miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga de Lella Ezcurra, Ana Laura; Bertolin, Agustina Paola; Kim, Kevin; Katz, Maximiliano Javier; Gándara, Lautaro; Misra, Tvisha; Luschnig, Stefan; Perrimon, Norbert; Melani, Mariana; Wappner, Pablo Cellular and systemic responses to low oxygen levels are principally mediated by Hypoxia Inducible Factors (HIFs), a family of evolutionary conserved heterodimeric transcription factors, whose alpha- and beta-subunits belong to the bHLH-PAS family. In normoxia, HIFα is hydroxylated by specific prolyl-4-hydroxylases, targeting it for proteasomal degradation, while in hypoxia the activity of these hydroxylases decreases due to low oxygen availability, leading to HIFα accumulation and expression of HIF target genes. To identify microRNAs required for maximal HIF activity, we conducted an overexpression screen in Drosophila melanogaster, evaluating the induction of a HIF transcriptional reporter. miR-190 overexpression enhanced HIF-dependent biological responses, including terminal sprouting of the tracheal system, while in miR-190 loss of function embryos the hypoxic response was impaired. In hypoxic conditions, miR-190 expression was upregulated and required for induction of HIF target genes by directly inhibiting the HIF prolyl-4-hydroxylase Fatiga. Thus, miR-190 is a novel regulator of the hypoxia response that represses the oxygen sensor Fatiga, leading to HIFα stabilization and enhancement of hypoxic responses.

Potent inhibition of Western Equine Encephalitis virus by a fraction rich in flavonoids and phenolic acids obtained from Achyrocline satureioides Sabini, Maria Carola; Cariddi, Laura Noelia; Escobar, Franco Matias; Mañas, Fernando Javier; Comini, Laura Raquel; Iglesias, Delvis; Larrauri, Mariana; Núñez Montoya, Susana Carolina; Sereno, José; Contigiani, Marta Silvia; Cantero, Juan Jose; Sabini, Liliana Ines Achyrocline satureioides (Lam.) DC. Asteraceae, -marcela del campo-, possess several pharmacologicalproperties. Previously we reported antiviral activity of an aqueous extract of A. satureioides against analphavirus, Western Equine Encephalitis virus. Alphaviruses are highly virulent pathogens which causeencephalitis in humans and equines. There are no effective antiviral to treat its infections. The aim ofthis study was to evaluate in vitro cytotoxic and antiviral activities against Western Equine Encephalitisvirus of five water extract chromatographic fractions from A. satureioides and identify the main com-pounds of the bioactive fraction. Also, it was to assess in vivo cytogenotoxic ability of the active fraction.Cytotoxicity studies revealed low toxicity of the most of fractions in Vero and in equine peripheral bloodmononuclear cells. Antiviral studies showed that the water crude extract - Sephadex LH 20 - fraction 3MeOH-H2O (Fraction 3) was active against Western Equine Encephalitis virus with Effective Concentra-tion 50% = 5 g/ml. Selectivity Indices were 126.0 on Vero and 133.6 on peripheral blood mononuclearcells, four times higher than aqueous extract selectivity index. Regarding the mechanism of action wedemonstrated that F3 exerted its action in intracellular replication stages. Further, fraction 3 showedimportant virucidal action. Fraction 3 contains, in order of highest to lowest: chlorogenic acid, luteolin,5,7,8-trimethoxyflavone, 3-O-methylquercetin and caffeic acid. Fraction 3 did not induce in vivo toxicnor mutagenic effect. Therefore, it is safe its application as antiviral potential. Further studies of antiviralactivity in vivo will be developed using a murine model.

Temporal and spatial changes in soil micronutrients in managed Nothofagus pumilio forest of Tierra del Fuego, Argentina Mansilla, Paula Romina; Nóvoa Muñoz, Juan Carlos; Pontevedra Pombal, Xabier; Pancotto, Veronica Andrea; Gómez Aarmesto, Antía; Escobar, Julio Martin; Moretto, Alicia Susana Soil organic components are important factors in the quality and productivity of forest ecosystems. Timber harvesting reduces plant cover and the amount of organic matter in forest floor layer, increases surface runoff, soil erosion and alters microclimatic conditions over large areas. These changes can have important implications for nutrient cycling dynamics and soil organic matter mineralization. Fueguian temperate forests of Nothofagus pumilio (lenga) have been intensely harvested for the last decades, mainly by shelterwood-cut silvicultural system. Harvesting removes nutrients contained in logs from the site, modifies light, temperature and soil humidity, constraining nutrient cycling process. In this study, we evaluate available copper (Cua), zinc (Zna), iron (Fea), and manganese (Mna) concentrations and reservoirs in stands that represent a chronosequence and their respective primary forests (controls): stands cut 1 year ago, stands cut 5–10 years ago, and stands harvested more than 50 years ago. Concentrations of Zna and Cua in primary forest were 39.9 and 2.6 mg/kg, and increased in harvested sites to 60.5 and 3.2 mg/kg, respectively. Fea and Mna concentrations showed similar ranges in both harvested and control sites. Recent harvested sites showed the highest Cua concentrations. Micronutrient reservoirs showed similar ranges in both harvested and primary forests. We concluded that micronutrient availability changes at short term after forest harvesting; thus, the inclusion of soil fertility assessment in forest management plans should be incorporated to preserve the fertility of lenga forests soils and ensure sustainability.

Franz Fanon y la Subalternidad: Un relato teórico y político de Oto, Alejandro José La escritura de Frantz Fanon se revela como una cantera de ideas y desarrollos producidos en el periodo de la descolonización de mediados del siglo xx que se acerca con un vocabulario diferente al problema de la subalternidad. Lejos de un abordaje filológico del concepto, se presenta aquí una aproximación al problema que pacta con los contextos, la política y la historia. Desde esa perspectiva, los textos de Fanon son activos participantes de la discusión de los problemas de la subjetividad en el colonialismo y de los procesos descolonizadores. De este modo pretendo conectar su escritura con nuestra memoria epistémica poscolonial.; Frantz Fanon’s writing is revealed as a quarry of ideas and developments occurred during the period of decolonization of mid-twentieth century which  produces a different vocabulary about the problem of subalternity. Far from a  philological approach of the concept, what I am dealing here is about contexts, politics and history. Thus, I consider Fanon’s texts are active participants into the ongoing discussion onsubjectivity both in colonial and decolonial processes. Furthermore, I try to link such a discussion to our postcolonial epistemic memory.

Análisis comparativo sobre trabajo rural en la forestoindustria, las semilleras y la fruticultura (Argentina 2008-2011) Mastrangelo, Andrea Veronica; Trpin, Verónica Este artículo analiza transversalmente estudios de caso sobre el trabajo rural en la Argentina entre 2008 y 2011 en unidades de producción de capital concentrado: fruticultura en el Alto Valle de Río Negro, forestación en el NO de Misiones y producción de semillas de maíz transgénico en la Zona Núcleo Cerealera. La metodología aplicada fue la etnografía multisitio. Para el análisis que se presenta en este artículo se aplicó el método comparativo, que permitió establecer continuidad entre los casos sobre la base de tres estrategias empresariales: la reducción de puestos de trabajo clásico distinguiendo producción y servicios; la ambientalización de las relaciones laborales y territorios diferenciados para la producción, y el trabajo y la residencia de los trabajadores.; This paper is based on case studies done among 2008-2011, on rural labor in concentrated investments. Economic sectors studied were fruticulture in Rio Negro Upper Valley, forestry in Misiones NW, and transgenic corn seeds in Buenos Aires North. Methodology was multisited ethnography searching on different actors’ point of view. Techniques applied were in field deep interviews and participant observation. Secondary analysis by comparative method shown in this paper allows us to point out three continuity issues: Enterprises strategy to discern between “production” and “services”, reduces classic employment positions. The environmentalization of labor relationship happens by means of quality management and total quality proceedings. This relationship link work (understood as “well done job”) with productivity growth. There are different territories one related with production, the other with work and workers dwelling.

Un modelo para comprender la dinámica de los territorios rurales: El caso de la Argentina; A model for understanding the dynamics of rural territory: The case of Argentina Sili, Marcelo Enrique Los territorios rurales de América Latina, y de la Argentina en particular, han sufrido cambios profundos en lasúltimas décadas producto de transformaciones en materia productiva, demográfica y social. Los cambios soncomplejos y han dado lugar a una multiplicidad de miradas y de enfoques sobre la nueva realidad. Frente a estacreciente complejidad, se plantea la construcción de un modelo interpretativo de la realidad rural de la Argentinaque bien puede contribuir también para abordar las realidades de otros mundos rurales latinoamericanos. Elmodelo conceptual que se ofrece se construyó a partir del análisis empírico de numerosos casos de territoriosrurales de la Argentina. Dicho modelo permite comprender los complejos procesos de organización y la dinámicarural, además de constituirse en una herramienta de prognosis para la definición de políticas públicas acordesque alienten nuevas dinámicas de desarrollo rural en la Argentina.; Over the past few decades, rural territories in Latin America and in Argentina in particular have undergone profound changes as a result of production, demographic and social transformations. Changes have been complex and originated a multiplicity of approaches and points of view on the new reality. Giving this increasing complexity, the construction of a model for the interpretation of Argentina’s rural reality is proposed here, which may well contribute too to address other rural realities of Latin America. This conceptual model has been built on the basis of the empirical analysis of numerous case studies in rural territories of Argentina. The model helps to understand the complex processes of rural organization and dynamics, besides constituting itself as a prognosis tool for the definition of public policies promoting new dynamics of rural development in Argentina.

Regulación génica del sistema lactocina Lac705. Aplicación en un sistema cárneo modelo Aristimuño Ficoseco, Maria Cecilia En el presente trabajo de Tesis se determinó que los niveles de lasbacteriocinas lactocina Lac705 y antilisteria AL705, producidas por Lactobacillus curvatus CRL705, varíandurante las fases de crecimiento del microorganismo y la temperatura de incubación:a 30ºC, mientras los niveles de AL705 se detectan a partir de estadios tempranosy se incrementan conforme avanza el crecimiento exponencial, los niveles deLac705 son detectables principalmente al final de la fase exponencial ycomienzos de la fase estacionaria. Los resultados de expresión de lospromotores divergentes del operón lactocina Lac705 sugieren un controlpost-transcripcional negativo a 39◦C. Los estudios bioinformáticos permitieronidentificar la presencia de los operones sakp/q y sakt/x en el cromosoma de Lb. curvatus CRL705. Los sistemas detransporte ABC en ambos operones serían inactivos: en el operón sakp/q por lapresencia de una secuencia IS de la familia IS30, y en el operón sakt/x por lapresencia de una secuencia IS y de dos fragmentos extra de ADN no caracterizados.La mayor identidad entre las proteínas ABC, peptidasas y secuencias líderes delos prepéptidos fue observada entre los sistemas de lactocina Lac705 y sakacinaSakPQ. Los resultados sugieren que la actividad antilisteria AL705 seríaatribuible a SakP. A pesar del reordenamiento genético y la pérdida de funciónobservada en los operones sakp/q y sakt/x de Lb. survatus CRL705, los mismos muestran una identidad >97% en sussecuencias nucleotídicas con operones similares presentes en otras cepas de Lb. sakei y Lb. curvatus, lo que indica que estos genes tienen un origen comúny que se diseminan permanentemente. Un aporte muy importante de este trabajo deTesis es haber definido las condiciones experimentales para el curado de losplásmidos naturalmente presentes en Lb.curvatus CRL705. La frecuencia de pérdida del plásmido pRC18 fue del 3-5% a39ºC; la gran estabilidad de este plásmido se atribuyó a la presencia de los operones  Lac705 y toxina-antitoxina (TA). Secaracterizó el sistema TA como un sistema ?híbrido? organizado en un operón queproduce una antitoxina de 92 aminoácidos (aa), miembro de la superfamiliaYefM/Phd, y una toxina de 118 aa, de la superfamilia RelE. El sistema TAcontribuye a una mayor sensibilidad a la bacteriocina Lac705 y al antibióticobacitracina en células susceptibles. Nuestro modelo propone que el receptorpara lactocina Lac705 es la proteína de membrana UppP, fosfatasa responsable dela defosforilación del undecaprenil-pirofosfato (Upp), compuesto esencial en labiosíntesis del péptido-glicano. Los fenotipos observados en la cepa Sac7, hipersensiblea Lac705, podrían explicarse por niveles aumentados de UppP en la misma. UppPactuaría como nexo entre el complejo toxina-antitoxina y el estrés generado porla unión de Lac705 a la fosfatasa o de la bacitracina a Upp; esto llevaría a unadegradación de la antitoxina dejando libre la toxina libre, la cual ejercerá suefecto tóxico a nivel intracelular. Así, el efecto de lactocina Lac705 seríapotenciado por la activación de la toxina del sistema TA, lo que ejercería unapotente presión selectiva contra células curadas de pRC18.

En una reunión de trabajo se presentaron las principales líneas de financiamiento de proyectos de desarrollo de tecnología para pequeñas y medianas empresas.

Charlas informativas sobre nuevas convocatorias del Fondo Tecnológico Argentino (FONTAR).

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOft) anuncia los resultados del proceso de evaluación para la convocatoria Becas Jóvenes Profesionales TIC 2015 mediante Resolución de Directorio N°116/16.

El Fondo Fiduciario de Promoción de la Industria del Software (FONsoft) anuncia los resultados del proceso de reconsideración para la convocatoria ANR FONSOFT 2014 C2 mediante Resolución de Directorio N°115/16.

El Fondo Fiduciario de Promoción de la Industria del Software (FONSOFT) anuncia los resultados del proceso de reconsideración para la convocatoria ANR Empresa Joven FONSOFT 2015 C1 mediante Resolución de Directorio N°114/16.

Los Museos De Montaña De Reinhold Messner Identidad, Turismo Y Sustentabilidad En Los Alpes De Sud Tirol Ceruti, Maria Constanza El presente trabajo describe un conjunto de museos de montaña emplazados en los Alpes Orientales y las Dolomitas, analizando su vinculación con la educación para la sustentabilidad, la identidad, el patrimonio cultural y el turismo en Sud Tirol. Se aborda la inserción de los Museos de Montaña en el paisaje tirolés teniendo en cuenta su emplazamiento y su importancia en el desarrollo sustentable de las comunidades que los albergan. La museografía y las colecciones se analizan en función de su papel en la construcción de la identidad regional y en la educación para la valoración y preservación del patrimonio cultural y natural de la montaña, tanto a escala local como universal. Para la realización de esta investigación la autora recorrió seis establecimientos que forman la red de los Messner Mountain Museum (MMM) y mantuvo entrevistas con su director, el Sr. Reinhold Messner, considerado por muchos como el más destacado alpinista de la historia.; This paper describes a group of mountain museums set amidst the Eastern Alps and the Dolomites, considering their significance for the cultural identity, heritage education and sustainable tourism in South Tirol. The importance of the Mountain Museums is analyzed in connection to their setting and to the development of the communities in the area. The exhibits are analyzed considering their role in the construction of a regional identity and in the education towards the appreciation and preservation of the natural and cultural heritage of mountains, locally and worldwide. For the purpose of this research, the author visited the six buildings belonging to the net of the Messner Mountain Museum and she conversed with the director, Mr. Reinhold Messner, who is often credited as the most remarkable alpinist in history.

La marca Viva Jujuy! Construcción de la identidad gráfica de una provincia turística; Brand Viva Jujuy! Representations and graphic identity of a touristy province Bergesio, Liliana del Carmen; Scalone, Lucía Beatriz La marca Viva Jujuy! actualmente representa, en términos gráficos, a la provincia de Jujuy (noroeste de Argentina) y es utilizada por la Secretaría de Turismo y Cultura de la Provincia en todas sus apariciones en los medios de comunicación. Su surgimiento se remite a una convocatoria de un concurso impulsado por esta misma Secretaría como paso primordial para la instalación de sus destinos turísticos en el marco de la postulación de la región de la Quebrada de Humahuaca como Patrimonio de la Humanidad ante la Organización de las Naciones Unidas para la Educación, la Ciencia y la Cultura (UNESCO).En este trabajo se describirá el proceso por el cual se seleccionó este isologotipo para luego realizar un análisis técnico/formal que permita comprender a esta marca en su complejidad en tanto producto cultural. De manera complementaria se analizan las representaciones e imaginarios que distintos actores sociales construyen en torno a la identidad gráfica de la provincia. Para ello, se realizaron encuestas semiestructuradas a turistas y pobladores de Jujuy que procuran cubrir distintos grupos etarios, sexuales, de niveles de instrucción, lugares de residencia y relación vincular con la actividad turística, para así poder reconocer cuáles son los rasgos identificatorios que distintos sectores provinciales, nacionales e internacionales destacan para Jujuy.; The brand Viva Jujuy! currently represents graphically to the province of Jujuy (northwestern Argentina) and it is used by the Ministry of Tourism and Culture of the Province in all its appearances in the mass media. Its origin refers to a launching for a competition by the same Secretary as a fundamental step for the installation of its touristy destinations in the context of the application of the region of the Quebrada de Humahuaca as a World Heritage Site to the United Nations Educational, Scientific and Cultural Organization (UNESCO). This paper will describe the process by which this isologotype was selected to carry out a technical/formal analysis that allows the understanding of the brand in its complexity as a cultural product. Complementarily, we analyze representations and imaginary that different social actors build around the graphic identity of the province. To achieve this, semi-structured surveys were conducted among tourists and residents of Jujuy seeking to cover different ages, sex groups, levels of instruction, places of residence and relationship link with tourism, in order to recognize what the identifying the identifying features that different sectors provincial, national and international stand to Jujuy.

Primer reporte de Sweet potato leaf curl virus en las provincias de Córdoba y Santiago del Estero de Argentina Martino, Julia Andrea; Di Feo, Liliana del Valle; Rodríguez-Pardina, Patricia Elsa La superficie con batata en Argentina experimentó notable reducción, causada por virosis que ocasionan daños en todas las regiones productoras, debido al intercambio indiscriminado de material de propagación y consiguiente ingreso de virus antes no citados, tales como los begomovirus de batata (sweepovirus), recientemente caracterizados en Bella Vista, Corrientes. En este trabajo, se analizaron secuencias parciales del genoma de dos aislamientos del Centro de Argentina, con las de uno previamente caracterizado en nuestro país (Bella Vista) y con las de otros begomovirus citados globalmente. Ambos aislamientos mostraron 97-99% de identidad de nucleótidos con Sweet potato leaf curl virus, de Bella Vista (JQ349087.1), por lo que según lo establecido por el International Committee on Virus Taxonomy (ICTV), ambos pertenecen a la misma raza. Sin embargo, es la primera vez que se caracteriza a este patogéno en la provincia de Córdoba y Santiago del Estero, Argentina; por lo que este trabajo es un aporte al esclarecimiento del complejo panorama de virosis en cultivo de batata en nuestro país.; The surface with sweet potato in Argentina experienced a significant reduction produced by an important loss of yield due to virus diseases. The introduction of virus, such as sweepoviruses (sweet potato begomoviruses), is generally caused by the indiscriminate exchange of propagation material between different regions. In this paper we analyzed partial sequences of the genome of two begomovirus isolates collected in the Central región of Argentina. These sequences were compared with those of one previously characterized in our country (Bella Vista) (JQ349087.1), and with other begomoviruses cited globally. Both isolates showed 97-99% homology with Sweet potato leaf curl virus, Bella Vista, so that according to what is established by the International Committee on Virus Taxonomy (ICTV), both isolates belong to the same strain. However, this is the first time that this pathogen is characterized in Cordoba and Santiago del Estero, Argentina; so this work is a contribution to the elucidation of the complex panorama of viruses in of sweet potatoes crops in our country.

Evolution of the electronic structure during the epitaxial growth of Au on Pt(100) Bengió, Silvina; Walczak, Łukasz; Vobornik, Ivana; Segovia, Pilar; Michel, Enrique G. We report an angle-resolved photoemission study of the electronic structure of Au layers grown epitaxially on Pt(100) in the coverage range 1-10 monolayers (ML). Our results include an analysis of the electronic band structure and the Fermi surface, combined with structural information from low-energy electron diffraction. The Au films grow epitaxially with a (1 × 1) pattern up to 4-5 ML. We monitor the electronic band structure near the surface X¯-point vs. Au coverage. In the 1-3 ML range we observe interface electronic states related to the formation of a Au-Pt alloy in this coverage range. Starting at 2-3 ML coverage, we identify quantum well states from the incipient Au sp band, which converge into a bulk like Au sp band near 6 ML. After 5-6 ML, a (1 × 7) pattern is observed, due to the formation of a surface reconstruction in the epitaxial Au film with a topmost hexagonal layer, as in the reconstruction of bulk Au(100). We identify specific electronic states of quasi-one-dimensional character coming from the corrugated hexagonal layer. We obtain a complete picture and understanding of the electronic structure of Au/Pt(100), including sp Au band formation, hybridization and electronic confinement, and with implications in the understanding of the distinct electronic behavior of Au layers and particles in the nm size range.

Algunas relaciones entre el holismo de la confirmación y el holismo semántico:Estudio de caso; Some Relations between the Confirmation Holism and Semantic Holism: A Case Study Ginnobili, Santiago La tesis del holismo de la confirmación aparece por primera vez presentada de manera explícita y extensa en los escritos de Duhem. Años después, es defendida por Quine, pero no en base a la discusión de teorías científicas particulares, sino en relación con su posición semántica. Desde entonces las relaciones entre el holismo semántico y el holismo de la contrastación han sido discutidas, aunque generalmente de un modo algo despegado del análisis de teorías específicas y sus relaciones. Pretendo mostrar a partir del análisis de un caso, el de las relaciones entre la genética de poblaciones y la teoría de la selección natural, un sentido en el que el holismo de la confirmación puede ser derivado del holismo semántico.; The thesis of the confirmation holism appears for the first time explicitly and extensively in the writings of Duhem. Years later, it is defended by Quine, but not based on the discussion of particular scientific theories, but in relation to its semantic position. Since then, the relations between semantic holism and confirmation holism have been discussed, although generally somewhat detached from the analysis of specific theories and their relations. I intend to show from the analysis of a case, that of the relations between population genetics and the theory of natural selection, a sense in which the holism of confirmation can be derived from semantic holism.

Ca(II) and Ce(III) homogeneous alginate hydrogels from parent alginic acid precursor: a structural study Sonego, Juan Manuel; Santagapita, Patricio Roman; Perullini, Ana Mercedes; Jobbágy, Matías Alginate hydrogels are suitable for the encapsulation of biomolecules and microorganisms for the building of bioactive materials. Several alternatives to the conventional alginate formulation are being studied for a broad range of biotechnological applications; among them the crosslinking of alginate by lanthanide cations, Ln(III), envisages expanded biomedical applications. The performance of these functional materials is highly related to the microstructure of the alginate matrix, which in turn is affected by the conditions of synthesis. In particular, when a diffusing gradient of the crosslinking cation is involved, microstructure inhomogeneities are expected at the macroscopic level. Here we discuss the subtle differences in the microstructure, as assessed by SAXS (Small Angle X-ray Scattering), established in the direction of the gradient of diffusion of Ca(II) or Ce(III).

Formation of volatile compounds, peptidolysis and carbohydrate fermentation by mesophilic lactobacilli and streptoccocci cultures in a cheese extract Peralta, Guillermo Hugo; Wolf, Irma Veronica; Perotti, Maria Cristina; Bergamini, Carina Viviana; Hynes, Erica Rut Many studies about influence of Lactococcus lactis on cheese flavour have been reported, while the impact of mesophilic lactobacilli and Streptococcus thermophilus, either as single or mixed cultures, have been less studied. The ability of Lactobacillus paracasei 90, Lb. casei 72 (INLAIN collection) and Streptococcus thermophilus 2 (commercial strain) to produce flavour-related biochemical changes, as single or mixed (lactobacilli + streptococci) cultures, was assessed in a cheese model. These three strains, with different activities of glutamate dehydrogenase (GDH) and aminotransferases (AT), were incubated (14d/37 ºC) alone or in mixed cultures in a cheese model consisting of a sterile extract of a fresh cheese. Mesophilic lactobacilli showed fermentation of carbohydrates, an increase of peptidolysis and production of volatile compounds that were correlated with their AT activities. In addition, thesestrains also produced completely different profiles of the amino acceptor compounds: pyruvate and α-ketoglutarate. S. thermophilus 2 increased the level of α ketoglutarate due to its high GDH activity, but its ontribution to flavour compound production was negligible; Virtually no small additional hanges existed when S. thermophilus 2 was mixed with the lactobacilli. Biochemical changes leading to flavour formation were mainly due to the activity of lactobacilli. Our results suggest hat the AT profile and the peptidolytic activity of each strain influenced the volatilome of the extracts during incubation. So, both lactobacilli strains could be used as adjunct cultures in cheeses to increase/diversify the flavour, but more studies are needed to deepen the knowledge about the potential of S. thermophilus 2 for the production of flavour compounds.

A new algorithm for epilepsy seizure onset detection and spread estimation from EEG signals Antonio Quintero, Rincón; Pereyra, Marcelo Fabián; D'Giano, Carlos; Batatia, Hadj; Risk, Marcelo Appropriate diagnosis and treatment of epilepsy is a main public health issue. Patients suffering from this disease often exhibit different physical characterizations, which result from the synchronous and excessive discharge of a group of neurons in the cerebral cortex. Extracting this information using EEG signals is an important problem in biomedical signal processing. In this work we propose a new algorithm for seizure onset detection and spread estimation in epilepsy patients. The algorithm is based on a multilevel 1-D wavelet decomposition that captures the physiological brain frequency signals coupled with a generalized gaussian model. Preliminary experiments with signals from 30 epilepsy crisis and 11 subjects, suggest that the proposed methodology is a powerful tool for detecting the onset of epilepsy seizures with his spread across the brain.