Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Galluzzi, Lorenzo; Vitale, Ilio; Aaronson, Stuart A.; Abrams, John M.; Adam, Dieter; Agostinis, Patrizia; Alnemri, Emad S.; Altucci, Lucia; Amelio, Ivano; Andrews, David W.; Annicchiarico Petruzzelli, Margherita; Antonov, Alexey V.; Arama, Eli; Baehrecke, Eric H.; Barlev, Nickolai A.; Bazan, Nicolas G.; Bernassola, Francesca; Bertrand, Mathieu J. M.; Bianchi, Katiuscia; Blagosklonny, Mikhail V.; Blomgren, Klas; Borner, Christoph; Boya, Patricia; Brenner, Catherine; Campanella, Anibal; Candi, Eleonora; Carmona Gutierrez, Didac; Cecconi, Francesco; Chan, Francis K. M.; Chandel, Navdeep S.; Cheng, Emily H.; Chipuk, Jerry E.; Cidlowski, John A.; Ciechanover, Aaron; Cohen, Gerald M.; Conrad, Marcus; Cubillos Ruiz, Juan R.; Czabotar, Peter E.; D´Angiolella, Vincenzo; Dawson, Ted M.; Dawson, Valina L.; De Laurenzi, Vincenzo; De Maria, Ruggero; Debatin, Klaus Michael; De Berardinis, Ralph J.; Deshmukh, Mohanish; Di Daniele, Nicola; Di Virgilio, Francesco; Dixit, Vishva M.; Dixon, Scott J.; Duckett, Colin S.; Dynlacht, Brian D.; El Deiry, Wafik S.; Elrod, John W.; Fimia, Gian Maria; Fulda, Simone; García Sáez, Ana J.; Garg, Abhishek D.; Garrido, Carmen; Gavathiotis, Evripidis; Golstein, Pierre; Gottlieb, Eyal; Green, Douglas R.; Greene, Lloyd A.; Gronemeyer, Hinrich; Gross, Atan; Hajnoczky, Gyorgy; Hardwick, J. Marie; Harris, Isaac S.; Hengartner, Michael O.; Hetz, Claudio; Ichijo, Hidenori; Jäättelä, Marja; Joseph, Bertrand; Jost, Philipp J.; Juin, Philippe P.; Kaiser, William J.; Karin, Michael; Kaufmann, Thomas; Kepp, Oliver; Kimchi, Adi; Kitsis, Richard N.; Klionsky, Daniel J.; Knight, Richard A.; Kumar, Sharad; Lee, Sam W.; Lemasters, John J.; Levine, Beth; Linkermann, Andreas; Lipton, Stuart A.; Lockshin, Richard A.; López Otín, Carlos; Lowe, Scott W.; Luedde, Tom; Lugli, Enrico; MacFarlane, Marion; Madeo, Frank; Malewicz, Michal; Malorni, Walter; Manic, Gwenola; Marine, Jean-Christophe; Martin, Seamus J.; Martinou, Jean Claude; Medema, Jan Paul; Mehlen, Patrick; Meier, Pascal; Melino, Sonia; Miao, Edward A.; Molkentin, Jeffery D.; Moll, Ute M.; Muñoz Pinedo, Cristina; Nagata, Shigekazu; Nuñez, Gabriel; Oberst, Andrew; Oren, Moshe; Overholtzer, Michael; Pagano, Michele; Panaretakis, Theocharis; Pasparakis, Manolis; Penninger, Josef M.; Pereira, David M.; Pervaiz, Shazib; Peter, Marcus E.; Piacentini, Mauro; Pinton, Paolo; Prehn, Jochen H.M.; Puthalakath, Hamsa; Rabinovich, Gabriel Adrián; Rehm, Markus; Rizzuto, Rosario; Rodrigues, Cecilia M.P.; Rubinsztein, David C.; Rudel, Thomas; Ryan, Kevin M.; Sayan, Emre; Scorrano, Luca; Shao, Feng; Shi, Yufang; Silke, John; Simon, Hans Uwe; Sistigu, Antonella; Stockwell, Brent R.; Strasser, Andreas; Szabadkai, Gyorgy; Tait, Stephen W.G.; Tang, Daolin; Tavernarakis, Nektarios; Thorburn, Andrew; Tsujimoto, Yoshihide; Turk, Boris; Vanden Berghe, Tom; Vandenabeele, Peter; Vander Heiden, Matthew G.; Villunger, Andreas; Virgin, Herbert W.; Vousden, Karen H.; Vucic, Domagoj; Wagner, Erwin F.; Walczak, Henning; Wallach, David; Wang, Ying; Wells, James A.; Wood, Will; Yuan, Junying; Zakeri, Zahra; Zhivotovsky, Boris; Zitvogel, Laurence; Melino, Gerry; Kroemer, Guido
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.
La intervención del Estado en lo social y modelo agroalimentario en la Argentina posneoliberal; The intervention of the State in the social and agro-food model in post-neoliberal Argentina
Ambrosi, Daniela Celeste
En el nuevo milenio y en el marco del ‘giro a la izquierda’, luego de las transformaciones y consecuencias políticas, económicas y sociales producto del proyecto neoliberal y ante la presencia de actores sociales organizados y movilizados, desde el Estado se han implementado diversas estrategias de intervención en lo social, tanto en Argentina como en diversos países de América Latina. En esos sentidos, el presente artículo pretende aportar a las discusiones sobre la relación Estado, sociedad civil y mercado en el campo de las políticas sociales en Argentina. En términos de objetivos y a partir de la revisión de fuentes secundarias, se busca analizar las relaciones entre las políticas sociales y el modelo agroalimentario durante los diversos gobiernos en el contexto posneoliberal, identificando las estrategias políticas, económicas y sociales desplegadas desde el Estado, pero también aquellas prácticas y sentidos de apropiación cotidiana por parte de sus usuarios, evitando un enfoque instrumental de las mismas. En esta última dirección, hacia el final, se presentará el caso de la asignación universal por hijo (AUH) y la dimensión alimentaria.; In the new millennium, after the transformations and political, economic and social consequences, product of the neoliberal project and in the face of the presence of organized and mobilized social actors, from the government has implemented, in the context of the ‘left turn’, varied intervention strategies in the social item, in Argentina and many countries of Latin America. The present article aims to contribute to the discussions on the relationship between State, civil society and market in the field of social politics in Argentina. In terms of objectives and from the review of secondary sources, it seeks to analyze the relationships between social politics and the agro-food model during the several governments in the post-neoliberal context, identifying the political, economic and social strategies deployed from the State, but also those practices and meanings of daily appropriation by its users, avoiding an instrumental focus approach to them. In this last direction, towards the end, the case of the Asignación Universal por Hijo (Universal Child Allowance) will be presented on the food dimension.
