Por amor al arte: El problema de la autonomía en el asociacionismo cultural bonaerense(La Asociación Cultural de Bahía Blanca, 1919-1927) Agesta, María de Las Nieves El presente trabajo se propone abordar el problema de las relaciones entre las asociaciones culturales del interior de la provincia de Buenos Aires, el mercado y el Estado a principios del siglo XX. El doble reclamo de autonomía ligado al asociacionismo moderno y a la configuración de una esfera específica de las artes, suponía para ellas una permanente fuente de tensiones que las enfrentaba al dilema de sostener su independencia y sufrir la endémica carencia de fondos o acudir a instancias externas de provisión de recursos y así garantizar su funcionamiento. Esta situación fue la que enfrentó la Asociación Cultural de Bahía Blanca entre 1919 y 1927. Surgida en una ciudad intermedia de sudoeste bonaerense, la agrupación debió sobrevivir en diálogo con un Estado municipal donde las cuestiones culturales no eran objeto de una política sistemática y en un medio en el que el circuito de la música académica continuaba aún vinculado fuertemente al diletantismo. Sumado a ello, los incipientes mecanismos del mercado cultural pugnaban por introducir una lógica económica que se oponía a la primacía del desinterés que se estaba consolidando como principio de legitimidad en el mundo de las artes.; This article examines the problem of the relations between cultural associations, the market and the State in the province of Buenos Aires at the beginning of the 20th century. The double claim of autonomy linked to modern associationism and to the configuration of a specific sphere of the arts, was a permanent source of tensions that confronted them with the dilemma of sustaining their independence and suffering the endemic lack of funds or asking for external resources and thus assure its survival. This situation was faced by the Asociación Cultural de Bahía Blanca between 1919 and 1927. Emerged in an intermediate city of southwest Buenos Aires, this entity had to survive in dialogue with a municipal state where cultural issues were not subject of a systematic policy and in an environment in which the circuit of academic music continued to be strongly linked to dilettantism. Added to this, the incipient mechanisms of the cultural market struggled to introduce an economic logic that opposed the primacy of "disinterest" that was consolidating as a principle of legitimacy in the world of arts.

Outcome of Applying the ESC 0/1-hour Algorithm in Patients With Suspected Myocardial Infarction Twerenbold, Raphael; Costabel, Juan Pablo; Nestelberger, Thomas; Campos, Roberto; Wussler, Desiree; Arbucci, Rosina; Cortes, Marcia; Boeddinghaus, Jasper; Baumgartner, Benjamin; Nickel, Christian H.; Bingisser, Roland; Badertscher, Patrick; Puelacher, Christian; du Fay de Lavallaz, Jeanne; Wildi, Karin; Rubini Giménez, Maria; Walter, Joan; Meier, Mario; Hafner, Benjamin; Lopez Ayala, Pedro; Lohrmann, Jens; Troester, Valentina; Koechlin, Luca; Zimmermann, Tobias; Gualandro, Danielle M.; Reichlin, Tobias; Lambardi, Florencia; Resi, Silvana; Alves de Lima, Alberto Enrique; Trivi, Marcelo Ricardo; Mueller, Christian Background: The European Society of Cardiology (ESC) recommends the 0/1-h algorithm for rapid triage of patients with suspected non–ST-segment elevation myocardial infarction (MI). However, its impact on patient management and safety when routinely applied is unknown. Objectives: This study sought to determine these important real-world outcome data. Methods: In a prospective international study enrolling patients presenting with acute chest discomfort to the emergency department (ED), the authors assessed the real-world performance of the ESC 0/1-h algorithm using high-sensitivity cardiac troponin T embedded in routine clinical care and its associated 30-day rates of major adverse cardiac events (MACE) (the composite of cardiovascular death and MI). Results: Among 2,296 patients, non–ST-segment elevation MI prevalence was 9.8%. In median, 1-h blood samples were collected 65 min after the 0-h blood draw. Overall, 94% of patients were managed without protocol violations, and 98% of patients triaged toward rule-out did not require additional cardiac investigations including high-sensitivity cardiac troponin T measurements at later time points or coronary computed tomography angiography in the ED. Median ED stay was 2 h and 30 min. The ESC 0/1-h algorithm triaged 62% of patients toward rule-out, and 71% of all patients underwent outpatient management. Proportion of patients with 30-day MACE were 0.2% (95% confidence interval: 03% to 0.5%) in the rule-out group and 0.1% (95% confidence interval: 0% to 0.2%) in outpatients. Very low MACE rates were confirmed in multiple subgroups, including early presenters. Conclusions: These real-world data document the excellent applicability, short time to ED discharge, and low rate of 30-day MACE associated with the routine clinical use of the ESC 0/1-h algorithm for the management of patients presenting with acute chest discomfort to the ED.

Diet-Induced Pulmonary Inflammation and Incipient Fibrosis in Mice: a Possible Role of Neutrophilic Inflammation Della Vedova, Maria Cecilia; Soler Garcia, Florencia Martina; Muñoz, Marcos David; Fornes, Miguel Walter; Gomez-Mejiba, Sandra Esther; Gomez, Nidia Noemí; Ramirez, Dario Chicken fat and fructose are added into food-processing to reduce costs and enhance acceptability; however, these additives turn food into unhealthy and hypercaloric meals. Herein we have hypothesized that chronic feeding with chicken fat and fructose, together or by separate, can cause pulmonary redox and inflammatory changes. These changes are particularly related to neutrophils and myeloperoxidase, with consequent changes in the organ histophysiology. To test this hypothesis, we fed mice for 16 weeks with either control food (low-fat diet, LFD) or control food supplemented with 22% chicken fat and with or without 10% fructose in the drinking water. At the end of the feeding regimen, we measured redox and inflammatory changes in the lung with particular emphasis on neutrophil accumulation/activation and molecular-histological markers of fibrosis. Our results suggest that a diet supplemented with chicken fat and fructose causes additive effects on pulmonary oxidative stress, inflammation, and a pro-fibrotic status. Neutrophilic inflammation may play a critical role in pulmonary pathology associated with metabolic syndrome.

New species of Capronia (Herpotrichiellaceae, Ascomycota) from Patagonian forests, Argentina Sanchez, Romina Magali; Miller Andrew, N.; Bianchinotti, Maria Virginia Three new species belonging to Capronia are described from plants native to the Andean Patagonian forests, Argentina. The first record of C. chlorospora in South America is also reported. The identity of the three new species is based on detailed morpho-anatomical observations as well as analyses of ITS and LSU nuclear rDNA. A key to the Capronia species present in Argentina is provided.

A combinatorial analysis of the permutation and non-permutation flow shop scheduling problems Rossit, Daniel Alejandro; Vásquez, Óscar C.; Tohmé, Fernando Abel; Frutos, Mariano; Safe, Martin Dario In this paper we introduce a novel approach to the combinatorial analysis of flow shop scheduling problems for the case of two jobs, assuming that processing times are unknown. The goal is to determine the dominance properties between permutation flow shop (PFS) and non-permutation flow shop (NPFS) schedules. In order to address this issue we develop a graph-theoretical approach to describe the sets of operations that define the makespan of feasible PFS and NPFS schedules (critical paths). The cardinality of these sets is related to the number of switching machines at which the sequence of the previous operations of the two jobs becomes reversed. This, in turn, allows us to uncover structural and dominance properties between the PFS and NPFS versions of the scheduling problem. We also study the case in which the ratio between the shortest and longest processing times, denoted ρ, is the only information known about those processing times. A combinatorial argument based on ρ leads to the identification of the NPFS schedules that are dominated by PFS ones, restricting the space of feasible solutions to the NPFS problem. We also extend our analysis to the comparison of NPFS schedules (with different number of switching machines). Again, based on the value of ρ, we are able to identify NPFS schedules dominated by other NPFS schedules.

Detection and first molecular characterization of bovine papular stomatitis virus in dairy calves in Argentina Micheloud, Juan Francisco; Aguirre Castro, Laura Sabrina; Sandoval, Gabriela Virginia; Avellaneda Caceres, Agustin; Diodati, Julian Angel; Peralta, Andrea Verónica Bovine papular stomatitis virus (BPSV) is a parapoxvirus associated with papular and erosive lesions on the muzzle, lips, and oral mucosa of cattle. BPSV infection occurs worldwide; however, it has still not been unequivocally diagnosed. The present report describes an outbreak of BPSV infection affecting dairy calves in northwestern Argentina and provides the first molecular characterization of this virus in the country. The disease was detected in a dairy farm, affecting 33 calves between 2 and 20 days of age. The signs included reddish papules, ulcers, and scabby proliferative lesions on muzzle, lips, and oral mucosa. The affected calves resisted to being fed due to severe local pain. Two necropsies were performed; papulas and ulcers were observed in ruminal and omasal mucosa. Histologically, the affected areas of the skin showed acanthosis, spongiosis, and parakeratotic hyperkeratosis with adjacent focally extensive ulcers and multifocal inflammatory infiltrate in the epidermis. Eosinophilic inclusion bodies were detected in the cytoplasm of epithelial cells. DNA extracted from scab samples was analyzed by PCR using pan-parapoxvirus primers for the B2L gene. The sequence analysis revealed 99%, 85%, and 84% similarity with BPSV, Pseudocowpox virus, and Orf virus, respectively. A phylogenetic tree constructed using the B2L sequence showed that the virus clustered with BPSV isolates. Although clinical cases compatible with BSPV infection have been frequently described in Argentina, the present report is the first to identify the agent associated with cattle disease in the country.

Controversias en torno a la terminalidad educativa y la empleabilidad de mujeres destinatarias de programas sociales: Virajes de gestión en torno al programa Hacemos Futuro Voria, María Andrea; Míguez, María Eugenia En este artículo nos proponemos indagar las controversias en torno a la terminalidad educativa y la empleabilidad en programas sociales del Ministerio de Desarrollo Social de la Nación (MDS), en particular el ex Programa Ingreso Social con Trabajo –Argentina Trabaja– (PRIST-AT) (2009-2018) y su línea programática Ellas Hacen (EH) (2013-2018), unificados desde febrero del 2018 bajo el programa Hacemos Futuro (HF). El objetivo del artículo consiste en problematizar, desde una perspectiva de género, la terminalidad educativa y la empleabilidad en las mujeres destinatarias, especialmente en el “período bisagra” entre el fin de la gestión kirchnerista y los primeros años de gobierno de la Alianza Cambiemos. El corpus de análisis se basó en la revisión de fuentes secundarias (normativa, informes de gestión y pedidos de informes); fuentes primarias a partir de entrevistas en profundidad a cuadros intermedios del MDS y el desarrollo de dos grupos focales con mujeres titulares del ex AT como de EH, en los distritos de Tigre y San Fernando de la Provincia de Buenos Aires, durante 2017 y 2018. Los resultados que hemos, provisoriamente, alcanzado dejan planteadas una serie de controversias relativas al peso diferencial que adquieren entre uno y otro programa (AT-EH), como entre una y otra gestión del MDS, los componentes de terminalidad educativa y empleabilidad sobre las titulares, y sus implicancias en términos de reconocimiento social, responsabilidades de cuidado e integridad frente a la problemática de la violencia de género.; In this article we propose to investigate the controversies about educational terminality and employability in social programs of the Ministry of Social Development of the Nation (MSD), particularly, the ex “Programa Ingreso Social con Trabajo - Argentina Trabaja” (PRISTAT) (2009-2018) and its operational guideline “Ellas Hacen” (2013- 2018), unified under the program Hacemos Futuro (HF) since February 2018. The objective of this article consists of putting into question,from a gender perspective, the educational terminality and employability in women receiving, specially, during the hinge period between the ending of the Kirchnerist government and the first years of the Alianza Cambiemos government. The corpus of the exploration is based on the revision of secondary sources (rules, management reports and reporting orders); primary sources (in-deph interviews to middle management personnel of the MDS, and two focus groups of women receiving of the mentioned social programs ex-AT and EH, in Tigre and San Fernando neigborhoods, Province of Buenos Aires), during 2017 and 2018. The provisionally results we obtained raise an issue about a chain of controversies related to the different weight that acquire, between one and the other program (AT-EH) as well between one and the other management ministery, the components of educational terminality and employability on the women receiving and its specific consequences in social recognition, care responsabilities, and dignity in cases of gender violence.

Periodic dietary restriction ameliorates amyloid pathology and cognitive impairment in PDAPP-J20 mice: Potential implication of glial autophagy Gregosa, Amal; Vinuesa, María Angeles; Todero, María Florencia; Pomilio, Carlos Javier; Rossi, Soledad Paola; Bentivegna, Melisa Inés María; Presa, Jessica; Wenker, Shirley Denise; Saravia, Flavia Eugenia; Beauquis, Juan Dietary restriction promotes cell regeneration and stress resistance in multiple models of human diseases. One of the conditions that could potentially benefit from this strategy is Alzheimer´s disease, a chronic, progressive and prevalent neurodegenerative disease. Although there are no effective pharmacological treatments for this pathology, lifestyle interventions could play therapeutic roles. Our objectives were 1) to evaluate the effects of dietary restriction on cognition, hippocampal amyloid deposition, adult neurogenesis and glial reactivity and autophagy in a mouse model of familial Alzheimer´s disease, and 2) to analyze the role of glial cells mediating the effects of nutrient restriction in an in vitro model. Therefore, we established a periodic dietary restriction protocol in adult female PDAPP-J20 transgenic mice for 6 weeks. We found that dietary restriction, not involving overall caloric restriction, attenuated cognitive deficits, amyloid pathology and microglial reactivity in transgenic mice when compared with ad libitum-fed transgenic animals. Also, transgenic mice showed an increase in the astroglial positive signal for LC3, an autophagy-associated protein. In parallel, hippocampal adult neurogenesis was decreased in transgenic mice whereas dietary-restricted transgenic mice showed a neurogenic status similar to controls. In vitro experiments showed that nutrient restriction decreased astroglial and, indirectly, microglial NFκB activation in response to amyloid β peptides. Furthermore, nutrient restriction was able to preserve astroglial autophagic flux and to decrease intracellular amyloid after exposure to amyloid β peptides. Our results suggest neuroprotective effects of nutrient restriction in Alzheimer´s disease, with modulation of glial activation and autophagy being potentially involved pathways.

Novel Synthesis Without Separation and Purification Processes of Carbon Dots and Silver/Carbon Hybrid Nanoparticles Arroyave Rodriguez, Jeison Manuel; Springer, Valeria Haydee; Centurión, María Eugenia This paper presents two bottom-up methods for the green synthesis of spherical carbon dots (Cdots) and silver/Cdots (Ag@Cdots) nanoparticles at alkaline medium. Both syntheses are carried out without separation and purification steps with a microwave exposure time between 30 and 60 s. In both case a natural product as glucose was used as precursor and capping agent. The obtained Cdots and Ag@Cdots hybrid are spherical in shape and monodisperse, with average particle size of lower than 10 nm and 13 nm respectively. In comparison with the methods previously reported, which need high energy consumption and/or long reaction time. The proposed methodologies are simple, low cost, environment-friendly and in accordance with green chemistry research. The morphology, composition and structure of the obtained nanoparticles were characterized by Zeta Potential and hydrodynamic size measurements, transmission electron microscopy (TEM), X-ray diffraction (XRD), ATR-FTIR spectrophotometry and thermogavimetric analysis (TGA). The synthesized nanoparticles were applied to sense tetracycline residues taking into account their fluorescent properties.

Cosmological horizons, Noether charges and entropy Donnay, Laura; Giribet, Gaston Enrique It has recently been shown that, in the vicinity of their event horizons, black holes exhibit an infinite-dimensional symmetry. This symmetry captures relevant physical information about the black hole, and in particular about its thermodynamics. Here, we show that the same holds in a cosmological setup. More precisely, we show that around the de Sitter cosmological horizon, an infinite set of diffeomorphisms preserving a sensible set of boundary conditions emerges. These boundary conditions are similar to those considered by Price and Thorne in the context of the membrane paradigm, and permit to accommodate interesting gravity solutions. As for other boundary conditions considered previously, they are preserved by an infinite-dimensional asymptotic isometry algebra that includes supertranslations and two copies of the Virasoro algebra. This symmetry has associated a set of Noether charges that turn out to be conserved, finite, and integrable. We derive these charges explicitly using the covariant formalism and analyze their physical meaning by evaluating them to the case of de Sitter space. In this case, the zero-mode of the charge is found to account for the Gibbons-Hawking entropy of the cosmological horizon. We then consider a much more general set of solutions, including asymptotically de-Sitter black holes and asymptotically Taub-NUT-de Sitter black holes.

A history of the homosexual liberation front and left-wing politics in Argentina; Una historia del frente de liberación homosexual y la izquierda en Argentina; Uma história da Frente de Libertação Homossexual e a esquerda na Argentina. Insausti, Santiago Joaquin Emerging during the seventies in Argentina during the political radicalization and inspired by the rise of the New Left, the Homosexual Liberation Front (Spanish acronym FLH) attempted an alliance with a variety of organizations on the left. My research will trace the mutations in the political discourse and strategies shaping the attempts at allying with the left-wing over time, as well as the tensions and contradictions that it created among both the rank and file, within the FLH, and other organizations.; Surgido en la década del setenta en Argentina en un clima de radicalización política y dentro del marco de la nueva izquierda, el “Frente de Liberación Homosexual” apostará a una alianza con las organizaciones de izquierda. La investigación analizará diacrónicamente tanto las mutaciones en los discursos políticos y en las estrategias de lucha que se articularon en el diseño de esta alianza como las tensiones y contradicciones que esta propuesta generó en relación con las bases, al interior de la agrupación, y con el resto de las organizaciones militantes.; Surgindo durante os anos setenta na Argentina em meio à radicalização política e inspirada pelo surgimento da Nova Esquerda, a Frente de Libertação Homossexual (FLH) tentou uma aliança com as organizações de esquerda. Esta pesquisa visa conhecer, diacronicamente, tanto as mutações no discurso político do FLH e suas estratégias de luta que se articularam no projeto dessa aliança, quanto as tensões e contradições surgidas em relação às bases, dentro do próprio FLH, e com as outras organizações ativistas.

Nota a Verg., Aen. 10.800: El escudo como clave de lectura del enfrentamiento desigual entre Eneas y Lauso Sisul, Ana Clara Al oponerse a Eneas en defensa de su padre herido, Lauso ocupa el lugar de un guerrero consagrado siendo, aún, inexperto. La escena evidencia el conocido motivo virgiliano de la batalla desigual, anticipado en la introducción del personaje en el décimo canto de la Eneida (mox illos sua fata mament maiore sub hosteen Verg. Aen. 10.438) y explicitado en las palabras que el protagonista pronuncia, en vano, para disuadirlo de combatir(...maioraque viribus audes en Aen. 10.811). En este breve trabajo destacamos otro modo utilizado por Virgilio para señalar el desequilibrio: la variación léxica en la nomenclatura de los escudos de los personajes. A continuación, explicitaremos cómo funciona esta estrategia.

A high-quality genome of Eragrostis curvula grass provides insights into Poaceae evolution and supports new strategies to enhance forage quality Carballo, José; Santos, B. A. C. M.; Zappacosta, Diego Carlos; Garbus, Ingrid; Selva, Juan Pablo; Gallo, Cristian Andrés; Diaz, Alejandra Raquel; Albertini, Emiliano; Cáccamo, Mario José; Echenique, Carmen Viviana The Poaceae constitute a taxon of fowering plants (grasses) that cover almost all Earth?s inhabitable range and comprises some of the genera most commonly used for human and animal nutrition. Many of these crops have been sequenced, like rice, Brachypodium, maize and, more recently, wheat. Some important members are still considered orphan crops, lacking a sequenced genome, but having important traits that make them attractive for sequencing. Among these traits is apomixis, clonal reproduction by seeds, present in some members of the Poaceae like Eragrostis curvula. A de novo, high-quality genome assembly and annotation for E. curvula have been obtained by sequencing 602Mb of a diploid genotype using a strategy that combined long-read length sequencing with chromosome conformation capture. The scafold N50 for this assembly was 43.41Mb and the annotation yielded 56,469 genes. The availability of this genome assembly has allowed us to identify regions associated with forage quality and to develop strategies to sequence and assemble the complex tetraploid genotypes which harbor the apomixis control region(s). Understanding and subsequently manipulating the genetic drivers underlying apomixis could revolutionize agriculture.

Normalismo y mujeres. Las maestras en el Quién es Quién en La Plata (1972): trayectorias de una élite intelectual y profesional; Normalism and women. Teachers in the Who is Who in La Plata (1972): trajectories of intellectual and professional elite Rodríguez, Laura Graciela En este artículo abordaremos un tema poco tratado aún y es el estudio de un grupo de maestras normalistas pertenecientes a distintas generaciones, que fueron consideradas parte de la élite intelectual y profesional de la ciudad capital de la provincia de Buenos Aires y por esa razón, sus nombres aparecieron en la edición del diccionario biográfico Quién es Quién en La Plata del año 1972. En este trabajo nos proponemos analizar quiénes fueron estas 31 maestras destacadas a partir de un estudio basado en esta fuente, donde relevaremos: en qué institución/es estudiaron y en qué año/s se titularon, cuál era su estatus civil, qué trabajos tuvieron y cuáles fueron sus otras actividades por fuera del ámbito laboral.; In this article we will present the study of a group of normal teachers belonging to different generations, which were considered part of the intellectual and professional elite of the capital city of the province of Buenos Aires and for that reason, their names appeared in the edition of the biographical dictionary, Who's Who in La Plata of the year 1972. In this work we propose to analyze who were these 31 teachers featured from a study based on this source, where we will show: on what institution they studied and what year/s were titled, what was their civil status, jobs had and which they were their other activities.

"Trasvasamiento generacional no es trasvasamiento ideológico". La revista Extra y el conflicto interno en el peronismo (1973-1974); Generational transfer is not ideological transfer: The Extra magazine and the internal conflict in Peronism (1973-1974) Iturralde, Micaela; Borrelli, Marcelo Hernan Este artículo analiza el posicionamiento editorial de la revista Extra dirigida por Bernardo Neustadt frente al conflicto interno en el peronismo desde la asunción de Héctor Cámpora a la presidencia en mayo de 1973 hasta el fallecimiento del entonces presidente Juan Domingo Perón en julio de 1974. El objetivo es analizar discursivamente el tratamiento que dio a estas disputas, a la creciente radicalización política de sus facciones y al proceso de "depuración ideológica" contra su sector revolucionario de izquierda desde fines de 1973. El trabajo concluye que Extra intentó posicionarse como representante del "centro político", destacando el rol de Perón como eje para la "unidad nacional" y criticando a los sectores revolucionarios de la izquierda peronista.; This article analyzes the editorial positioning of the magazine Extra directed by Bernardo Neustadt against the internal conflict in Peronism since the assumption of Héctor Cámpora to the presidency in May 1973 until the death of the then president Juan Domingo Perón in July 1974. The objective is to discursively analyze the treatment that gave rise to these disputes, to the growing political radicalization of their factions and to the process of "ideological depuration" against their leftist revolutionary sector since the end of 1973. The paper concludes that Extra tried to position itself as representative of the "political center", highlighting the role of Perón as the axis for "national unity" and criticizing the revolutionary sectors of the Peronist left.

A High-Density Linkage Map of the Forage Grass Eragrostis curvula and Localization of the Diplospory Locus Zappacosta, Diego Carlos; Gallardo, Jimena Alicia; Carballo, José; Meier, Mauro Sebastián; Rodrigo, Juan Manuel; Gallo, Cristian Andrés; Selva, Juan Pablo; Stein, Juliana; Ortiz, Juan Pablo Amelio; Albertini, Emidio; Echenique, Carmen Viviana Eragrostis curvula (Schrad.) Nees (weeping lovegrass) is an apomictic species native to Southern Africa that is used as forage grass in semiarid regions of Argentina. Apomixis is a mechanism for clonal propagation through seeds that involves the avoidance of meiosis to generate an unreduced embryo sac (apomeiosis), parthenogenesis, and viable endosperm formation in a fertilization-dependent or -independent manner. Here, we constructed the first saturated linkage map of tetraploid E. curvula using both traditional (AFLP and SSR) and high-throughput molecular markers (GBS-SNP) and identified the locus controlling diplospory. We also identified putative regulatory regions affecting the expressivity of this trait and syntenic relationships with genomes of other grass species. We obtained a tetraploid mapping population from a cross between a full sexual genotype (OTA-S) with a facultative apomictic individual of cv. Don Walter. Phenotypic characterization of F1 hybrids by cytoembryological analysis yielded a 1:1 ratio of apomictic vs. sexual plants (34:27, X2 = 0.37), which agrees with the model of inheritance of a single dominant genetic factor. The final number of markers was 1,114 for OTA-S and 2,019 for Don Walter. These markers were distributed into 40 linkage groups per parental genotype, which is consistent with the number of E. curvula chromosomes (containing 2 to 123 markers per linkage group). The total length of the OTA-S map was 1,335 cM, with an average marker density of 1.22 cM per marker. The Don Walter map was 1,976.2 cM, with an average marker density of 0.98 cM/marker. The locus responsible for diplospory was mapped on Don Walter linkage group 3, with other 65 markers. QTL analyses of the expressivity of diplospory in the F1 hybrids revealed the presence of two main QTLs, located 3.27 and 15 cM from the diplospory locus. Both QTLs explained 28.6% of phenotypic variation. Syntenic analysis allowed us to establish the groups of homologs/homeologs for each linkage map. The genetic linkage map reported in this study, the first such map for E. curvula, is the most saturated map for the genus Eragrostis and one of the most saturated maps for a polyploid forage grass species.

Experiencias en el proceso de reaparición de detenidas y detenidos desaparecidos sobrevivientes en la Sub-Zona 51 durante la última dictadura militar (1976-1983) y en el resto de la década del ‘80 (1983-1989) Rama, Cristian Nahuel El presente trabajo intenta exponer algunos avances de mi tesis de doctorado en Historia, la cual busca indagar en las experiencias de un conjunto de detenidas y detenidos desaparecidos sobrevivientes de los espacios de detención clandestina de la Sub-Zona 51 en distintos contextos políticos, durante la última dictadura cívico-militar y en el resto de la década del 80.La relevancia que justifica el estudio de estos actores está en el hecho de que fueron protagonistas de la conflictividad política de los años 60 y 70, siendo por ello de los principales sujetos represaliados. Además, porque al haber sobrevivido a esa experiencia resultaron ser uno de los principales canales para conocer los alcances de la represión clandestina dictatorial. Se presentará en este trabajo la delimitación del objeto de estudio y el problema de investigación, los principales objetivos, la metodología a utilizar, el marco teórico elegido y algunos de los resultados preliminares.; The present work tries to expose some advances of my thesis of doctorate in History that proposes to investigate in the experiences of a set of detainees disappeared survivors of the spaces of clandestine detention centers of the Sub-Zone 51 in different political contexts, during the last military dictatorship and in the rest of the decade of the eighties. The relevance that justifies the study of these actors is the fact that they were protagonists of the political unrest of the sixties and seventies, being for this reason some of the main subjects of repression; and also, because having survived that experience turned out to be one of the main channels for knowing the scope of dictatorial clandestine repression. The delimitation of the object of study and the research problem, the main objectives, the methodology to be used, the theoretical framework chosen and some of the preliminary results will be presented; O presente trabalho tenta expor alguns avanços da minha tese de doutorado em História, que propõe indagar nas experiências de um conjunto de detentas e detentos desaparecidos sobreviventes dos espaços de detenção clandestina da Sub-Zona 51 em diferentes contextos políticos, durante a última ditadura militar e no resto da década do 80. A relevância que justifica o estudo destes atore estáem que foram protagonistas da conflitividade política dos anos 60 e 70, sendo por isso dos principais sujeitos represaliados. Ademais, porque ao ter sobrevivido a essa experiência resultaram ser um dos principais canais para conhecer os alcances da repressão clandestina ditatorial. Apresentar-se-á a delimitação do objeto de estudo e o problema de investigação, os principais objetivos, a metodologia a ser utilizado, o marco teórico eleito e alguns dos resultados preliminares.

Comparison of the optical light curves of hydrogen-rich and hydrogen-poor type II supernovae Pessi, Priscila Jael; Folatelli, Gaston; Anderson, J. P.; Bersten, Melina Cecilia; Burns, C.; Contreras, C.; Davis, S.; Englert Urrutia, Brenda Nahir; Hamuy, M.; Hsiao, Eric; Martinez, Laureano; Morrell, Nidia Irene; Phillips, M. M.; Suntzeff, N.; Stritzinger, M. D. Type II supernovae (SNe II) show strong hydrogen features in their spectra throughout their whole evolution, while type IIb supernovae (SNe IIb) spectra evolve from dominant hydrogen lines at early times to increasingly strong helium features later on. However, it is currently unclear whether the progenitors of these SN types form a continuum in pre-SN hydrogen mass or whether they are physically distinct. SN light-curve morphology directly relates to progenitor and explosion properties such as the amount of hydrogen in the envelope, the pre-SN radius, the explosion energy, and the synthesized mass of radioactive material. In this work, we study the morphology of the optical-wavelength light curves of hydrogen-rich SNe II and hydrogen-poor SNe IIb to test whether an observational continuum exists between the two. Using a sample of 95 SNe (73 SNe II and 22 SNe IIb), we define a range of key observational parameters and present a comparative analysis between both types. We find a lack of events that bridge the observed properties of SNe II and IIb. Light-curve parameters such as rise times and post-maximum decline rates and curvatures clearly separate both SN types and we therefore conclude that there is no continuum, with the two SN types forming two observationally distinct families. In the V band a rise time of 17 d (SNe II lower and SNe IIb higher), and a magnitude difference between 30 and 40 d post-explosion of 0.4 mag (SNe II lower and SNe IIb higher) serve as approximate thresholds to differentiate both types.

Generaciones y configuraciones militantes en un sindicato docente: ATEN, 1997-2007; Generations and militant configurations in a teachers trade union: ATEN, 1997-2007 Aiziczon, Fernando Cristian El siguiente artículo tiene como objetivo indagar los cambios generacionales ocurridos en la militancia del sindicato docente neuquino ATEN (Asociación de Trabajadores de la Educación de Neuquén) en torno a la última gran huelga de 2007, en la que fue asesinado el maestro Carlos Fuentealba. A partir de entonces, se puede delimitar una trayectoria política generacional contemporánea en la militancia gremial de ATEN, tomando como punto de partida previo la primera gran huelga docente ocurrida en 1997. Considerando el impacto retrospectivo que ocasionó la última acción huelguística (2007), y sobre el análisis de entrevistas orales y documentos sindicales, el artículo demarca los períodos históricos en que las nuevas generaciones comprenden la construcción de su identidad y despliegan su militancia al interior del sindicato. Nuestra hipótesis es que el modo traumático en que fue experimentada la última gran huelga arroja luz sobre transformaciones previas que venían operando en la subjetividad de las nuevas generaciones de docentes, las que indican un cuestionamiento a las prácticas que constituyeron la novel tradición de este sindicato.; The following article aims to enquire about the generational changes that occurred in the trade union militancy of teacher’s ATEN (Association of Education Workers of Neuquén) around the last great strike in 2007, where the teacher Carlos Fuentealba was assassinated. Thereafter it can be delimited a contemporary generational political trajectory in ATEN’s unión militancy, taking as a starting point the first great strike that took place in 1997. Considering the retrospective impact caused by the last strike action (2007), and on the analysis of oral interviews and trade union documents, this article demarcates historical periods in which the new generations understand the construction of their identity and deploy their militancy within the union. Our hypotesis is that the traumatic way in which the last strike was experienced, shed light about previous transformations that were operating in the subjetivity of the new generations of teachers, which indicates a question mark on the practices that constituted the novel tradition of this trade union.

Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPARα/PPARγ Agonist Activity and Anti-inflammatory Effect Bermejo, Almudena; Collado, Aida; Barrachina, Isabel; Marqués, Patrice; El Aouad, Noureddine; Franck, Xavier; Garibotto, Francisco Matías; Dacquet, Catherine; Caignard, Daniel H.; Suvire, Fernando Daniel; Enriz, Ricardo Daniel; Piqueras, Laura; Figadère, Bruno; Sanz, María-Jesús; Cabedo, Nuria; Cortes, Diego Dual peroxisome proliferator-activated receptor-α/γ (PPARα/γ) agonists regulate both lipid and glucose homeostasis under different metabolic conditions and can exert anti-inflammatory activity. We investigated the potential dual PPARα/γ agonism of prenylated benzopyrans polycerasoidol (1) and polycerasoidin (2) and their derivatives for novel drug development. Nine semisynthetic derivatives were prepared from the natural polycerasoidol (1) and polycerasoidin (2), which were evaluated for PPARα, -γ, -δ and retinoid X receptor-α activity in transactivation assays. Polycerasoidol (1) exhibited potent dual PPARα/γ agonism and low cytotoxicity. Structure–activity relationship studies revealed that a free phenol group at C-6 and a carboxylic acid at C-9′ were key features for dual PPARα/γ agonism activity. Molecular modeling indicated the relevance of these groups for optimal ligand binding to the PPARα and PPARγ domains. In addition, polycerasoidol (1) exhibited a potent anti-inflammatory effect by inhibiting mononuclear leukocyte adhesion to the dysfunctional endothelium in a concentration-dependent manner via RXRα/PPARγ interactions. Therefore, polycerasoidol (1) can be considered a hit-to-lead molecule for the further development of novel dual PPARα/γ agonists capable of preventing cardiovascular events associated with metabolic disorders.