoride (F) depends mainly on the intake of this element with drinking water. When administered during gestation and lactation, F has been associated with cognitive deficits in the offspring. However, the mechanisms underlying the neurotoxicity of F remain obscure. In the current study, we investigated the effects of oral exposure to low levels of F during the gestational and lactation periods, on the memory of adult female rat offspring. We also considered a possible underlying neurotoxic mechanism. Our results showed that this exposure reduced step-down latency in the inhibitory avoidance task, and decreased both mRNA expression of the α7 nicotinic receptor (nAChR) and catalase activity in hippocampus. Our data indicates that low F concentrations administrated during gestation and lactation decrease the memory of 90-day-old female offspring. This suggests that the mechanism might be connected with an α7 nAChR deficit in the hippocampus, induced by oxidative stress.

Base de datos para perfil de FE según la creatividad Base de datos para el estudio del perfil de funciones ejecutivas según la creatividad verbal y figurativa. La muestra, no probabilística por conveniencia, estuvo compuesta por un total 200 niños escolarizados de 8 a 12 años niños y niñas. Los criterios de inclusión que se tuvieron en cuenta fueron: (a) niños que no presenten antecedentes clínicos, neurológicos ni psiquiátricos, (b) que cursen estudios escolares con regularidad, (c) sin repitencia escolar. Además, se evaluó la inteligencia como variable de control. En la base están los datos del dos pruebas de creatividad: CREA y TTCT, de las funciones ejecutivas: memoria de trabajo, inhibición, fluidez verbal y no verbal, y planificación.

Palinología de la Cuenca Neuquina, provincia de Neuquén, Argentina Se realizó el análisis palinológico (palinoestratigráfico y palinofacial) de diferentes unidades jurásico-cretácicas de la Cuenca Neuquina con el fin de refinar su ubicación bioestratigráfica, paleoambiental y paleoecológica.

Mediciones para el estudio de sensores piezoeléctricos de banda ancha con metalización Mediciones que se usaron para el estudio de las posibles fuentes de ruido de los sensores ultrasónicos para tomografía optoacústica, previamente desarrollados en el GLOmAe. Bajo la premisa de no modificar el esquema básico constructivo ya establecido, se probaron dos esquemas de blindaje. En uno de ellos se logró reducir notablemente la presión equivalente de ruido sin afectar la sensibilidad del detector.

Registros fotográficos de trabajo de campo. Peregrinación tradicional de los Tres Pueblos a la Basílica de Itatí El santuario de la Virgen de Itatí, ubicado en la provincia de Corrientes, es uno de los principales centros de peregrinaje mariano del Nordeste argentino (NEA). Recibe cerca de dos millones de promeseros en diferentes peregrinaciones anuales. Entre ellas, se destaca la “Peregrinación de los Tres Pueblos” que protagonizan Santa Ana de los Guácaras, Paso de la Patria y San Cosme en el mes de abril. La manifestación se desplaza hace más de 100 años sobre el actual trazado de la ruta nacional N°12, también llamada “la Ruta de la fe” en la región NEA. Estos datos de investigación incluyen los registros fotográficos del trabajo de campo desarrollado entre 2011 y 2015 para la elaboración del capítulo "Peregrinos de la Virgen de Itatí. Legados e identidades en la Ruta de la Fe". El trabajo describe las singularidades que adopta esta peregrinación de perfil predominantemente tradicional, regida por la lógica del legado religioso y cultural de base vincular familiar, comunitaria e intercomunitaria regional, en relación a otras movilizaciones anuales que tienen como destino Itatí; recupera narrativas históricas, relatos y prácticas de los promeseros en relación a marcadores socio-religiosos, fijos y móviles, observables en este trayecto. El propósito es observar las maneras en que los peregrinos se vinculan con la Virgen, los santos patronos y otras figuras sagradas y delinean en la apropiación del espacio esta “geografía de lo sagrado”. Al mismo tiempo, busca reflexionar cómo los pueblos actualizan y reconfiguran legados e identidades en el camino, en vinculación con procesos de movilidad socio- cultural más amplios.