El Fondo Argentino Sectorial (FONARSEC) anuncia la lista con los evaluadores que integran la comisión EBT 2.0 mediante Resolución de Directorio N° 043/18 del día 01/02/2018

El Fondo Argentino Sectorial (FONARSEC) anuncia los resultados de proceso de adjudicación para enzimas, medicina de precisión y alimentos para adultos mayores mediante la resolución 609, 563 y 509/17.

El Fondo Argentino Sectorial (FONARSEC) anuncia los resultadoos de la convocatoria INNOVACUA 2016 mediante Resolución de Directorio N° 471/17.

El Fondo Argentino Sectorial (FONARSEC) anuncia el resultado del proceso de adjudicación para Desarrollos de partes nacionales para satélites mediante la resolución 479, 619/17.

La Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT), a través de su Fondo para la Investigación Científica y Tecnológica (FONCyT), llama a concurso de Proyectos de Investigación destinados a la compra de Equipamiento Científico – PICTE -, con el objeto de financiar la adquisición de equipamiento científico destinado a Unidades Ejecutoras de I+D pertenecientes a Instituciones Públicas dedicadas a la investigación científica o tecnológica.

Mutation of Agr Is Associated with the Adaptation of Staphylococcus aureus to the Host during Chronic Osteomyelitis Suligoy Lozano, Carlos Mauricio; Lattar, Santiago Martín; Noto Llana, Mariangeles; Gonzalez, Cintia Daniela; Alvarez, Lucía Paula; Robinson, D. Ashley; Gómez, Marisa Ileana; Buzzola, Fernanda Roxana; Sordelli, Daniel Oscar Selection pressures exerted on Staphylococcus aureus by host factors may lead to the emergence of mutants better adapted to theevolving conditions at the infection site. This study was aimed at identifying the changes that occur in S. aureus exposed to thehost defense mechanisms during chronic osteomyelitis and evaluating whether these changes affect the virulence of the organism.Genome assessment of two S. aureus isolates collected 13 months apart (HU-85a and HU-85c) from a host with chronicosteomyelitis was made by full genome sequencing. Agr functionality was assessed by qRT-PCR. Isolates were tested in a rat modelof osteomyelitis and the bacterial load (CFU/tibia) and the morphometric osteomyelitic index (OI) were determined. The ability ofthe isolates to trigger the release of proinflammatory cytokines was determined on macrophages in culture. Persistence of S.aureus within the host resulted in an agrC frameshift mutation that likely led to the observed phenotype. The capacity to causebone tissue damage and trigger proinflammatory cytokines by macrophages of the agr-deficient, unencapsulated derivative(HU-85c) was decreased when compared with those of the isogenic CP8-capsulated parental strain (HU-85a). By comparison, nosignificant differences were found in the bacterial load or the OI from rats challenged with isogenic Reynolds strains [CP5, CP8 andnon-typeable (NT)], indicating that lack of CP expression alone was not likely responsible for the reduced capacity to cause tissuedamage in HU-85c compared with HU-85a. The production of biofilm was significantly increased in the isogenic derivative HU-85c.Lack of agr-dependent factors makes S. aureus less virulent during chronic osteomyelitis and alteration of the agr functionalityseems to permit better adaptation of S. aureus to the chronically infected host.

Water Resource Distribution and Tectonics in the Tulum Valley, Western Central Argentina Rodríguez, Aixa Inés; Martínez, Myriam Patricia; Abarca, María Graciela A gravimetric analyse over the Tulum Valley was made. This data was used to reveal the tectonic structures in the Valley. Gravity data was processed using upward continuation and vertical derivative filters and all the results were compared with drainage systems and groundwater maps of the area. Both groundwater and surface-water are highly demanded resources due to theirscarcity. The drainage network and groundwater are influenced by tectonic structures in the Tulum valley. In the piedmont of the Sierra Chica de Zonda the broom-shaped river pattern correspond to Quaternary faults. While in the central Tulum Valley, the depocenter basin is a water recipient, the groundwater table permanently close to the surface and they are considered discharge. The depocenter is linked to paleo-swamps and wetlands in a pastwetter environment. In the Tulum fault systems area, streams adapt its drainagenetwork bordering basements blocks uplifts. In turn, the blocks uplift behavesas a hydrogeological barrier for the groundwater basin. Also, in the alluvial fan of San Juan River the free aquifer is affected by a Tertiary uplift block.From this study, it was concluded that tectonic structures control surface and groundwater resources in the Tulum Valley.

Vaccine potential of antigen cocktails composed of recombinant Toxoplasma gondii TgPI-1, ROP2 and GRA4 proteins against chronic toxoplasmosis in C3H mice Picchio, Mariano Sergio; Sánchez, Vanesa Roxana; Arcon, Nadia; Soto, Ariadna Soledad; Perrone Sibilia, Matias; Aldirico, María de Los Ángeles; Urrutia, Mariela; Moretta, Rosalia Ester; Fenoy, Ignacio Martín; Goldman, Alejandra; Martín, Valentina The development of an effective and safe vaccine to prevent Toxoplasma gondii infection is an important aim due to the great clinical and economic impact of this parasitosis. We have previously demonstrated that immunization with the serine protease inhibitor-1 (TgPI-1) confers partial protection to C3H/HeN and C57BL/6 mice. In order to improve the level of protection, in this work, we combined this novel antigen with ROP2 and/or GRA4 recombinant proteins (rTgPI-1+rROP2, rTgPI-1+rGRA4, rTgPI-1+rROP2+rGRA4) to explore the best combination against chronic toxoplasmosis in C3H/HeN mice. All tested vaccine formulations, administered following a homologous prime-boost protocol that combines intradermal and intranasal routes, conferred partial protection as measured by the reduction of brain cyst burden following oral challenge with tissue cysts of Me49 T. gondii strain. The highest level of protection was achieved by the mixture of rTgPI-1 and rROP2 proteins with an average parasite burden reduction of 50% compared to the unvaccinated control group. The vaccine-induced protective effect was related to the elicitation of systemic cellular and humoral immune responses that included antigen-specific spleen cell proliferation, the release of Th1/Th2 cytokines, and the generation of antigen-specific antibodies in serum. Additionally, mucosal immune responses were also induced, characterized by secretion of antigen-specific IgA antibodies in intestinal lavages and specific mesenteric lymph node cell proliferation. Our results demonstrate that rTgPI-1+rROP2 antigens seem a promising mixture to be combined with other immunogenic proteins in a multiantigenic vaccine formulation against toxoplasmosis.

Transformaciones y permanencias en lo tipificado como violento en el espacio escolar (1993-2011); Transformations and stays in defined as violent in the school space (1993-2011); Transformações e permanência no que é classificado como violento no espaço escolar (1993-2011) Saez, Virginia El presente trabajo analiza las transformaciones y permanencias de lo tipificado como violento en el espacio escolar, en la prensa argentina, durante el período 1993-2011. Dadas las características del objeto de indagación, el abordaje metodológico fue cualitativo y la información se analizó en el marco del análisis socioeducativo del discurso. Entre los resultados obtenidos observamos que durante los dieciocho años se visibilizan once temáticas comunes que asocian las violencias al espacio escolar. Así también, se identificaron desplazamientos de sentido que asociaron las violencias a la escuela desde diferentes referentes. Por su originalidad, este estudio constituye un antecedente para futuras indagaciones sobre las representaciones mediáticas de las violencias en el espacio escolar y sus mutaciones de sentido.; The present work analyzes the changes and permanencies of defined as violent in the school space, in the press in Argentina during the period 1993-2011. Given the characteristics of the object of inquiry, the methodological approach was qualitative, and the information is analyzed in the framework of the educational discourse analysis. Among the results obtained we note that during the 18 years become visible, eleven thematic linking violence to the school space. Well, it was identified that displacement associated violence to school from different referents. For its originality, this study constitutes a precedent for future inquiries on media representations of violence in the school space and its mutations of sense.; O presente trabalho analisa as transformações e permanências do tipificado como violento no espaço escolar, na imprensa argentina, durante o período de 1993-2011. Dadas as características do objeto de indagação, a abordagem metodológica foi qualitativa e a informação foi analisada no contexto da análise socioeducativa do discurso. Entre os resultados obtidos, observamos que, durante os dezoito anos, são visíveis onze temas comuns que associam violência ao espaço escolar. Além disso, foram identificados deslocamentos de significado que associaram a violência à escola de diferentes referentes. Por causa da sua originalidade, este estudo constitui um precedente para futuros inquéritos sobre as representações da mídia na violência no espaço escolar e suas mutações sensoriais.

Search for the Decay of the Higgs Boson to Charm Quarks with the ATLAS Experiment Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Alconada Verzini, María Josefina; Alonso, Francisco; Arduh, Francisco Anuar; Dova, Maria Teresa; Hoya, Joaquín; Monticelli, Fernando Gabriel; Wahlberg, Hernan Pablo; Bossio Sola, Jonathan David; Daneri, María Florencia; Devesa, Maria Roberta; Marceca, Gino; Otero y Garzon, Gustavo Javier; Piegaia, Ricardo Nestor; Sacerdoti, Sabrina; Zinonos, Z.; Zinser, M.; Ziolkowski, M.; Živković, L.; Zobernig, G.; Zoccoli, A.; Zoch, K.; Nedden, M. zur; Zorbas, T. G.; Zou, R.; Zwalinski, L.; The ATLAS Collaboration A direct search for the Standard Model Higgs boson decaying to a pair of charm quarks is presented. Associated production of the Higgs and Z bosons, in the decay mode ZH → ` + ` − cc¯ is studied. A dataset with an integrated luminosity of 36.1 fb−1 of pp collisions at √ s = 13 TeV recorded by the ATLAS experiment at the LHC is used. The H → cc¯ signature is identified using charm-tagging algorithms. The observed (expected) upper limit on σ(pp → ZH) × B(H → cc¯) is 2.7 (3.9 +2.1 −1.1 ) pb at the 95% confidence level for a Higgs boson mass of 125 GeV, while the Standard Model value is 26 fb.

Validación externa de ecuaciones de riesgo cardiovascular en el Cono Sur de Latinoamérica: ¿cuál predice mejor?; External Validation of Cardiovascular Risk Scores in the Southern Cone of Latin America: Which Predicts Better? Gulayin, Pablo Elías; Danaei, Goodarz; Gutierrez, Laura; Poggio, Rosana; Ponzo, Jaqueline; Lanas, Fernando; Rubinstein, Adolfo Luis; Irazola, Vilma Introducción: La estimación inexacta del riesgo cardiovascular poblacional puede llevar a un manejo inadecuado de las intervenciones médicas preventivas, como, por ejemplo, el uso de estatinas. Objetivo: Evaluar la validez externa de ecuaciones de predicción de riesgo cardiovascular en población general del Cono Sur de Latinoamérica. Material y métodos: Se evaluaron ecuaciones que incluyen variables evaluadas en el estudio CESCAS y que predicen tanto morbilidad como mortalidad cardiovascular global (CUORE, Framingham, Globorisk y Pooled Cohort Studies Equations). Para cada ecuación se realizó un análisis independiente en el que se tuvieron en cuenta los eventos cardiovasculares relevados. Se evaluó la discriminación de cada ecuación a través del cálculo del estadístico-C y el índice Harrell C. Para evaluar la calibración se graficó la proporción de riesgos observados vs. estimados por quintilos de riesgo para cada ecuación y se calculó la pendiente β de regresión lineal para las estimaciones. Se calculó sensibilidad y especificidad para la detección de personas con elevado riesgo cardiovascular. Resultados: La mediana del tiempo de seguimiento de la cohorte al momento del análisis es de 2,2 años, con un rango intercuartilo de 1,9 a 2,8 años. Se incorporaron a los análisis 60 eventos cardiovasculares. Todos los valores de estadístico-C y del índice de Harrell fueron superiores a 0,7. El valor de la pendiente β más alejado de 1 fue el de Pooled Cohort Studies Euations. Conclusiones: Si bien los parámetros de validación externa evaluados fueron similares, CUORE, Globorisk y el índice de Framingham fueron las ecuaciones con mejores indicadores globales de predicción de riesgo cardiovascular.; Background: Inaccurate estimates of demographic cardiovascular risk may lead to an inadequate management of preventive medical interventions such as the use of statins. Objectives: The aim of this study was to evaluate the external validity of cardiovascular risk equations in the general population of the Southern Cone of Latin America. Methods: Equations including variables evaluated in the CESCAS cohort study and that estimate overall cardiovascular mortality (CUORE, Framingham, Globorisk and Pooled Cohort Studies) were assessed. For each equation, an independent analysis was performed taking into account the cardiovascular events originally considered. Discrimination of each equation was evaluated through C-statistic and Harrell’s C-index. To assess calibration, a graph was built for each equation with the proportion of observed events vs. the proportion of estimated events by risk quintiles and the β slope of the resulting linear regression was calculated. Sensitivity and specificity were determined for the detection of people at high cardiovascular risk. Results: The median follow-up time of the cohort at the time of the analysis was 2.2 years, with an interquartile range of 1.9 to 2.8 years. Sixty cardiovascular events were incorporated into the analysis. All C-statistic and Harrell’s-C index values were greater than 0.7. The value of the β slope farthest from 1 was that of the Pooled Cohort Studies score. Conclusions: Although the external validation parameters evaluated were similar, CUORE, Globorisk and the Framingham equations showed the best global performance for cardiovascular risk estimation in our population.

Vibrational assignments of two polymorphic forms of metaxolone by using DFT calculations and the SQM methodology Iramain, Maximiliano Alberto; Márquez, María J.; Ledesma, Ana Estela; Brandan, Silvia Antonia A theoretical study has been performed on the musclerelaxant 5-[(3, 5-dimethylphenoxy)methyl]-1,3-oxazolidin-2-one, of generic name metaxolone (MTX), by using the hybridB3LYP/6-31G calculations in the gas phase and theexperimental available infrared and Raman spectra in thesolid phase. Three C1, C2 and C3 isomers were found in thepotential energy surface (PES) but only two of them, C1 andC2 correspond to those experimentally reported polymorphicforms A and B, respectively. The absence of C3 isomer couldbe easily explained by the quite high values in the dihedralC5-C7-O2-C9 and O1-C5-C7-O2 angles different from thoseexperimental structures reported for the two polymorphicforms A and B of MTX. On the other hand, the higher bondorders values together with the high topological propertiesobserved for the oxazolidinone ring of C1 could possiblysupport their existence despite this isomer has highest energythan C2 and C3. The natural bond orbital (NBO) analysesreveal the high stabilities of C1 and C2 while the atoms inmolecules(AIM) study suggests that the ringdimethylphenoxy-methyl practically do not have influence onthe properties of MTX. The frontier orbitals show that theisomers of MTX have reactivities and electrophilicity indexessimilar to antiviral thymidine while their nucleophilicityindexes present values closer to antimicrobial thione. Inaddition, the complete vibrational assignments of those twostable isomers were performed by using the experimentalavailable FT-IR and FT-Raman spectra, their normal internalcoordinates,the scaled quantum mechanical force field(SQMFF) methodology and the Molvib program.Theharmonic force fields for the two isomers and theircorresponding force constants were also reported. The forceconstants values are in agreement with values reported in theliterature for species with similar groups.

Protein Fluctuations and Cavity Changes Relationship Barletta Roldan, Patricio German; Fernández Alberti, Sebastián Protein cavities and tunnels are critical for function. Ligand recognition and binding, transport, and enzyme catalysis require cavities rearrangements. Therefore, the flexibility of cavities should be guaranteed by protein vibrational dynamics. Molecular dynamics simulations provide a framework to explore conformational plasticity of protein cavities. Herein, we present a novel procedure to characterize the dynamics of protein cavities in terms of their volume gradient vector. For this purpose, we make use of algorithms for calculation of the cavity volume that result robust for numerical differentiations. Volume gradient vector is expressed in terms of principal component analysis obtained from equilibrated molecular dynamics simulations. We analyze contributions of principal component modes to the volume gradient vector according to their frequency and degree of delocalization. In all our test cases, we find that low frequency modes play a critical role together with minor contributions of high frequency modes. These modes involve concerted motions of significant fractions of the total residues lining the cavities. We make use of variations of the potential energy of a protein in the direction of the volume gradient vector as a measure of flexibility of the cavity. We show that proteins whose collective low frequency fluctuations contribute the most to changes of cavity volume exhibit more flexible cavities.

Phocoena spinipinnis, Burmeister's Porpoise Félix, F.; Alfaro Shigueto, J.; Reyes, J.; Mangel, J.; Dellabianca, N.; Heinrich, S.; Crespo, Enrique Alberto El texto incluye una revisión taxonómica, el rango de distribución, información poblacional, ecológica, genética, amenazas y estado de conservación.

De fiesta antes de la fiesta: relación entre esta práctica de consumo de alcohol con los problemas derivados del uso de alcohol en jóvenes argentinos; Association between attendance to pregaming events and alcohol-related consequences in argentinean youth Pilatti, Angelina; Etkin, Paula; Urioste Parra, Eugenia; Pautassi, Ricardo Marcos Objetivos: Este trabajo describe el perfil de consumo de alcohol de jóvenes asistentes a previas y analiza la relación entre la frecuencia de asistencia a previas, y el consumo de alcohol en las mismas, con la experimentación de consecuencias negativas, así como la modulación de estas variables por la edad de inicio de consumo. Se examina el poder predictivo de la frecuencia de asistencia a previas sobre la cantidad de problemas por consumo de alcohol controlando el efecto de variables sociodemográficas, volumen de alcohol consumido, frecuencia de consumo episódico elevado y edad de inicio del consumo de alcohol. Método: 493 participantes (62.3% mujeres) completaron una encuesta online para determinar la frecuencia de asistencia a previas y cantidad de consumo de alcohol en previas, consumo riesgoso de alcohol, consumo de alcohol durante una semana típica de consumo y durante la semana de consumo más intensa y consecuencias negativas del consumo de alcohol. Resultados: se encontró una correlación significativa y positiva entre la frecuencia y cantidad de consumo de alcohol en previas con la frecuencia de consumo riesgoso de alcohol y con la cantidad de problemas experimentados. El efecto de la frecuencia de asistencia a previas sobre la cantidad de consecuencias negativas fue significativo controlando el efecto de otras variables independientes. Conclusiones: Los resultados de este trabajo indican que el contexto recreativo de las previas implicaría riesgos distintivos, representando un factor de vulnerabilidad para el desarrollo de un mayor número de problemas con el alcohol.; Aims. This work described patterns of alcohol drinking in youth that attended pregaming events (i.e., the practice of drinking alcoholic beverages before attending a social/sporting event) and analyzed the relationship between frequency of pregaming, alcohol consumption at pregaming and alcohol-related negative consequences; and the modulation of these variables by the age of onset of alcohol drinking. Methods. 493 participants (62.3% women) completed an online survey that determine the frequency of attendance at pregaming events, the quantity of alcohol consumed in those events, risky alcohol drinking, alcohol consumption during a typical drinking week or during the most intense drinking week, and the number of negative alcohol-related consequences. Results. There was a significant and positive correlation between frequency and quantity of alcohol consumed at pregaming with frequency of risky drinking, and with the number of negative alcohol-related consequences. The effect of frequency of attendance at pregaming events upon the number of negative alcoholrelated consequences was significant after controlling for the effect of the other independent variables. Conclusions. The results suggest that this consumption practice (i.e., pregaming) involves distinctive risks and represents a vulnerability factor for the development of negative alcohol-related consequences.

TT-deformations, AdS/CFT and correlation functions Giribet, Gaston Enrique A solvable irrelevant deformation of AdS3/CFT2 correspondence leading to a theory with Hagedorn spectrum at high energy has been recently proposed. It consists of a single trace deformation of the boundary theory, which is inspired by the recent work on solvable TT¯ deformations of two-dimensional CFTs. Thought of as a worldsheet σ-model, the interpretation of the deformed theory from the bulk viewpoint is that of string theory on a background that interpolates between AdS3 in the IR and a linear dilaton vacuum of little string theory in the UV. The insertion of the operator that realizes the deformation in the correlation functions produces a logarithmic divergence, leading to the renormalization of the primary operators, which thus acquire an anomalous dimension. We compute this anomalous dimension explicitly, and this provides us with a direct way of determining the spectrum of the theory. We discuss this and other features of the correlation functions in presence of the deformation.

A QQ → QQ planar double box in canonical form Bianchi, Marco S.; Leoni Olivera, Matías We consider a planar double box with four massive external momenta and two massive internal propagators. We derive the system of differential equations for the relevant master integrals, cast it in canonical form, write it as a dlog form and solve it in terms of iterated integrals up to depth four.

Measurements of Higgs boson properties in the diphoton decay channel with 36 fb−1 of pp collision data at s√=13 TeV with the ATLAS detector Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Alconada Verzini, María Josefina; Alonso, Francisco; Arduh, Francisco Anuar; Dova, Maria Teresa; Hoya, Joaquín; Monticelli, Fernando Gabriel; Wahlberg, Hernan Pablo; Bossio Sola, Jonathan David; Marceca, Gino; Otero y Garzon, Gustavo Javier; Piegaia, Ricardo Nestor; Sacerdoti, Sabrina; Zibell. A.; Zieminska, D.; Zimine, N. I.; Zimmermann, C.; Zimmermann, S.; Zinonos, Z.; Zinser, M.; Ziolkowski, M.; Živković, L.; Zobernig, G.; Zoccoli, A.; Nedden, M. zur; Zurzolo, G.; Zwalinski, L.; The ATLAS Collaboration Properties of the Higgs boson are measured in the two-photon final state using 36.1 fb−1 of proton-proton collision data recorded at s√=13 TeV by the ATLAS experiment at the Large Hadron Collider. Cross-section measurements for the production of a Higgs boson through gluon-gluon fusion, vector-boson fusion, and in association with a vector bosonor a top-quark pair are reported. The signal strength, defined as the ratio of the observed to the expected signal yield, is measured for each of these production processes as well as inclusively. The global signal strength measurement of 0.99±0.14 improves on the precision of the ATLAS measurement at s√=7 and 8 TeV by a factor of two. Measurements of gluon-gluon fusion and vector-boson fusion productions yield signal strengths compatible with the Standard Model prediction. Measurements of simplified template cross sections, designed to quantify the different Higgs boson production processes in specific regions of phase space, are reported. The cross section for the production of the Higgs boson decaying to two isolated photons in a fiducial region closely matching the experimental selection of the photons is measured to be 55±10 fb, which is in good agreement with the Standard Model prediction of 64±2 fb. Furthermore, cross sections in fiducial regions enriched in Higgs boson production in vector-boson fusion or in association with large missing transverse momentum, leptons or top-quark pairs are reported. Differential and double-differential measurements are performed for several variables related to the diphoton kinematics as well as the kinematics and multiplicity of the jets produced in association with a Higgs boson. No significant deviations from a wide array of Standard Model predictions are observed.

Asymmetric synthesis of: Trans -4,5-disubstituted γ-butyrolactones involving a key allylboration step. First access to (-)-nicotlactone B and (-)-galbacin Henrion, S.; Macé, A.; Vallejos, Margarita; Roisnel, T.; Carboni, B.; Villalgordo, J.M.; Carreaux, Francois An efficient asymmetric synthesis of trans-4,5-disubstituted γ-butyrolactones from aldehydes and enantioenriched γ-carbamate alkenylboronates is reported. The cornerstone of this strategy is the implementation of sequential [3,3]-allyl cyanate rearrangement/allylboration/nucleophilic addition/cyclisation reactions. Diverse γ-butyrolactones such as the flavouring compounds, (+)-trans-whiskey lactone and (+)-trans-cognac lactone, as well as an advanced intermediate towards the first synthesis of natural products, (-)-nicotlactone B and (-)-galbacin, have thus been obtained.

Encapsulation of Compounds Biphenyls Into SBA-15: Synthesis of Composites for Application Guntero, Vanina Alejandra; Ferretti, Cristián Alejandro; Mancini, Pedro Maximo Emilio; Kneeteman, Maria Nelida Two novel hybrid mesoporous material BVA-SBA and BEG-SBA were designed and synthesized by a process assisted by microwave. The nanoparticles were studied by UV-vis and fluorescence spectroscopy, elemental analysis, nitrogen adsorption-desorption, RMN and FTIR. The results obtained indicates the successful immobilization of BVA and BEG in the mesoporous composite. These systems present the possibility of activating the release of the organic molecules encapsulated into SBA-15, depending on the liquid medium in which the composite are suspended.