Emergent networks in fractional percolation Es el algoritmo que se usó para la siguiente publicación: Valdez, Lucas D., and L. A. Braunstein. "Emergent networks in fractional percolation." Physica A: Statistical Mechanics and its Applications 594 (2022): 127057.

Rearranging Marital Settlement Agreements post-pandemics; Revisión de los acuerdos económicos post divorcio ante la crisis Gonzalez, Eliana Mabel Los efectos de la pandemia pueden medirse no sólo por su impacto directo en la salud de la población, sino también por sus efectos colaterales. Este trabajo examina el posible impacto de la crisis en los acuerdos económicos post divorcio. La pandemia pudo haber provocado que la situación económica de las partes haya cambiado drásticamente, incluso en algunos casos de forma permanente, desencadenando un incumplimiento de estos acuerdos. Incluso pueden haberse modificado las circunstancias que habían sido tenidas en cuenta por las partes o por los jueces para atribuir algunos derechos. Por ello, nos preguntamos si los acuerdos que contemplan previsiones económicas post divorcio podrían ser revisados. Si bien el legislador argentino ha previsto expresamente que el convenio homologado o la decisión judicial puedan ser revisados si la situación se ha modificado sustancialmente (Art.440), la diferente naturaleza jurídica de cada uno de los dispositivos (alimentos, atribución del uso de la vivienda, compensaciones económicas, distribución de bienes, etc.) amerita un tratamiento diferenciado. Entre los recursos que nos ofrece el Derecho Privado Argentino vigente, destacamos la posibilidad de aplicar la Teoría de la imprevisión, cuando la prestación a cargo de al menos una de las partes se ha tornado excesivamente onerosa por una alteración extraordinaria de las circunstancias. Por esta vía podría obtenerse la resolución del convenio o tal vez su reajuste. Son tiempos difíciles, y requieren de la mejor predisposición de todos para pensar soluciones creativas y temporarias, en términos de necesidades y posibilidades, atendiendo a las circunstancias excepcionales que pueden estar atravesando las partes, sobre todo los más vulnerables. En este contexto, es esencial crear un clima colaborativo; pero también que la mala conducta de las partes durante la crisis sea duramente sancionada. Finalmente, un criterio que no puede soslayarse es el impacto desproporcionado de la crisis en sujetos vulnerables (mujeres, niños, adultos mayores, etc.), que siempre deberá inclinar la balanza en favor de su protección.; The effects of the pandemic can be measured not only by its direct impact on the health of the population, but also by its collateral effects. This paper examines the possible impact of the crisis on marital settlement agreements. The pandemic might have caused personal financial situations to change dramatically, some permanently, which could be the trigger of contract breach. Also, the lockdown might have modified the circumstances that have been taken into account by the parties when making those agreements. We therefore wonder if these agreements could be reviewed. The Argentinian legislator has provided that an approved agreement or even a judicial decision can be reviewed if the situation has changed substantially (Article 440 Argentinian Civil and Commercial Code). However, the different legal nature of these financial provisions (alimony, child support, attribution of the use of the marital home, economic compensation, property distribution, etc.) forces us to adopt a differentiated approach. Among the legal tools offered by our Private Law, we highlight the possibility of applying the ‘Theory of Unpredictability’ which takes place when the contractual duties have become excessively onerous due to an extraordinary alteration of the circumstances. As a result, the contract could be renegotiated (which would permit its continuation), or terminated. During these difficult times, it is essential to find creative solutions, taking into account the exceptional circumstances the parties may be going through (especially the most vulnerable) and their needs and possibilities. It is vital to build a collaborative climate; but also, that the misconduct of the parties during the crisis is severely punished. Finally, a criterion that cannot be ignored is the disproportionate impact of the crisis on vulnerable individuals (women, children, elderly, etc.), which must always tip the balance in favor of their protection.

Izquierda y derecha peronista como categorías de análisis o los 34 días de disputa institucional en torno a la Universidad de Buenos Aires, 1974; Peronist Left and Peronist Right as Analytic Categories or 34 Days of Institutional Disputes around the University of Buenos Aires, 1974 Friedemann, Sergio Martín El artículo contribuye al debate acerca de la pertinencia de las categorías de izquierda y derecha para abordar los conflictos intraperonistas de los 60/70 en Argentina. A través de fuentes orales y escritas, se analizan las disputas en torno a las políticas universitarias entre la Universidad de Buenos Aires y el Poder Ejecutivo Nacional a poco de comenzar el gobierno de Isabel Perón. Asimismo, se observan posiciones moderadas, centristas o con pretensión de equidistancia, concluyendo que izquierda y derecha peronista resultan categorías válidas como polos de un continuum más que como expresiones dicotómicas y excluyentes, aún en un contexto de polarización y competencia centrífuga.; This paper contributes to the debate on the pertinence of the categories of Left and Right to address the conflicts within Peronist factions in Argentina during the seventies. Through oral and written sources, it analyzes the disputes on higher education policies between the University of Buenos Aires and the National Executive Power shortly after the beginning of Isabel Perón’s government. Additionally, moderates, centrists, and so claimed equidistant positions are observed, concluding that Left and Right Peronism are valid categories as poles of a continuum rather than as dichotomous and mutually exclusive expressions, even in a context of polarization and centrifugal competition within the party.

Testing the monophyly of Chaetarthriinae (Coleoptera, Hydrophilidae) and the phylogenetic position of Guyanobius with larval characters Archangelsky, Miguel; Rodriguez, Valeria Georgina; Torres, Patricia Laura Maria The subfamily Chaetarthriinae includes morphologically distinct larvae that are adapted to a diversity of environments. Based on larval characters, cladistic analyses (maximum parsimony (MP) and Bayesian inference (BI) with homoplasy as a partitioning scheme) were performed to test the monophyly of the subfamily and the relationships of the two tribes included in it: Chaetarthriini and Anacaenini. The chaetotaxy of a third instar larva Guyanobius adocetus is described and illustrated in detail, including morphometric characters. This larva is compared to those of the known larvae of the tribe Chaetarthriini belonging to the genus Chaetarthria, and Pseudorygmodus, Crenitis, and Crenitulus from Anacaenini. None of the unconstrained analyses recover Chaetarthriinae as monophyletic. Chaetarthria diverges in an early branch, probably due to a series of unique morphological modifications associated with a riparian lifestyle whereas Guyanobius appears closely related to Anacaenini. Two alternative positions of Guyanobius are revealed: (1) as sister of all Anacaenini (unconstrained MP) or (2) nested within Anacaenini as sister of Crenitis + Crenitulus (constrained MP and unconstrained BI). The genera Paracymus and Tormus (tribe Laccobiini) diverge as two successive branches subordinate to Chaetarthriinae (excluding Chaetarthria) in the unconstrained MP analysis. However, the support is rather weak, and the position of Paracymus and Tormus is an artifact produced by some homoplastic characters. In this regard, homoplasy partitioning resulted a useful technique to solve some artifacts generated by convergent morphologies.

Mathematical models for rescheduling Ecuador's 2020 professional football league season disrupted by COVID-19 Duran, Guillermo Alfredo; Guajardo, Mario; zamorano, gonzalo The year 2020 saw the world turned upside down by the coronavirus pandemic. Countless human activities were suspended or cancelled as the virus spread across the globe. In this paper, we show how the regular season matches of Ecuador's professional football league were rescheduled due to the disruption caused by the pandemic. As with many others, this league had to reschedule its remaining games to fit within in a much shorter period of time than originally planned. To address this problem, we developed two mathematical models that designed new match calendars. The first one, a round assignment model, rescheduled the various rounds in the season still to be played while the second one, a day assignment model, took the solutions of the first model as input to assign the matches within each round to specific days. The implementation of our models secured a well-balanced number of days off before each match across all of the teams. Also, it enabled the league to conclude a full season without cancelling any matches or changing the schedule format, unlike what occurred in many other leagues, and won the approval of all stakeholders including league officials, players, team coaches, the TV broadcaster and fans.

Algunos apuntes acerca de la controversial relación teórica entre comunicación audiovisual y narración; Some Notes about the Controversial Theoretical Relationship between Audiovisual Communication and Narrative Figueredo, Mauro Horacio En este trabajo nos proponemos trazar algunas reflexiones exploratorias en el campo de la comunicación audiovisual. Nos interesa, particularmente, deconstruir la indisoluble relación entre la «matriz narrativa» y los «distintos dispositivos audiovisuales» que performan las gramáticas tecnoperceptivas. En otras palabras, buscamos repensar las continuas discontinuidades, es decir, el «lazo» y la «diferencia» de la comunicación audiovisual con la narración.; This paper attempts to draw some exploratory reflections within the field of audiovisual communication. We are particularly interested in a deconstruction of the indissoluble relationship between the “narrative matrix” and the “different audiovisual devices” that perform techno-perceptive grammars. In other words, we expect to rethink the continuous discontinuities configurating both the nexus and the difference between the audiovisual communication and the narrative.

Core and strongly core orthogonal matrices Ferreyra, David Eduardo; Malik, Saroj B. In this paper we define two new concepts for a pair of complex square matrices of the index at most 1, the core orthogonal pair and strongly core orthogonal pair. The relationship between core orthogonality (resp. strong core orthogonality) and associated projectors of a pair of matrices is established. Using the core commutativity of two matrices of the index at most 1, a characterization of strongly core orthogonal matrices is also provided. We give several sufficient conditions under which a given pair of matrices is core orthogonal (resp. strongly core orthogonal). A canonical form for a pair of core orthogonal (resp. strong core orthogonal) matrices is developed to obtain characterizations of core orthogonality (resp. strongly core orthogonality). The properties of core orthogonality, strong core orthogonality, core additivity, and rank additivity are studied and their possible interrelationships are discussed. Further, connections of each one of these with the core partial order are also investigated.

Peces fósiles de Monte Bolca (Verona, Italia) en el Museo de Ciencias Naturales y Antropológicas “Profesor Antonio Serrano”, Paraná, Provincia de Entre Ríos, Argentina; Fossil fishes from Monte Bolca (Verona, Italy) at the Museum of Natural and Anthropological Sciences “Prof. Antonio Serrano”, Paraná, Entre Ríos Province Bogan, Sergio; Agnolin, Federico; Ibargoyen, Graciela María En esta contribución se busca visibilizar un conjunto de fósiles procedentes de la conocida localidad fosilífera de Monte Bolca, Verona, Italia. El conjunto forma parte del patrimonio paleontológico que resguarda el Museo de Ciencias Naturales y Antropológicas “Prof. Antonio Serrano” de Paraná, Entre Ríos. Los materiales fueron adquiridos del Museo Cívico de Verona por el Dr. Joaquín Frengüelli y fueron donados al Museo durante las primeras décadas del siglo XX, probablemente en la década de 1920, en el lapso en el que Frengüelli dictó clases de Geología y Paleontología en la Facultad de Ciencias de la Educación de la Universidad Nacional del Litoral en la ciudad de Paraná. Esta colección se compone de 19 piezas, 6 de las cuales corresponden a restos de peces y 13 son restos vegetales. Los materiales cuentan con sus etiquetas originales y números establecidos por el Museo Cívico de Verona. En el trabajo buscamos destacar el conjunto de peces. De la revisión de los materiales surge que el conjunto se integra únicamente por teleósteos y todos proceden del Eoceno de Bolca, de igual forma en la colección se conservan varias improntas de vegetales típicos de este sitio. El análisis del conjunto permitió separar algunos fósiles de vegetales que proceden de otra localidad del norte de Italia: Chiavon sitio de Vicenza que data del Oligoceno medio. A lo largo del texto se busca destacar la figura de Frengüelli, especialmente en su etapa inicial de trabajo científico en Paraná y buscamos trasmitir el valor histórico que presentan los materiales, sumando la importancia paleontológica que representan los fósiles de peces de Monte Bolca en un contexto general.; In this contribution, we seek to make visible a set of fossils from the well-known fossiliferous locality of Monte Bolca, Verona, Italy. The set is part of the paleontological heritage that protects the Museum of Natural and Anthropological Sciences “Prof. Antonio Serrano” of Paraná, Entre Ríos. The materials were acquired from the Civic Museum of Verona by Dr. Joaquín Frengüelli and were donated to the Museum during the first decades of the 20th century, probably in the 1920s, during the period in which Frengüelli teach Geology and Paleontology at the Educational Sciences Faculty, Universidad Nacional del Litoral in Paraná city. This collection is made up of 19 pieces, 6 of which correspond to fish remains and 13 are plant remains. The materials had their original labels and numbers established by the Civic Museum of Verona. In this work, we seek to highlight this set of fish. From the review of the materials, it emerges that the group is made up only of teleosts and all of them come from the Eocene of Bolca. Likewise, several plant imprints typical of this site are preserved in the collection. The analysis of the assemblage made it possible to separate some fossil plants that come from another locality in northern Italy: the Chiavon site of Vicenza, dating from the middle Oligocene. Throughout the text, we seek to highlight the figure of Frengüelli, especially in his initial stage of scientific work in Paraná, and we seek to convey the historical value that the materials present, added to the paleontological importance that the fish fossils of Monte Bolca represent in a general context.

Habilidad competitiva de cultivares comerciales de trigo pan de la Argentina Figueruelo, Andrea Mariana; Dillchneider Loza, Alexandra; Porta Siota, Fernando; Funaro, Daniel Oscar La habilidad competitiva es la capacidad de una especie de capturar recursos limitantes cuando crece en mezclas con otras especies y puede variar por las condiciones ambientales. La competitividad de los diferentes cultivares de trigo es una herramienta que contribuye con el manejo de malezas en sistemas de bajos insumos. Mediante el índice de agresividad (IA), durante el año 2020 fueron evaluados, en INTA EEA Anguil, 21 cultivares comerciales de trigo pan (Triticum aestivum L.), tomando como especiecompetidora a Avena sativa L. (cv. Florencia INTA). El diseño utilizado fue en franjas con tres repeticiones en bloques para cada tratamiento: (i) trigo, (ii) trigo + avena, (iii) avena. La siembra fue el 5 de julio del 2020 a una densidad de 220 y 180 pl m-2 para trigo y avena, respectivamente. Se midió la biomasa seca en dos momentos fenológicos, macollaje (Z2.3) y a cosecha (Z9) y se calculó el IA en ambos estados (IAm y IAc respectivamente). El IAm presentó valores entre 0,08 y 0,57 sin diferencias significativas entre los cultivares evaluados. El IAc varió entre -0,45 y 0,68. Cedro y MS INTA 119 fueron los cultivares menos competitivos y presentaron diferencias con el resto de los cultivares, sin presentar diferencias entre sí. Se destacan con mayor habilidad competitiva K. Serpiente, K. Mercurio, K. 100 años, K. Liebre, ACA 365, Buck Bellaco, Lapacho, SY 211, Buck Peregrino, Guayabo y Buck Destello con valores de IAc> 0,3. El IAc explicó el 65% de la variabilidad en el rendimiento relativo en granos.; Competitive ability is the capacity of a spe - cies to capture limiting resources when it grows in mixtures with other species and can vary due to environmental conditions. The competitiveness of the different wheat cultivars is a tool that contributes to the man - agement of weeds in low-input systems. Us - ing the aggressiveness index (AGR), during the year 2020, 21 commercial cultivars of bread wheat (Triticum aestivum L.) were evaluated in INTA EEA Anguil, taking as a competing species Avena sativa L. (cv. Florence INTA). The design used was in strips with three replications in blocks for each treatment: (i) wheat, (ii) wheat + oats, (iii) oats. Planting was on July 5, 2020 at a density of 220 and 180 pl m-2 for wheat and oats, respectively. Dry biomass was measured at two phenological moments, potting (Z2.3) and harvest (Z9) and ai was calculated in both states (AGRm and AGRc respectively). The AGRm presented values between 0.08 and 0.57 without significant differences between the cultivars evaluated. The AGRc ranged from -0.45 to 0.68. Cedro and MS INTA 119 were the least competi - tive cultivars and presented differences with the rest of the cultivars, without presenting differences between them. Stand out with greater competitive hability K. Serpiente, K. Mercurio, K. 100 years, K. Liebre, ACA 365, Buck Bellaco, Lapacho, SY 211, Buck Peregrino, Guayabo and Buck Flash with values of AGRc> 0.3. The AGRc explained 65% of the variability in relative yield in grains.

Efecto del 17α-etinilestradiol (EE2) como perturbador endócrino reproductivo en el pez Aequidens metae; Effect of 17α-ethinylestradiol (EE2) as a reproductive endocrine disruptor in the fish Aequidens metae Pahí Rosero, Ana María; Velasco Santamaría, Yohana María El 17α-etinilestradiol (EE2) es un esteroide sintético que interfiere en el sistema endócrino reproductivo de los peces. En este estudio se evaluó el efecto del EE2 como posible perturbador endócrino en hembras y en machos adultos de Aequidens metae expuestos a 0.5, 5, 50 y 250 ng/L por 21 días. Se incluyó un testigo negativo (C) y un testigo con solvente (etanol) (CE). Finalizada la exposición al EE2, la sangre fue colectada para determinar calcio y fósforo plasmático y en las gónadas e hígado se evaluaron los índices somáticos y las alteraciones histológicas. Los índices gonadosomático y hepatosomático no presentaron diferencias significativas. A nivel histológico, en los ovarios se encontró congestión, fibrosis intersticial, apoptosis, atresia y material vitelogénico. A nivel testicular, se observó acumulación de material de melanomacrófagos, degeneración testicular, fibrosis intersticial, atrofia y engrosamiento de la pared intersticial. Y en hígado, en ambos sexos, se observó mayor picnosis degenerativa, activación de macrófagos, apoptosis, infiltraciones, dilatación y congestión, en comparación con los grupos testigo. Las hembras no presentaron diferencias significativas en calcio y fósforo plasmático. Los machos expuestos a las tres concentraciones más altas tuvieron valores significativamente mayores en el calcio plasmático en comparación con el grupo testigo. Con respecto al fósforo plasmático, en los machos expuestos a 250 ng/L se presentaron diferencias en comparación con el grupo testigo. Estos resultados permiten inferir que esta especie es sensible a los efectos de la perturbación endocrina generados por el EE2, y que la determinación de parámetros bioquímicos como los iones de calcio y fósforo pueden ser usados como biomarcadores adicionales del estado de salud de los peces expuestos a xenobióticos.; The 17α-ethinylestradiol (EE2) is a synthetic steroid that interferes with the reproductive endocrine system of fish. This study evaluated the effect of EE2 as a possible endocrine disruptor in adult Aequidens metae females and males exposed to 0.5, 5, 50, and 250 ng/L for 21 days. Negative control and solvent control (ethanol) were included. After exposure, blood was collected to determine plasma calcium and phosphorus, and somatic indices and histology changes were evaluated in the gonads and liver. The gonadosomatic and hepatosomatic indices did not present significant differences. At histological level, congestion, interstitial fibrosis, apoptosis, atresia, and vitellogenic material were found in the ovary. At the testicular level, accumulation of melanomacrophage material, testicular degeneration, interstitial fibrosis, atrophy and thickening of the interstitial wall were observed. In the liver, in both sexes, was observed greater degenerative pyknosis, activation of macrophages, apoptosis, infiltrations, dilatation and congestion compared with the control groups. Females did not show significant differences in plasma calcium and phosphorus between treatments. The males exposed to the three highest EE2 concentrations had significantly higher values in plasma calcium compared to control group. Regarding plasma phosphorus, in males exposed to 250 ng/L there were differences compared to control groups. The results allow inferring that this species is sensitive to endocrine disruption effects generated by EE2 and that the determination of biochemical parameters such as plasma calcium and phosphorus ions can be used as additional biomarkers of the health status of fish exposed to xenobiotics.

Sobre la presencia de Coridromius chenopoderis Tatarnic & Cassis, 2008 (HEMIPTERA: HETEROPTERA: MIRIDAE) en la Argentina; On the presence of Coridromius chenopoderis Tatarnic y Cassis, 2008 (HEMIPTERA: HETEROPTERA: MIRIDAE) in Argentina Carpintero, Diego Leonardo; Holgado, Miriam M.; de Magistris, Alberto Antonio Se cita por primera vez para la Argentina a la especie Coridromius chenopoderis (Tatarnic y Cassis) (Heteroptera: Miridae: Orthotylinae: Coridromiini). Se muestran imágenes de ejemplares colectados y se dan sus caracteres diagnósticos. Se comenta brevemente la importancia de la aparición de esta especie en el país.; The species Coridromius chenopoderis (Tatarnic and Cassis) (Heteroptera: Miridae: Orthotylinae: Coridromiini) is recorded for the first time for Argentina. Images of collected specimens are shown and their diagnostic characters are given. The importance of the appearance of this species in the country is briefly commented.

Metaecología: Integrar para trascender; Metaecology: Integrating for Transcendence Herrera, Lorena Paola A lo largo de la historia de la humanidad, el ser humano ha experimentado una profunda desconexión con la naturaleza de la cual forma parte. Como consecuencia, los problemas ambientales y la pérdida de biodiversidad a nivel global han ido en aumento. Aquí proponemos el término metaecologia como una forma de comprender los procesos que involucran a la relación de los seres vivos entre si y con su entorno desde un lugar más integral, global y espiritual. Este nuevo concepto promueve que es posible “deconstruir” muchas de nuestras bases, buscar el denominador común que relaciona la ecología con “la” vida y “nuestra” vida para transcender nuestros planteamientos y actitudes en el cotidiano hacia el bien común.; Over the course of history, human beings have experienced a profound disconnection from the nature of which they form part. As a consequence, environmental problems and the global loss of biodiversity have increased. Here we suggest the term “metaecology” as a way of understanding processes that involve the relationships between living things and with their environment through a more comprehensive, global and spiritual approach. This new concept argues that it is possible to “deconstruct” many of our foundations, find the common denominator that unites ecology with “life” —“our life—to transcend our everyday approaches and attitudes toward the common good.

Obtaining xylitol by hydrolysis-hydrogenation of liquors derived from sugarcane bagasse Cerioni, Julieta Lucia; Vallejos, María Evangelina; Felissia, Fernando Esteban; Area, Maria Cristina; Nichio, Nora Nancy; Santori, Gerardo Fabian This work presents the study of heterogeneous catalysis of sugarcane bagasse hydrothermal treatment spent liquors using a sulfonated resin. Besides, results were compared with those obtained by a conventional route using sulfuric acid as a homogeneous catalyst. Heterogeneous catalysis is suitable for the hydrolysis of sugarcane bagasse hydrothermal liquors under mild conditions (100 °C and 6 h). The obtained maximum xylose yield was 82% due to furfural formation, which causes a xylose selectivity drop. The hydrogenation of this xylose-rich liquor at 100 °C and 3 MPa of hydrogen pressure employing a supported Ni/γ-Al2O3 produced the total conversion of xylose with a selectivity towards xylitol of 100% by using a catalyst to xylose mass ratio of 0.5. Heterogeneous catalysis in a two-step route (hydrolysis and hydrogenation) constitutes an outstanding alternative to producing xylitol from sugarcane bagasse hydrothermal spent liquors since materials can be easily separated and reused in several reaction cycles.

Cambrian trilobites from the Glossopleura walcotti Zone (Miaolingian Series, Wuliuan Stage) of Mendoza, western Argentina Tortello, Marcelo Franco he Museo de La Plata houses numerous Miaolingian and Furongian fossils from the southern Precordillera of Mendoza, western Argentina, collected by Ángel V. Borrello during the 1960s. Early Miaolingian (Wuliuan) trilobites from these collections are described herein. The specimens studied come from allochthonous limestone blocks (San Isidro Olistoliths) of key fossiliferous localities of the San Isidro area (Cerro Martillo, Quebrada Oblicua, Quebrada Empozada, Quebrada San Isidro). Taxa comprise Athabaskia anax (Walcott), Glossopleura leona Lochman, Kootenia aff. K. incerta (Rusconi), Kootenia crassa Fritz, Oryctocephalites reynoldsi (Reed), Zacanthoides sp., Spencia? sp., Amecephalus normale? (Resser), Amecephalus laticaudum? (Resser), and Amecephalus sp. This assemblage is representative of the North American Glossopleura walcotti Zone, and closely allied to faunas from the Great Basin (Spence Shale), Sonora, and to a lesser extent from northwestern Idaho.

¿Renace un ícono en Mar del Plata? Procesos de renovación urbana: Caso Hotel Royal; Is an icon reborn in mar del plata? urban renewal processes: Case Royal Hotel Bertolotti, Florencia Lucia El presente artículo exhibe los resultados principales de una investigación realizada en el marco de una tesina de grado, centrada en el estudio de caso de renovación urbana de la manzana del ex Hotel Royal, ahora complejo residencial-comercial Royal Park, en Mar del Plata, Argentina (período 2016-2020). A través de un estudio de índole cualitativo, y desde categorías analíticas de la sociología urbana, el trabajo muestra cómo se materializan las lógicas del capital en un área fundacional, central y estratégica de la ciudad. La particularidad que subyace en esta transformación es la condición de abandono que perduró durante más de tres décadas ininterrumpidas a pesar de la impronta histórica y emblemática iniciales del hotel, evidenciando, por un lado, cómo para que exista un proceso de renovación urbana de gran escala, es necesario que se inter-relacionen los intereses privados a lógicas mercantiles, pero también a la esfera pública. Por otro, el modo en que las estrategias de los sectores dominantes se expresan en la configuración urbana, generando impactos sobre el uso del suelo y la vivienda.; This article exhibits the main results of a research carried out within the framework of a degree thesis, focused on the case study of urban renewal of the block of the former Royal Hotel, now a Royal Park residential-commercial complex, in Mar del Plata, Argentina (period 2016-2020). Through a qualitative study, and from analytical categories of urban sociology, the work shows how the logics of capital materialize in a foundational, central and strategic area of the city. The particularity that underlies this transformation is the condition of abandonment that lasted for more than three uninterrupted decades despite the initial historical and emblematic imprint of the hotel, evidencing, on the one hand, how for there to be a process of largescale urban renewal, it is necessary that private interests are inter-related to commercial logics, but also to the public sphere. On the other hand, the way in which the strategies of the dominant sectors are expressed in the urban configuration, generating impacts on land use and housing.

Depletion of Mannose Receptor–Positive Tumor-associated Macrophages via a Peptide-targeted Star-shaped Polyglutamate Inhibits Breast Cancer Progression in Mice Lepland, Anni; Malfanti, Alessio; Haljasorg, Uku; Asciutto, Eliana Karina; Pickholz, Mónica Andrea; Bringas, Mauro; Đorđević, Snežana; Salumäe, Liis; Peterson, Pärt; Teesalu, Tambet; Vicent, María J.; Scodeller, Pablo Although many studies have explored the depletion of tumor-associated macrophages (TAM) as a therapeutic strategy for solid tumors, currently available compounds suffer from poor efficacy and dose-limiting side effects. Here, we developed a novel TAM-depleting agent (“OximUNO”) that specifically targets CD206+ TAMs and demonstrated efficacy in a triple-negative breast cancer (TNBC) mouse model. OximUNO comprises a star-shaped polyglutamate (St-PGA) decorated with the CD206-targeting peptide mUNO that carries the chemotherapeutic drug doxorubicin (DOX). In the TNBC model, a fluorescently labeled mUNO-decorated St-PGA homed to CD206+ TAMs within primary lesions and metastases. OximUNO exhibited no acute liver or kidney toxicity in vivo. Treatment with OximUNO reduced the progression of primary tumor lesions and pulmonary metastases, significantly diminished the number of CD206+ TAMs and increased the CD8/FOXP3 expression ratio (indicating immunomodulation). Our findings suggest the potential benefit of OximUNO as a TAM-depleting agent for TNBC treatment. Importantly, our studies also represent a novel design of a peptide-targeted St-PGA as a targeted therapeutic nanoconjugate.

Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation Holubiec, Mariana Ines; Romero, Juan Ignacio; Urbainsky, Claudia; Gellert, Manuela; Galeano, Pablo; Capani, Francisco; Lillig, Christopher Horst; Hanschmann, Eva Maria Nucleoredoxin (Nrx) belongs to the Thioredoxin protein family and functions in redox-mediated signal transduction. It contains the dithiol active site motif Cys-Pro-Pro-Cys and interacts and regulates different proteins in distinct cellular pathways. Nrx was shown to be catalytically active in the insulin assay and recent findings indicate that Nrx functions, in fact, as oxidase. Here, we have analyzed Nrx in the mammalian retina exposed to (perinatal) hypoxia-ischemia/reoxygenation, combining ex vivo and in vitro models. Our data show that Nrx regulates cell differentiation, which is important to (i) increase the number of glial cells and (ii) replenish neurons that are lost following the hypoxic insult. Nrx is essential to maintain cell morphology. These regulatory changes are related to VEGF but do not seem to be linked to the Wnt/β-catenin pathway, which is not affected by Nrx knock-down. In conclusion, our results strongly suggest that hypoxia-ischemia could lead to alterations in the organization of the retina, related to changes in RPE cell differentiation. Nrx may play an essential role in the maintenance of the RPE cell differentiation state via the regulation of VEGF release.

Aves de Montiel Reales, César Fabricio; Jordan, Emilio Ariel; Lapido, Rocío; Mancini, Jeremías Aunque estrictamente no sea una selva, los viajeros naturalistas del siglo XIX así la bautizaron cuando conocieron su enorme extensión y espesura. En el centro-norte de la provincia de Entre Ríos, la Selva de Montiel ocupaba aproximadamente un tercio del territorio entrerriano y encerraba pequeños poblados, generando una rica historia ambiental y cultural. Sin embargo, el avance de la frontera agropecuaria produjo una drástica reducción, quedando relictos aislados del centro-norte y centro-oeste de Entre Ríos con distintos niveles de degradación.

Atravesar el "valle" entre el laboratorio y la sociedad: Experiencias de transferencia científico-tecnológica en Argentina durante la pandemia por COVID-19 Córdoba, María Soledad; Ferroni, Luana Noelia; Hurtado de Mendoza, María Sol; Azcurra, Karen Ailin; Smal, Clara; Munaretto, Héctor Pedro; Bilañski, Gisele Andrea; Diez, Michay; Smulski, Mariana Celeste A partir de los relatos de experiencia de los equipos de investigación que tuvieron un rol en el desarrollo de productos científico-tecnológicos para enfrentar la pandemia por el virus SARS-CoV-2, nos proponemos reflexionar sobre las dinámicas de la ciencia que se pusieron en evidencia en un contexto de emergencia del todo excepcional. Observando los modos de adaptación y respuesta a esa crisis en seis equipos de investigación, este trabajo focaliza en las expectativas, los alcances y las limitaciones de la transferencia de conocimiento y tecnología a la sociedad. Asimismo, se complejiza la noción misma de transferencia, en el marco de una política científica que impulsó la producción científico-tecnológica nacional para hacer frente a un problema de salud pública de gran impacto.; Based on the experience reports of principal investigators and graduate students who played a role in developing scientific and technological products to address the SARS-CoV-2 virus pandemic, we aim to reflect on the dynamics of science that were brought to light in an entirely exceptional emergency context. By observing the modes of adaptation and response to the crisis of six research teams, this work focuses on the expectations, scopes, and limitations of knowledge and technology transfer to society. The complexity of the notion of “transference” is analyzed within the framework of a scientific policy that promotes national scientific-technological production to deal with a public health problem of enormous impact.

In Silico Antiprotozoal Evaluation of 1,4-Naphthoquinone Derivatives against Chagas and Leishmaniasis Diseases Using QSAR, Molecular Docking, and ADME Approaches Prieto Cárdenas, Lina S.; Arias Soler, Karen A.; Nossa González, Diana Lisseth; Rozo Núñez, Wilson E.; Cárdenas-Chaparro, Agobardo; Duchowicz, Pablo Román; Gómez Castaño, Jovanny Arles Chagas and leishmaniasis are two neglected diseases considered as public health problems worldwide, for which there is no effective, low-cost, and low-toxicity treatment for the host. Naphthoquinones are ligands with redox properties involved in oxidative biological processes with a wide variety of activities, including antiparasitic. In this work, in silico methods of quantitative structure–activity relationship (QSAR), molecular docking, and calculation of ADME (absorption, distribution, metabolism, and excretion) properties were used to evaluate naphthoquinone derivatives with unknown antiprotozoal activity. QSAR models were developed for predicting antiparasitic activity against Trypanosoma cruzi, Leishmania amazonensis, and Leishmania infatum, as well as the QSAR model for toxicity activity. Most of the evaluated ligands presented high antiparasitic activity. According to the docking results, the family of triazole derivatives presented the best affinity with the different macromolecular targets. The ADME results showed that most of the evaluated compounds present adequate conditions to be administered orally. Naphthoquinone derivatives show good biological activity results, depending on the substituents attached to the quinone ring, and perhaps the potential to be converted into drugs or starting molecules.