La constitución de la conciencia volitiva y sus implicancias para la ética fenomenológica en Husserl; The constitution of volitional consciousness and its implications for phenomenological ethics in Husser Cabrera, Celia Olga El artículo aborda los aspectos centrales de la concepción husserliana de la conciencia volitiva, atendiendo a su estructura, sus modalidades y sus implicancias éticas. Luego de establecer los lineamientos fundamentales de la fenomenología temprana de la voluntad, se analiza su significado desde el punto de vista de la racionalidad práctica, enfatizando la relación entre la voluntad y lo prácticamente posible. Finalmente, se profundiza el análisis de este vínculo mediante la consideración de la ética tardía.; The paper approaches the central aspects of Husserl´s conception of volitional consciousness, concentrating on its structure, its modalities and its ethical implications. After dealing with the fundamental traits of the early phenomenology of will, we address its meaning from the point of view of practical reason, emphasising the relationship between the will and practical possibility. Finally, we go deeper in the analysis of this relationship by taking into account Husserl’s late ethics.

Interculturalidades en danza: Recreaciones del imaginario identitario argentino Citro, Silvia Viviana This article analyzes how Argentine cultural policies between 2010 and 2015 sought to challenge the traditional identity imaginary of Argentinians as White Europeans. For this purpose, I initially made a genealogy of the main transformations of these policies and imaginaries to later focus on the performances of the Combinado Argentino de Danza (CAD) in the celebrations to commemorate the birth of Argentina as a nation state organized by the National Cultural Ministry. CAD was the first group on the local scene to propose combining national folk genres that reevaluate indigenous influences with hip hop, modern dance and electronic music, prompting artists from different regional and esthetic origins to work together. This case forms the basis for my examination of the ways in which global multiculturalist ideologies have been reworked locally as political attempts to legitimize a new intercultural, popular and non-sexist national imaginary.

The need for standardized reporting of research findings in the field of quality of care Garcia Elorrio, Ezequiel; Aziz, Sheikh The fields of healthcare quality and patient safety are not immune to the concerns being expressed across several disciplines about the lack of transparency and reproducibility of research. The use of reporting guidelines is not a panacea, but it can help in promoting more consistent and complete reporting of research findings. This year, we will strongly be encouraging authors of submissions to IJQHC to, where it exists, complete an accompanying checklist of the relevant reporting guideline, and from 2022 we plan to insist on this for all relevant research articles.

Two new freshwater planarian species (Platyhelminthes: Tricladida: Dugesiidae) partially sympatric in Argentinean Patagonia Lenguas Francavilla, Marina Matilde; Negrete, Lisandro Hector Luis; Martinez Aquino, Andres; Damborenea, Maria Cristina; Brusa, Francisco Girardia Ball, 1974 is the most diverse and widely distributed genus of the family Dugesiidae (Platyhelminthes: Continenticola) in the Neotropical region. Seven out of the 52 species of the genus are known for Argentina. The Somuncurá Plateau is a region in northern Patagonia with several endemic flora and fauna, but little is known about the free-living Platyhelminthes. We describe two new species of Girardia partially inhabiting in sympatry in the Somuncurá Plateau: Girardia somuncura sp. nov. and Girardia tomasi sp. nov. The identification criteria that we followed was an integrative taxonomic approach based on morphological and molecular data. Thus, we used anatomical features focused on the reproductive system, together with a phylogenetic analysis, using a mitochondrial (COI barcode region) genetic marker. This study is the first phylogenetic analysis of the genus Girardia in which we include the southernmost representatives of America here described, thus making it possible to incorporate them in global phylogenies.; : Girardia Ball, 1974 est le genre de la famille des dugésides (plathelminthes : continenticoles) qui présente la plus grande diversité et la plus grande aire de répartition géographique dans la région néotropicale. Sept des cinquante-deux espèces connues du genre ont été recensées en Argentine. Le plateau de Somuncurá est une région du nord de la Patagonie comptant plusieurs assemblages floristiques et fauniques endémiques, mais les connaissances sur les plathelminthes libres sont très limitées. Nous décrivons deux nouvelles espèces de Girardia vivant en sympatrie partielle sur le plateau de Somuncurá : Girardia somuncura sp. nov. et Girardia tomasi sp. nov. Le critère d’identification que nous avons utilisé consiste en une approche taxonomique intégrée reposant sur des données morphologiques et moléculaires. Ainsi, nous avons utilisé des éléments anatomiques centrés sur le système reproducteur, combinés à l’analyse phylogénétique ayant recours à un marqueur génétique mitochondrial (région des codes à barres COI). L’étude constitue la première analyse phylogénétique du genre Girardia, dans lequel nous incluons les représentants les plus méridionaux des Amériques, décrits dans l’article, ce qui permet de les incorporer aux phylogénies mondiales.

Effects of time perspective and self-control on psychological distress: A cross-sectional study in an Argentinian sample Germano, Guadalupe; Brenlla, María Elena Time perspective (TP) is a fundamental trait of human's psychological perception of time and can affect different aspects of psychological functioning. The current study proposes that TP and self-control can be considered as predictors of Psychological Distress (PD). 328 men and women from Buenos Aires, Argentina, completed the Zimbardo Time Perspective Inventory, which assesses five dimensions of TP, the Self-Control Scale and the Psychological Distress scale. Hierarchical regression analysis showed that past negative, past positive and self-control explain 31% of variance in PD. Afterwards, a path analysis was conducted. Results showed that future, past negative, and present orientations have a direct effect on self-control. Also, PD is predicted by past negative, past positive and self-control. Finally, future, past negative, and present orientations have an indirect effect on PD trough self-control. These findings support the idea that TP is related to self-control and suggest that both, TP and self-control, can be predictors of PD. These results add to the theoretical concept of TP and shed new light on the value of considering self-control as a mediator variable between TP and someone's psychological state. Theoretical and practical implications of these findings are discussed.

The importance of studying the role of filled pauses in the construction of a coherent representation of spontaneous spoken discourse Cossavella, Francisco; Yomha Cevasco, Jazmin Filled pauses indicate that the speaker is searching for information or deciding how to continue. In this review, we summarize recent research on the production and comprehension of these pauses. We also present studies that have focused on the establishment of meaningful connections during discourse comprehension, and preliminary research on the role of filled pauses in the establishment of these connections. Overall, these studies suggest that filled pauses promote that listeners focus attention on upcoming speech, and that research on this topic has not tended to focus on the comprehension of connected discourse. Studies on the comprehension of connected discourse suggest that the establishment of causal connections plays a central role, and that the presence of filled pauses does not create a break with information that is relevant to their establishment. Finally, this review presents an integrated view of research on the processing of disfluencies and discourse connections.

Nuclear-lipid-droplet proteome: carboxylesterase as a nuclear lipase involved in lipid-droplet homeostasis Lagrutta, Lucía Carolina; Layerenza, Juan Pablo; Bronsoms, Silvia; Trejo, Sebastian Alejandro; Ves Losada, Ana Nuclear-lipid droplets (nLD)—a dynamic cellular organelle that stores neutral lipids, within the nucleus of eukaryotic cells—consists of a hydrophobic triacylglycerol –cholesterol-ester core enriched in oleic acid (OA) surrounded by a monolayer of polar lipids, cholesterol, and proteins. nLD are probably involved in nuclear-lipid homeostasis serving as an endonuclear buffer that provides or incorporates lipids and proteins participating in signaling pathways, as transcription factors and enzymes of lipid metabolism and nuclear processes. In the present work, we analyzed the nLD proteome and hypothesized that nLD-monolayer proteins could be involved in processes similar as the ones occurring in the cLD including lipid metabolism and other cellular functions. We evaluated the rat-liver–nLD proteome under physiological and nonpathological conditions by GeLC-MS2. Since isolated nLD are highly diluted, a protein-concentrating isolation protocol was designed. Thirty-five proteins were identified within the functional categories: cytoskeleton and structural, transcription and translation, histones, protein-folding and posttranslational modification, cellular proliferation and/or cancer, lipid metabolism, and transport. Purified nLD contained an enzyme from the lipid-metabolism pathway, carboxylesterase 1d (Ces1d/Ces3). Nuclear Carboxylesterase localization was confirmed by Western blotting. By in-silico analyses rat Ces1d/Ces3 secondary and tertiary structure predicted would be equivalent to human CES1. These results—the first nLD proteome—demonstrate that a tandem-GeLC-MS2-analysis protocol facilitates studies like these on rat-liver nuclei. A diversity of cellular-protein function was identified indicating the direct or indirect nLD participation and involving Ces1d/Ces3 in the LD-population homeostasis.

El aborto como campo de batalla Scherbovsky, Natacha La lucha por el aborto legal seguro y gratuito en la Argentina formó parte de una batalla histórica que atravesó política y socialmente más de treinta años. En este texto comentaremos dos hitos que inscribieron la lucha en jornadas inolvidables. Aquellas que se llevaron a cabo en junio y agosto del 2018 durante el gobierno del presidente Mauricio Macri y la del 10 y 30 de diciembre del 2020 durante el gobierno del presidente Alberto Fernández. Los conflictos, tensiones, disputas y lo que queda abierto luego de la aprobación finalmente de la Ley de Interrupción legal del embarazo.

El teatro judío como corriente modernizadora: la escena ídish y su influencia en el campo teatral de Buenos Aires Ansaldo, Paula Nora En el período de entre guerras, y especialmente a partir de 1930, Buenos Aires se posicionó como un centro teatral judío de importancia internacional gracias su gran población de judíos ídish-parlantes y al desarrollo de un circuito teatral en ídish. Buenos Aires se convirtió así en un destino privilegiado en las giras de los artistas y compañías itinerantes del teatro judío y en un polo teatral que atraía a una gran cantidad de actores, actrices y directores judíos que buscaban radicarse en el continente americano. ¿Cuáles fueron las concepciones teatrales y estéticas que llegaron a la Argentina a través de los artistas judíos que arribaron en el país? ¿De qué manera y en qué medida los repertorios y las poéticas actorales y de puesta en escena que se desarrollaron en los escenarios judíos influenciaron al teatro nacional? En este trabajo buscaremos responder a estas preguntas a partir de la hipótesis de que el teatro judío funcionó como una corriente modernizadora que influyó notablemente en el campo teatral de Buenos Aires, ya que debido a su carácter itinerante y por vía del ídish llegaron a la Argentina concepciones teatrales, repertorios, poéticas de actuación y estéticas modernas que aún no se habían desarrollado en los escenarios porteños y que tuvieron un gran impacto sobre las compañías y artistas locales.; During the interwar period, Buenos Aires established itself as a Jewish city of international cultural relevance. In the 1930s in particular, a rich Yiddish theatre circuit was developed and supported by the city’s large population of Yiddish-speaking Jews. Buenos Aires soon became a privileged destination in the tours of itinerant Jewish artists and a theatrical center that attracted a large number of Jewish actors and directors seeking to settle on the American continent. This article focuses on the aesthetic conceptions that Jewish artists brought to Argentina and argues that Yiddish theatre served as a modernizing force that deeply influenced the larger theatre scene of Buenos Aires. With its itinerant nature and genuinely international language, Yiddish theatre brought modern ideas, avant-garde aesthetics, and new repertoires.

Impacto de la conquista hispánica en el humedal del Paraná inferior (Argentina): una perspectiva histórica y genética mitocondrial; Impact of the hispanic conquest at the lower Parana wetland (Argentina): an historical and mitochondrial genetic perspec-tive; Impacto da conquista hispânica na humedal do Paraná inferior (Argentina): uma perspectiva histórica e genética mitocondrial Cardozo, Dario Gonzalo; Dejean, Cristina Beatriz; Russo, Maria Gabriela; Mazza, Bárbara Pamela; Loponte, Daniel Marcelo; Acosta, Alejandro Alberto; Feuillet, María Rosario; Cornero, Silvia Elena; Kozameh, Livia Febes; Tapia, Alicia Haydeé Para indagar sobre el impacto genético que habría generado la conquista hispánica en los grupos nativos asentados en el Paraná Medio e Inferior se analizaron muestras de individuos pre y posthispánicos de la región. Se identificaron los haplogrupos de ADN mitocondrial empleando Polimorfismos de Longitud de Fragmentos de Restricción (RFLP). Los datos obtenidos se compararon con los de otros sitios arqueológicos pre y posthispánicos y con muestras contemporáneas. Se observó mayor prevalencia del haplogrupo nativo B en las muestras posthispánicas, aunque sin diferenciación significativa con el grupo prehispánico de la región del Paraná Medio e Inferior. Ambos grupos presentan frecuencias de haplogrupos similares a muestras modernas provenientes del Gran Chaco y la provincia de Córdoba. Esto se corresponde con datos arqueológicos y de fuentes documentales de la reducción de Santiago del Baradero (provincia de Buenos Aires), con la prohibición de la salida de mujeres de la reducción y la escasez de individuos foráneos.; In order to investigate the genetic impact that the Hispanic conquest would have generated in the native groups settled in the Middle and Lower Paraná, samples of pre and post-Hispanic individuals of this region were analyzed. Mitochondrial DNA haplogroups were identified using restriction fragment length polymorphism (RFLP). The data were compared with those from other pre- and post-Hispanic archaeological sites and with contemporary samples. We observed a higher prevalence of native B haplogroup, in the post-Hispanic samples, without significant difference with the pre-hispanic group of the lower and middle Parana region. Both groups present similar haplogroup frequencies of those found in samples from Gran Chaco and the Córdoba province. This corresponds with archaeological data and the documentary sources about the Santiago del Baradero reduction (Buenos Aires province), with the prohibition of the departure of women from the reduction and the shortage of foreigners.; Para investigar o impacto genético que a conquista hispânica teria gerado nos grupos nativos assentados no Médio e Baixo Paraná, amostras de indivíduos pré e pós-hispânicos da região foram analisadas. Os haplogrupos de DNA mitocondrial foram identificados usando polimorfismos de comprimento de fragmento de restrição (RFLP). Os dados obtidos foram comparados com os de outros sítios arqueológicos pré e pós-hispânicos e com amostras contem-porâneas. Uma maior prevalência do haplogrupo B nativo foi observada nas amostras pós-hispânicas, embora sem diferenciação significativa em relação ao grupo pré-hispânico da região do Médio e Baixo Paraná. Ambos grupos apresentam freqüências semelhantes de haplogrupos que aquelas amostras modernas do Gran Chaco e da província de Córdoba. Isto se correlaciona con os dados arqueológicos y de fontes documentais sobre a redução em Santiago del Baradero (província de Buenos Aires), com a proibição de mulheres para sair da redução e a escassez de indivíduos estrangeiros.

Dialéctica de lo existente Galafassi, Guido Pascual Uno de los tópicos fundantes y vertebradores de toda la discusión y argumentación filosófica y sociológica radica en la discriminación entre totalidad y particularidad y de la identidad o no entre sujeto y objeto. Y para el análisis de la conflictividad este considerando es crucial para adentrarse en el debate existente y plantear una alternativa que pueda rebasarlo. La dialéctica es el instrumento que nos permite salvar la vulgar dicotomía en la que ha caído mayoritariamente este debate. ¿El mundo funciona articulado en un entretejido de relaciones o por el contrario cada ente tiene una autonomía que lo dota de libertad plena en su accionar? Explícita o implícita, y a veces oculta, esta es una pregunta guía que orienta todo el pensamiento sobre la existencia. Concatenadamente y consecuentemente, el interrogarse sobre los procesos de interacción entre sujeto y objeto y de ambos con la particularidad y la totalidad constituye la continuidad lógica que necesariamente se desprende de lo primero. Esta secuenciación ya implicaría un posible derrotero de respuesta a las preguntas, por cuanto, y dependiendo del marco conceptual, es factible intercambiar el orden de los interrogantes o privilegiar una y despreciar la otra, en una clara toma de posición argumentativa. La primacía de la estructura en tanto sistema que más permisiva o coactivamente incide sobre las decisiones del sujeto ha guiado y sigue guiando el debate sociológico a lo largo de los últimos dos siglos. Por el contrario, la primacía del sujeto y sus procesos de identidad y subjetividad, despreciando toda restricción estructural ha sido a su vez la respuesta a la mirada estructural. Múltiples variantes que intentan amalgamar estas posiciones extremas han visto la luz, replanteándose cada uno de ellas como la nueva solución al viejo problema y la culminación así del debate...

Expression of internal reproductive barriers in a germplasm bank accession of the wild potato Solanum chacoense Bitter in three ex situ regeneration cycles Poulsen Hornum, Anabela; Camadro, Elsa Lucila Wild potatoes (Solanum sp.) are important reservoirs of desirable genes for potato breeding. Most of them are diploid and obligate outcrossers, with both sexual and asexual reproduction. Samples of natural populations are ex situ conserved as accessions in germplasm banks for basic and applied ends, and are regenerated when seed number, seed viability or both decrease. The possible action of within accession internal reproductive barriers is not considered in the current seed regeneration protocols, in which 20 to 25 plants are cultivated for the crossing work. Notwithstanding, the effective number of progenitors (Ne) in every seed regeneration cycle might be reduced in relation to the real number (N) of plants if internal reproductive barriers were acting; this process can eventually lead to gene erosion. To ascertain if Ne = N in seed regeneration of one randomly provided accession of S. chacoense Bitter, pollen viability and size, plus pollen-pistil relationships and number and type (according to endosperm development) of seeds/fruit were studied, respectively, at the individual plant and genotypic combination levels. Two types of barriers, pre-zygotic (pollen-pistil self- and cross-incompatibility) and post-zygotic (male sterility and inviability and weakness of F1 hybrids) were detected in three growing seasons, indicating that not all genotypes in this accession made an equal allele contribution to the next generation. These results should be an alert for germplasm bank curators of wild potatoes and other crop wild relatives. Since the objective of germplasm banks is the ex situ maintenance of the natural genetic diversity, strategies need to be devised based on genetic premises.

Natural modes of the two-fluid model of two-phase flow Clausse, Alejandro; López de Bertodano, Martín A physically based method to derive well-posed instances of the two-fluid momentum transport equations from first principles is presented. The basic tools used in this endeavor are the variational principles of field theory, namely, the Hamilton principle and the virtual power principle. The state of the two-fluid flow is represented by the superficial velocity and the drift flux, instead of the average velocities of each fluid. This generates the conservation equations of the two principal motion modes naturally: the global center-of-mass flow and the relative velocity between fluids. Well-posed equations can be obtained by modeling the storage and exchange of kinetic energy in fluctuations structures induced by the interaction between fluids, like wakes and vortexes. In this way, the equations can be regularized without losing in the process the kinetic instabilities responsible for flow-patterns formation and transition. A specific case of vertical air-water flow is analyzed showing the capability of the present model to predict the formation of the slug flow regime as a train of solitons.

Problemáticas urbano ambientales en torno a la expansión urbana en el Partido de La Plata, Buenos Aires, Argentina Rodriguez Tarducci, Rocio; Cortizo, Daniela Ethel; Frediani, Julieta Constanza El proceso de urbanización territorial muchas veces con escasa planificación y casi sin regulación por parte del Estado, produce transformaciones que impactan directamente sobre el uso y cobertura del suelo. En el Partido de La Plata, Buenos Aires, Argentina, el avance urbano residencial y la ocupación de suelo sobre áreas no urbanizables en el sector periurbano se intensificaron durante los últimos años, con el incremento de problemáticas urbano ambientales perjudiciales para el territorio y población. El objetivo de esta publicación consiste en analizar algunas de las problemáticas urbano ambientales más relevantes actuales producto de la expansión y ocupación del suelo, y las consecuencias que podrían ocasionarse a futuro si no se toman las medidas que incluyan la regulación y planificación urbana. La metodología se plantea principalmente a través del análisis de la cartografía temática y el cruce de los datos y variables existentes. Los resultados de la investigación demuestran la complejidad de los procesos territoriales, así como la necesidad de conocer y estudiar en profundidad estas cuestiones para pensar en posibles estrategias de abordaje del territorio al momento de planificar el crecimiento de la ciudad, con el fin de promover ciudades más sustentables y justas.

Fusarium tricinctum associatted with Head Blight on barley in Argentina: pathogenicity and potential degradation of different hordein fractions Martínez, Mauro; Dinolfo, María Inés; Nogueira, María Soledad; Stenglein, Sebastian Alberto The objective of the present work was to evaluate the pathogenicity of Fusarium tricinctum in barley and to determine the potential effects on grain quality, more specifically regarding the hordein fractions. For this purpose, Koch´s postulates were carried out to evaluate the pathogenicity of F. tricinctum in barley, under greenhouse conditions. Furthermore, the ability of F. tricinctum to degrade hordeins was tested by a sequential extraction method, and separated by polyacrilamide gel electrophoresis (SDS-PAGE). Finally, the relative abundance of each hordein fractions (D, C, and B-hordeins) was measured. The results demonstrated that F. tricinctum was pathogenic when barley spikes were inoculated, also showing that F. tricinctum could degrade barley C-hordeins by 21.80% of the total C-hordein content.

Assessment of lignocellulosic residues from Northern Patagonian Andes (Argentina) for cultivation of Pleurotus ostreatus Roggero Luque, Juan Manuel; Rugolo, Maximiliano; Rajchenberg, Mario; Barroetaveña, Carolina This work evaluated mycelial growth rate (Kr) and fruiting of two Pleurotus ostreatus commercial strains (A01, 129) on formulations composed of lignocellulosic residues from farming and agroindustry of Northern Patagonian Andes, and of woody materials from invasive plants. Rosehip fluffs (RF), rosehip woodchips (RWC), southern beech wood shavings (SBWS), wheat straw (WS), and willow woodchips (WWC) were used as base substrates, and brewing bagasse (BB) as an alternative supplement to wheat bran (WB). Kr was higher in WS-WB and WS-BB for both strains. Experiments in fruiting chambers showed biological efficiencies (BEs) above 40% in WS-BB (both strains) and WS-WB (strain 129). Formulations using RWC or WWC gave BEs under 40%, while those composed of SBWS or RF showed lower Kr and contamination by moulds. Medium-scale fruiting experiments using strain A01 showed the highest BEs in WS-BB and RWC-WB. These results suggest that WS is the best substrate for Pleurotus ostreatus culture, although scarce in Northern Patagonian Andes. Nevertheless,WWC and RWC are suggested as alternative substrates, while BB is cheap and abundant, suitable as an alternative supplement to WB.

Performance evaluation of Baermann techniques: the quest for developing a microscopy reference standard for the diagnosis of Strongyloides stercoralis Gelaye, Woyneshet; Williams, Nana Aba; Kepha, Stella; Messa Junior, Augusto; Fleitas, Pedro Emanuel; Marti Soler, Helena; Damtie, Destaw; Menkir, Sissay; Krolewiecki, Alejandro Javier; Van Lieshout, Lisette; Enbiale, Wendemagegn Background: Soil-transmitted helminths (STH) are common in low and middle income countries where there is lack of access to clean water and sanitation. Effective diagnosis and treatment are essential for the control of STH infections. However, among STH parasites, Strongyloides stercoralis is the most neglected species, both in diagnostics and control strategies. Diagnostic methods cover different approaches, each with different sensitivities and specificities, such as serology, molecular techniques and microscopy based techniques. Of the later, the Baermann technique is the most commonly used procedure. In the literature, several ways have been described to perform the Baermann method, which illustrates the overall lack of a ‘(gold) reference standard’ method for the diagnosis of S. stercoralis infection. In this study we have evaluated the performance of three Baermann techniques in order to improve the reference standard for the microscopic diagnosis of S. stercoralis infection thereby facilitating individual case detection, mapping of the disease and proper evaluation of treatment responses. Methods/Principal findings: A community based cross sectional study was conducted at Zenzelima, Bahir Dar Zuria Ethiopia. A total of 437 stool samples were collected and analyzed by the following procedures: conventional Baermann (CB), modified Baermann (MB), and modified Baermann with charcoal pre-incubation (MBCI). The diagnostic sensitivity and Negative Predictive Value (NPV) of each technique was calculated using the combination of all the three techniques as a composite reference standard. Our result indicated that larvae of S. stercoralis were detected in 151 (34.6%) stool samples. The prevalence of S. stercoralis infection based on the three diagnostic methods was 9.6%, 8.0%, and 31.3% by CB, MB, and MBCI respectively. The sensitivity and NPV for CB, MB, and MBCI were 26.7% and 70.8%, 22.1% and 69.6%, and 87.0% and 93.2%, respectively. The MBCI showed significant difference (P- value = <0.001) in the sensitivity and NPV values when compared with CB and MB values. The agreement between CB, MB, and MBCI with the composite reference standard was 31.8%, 26.7%, 89.6%, respectively. Conclusion/Significance: Our results suggest the superior performance of MBCI. It is relatively easy to implement, simple to perform and comparatively cheaper. The CB is by far the commonly used method in routine diagnostic although this technique significantly underestimates the true burden of the disease and thereby contributing to the exclusion of S. stercoralis from the control strategies. Therefore, MBCI is recommended as a routine microscopy-based diagnostic test for S. stercoralis infection, particularly in settings where molecular procedures are not available.

Alfabetización genética y adaptación psicológica en adolescentes con enfermedades genéticas; Genetic literacy and psychological adaptation in adolescents with genetic diseases; Alfabetização genética e adaptação psicológica em adolescentes com doenças genéticas Ortega, Javiera; Vázquez, Natalia; Arberas, Claudia Liliana Introducción: La convivencia con una condición genética es compleja y puede resultar limitante para el adolescente. Esta situación constituye un estresor y un factor de riesgo para la salud mental tanto del paciente como de su familia. Objetivo: Estudiar los niveles de adaptación psicológica y alfabetización genética en adolescentes con enfermedades genéticas, residentes en Argentina. Métodos: Alcance descriptivo correlacional, de diseño cuantitativo y corte transversal. El protocolo administrado consistió en un consentimiento informado, un cuestionario de datos socio-demográficos, y los instrumentos Genetic Health Literacy Screening Tool (REAL G) y Psychological Adaptation Scale (PAS). El muestreo fue intencional y la muestra fue de 68 casos. Resultados: El REAL G indicó bajos niveles de de alfabetización genética en todos sus componentes (decodificación, familiaridad, comprensión, aritmética). En cuanto a la adaptación psicológica, se encontró una M=4,02 (DE= 0.8) para la escala general y puntuaciones elevadas para todas las dimensiones. Conclusión: Los adolescentes diagnosticados con enfermedades genéticas en Argentina poseen un buen nivel de adaptación psicológica a su enfermedad, a pesar de tener bajos niveles de alfabetización genética.; Introduction: Living with a genetic condition is complex and may be limiting for the adolescent. This situation is considered a stress factor and risk factor for the mental health of both the patient and his family. Objective: To study the levels of psychological adaptation and genetic literacy in adolescents with genetic diseases residing in Argentina. Methods: Correlational and quantitative design and cross sectional scope. The protocol consisted of an informed consent, a sociodemographic data questionnaire, and the Genetic Health Literacy Screening Tool (REAL G) and Psychological Adaptation Scale (PAS) instruments. The sampling was intentional and composed by 68 cases. Results: The REAL G indicated low levels of genetic literacy in all its components (decoding, familiarity, comprehension, arithmetic). Regarding psychological adaptation, an M = 4.02 (SD = 0.8) was found for the general scale and high scores for all the dimensions. Conclusion: Adolescents diagnosed with genetic diseases in Argentina have a good level of psychological adaptation to their disease, despite having low levels of genetic literacy.; Introdução: Viver com uma condição genética é complexo e pode ser limitante para o adolescente. Essa situação é considerada um fator de estresse e fator de risco para a saúde mental tanto do paciente quanto de sua família. Objetivo: Estudar os níveis de adaptação psicológica e alfabetização genética em adolescentes com doenças genéticas residentes na Argentina. Métodos: Desenho correlacional e quantitativo e escopo transversal. O protocolo consistiu de um termo de consentimento livre e esclarecido, um questionário de dados sociodemográficos e os instrumentos da Ferramenta de Seleção de Alfabetização em Saúde Genética (REAL G) e da Escala de Adaptação Psicológica (PAS). A amostragem foi intencional e composta por 68 casos. Resultados: O REAL G indicou baixos níveis de alfabetização genética em todos os seus componentes (decodificação, familiaridade, compreensão, aritmética). Em relação à adaptação psicológica, encontrou-se M = 4,02 (DP = 0,8) para a escala geral e altos escores para todas as dimensões. Conclusão: Adolescentes diagnosticados com doenças genéticas na Argentina apresentam bom nível de adaptação psicológica à doença, apesar de apresentarem baixo nível de alfabetização genética.

Artistas plásticos y partidos comunistas: el viaje de David Alfaro Siqueiros a Montevideo y Buenos Aires en 1933 y su impacto en los debates estético-políticos; Plastic Artists and Communist Parties: David Alfaro Siqueiros’ Trip to Montevideo and Buenos Aires in 1933 and Its Impact on Aesthetic-Political Debates; Artistas plásticos e partidos comunistas: a viagem de David Alfaro Siqueiros a Montevidéu e Buenos Aires em 1933 e seu impacto nos debates estético-políticos Prado Acosta, Laura Objetivo/Contexto: el artículo indaga los vínculos entre grupos de artistas plásticos y partidos comunistas en el Cono Sur en los años treinta del siglo xx. Se toman las visitas de David Alfaro Siqueiros a Montevideo y Buenos Aires en 1933 como una vía de entrada para abordar un ‘momento intenso’ del cruce entre arte y política. La investigación se inscribe en una perspectiva de historia intelectual. Por un lado, se propone estudiar a los artistas en tanto intelectuales, debido a que formularon postulados estético-políticos tanto a través de sus obras como en escritos que reflexionaron sobre la función social del arte. Por otro lado, se analiza el entramado de ideas, contextos, dinámicas y tensiones propios de grupos artístico-intelectuales. Metodología: se pone en relieve el análisis e interpretación de fuentes primarias, tanto de obras plásticas como de escritos sobre arte, y se dialoga con bibliografía secundaria sobre historia del arte, historia del comu-nismo e historia cultural. Originalidad: el artículo sitúa a los grupos comunistas en una ‘zona’ de los campos culturales del Cono Sur. De este modo, logra percibir las articulaciones entre la pertenencia partidaria y la inserción en los circuitos artísticos, y formula una nueva mirada sobre el vínculo entre comunismo y arte en regiones en las que el comunismo no era un partido en el gobierno. Conclusiones: las visitas de Siqueiros a las metrópolis rioplatenses generaron un escenario en el que se produjo una convergencia singular entre arte y política, que, a diferencia de aquella ocurrida en los años sesenta y setenta en la región, no negó ni quebró los modos de funcionamiento del campo artístico, sino que dio una batalla por transformarlo desde adentro.; Objective/Context: the article investigates the links between groups of plastic artists and communist parties in the Southern Cone in the 1930s. The visits of David Alfaro Siqueiros to Montevideo and Buenos Aires in 1933 are taken as a gateway to address an ‘intense moment’ of the intersection between art and politics. The research adopts intellectual history as its main framework. On the one hand, it aims to study artists qua intellectuals because they formulated aesthetic-political postulates both through their works and writings that reflected on the social function of art. On the other hand, the framework of ideas, contexts, dynamics, and tensions typical of artistic-intellectual groups is analyzed. Methodology: the analysis and interpretation of primary sources is highlighted, both of visual works and writings on art, and there is a dialogue with secondary bibliography on the history of art, the history of communism, and cultural history. Originality: the article places communist groups in a ‘zone’ of the cultural fields of the Southern Cone. Thus, it captures the articulations between party membership and insertion in artistic circuits and formulates a new look at the link between communism and art in regions where communism was not a ruling party. Conclusions: Siqueiros’ visits to the Rio de la Plata metropolises generated a scenario in which a singular convergence between art and politics took place, which, unlike that which occurred in the 1960s and 1970s in the region, did not deny or break the modes of operation of the artistic field, but fought a battle to transform it from within.; Objetivo/Contexto: este artigo indaga os vínculos entre grupos de artistas plásticos e partidos comunistas no Cone Sul nos anos trinta do século XX. São consideradas as visitas de David Alfaro Siqueiros a Montevidéu e a Buenos Aires em 1933 como uma via de entrada para abordar um ‘momento intenso’ do cruzamento entre arte e política. Esta pesquisa está inscrita em uma perspectiva de história intelectual. Por um lado, propõe-se a estudar os artistas enquanto intelectuais, devido a que formularam princípios estético-políticos tanto por meio de suas obras quanto de seus textos, que refletiram sobre a função social da arte. Por outro, analisam-se a rede de ideias, os contextos, as dinâmicas e as tensões próprios de grupos artístico-intelectuais. Metodologia: destacam-se a análise e a interpretação de fontes primárias, tanto de obras plásticas como de textos sobre arte, e dialoga-se com a bibliografia secundária sobre história da arte, história do comunismo e história cultural. Originalidade: este artigo situa os grupos comunistas em uma ‘zona’ dos campos culturais do Cone Sul; desse modo, consegue perceber as articulações entre o pertencimento partidário e a inserção nos circuitos artísticos, além de formular uma visão sobre o vínculo entre comunismo e arte em regiões nas quais o comunismo não era um partido no governo. Conclusões: as visitas de Siqueiros às metrópoles rio-platenses geraram um cenário no qual se produziu uma convergência singular entre arte e política, que, à diferença da ocorrida nos anos sessenta e setenta na região, não negou nem rompeu os modos de funcionamento do campo artístico, mas sim contribuiu para transformá-lo a partir de dentro.

MageC2 protein is upregulated by oncogenic activation of MAPK pathway and causes impairment of the p53 transactivation function Pascucci, Franco Andrés; Ladelfa, Maria Fatima; Toledo, Maria Fernanda; Escalada, Micaela Carolina; Suberbordes, Melisa del Valle; Monte, Martin Normal-to-tumor cell transition is accompanied by changes in gene expression and signal transduction that turns the balance toward cancer-cell phenotype, eluding by different mechanisms, the response of tumor-suppressor genes. Here, we observed that MageC2, a MAGE-I protein able to regulate the p53 tumor-suppressor, is accumulated upon MEK/ERK MAPK activation. Overexpression of H-RasV12 oncogene causes an increase in MageC2 protein that is prevented by pharmacologic inhibition of MEK. Similarly, decrease in MageC2 protein levels is shown in A375 melanoma cells (which harbor B-RafV600E oncogenic mutation) treated with MEK inhibitors. MageC2 protein levels decrease when p14ARF is expressed, causing an Mdm2-independent upregulation of p53 transactivation. However, MageC2 is refractory to p14ARF-driven downregulation when H-RasV12 is co-expressed. Using MageC2 knockout A375 cells generated by CRISPR/CAS9 technology, we demonstrated the relevance of MageC2 protein in reducing p53 transcriptional activity in cells containing hyperactive MEK/ERK signaling. Furthermore, gene expression analysis performed in cancer-genomic databases, supports the correlation of reduced p53 transcriptional activity and high MageC2 expression, in melanoma cells containing Ras or B-Raf driver mutations. Data presented here suggest that MageC2 can be a functional target of the oncogenic MEK/ERK pathway to regulate p53.